11 Mar 21. Featured Paper
The application of optical coherence tomography angiography in Alzheimer's disease: A systematic review
Introduction: Discovering non‐invasive & easily acquired biomarkers that are conducive to the accurate diagnosis of dementia is an urgent area of ongoing clinical research.
Recently, optical coherence tomography angiography (OCT‐A) has emerged as a promising new technology for imaging the microvasculature of the retina.
Methods: A systematic review & meta‐analysis was conducted to examine the application of OCT‐A in dementia.
Results: Fourteen studies assessing OCT‐A in preclinical Alzheimer's disease (AD), mild cognitive impairment, or AD were included.
Exploratory meta‐analyses revealed a significant increase in the foveal avascular zone area & a significant decrease in superficial parafoveal & whole vessel density in AD, although there was significant heterogeneity between studies.
Discussion: Although certain OCT‐A metrics may have the potential to serve as biomarkers for AD, the field requires further standardization to allow conclusions to be reached regarding their clinical utility.
- Alzheimer's disease
- Diagnostic tool
- Foveal avascular zone
- Mild cognitive impairment
- Optical coherence tomography angiography
- Perfusion density
- Retinal imaging
- Retinal vasculature
- Vessel density
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Featured paper: The application of optical coherence tomography angiography in Alzheimer's disease: A systematic review