Dr Michael Thrippleton (PhD (cantab))
Clinical Scientist, Senior Research Fellow
- Centre for Clinical Brain Sciences
- Edinburgh Imaging
Contact details
- Tel: +44 (0)1314 659529
- Email: m.j.thrippleton@ed.ac.uk
Address
- Street
-
Chancellor's Building
49 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4SB
Background
After graduating with a MSci in Natural Sciences, I remained at Cambridge University to obtain a PhD in the development of novel magnetic resonance (MR) pulse sequences. During this time I developed several techniques including the Thrippleton-Keeler filter for suppression of zero-quantum coherence artefacts. Following postdoctoral research in solid-state MR at the Massachusetts Institute of Technology and the University of Glasgow, I joined the University of Edinburgh in 2008 to work with Professor Hilary Critchley on a clinical trial of MR imaging of patients with uterine fibroids.
In my current role I support a large number of academic and commercial clinical studies requiring MR imaging. In 2016 I helped to establish the Edinburgh Imaging Facility at the Royal Infirmary of Edinburgh, where I continue to provide scientific input to facility operation. My research focus is presently advanced neuroimaging in cerebral small vessel disease and other conditions, including DCE-MRI and cerebrovascular reactivity measurement.
GitHub page (including Matlab software for processing DCE-MRI, relaxometry and magnetisation transfer ratio/saturation.)
Qualifications
HCPC-registered Clinical Scientist
Chartered Scientist
Full Member, Institute of Physics and Engineering in Medicine
Full Member, International Society for Magnetic Resonance in Medicine
PhD Natural Science, University of Cambridge
M.Sci Natural Sciences (First Class), University of Cambridge
Responsibilities & affiliations
Senior Research Fellow (Centre for Clinical Brain Sciences, Dementia Research Institute)
Medical Physicist and MR Safety Expert, Edinburgh Imaging Facility (Royal Infirmary of Edinburgh)
Undergraduate teaching
"Quantitative MRI" lecture, Department of Physics
Postgraduate teaching
Neuroimaging for Research MSc
Imaging MSc
- creation of online teaching material
- tutoring, marking
Current PhD students supervised
Emilie Sleight
Cameron Manning
Alasdair Morgan
Past PhD students supervised
Yulu Shi
Anna Heye
Jehill Parikh
Project activity
Current clinical studies:
- Investigate-SVDs (EU-funded multi-centre imaging study of cerebral small vessel disesase)
- TREAT-SVDs (EU-funded clinical trial in cerebral small vessel disease)
- Brain Changes in Sleep Apnoea (Fondation Leducq funded imaging study of sleep apnoea)
- Mild Stroke Study 3 (MRC/Fondation Leducq funded study of cerebral small vessel disease)
- FutureMS (Scotland-wide study of relapsing-onset multiple sclerosis)
- Theirworld Edinburgh Birth Cohort
-
Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies
(13 pages)
In:
Lancet Neurology, vol. 18, no. 7, pp. 653-665
DOI: https://doi.org/10.1016/S1474-4422(19)30197-8
Contribution to journal › Article (Published) -
Quantifying BBB leakage in small vessel disease: review and consensus recommendations
In:
Alzheimer's & Dementia
DOI: https://doi.org/10.1016/j.jalz.2019.01.013
Contribution to journal › Article (E-pub ahead of print) -
Tolerability, safety and intermediary pharmacological effects of cilostazol and isosorbide mononitrate, alone and combined, in patients with lacunar ischaemic stroke: The LACunar Intervention-1 (LACI-1) trial, a randomised clinical trial
In:
EClinicalMedicine
DOI: https://doi.org/10.1016/j.eclinm.2019.04.001
Contribution to journal › Article (E-pub ahead of print) -
Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration
In:
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, vol. 11, pp. 191-204
DOI: https://doi.org/10.1016/j.dadm.2019.01.002
Contribution to journal › Article (E-pub ahead of print) -
