01 May 21. Featured Paper
Zooming in on cerebral small vessel function in small vessel diseases with 7T MRI: Rationale & design of the “ZOOM@SVDs” study.
Hilde van den Brink, Anna Kopczak, Tine Arts, Laurien Onkenhout, Jeroen C.W. Siero, Jaco J.M. Zwanenburg, Marco Duering, Gordon W. Blair, Fergus N. Doubal, Michael S. Stringer, Michael J. Thrippleton, Hugo J. Kuijf, Alberto de Luca, Jeroen Hendrikse, Joanna M. Wardlaw, Martin Dichgans, Geert Jan Biessels, SVDs@target group
Yet, specific treatment strategies are lacking in part because of a limited understanding of the underlying disease processes.
There is therefore an urgent need to study SVDs at their core, the small vessels themselves.
Methods: ZOOM@SVDs is a prospective observational cohort study with two years follow-up.
ZOOM@SVDs recruits participants with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts & Leukoencephalopathy (CADASIL, N = 20), sporadic SVDs (N = 60), & healthy controls (N = 40).
Discussion: ZOOM@SVDs will deliver novel markers of cerebral small vessel function in patients with monogenic & sporadic forms of SVDs, & establish their relation with disease burden & progression.
These small vessel markers can support etiological studies in SVDs & may serve as surrogate outcome measures in future clinical trials to show target engagement of drugs directed at the small vessels.
- Cerebral small vessel disease
- High field strength MRI
- Small vessel function
- Sporadic SVD
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Featured paper: Zooming in on cerebral small vessel function in small vessel diseases with 7T MRI: Rationale & design of the “ZOOM@SVDs” study
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