30 Jun 21. Featured Paper
Imaging NeuroVascular, Endothelial & STructural Integrity in prepAration to TrEat Small Vessel Diseases. The INVESTIGATE-SVDs study Protocol. Part of the SVDs@Target Project.
Gordon W. Blair, Michael S. Stringer, Michael J. Thrippleton, Francesca M. Chappell, Kirsten Shuler, Iona Hamilton, Daniela Jaime Garcia, Fergus N. Doubal, Anna Kopczak, Marco Duering, Michael Ingrisch, Danielle Kerkhofs, Julie Staals, Hilde van den Brink, Tine Arts, Walter H Backes, Robert van Oostenbrugge, Geert Jan Biessels, Martin Dichgans, Joanna M. Wardlaw
Background: Sporadic cerebral small vessel disease (SVD) & cerebral autosomal dominant arteriopathy with subcortical infarcts & leukoencephalopathy (CADASIL) share clinical & neuroimaging features & possibly vascular dysfunction(s).
However few studies have included both conditions, assessed more than one vascular dysfunction simultaneously, or included more than one centre.
We will perform detailed clinical & neuropsychological phenotyping of the participants, & neuroimaging including structural MRI, cerebrovascular reactivity MRI (CVR: using carbon dioxide challenge), phase contrast MRI (arterial, venous & CSF flow & pulsatility), dynamic contrast-enhanced MRI (blood brain barrier (BBB) leakage) & multishell diffusion imaging.
Participants will measure their blood pressure (BP) & its variability over seven days using a telemetric device.
Additionally we will test feasibility of complex multisite MRI, provide reliable intermediary outcome measures & sample size estimates for future trials.
- Blood-brain barrier permeability
- Cerebral small vessel disease
- Cerebrovascular reactivity
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Featured paper: Imaging NeuroVascular, Endothelial & STructural Integrity in prepAration to TrEat Small Vessel Diseases. The INVESTIGATE-SVDs study Protocol. Part of the SVDs@Target Project.