Dr Michael Thrippleton (PhD (cantab))
Clinical Scientist, Senior Research Fellow
- Centre for Clinical Brain Sciences
- Edinburgh Imaging
Contact details
- Tel: +44 (0)1314 659529
- Email: m.j.thrippleton@ed.ac.uk
Address
- Street
-
Chancellor's Building
49 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4SB
Background
After graduating with a MSci in Natural Sciences, I remained at Cambridge University to obtain a PhD in the development of novel magnetic resonance (MR) pulse sequences. During this time I developed several techniques including the Thrippleton-Keeler filter for suppression of zero-quantum coherence artefacts. Following postdoctoral research in solid-state MR at the Massachusetts Institute of Technology and the University of Glasgow, I joined the University of Edinburgh in 2008 to work with Professor Hilary Critchley on a clinical trial of MR imaging of patients with uterine fibroids.
In my current role I support a large number of academic and commercial clinical studies requiring MR imaging. In 2016 I helped to establish the Edinburgh Imaging Facility at the Royal Infirmary of Edinburgh, where I continue to provide scientific input to facility operation. My research focus is presently advanced neuroimaging in cerebral small vessel disease and other conditions, including DCE-MRI and cerebrovascular reactivity measurement.
GitHub page (including Matlab software for processing DCE-MRI, relaxometry and magnetisation transfer ratio/saturation.)
Qualifications
HCPC-registered Clinical Scientist
Chartered Scientist
Full Member, Institute of Physics and Engineering in Medicine
Full Member, International Society for Magnetic Resonance in Medicine
PhD Natural Science, University of Cambridge
M.Sci Natural Sciences (First Class), University of Cambridge
Responsibilities & affiliations
Senior Research Fellow (Centre for Clinical Brain Sciences, Dementia Research Institute)
Medical Physicist and MR Safety Expert, Edinburgh Imaging Facility (Royal Infirmary of Edinburgh)
Undergraduate teaching
"Quantitative MRI" lecture, Department of Physics
Postgraduate teaching
Neuroimaging for Research MSc
Imaging MSc
- creation of online teaching material
- tutoring, marking
Current PhD students supervised
Emilie Sleight
Cameron Manning
Alasdair Morgan
Past PhD students supervised
Yulu Shi
Anna Heye
Jehill Parikh
Research summary
My research is currently focused on the development of advanced MR imaging techniques and their application in neurological diseases.
Disease areas:
- Cerebral small vessel disease
- Multiple sclerosis
- Pre-term birth
Techniques:
- Quantitative magnetic resonance imaging of the brain
- Dynamic contrast-enhanced MRI (DCE-MRI) for probing the blood-brain barrier
- MR cerebrovascular reactivity imaging
- MR imaging of fluid flow
- MR spectroscopy and brain temperature measurement
- MR relaxometry
- Magnetisation transfer
- MR phantom development
Past research interests:
- Solution-state nuclear magnetic resonance (NMR)
- pulse sequence development
- diffusion measurement
- accelerated acquisition and artefact reduction
- Solid-state NMR of spin-half and quadrupolar nuclei
- In-vivo and ex-vivo MRI of the uterus
Knowledge exchange
Member of HARNESS initiative to disseminate and standardise neuroimaging protocols for measuring the contributions of vascular disease to dementia and neurodegeneration.
