Dr Michael Thrippleton (PhD)

Senior Research Fellow, HCPC-registered Clinical Scientist

Background

Michael Thrippleton is a Senior Research Fellow and registered Clinical Scientist. He trained at Cambridge and MIT, and joined the Brain Research Imaging Centre as its Medical Physicist in 2012. Having helped to establish the Edinburgh Imaging Facility RIE, he now leads and supports magnetic resonance imaging (MRI) in a large number of clinical research studies. 

Techniques: DCE-MRI, quantitative MRI, cerebrovascular reactivity, blood flow, MR spectroscopy

Disease areas: small vessel disease, neonatal, multiple sclerosis, reproductive, healthy physiology

Citizenship

International groups

Taskforce lead, Open Source Initiative for Perfusion Imaging (OSIPI)

Contributor to STRIVE2 consensus initiative for imaging in small vessel disease

Lead, HARNESS blood-brain barrier permeability harmonisation group (consensus paper)

Task force lead, HARNESS initiative to disseminate and standardise neuroimaging protocols for measuring the contributions of vascular disease to dementia and neurodegeneration.

Open-source software

Python software for T1 measurement and DCE-MRI analysis

Matlab software for relaxometry, DCE-MRI and magnetisation transfer MRI

OSIPI DSC/DCE-MRI code collection

Research grants

2021 – 2022  Wellcome Trust-UoE ISSF award (Co-I): Investigating mechanisms of brain and cognitive development in children born preterm, £30,000

2019 – 2020  Wellcome Trust-UoE ISSF award (PI): Precision engineering of reference objects for quantitative in-vivo imaging: validation of blood-brain barrier integrity measurement, £25,000

2019 – 2021  Leducq Foundation pilot fund scheme (Co-I): Comparison of DW-ASL and DCE-MRI BBB permeability metrics in clinical and pre-clinical cerebral small vessel disease, $10,000

2017 – 2019   MRC-NIH Partnering Award (Co-I): Magnetic resonance imaging (MRI) of brain vascular changes and white matter hyperintensities (WMH) in humans, £9,442

2015 – 2017  Alzheimer’s Society Project Grant (Co-I): Preventing cognitive decline and dementia from cerebral microvascular disease, £255,385

2014 – 2015  Chief Scientist Office (Co-I): Non-invasive measurement of cerebrovascular reactivity and compliance in cerebral small vessel disease: feasibility and estimation of sample size for translational research and clinical trials, £137,420

Selected publications

Cerebrovascular Reactivity Measurement Using Magnetic Resonance Imaging: A Systematic Review. Front Physiol, 2021

Sources of systematic error in DCE-MRI estimation of low-level blood-brain barrier leakage, Magnetic Resonance in Medicine, 2021

A four-dimensional computational model of dynamic contrast-enhanced magnetic resonance imaging measurement of subtle blood-brain barrier leakage. Neuroimage, 2021.

Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendations. Alzheimers & Dementia, 2019

Blood-brain barrier failure as a core mechanism in cerebral small vessel disease and dementia: evidence from a cohort study. Alzheimers & Dementia, 2017

Tracer kinetic modelling for DCE-MRI quantification of subtle blood-brain barrier permeability. Neuroimage, 2016

Reliability of MRSI brain temperature mapping at 1.5 and 3 T. NMR in Biomedicine, 2014

Ex Vivo Water Diffusion Tensor Properties of the Fibroid Uterus at 7 T and Their Relation to Tissue Morphology. Journal of Magnetic Resonance Imaging, 2011

Satellite transitions acquired in real time by magic angle spinning (STARTMAS): "Ultrafast" high-resolution MAS NMR spectroscopy of spin I=3/2 nuclei. Journal of Chemical Physics, 2008

Thrippleton, M.J. and J. Keeler, Elimination of zero-quantum interference in two-dimensional NMR spectra. Angewandte Chemie, 2003

Studies supported (selected)

(work in progress)

Qualifications

2017    HCPC-registered Clinical Scientist

2004    PhD Natural Science, University of Cambridge

2000    M.Sci Natural Sciences (First Class), University of Cambridge

Responsibilities & affiliations

Senior Research Fellow  (Centre for Clinical Brain Sciences, Dementia Research Institute)

Medical Physicist, Edinburgh Imaging (RIE Facility)

Undergraduate teaching

Medical Physics module, Department of Physics

Postgraduate teaching

Neuroimaging for Research MSc, Imaging MSc

  • creation of online teaching material
  • tutoring, marking

Current PhD students supervised

Emilie Sleight

Cameron Manning

Alasdair Morgan

Sulaiman Sarwar

Past PhD students supervised

Yulu Shi

Anna Heye

Jehill Parikh

 

View all 86 publications on Research Explorer