17 Nov 21. Featured Paper
Prevalence of dementia in ischaemic or mixed stroke populations: systematic review & meta-analysis
Louise Craig, Zhi Liang Hoo, Toh Zeng Yan, Joanna Wardlaw, Terence J Quinn
An understanding of the epidemiology of poststroke dementia (PSD) is necessary to inform research, practice & policy.
With increasing primary studies, a contemporary review of PSD could allow for analyses of incidence & prevalence trends.
Databases were searched using a prespecified search strategy.
Meta-regression explored the effect of year of study.
Sensitivity analyses removed low-quality or outlier studies.
Of 12 505 titles assessed, 44 studies were included in the quantitative analyses.
At 1 year, the prevalence of PSD was 18.4% (95% CI 7.4% to 38.7%) & 20.4% (95% CI 14.2% to 28.2%) with prestroke dementia included. In studies including prestroke dementia there was a negative association between dementia prevalence & year of study (slope coefficient=−0.05 (SD: 0.01), p<0.0001).
Estimates were robust to sensitivity analyses.
Declining prevalence of prestroke dementia may explain apparent reduction in PSD over time.
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Featured paper: Prevalence of dementia in ischaemic or mixed stroke populations: systematic review & meta-analysis