01 Mar 21. Featured Paper
Cerebrovascular reactivity measurement using magnetic resonance imaging: a systematic review
Cerebrovascular reactivity (CVR) magnetic resonance imaging (MRI) probes cerebral haemodynamic changes in response to a vasodilatory stimulus.
MRI allows in vivo measurement of CVR but several different methods have been presented in the literature, differing in pulse sequence, hardware requirements, stimulus & image processing technique.
We systematically reviewed publications measuring CVR using MRI up to June 2020, identifying 235 relevant papers.
We summarised the acquisition methods, experimental parameters, hardware & CVR quantification approaches used, clinical populations investigated, & corresponding summary CVR measures.
Blood oxygen level dependent (BOLD) acquisitions with fixed inspired CO2 gas or end-tidal CO2 forcing stimulus are the most commonly used methods.
General linear modelling of the MRI signal with end-tidal CO2 as the regressor is the most frequently used method to compute CVR.
Our survey of CVR measurement approaches & applications will help researchers to identify good practice & provide objective information to inform the development of future consensus recommendations.
- Arterial spin labelling MRI
- Blood oxygen-level dependent
- Cerebrovascular reactivity
- Hypercapnia (CO(2)) inhalation
- Magnetic resonance imaging
- Systematic review
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Featured paper: Cerebrovascular reactivity measurement using magnetic resonance imaging: a systematic review