MRI Relaxometry for Quantitative Analysis of USPIO Uptake in Cerebral Small Vessel Disease
In:
International Journal of Molecular Sciences, vol. 20, no. 3, pp. 776
DOI: https://doi.org/10.3390/ijms20030776
Contribution to journal › Article (E-pub ahead of print) -
Convolutional Neural Networks for Direct Inference of Pharmacokinetic Parameters: Application to Stroke Dynamic Contrast-Enhanced MRI
In:
Frontiers in Neurology, vol. 9
DOI: https://doi.org/10.3389/fneur.2018.01147
Contribution to journal › Article (E-pub ahead of print) -
Neonatal Morphometric Similarity Networks Predict Atypical Brain Development Associated with Preterm Birth
DOI: https://doi.org/10.1007/978-3-030-00755-3_6
Chapter in Book/Report/Conference proceeding › Chapter (Published) -
Characterisation of tissue-type metabolic content in Secondary Progressive Multiple Sclerosis: a Magnetic Resonance Spectroscopic Imaging study
In:
Journal of Neurology
DOI: https://doi.org/10.1007/s00415-018-8903-y
Contribution to journal › Article (E-pub ahead of print) -
Direct Estimation of Pharmacokinetic Parameters from DCE-MRI using Deep CNN with Forward Physical Model Loss
Contribution to conference › Paper (Published) -
MRI measurement of blood-brain barrier leakage: filling the gaps
In:
Journal of Physiology
DOI: https://doi.org/10.1113/JP277425
Contribution to journal › Article (Published) -
Small vessel disease is associated with altered cerebrovascular pulsatility but not resting cerebral blood flow
In:
Journal of Cerebral Blood Flow and Metabolism, pp. 0271678X1880395
DOI: https://doi.org/10.1177/0271678X18803956
Contribution to journal › Article (Published) -
How does blood regulate cerebral temperatures during hypothermia?
In:
Scientific Reports
DOI: https://doi.org/10.1038/s41598-018-26063-7
Contribution to journal › Article (Published) -
Cerebrovascular reactivity measurement in cerebral small vessel disease: rationale and reproducibility of a protocol for MRI acquisition and image processing
In:
International Journal of Stroke
DOI: https://doi.org/10.1177/1747493017730740
Contribution to journal › Article (E-pub ahead of print) -
Preventing Cognitive Decline and Dementia from Cerebral Small Vessel Disease: The LACI-1 Trial. Protocol and statistical analysis plan of a phase IIa dose escalation trial testing tolerability, safety and effect on intermediary endpoints of isosorbide mononitrate and cilostazol, separately and in combination
In:
International Journal of Stroke
DOI: https://doi.org/10.1177/1747493017731947
Contribution to journal › Article (E-pub ahead of print) -
Variance components associated with long-echo-time MR spectroscopic imaging in human brain at 1.5T and 3T
In:
PLoS ONE
DOI: https://doi.org/10.1371/journal.pone.0189872
Contribution to journal › Article (E-pub ahead of print) -
Intracranial pulsatility in patients with cerebral small vessel disease: a systematic review
In:
Clinical science
DOI: https://doi.org/10.1042/CS20171280
Contribution to journal › Article (E-pub ahead of print) -
Modelling Ischemic Stroke and Temperature Intervention Using Vascular Porous Method
Chapter in Book/Report/Conference proceeding › Conference contribution (Published) -
White matter hyperintensity reduction and outcomes after minor stroke
In:
Neurology
DOI: https://doi.org/10.1212/WNL.0000000000004328
Contribution to journal › Article (E-pub ahead of print) -
Advanced neuroimaging of cerebral small vessel disease
In:
Current Treatment Options in Cardiovascular Medicine
DOI: https://doi.org/10.1007/s11936-017-0555-1
Contribution to journal › Article (E-pub ahead of print) -
Blood-brain barrier failure as a core mechanism in cerebral small vessel disease and dementia: evidence from a cohort study
In:
Alzheimer's & Dementia, vol. 13, no. 6
DOI: https://doi.org/10.1016/j.jalz.2016.09.006
Contribution to journal › Article (Published)
Organiser
British Chapter ISMRM 2014 Meeting and Workshop