Lead, HARNESS blood-brain barrier permeability group (consensus paper, Alzherimers & Dementia)
Taskforce lead, Open Source Initiative for Perfusion Imaging (OSIPI)
Affiliated research centres
Project activity
Current clinical studies:
- Investigate-SVDs (EU-funded multi-centre imaging study of cerebral small vessel disesase)
- TREAT-SVDs (EU-funded clinical trial in cerebral small vessel disease)
- Brain Changes in Sleep Apnoea (Fondation Leducq funded imaging study of sleep apnoea)
- Mild Stroke Study 3 (MRC/Fondation Leducq funded study of cerebral small vessel disease)
- FutureMS (Scotland-wide study of relapsing-onset multiple sclerosis)
- Theirworld Edinburgh Birth Cohort
-
The prevalence of paramagnetic rim lesions in multiple sclerosis: A systematic review and meta-analysis
In:
PLoS ONE, vol. 16, pp. e0256845
DOI: https://doi.org/10.1371/journal.pone.0256845
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Selective motion artefact reduction via radiomics and k-space reconstruction for improving perivascular space quantification in brain magnetic resonance imaging
Research output: Contribution to Conference › Paper (Published) -
Relationship between inferior frontal sulcal hyperintensities on brain MRI, ageing and cerebral small vessel disease
In:
Neurobiology of Aging, vol. 106, pp. 130-138
DOI: https://doi.org/10.1016/j.neurobiolaging.2021.06.013
Research output: Contribution to Journal › Article (Published) -
Imaging NeuroVascular, Endothelial and STructural Integrity in prepAration to TrEat Small Vessel Diseases. The INVESTIGATE-SVDs study Protocol
In:
Cerebral Circulation—Cognition and Behavior
Research output: Contribution to Journal › Article (Accepted/In press) -
A Comparison of CVR Magnitude and Delay Assessed at 1.5 and 3T in Patients With Cerebral Small Vessel Disease
In:
Frontiers in physiology, vol. 12
DOI: https://doi.org/10.3389/fphys.2021.644837
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Sources of systematic error in DCE‐MRI estimation of low‐level blood‐brain barrier leakage
In:
Magnetic Resonance in Medicine
DOI: https://doi.org/10.1002/mrm.28833
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Associations Between White Matter Hyperintensity Burden, Cerebral Blood Flow and Transit Time in Small Vessel Disease: An Updated Meta-Analysis
In:
Frontiers in Neurology, vol. 12
DOI: https://doi.org/10.3389/fneur.2021.647848
Research output: Contribution to Journal › Article (Published) -
Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies
In:
Lancet Neurology, vol. 20, pp. 294-303
DOI: https://doi.org/10.1016/S1474-4422(21)00024-7
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Lacunar Stroke Lesion Extent and Location and White Matter Hyperintensities Evolution 1 Year Post-lacunar Stroke
In:
Frontiers in Neurology, vol. 12
DOI: https://doi.org/10.3389/fneur.2021.640498
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Post-stroke Cognition at 1 and 3 Years Is Influenced by the Location of White Matter Hyperintensities in Patients With Lacunar Stroke
In:
Frontiers in Neurology, vol. 12
DOI: https://doi.org/10.3389/fneur.2021.634460
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3
(8 pages)
In:
European Stroke Journal, vol. 6, pp. 81-88
DOI: https://doi.org/10.1177/2396987320929617
Research output: Contribution to Journal › Article (Published) -
Cerebrovascular Reactivity Measurement Using Magnetic Resonance Imaging: A Systematic Review
In:
Frontiers in physiology, vol. 12
DOI: https://doi.org/10.3389/fphys.2021.643468
Research output: Contribution to Journal › Article (Published) -
Diurnal brain temperature rhythms and mortality after brain injury: a prospective and retrospective cohort study
DOI: https://doi.org/10.1101/2021.01.23.21250327
Research output: › Working paper (Published) -
A four-dimensional computational model of dynamic contrast-enhanced magnetic resonance imaging measurement of subtle blood-brain barrier leakage
In:
NeuroImage, vol. 230, pp. 117786
DOI: https://doi.org/10.1016/j.neuroimage.2021.117786
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Hierarchical complexity of the macro-scale neonatal brain
In:
Cerebral Cortex
DOI: https://doi.org/10.1093/cercor/bhaa345
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Maternal cortisol is associated with neonatal amygdala microstructure and connectivity in a sexually dimorphic manner
(18 pages)
In:
eLIFE, vol. 2020, pp. 1-18
DOI: https://doi.org/10.7554/eLife.60729
Research output: Contribution to Journal › Article (E-pub ahead of print) -
4D flow MRI for non-invasive measurement of blood flow in the brain: A systematic review
In:
Journal of Cerebral Blood Flow and Metabolism, pp. 0271678X2095201
DOI: https://doi.org/10.1177/0271678X20952014
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Interleukin-8 dysregulation is implicated in brain dysmaturation following preterm birth.
In:
Brain, Behavior, and Immunity
DOI: https://doi.org/10.1016/j.bbi.2020.09.007
Research output: Contribution to Journal › Article (Published) -
A Framework for Jointly Assessing and Reducing Imaging Artefacts Automatically Using Texture Analysis and Total Variation Optimisation for Improving Perivascular Spaces Quantification in Brain Magnetic Resonance Imaging
DOI: https://doi.org/10.1007/978-3-030-52791-4_14
Research output: › Chapter (peer-reviewed) (Published) -
Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3
In:
European Stroke Journal, pp. 239698732092961
DOI: https://doi.org/10.1177/2396987320929617
Research output: Contribution to Journal › Article (Published)
Organiser
British Chapter ISMRM 2014 Meeting and Workshop