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11 Oct 21. Edinburgh Imaging Radiochemistry - GP1

As the Edinburgh Imaging Radiochemistry facility temporarily closes for refurbishment, we look back at the facility's success with 18F-glycoprotein 1 (GP1) radiotracers.

18F-GP1 signal is increased in regions of prosthetic valve thrombus on autoradiography (left) & microPET-CT (middle), but also on bioprosthetic valve leaflets with no CT evidence of thrombus (right)
18F-GP1 signal is increased in regions of prosthetic valve thrombus on autoradiography (left) & microPET-CT (middle), but also on bioprosthetic valve leaflets with no CT evidence of thrombus (right)

The Edinburgh Imaging Radiochemistry facility was opened in 2010 & currently houses a cyclotron with supporting radiochemistry suites to create both GMP & research PET radiotracers.

The EI Radiochemistry facility has now temporarily closed for refurbishment.

18F-GP1 is a derivative of elarofiban with a high affinity for activated platelet glycoprotein IIb & IIIa. It has promising in vivo characteristics for thrombus (clot) imaging.

Edinburgh Imaging has carried out the first cardiac & neurological applications of this imaging tracer.

The Edinburgh Imaging facilities & radiochemistry team are integral to 18F-GP1 studies, both for production of the imaging tracer in our radiochemistry as well as the groundbreaking imaging using PET-CT & PET-MR in our Edinburgh Imaging QMRI facility.

We are currently involved with three 18F-GP1 studies: 

  • Biothrombus
  • iThrombus & 
  • Myothrombus

 

 

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As the Edinburgh Imaging Radiochemistry facility temporarily closes for refurbishment, we look back at the facility's success with 18F-glycoprotein 1 (GP1) radiotracers. 

@EdinUniMedicine @EdinburghBQ