11 Jun 21. Featured Paper
Diffusion-weighted imaging lesions & risk of recurrent stroke after intracerebral haemorrhage.
Kim Wiegertjes, Lynn Dinsmore, Jonathan Drever, Aidan Hutchison, Jacqueline Stephen, Maria C Valdés Hernández, Priya Bhatnagar, David P Minks, Mark A Rodrigues, David J Werring, Frank-Erik de Leeuw, Catharina JM Klijn, Rustam Al-Shahi Salman, Phillip M White, Joanna M Wardlaw
Methods: The REstart or STop Antithrombotics Randomised Trial (RESTART) assessed the effect of restarting versus avoiding antiplatelet therapy after ICH on major vascular events for up to 5 years.
Cox proportional hazards regression models were used to quantify associations.
Results: Of 537 participants in RESTART, 247 (median (IQR) age 75.7 (69.6–81.1) years; 170 men (68.8%); 120 started vs 127 avoided antiplatelet therapy) had DWI sequences on brain MRI at a median of 57 days (IQR 19–103) after ICH, of whom 73 (30%) had one or more DWI+ lesion.
During a median follow-up of 2 years (1–3), 18 participants had recurrent ICH & 21 had ischaemic stroke.
These findings provide a new perspective on the significance of DWI+ lesions, which may be markers of microvascular mechanisms associated with recurrent ICH.
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Featured paper: Diffusion-weighted imaging lesions & risk of recurrent stroke after intracerebral haemorrhage.