Dr Michael Thrippleton

Dr Michael Thrippleton (PhD (cantab))

Clinical Scientist, Senior Research Fellow

Centre for Clinical Brain Sciences
Edinburgh Imaging

Tel: +44 (0)1314 659529
Email: m.j.thrippleton@ed.ac.uk

Street: Chancellor's Building
49 Little France Crescent
City: Edinburgh
Post code: EH16 4SB

Biography

Background

After graduating with a MSci in Natural Sciences, I remained at Cambridge University to obtain a PhD in the development of novel magnetic resonance (MR) pulse sequences. During this time I developed several techniques including the Thrippleton-Keeler filter for suppression of zero-quantum coherence artefacts. Following postdoctoral research in solid-state MR at the Massachusetts Institute of Technology and the University of Glasgow, I joined the University of Edinburgh in 2008 to work with Professor Hilary Critchley on a clinical trial of MR imaging of patients with uterine fibroids.

In my current role I support a large number of academic and commercial clinical studies requiring MR imaging. In 2016 I helped to establish the Edinburgh Imaging Facility at the Royal Infirmary of Edinburgh, where I continue to provide scientific input to facility operation. My research focus is presently advanced neuroimaging in cerebral small vessel disease and other conditions, including DCE-MRI and cerebrovascular reactivity measurement.

GitHub page (including Matlab software for processing DCE-MRI, relaxometry and magnetisation transfer ratio/saturation.)

Qualifications

HCPC-registered Clinical Scientist

Chartered Scientist

Full Member, Institute of Physics and Engineering in Medicine

Full Member, International Society for Magnetic Resonance in Medicine

PhD Natural Science, University of Cambridge

M.Sci Natural Sciences (First Class), University of Cambridge

Responsibilities & affiliations

Senior Research Fellow (Centre for Clinical Brain Sciences, Dementia Research Institute)

Medical Physicist and MR Safety Expert, Edinburgh Imaging Facility (Royal Infirmary of Edinburgh)

Teaching & PhD supervision

Undergraduate teaching

"Quantitative MRI" lecture, Department of Physics

Postgraduate teaching

Neuroimaging for Research MSc

Imaging MSc

creation of online teaching material
tutoring, marking

Current PhD students supervised

Emilie Sleight

Cameron Manning

Alasdair Morgan

Past PhD students supervised

Yulu Shi

Anna Heye

Jehill Parikh

Research

Research summary

My research is currently focused on the development of advanced MR imaging techniques and their application in neurological diseases.

Disease areas:

Cerebral small vessel disease
Multiple sclerosis
Pre-term birth

Techniques:

Quantitative magnetic resonance imaging of the brain
Dynamic contrast-enhanced MRI (DCE-MRI) for probing the blood-brain barrier
MR cerebrovascular reactivity imaging
MR imaging of fluid flow
MR spectroscopy and brain temperature measurement
MR relaxometry
Magnetisation transfer
MR phantom development

Past research interests:

Solution-state nuclear magnetic resonance (NMR)
- pulse sequence development
- diffusion measurement
- accelerated acquisition and artefact reduction
Solid-state NMR of spin-half and quadrupolar nuclei
In-vivo and ex-vivo MRI of the uterus

Knowledge exchange

Member of HARNESS initiative to disseminate and standardise neuroimaging protocols for measuring the contributions of vascular disease to dementia and neurodegeneration.

Lead, HARNESS blood-brain barrier permeability group (consensus paper, Alzherimers & Dementia)

Taskforce lead, Open Source Initiative for Perfusion Imaging (OSIPI)

Affiliated research centres

Projects

Project activity

Current clinical studies:

Investigate-SVDs (EU-funded multi-centre imaging study of cerebral small vessel disesase)
TREAT-SVDs (EU-funded clinical trial in cerebral small vessel disease)
Brain Changes in Sleep Apnoea (Fondation Leducq funded imaging study of sleep apnoea)
Mild Stroke Study 3 (MRC/Fondation Leducq funded study of cerebral small vessel disease)
FutureMS (Scotland-wide study of relapsing-onset multiple sclerosis)
Theirworld Edinburgh Birth Cohort
Circadian Brain Temperature Study

Publications

Interleukin-8 dysregulation is implicated in brain dysmaturation following preterm birth. 5 Sep 2020 In: Brain, Behavior, and Immunity
Research output: Contribution to Journal › Article (Published)
A Framework for Jointly Assessing and Reducing Imaging Artefacts Automatically Using Texture Analysis and Total Variation Optimisation for Improving Perivascular Spaces Quantification in Brain Magnetic Resonance Imaging 8 Jul 2020
DOI: https://doi.org/10.1007/978-3-030-52791-4_14
Research output: › Chapter (Published)
Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3 5 Jun 2020 In: European Stroke Journal, pp. 239698732092961
DOI: https://doi.org/10.1177/2396987320929617
Research output: Contribution to Journal › Article (Published)
Intracranial haemodynamic relationships in patients with cerebral small vessel disease May 2020 In: Neurology, vol. 94
DOI: https://doi.org/10.1212/WNL.0000000000009483
Research output: Contribution to Journal › Article (Published)
Relationship Between Venules and Perivascular Spaces in Sporadic Small Vessel Diseases 8 Apr 2020 In: Stroke
DOI: https://doi.org/10.1161/STROKEAHA.120.029163
Research output: Contribution to Journal › Article (Published)
Peak width of skeletonized water diffusion MRI in the neonatal brain 3 Apr 2020 In: Frontiers in Neurology
DOI: https://doi.org/10.3389/fneur.2020.00235
Research output: Contribution to Journal › Article (Published)
Impact of preterm birth on brain development and long-term outcome: protocol for a cohort study in Scotland 4 Mar 2020 In: BMJ Open
DOI: https://doi.org/10.1136/ bmjopen-2019-035854
Research output: Contribution to Journal › Article (Published)
Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies (13 pages) Jul 2019 In: Lancet Neurology, vol. 18, pp. 653-665
DOI: https://doi.org/10.1016/S1474-4422(19)30197-8
Research output: Contribution to Journal › Article (Published)
Quantifying BBB leakage in small vessel disease: review and consensus recommendations 25 Apr 2019 In: Alzheimer's & Dementia
DOI: https://doi.org/10.1016/j.jalz.2019.01.013
Research output: Contribution to Journal › Article (E-pub ahead of print)
Tolerability, safety and intermediary pharmacological effects of cilostazol and isosorbide mononitrate, alone and combined, in patients with lacunar ischaemic stroke: The LACunar Intervention-1 (LACI-1) trial, a randomised clinical trial 23 Apr 2019 In: EClinicalMedicine
DOI: https://doi.org/10.1016/j.eclinm.2019.04.001
Research output: Contribution to Journal › Article (E-pub ahead of print)
Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration 26 Feb 2019 In: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, vol. 11, pp. 191-204
DOI: https://doi.org/10.1016/j.dadm.2019.01.002
Research output: Contribution to Journal › Article (E-pub ahead of print)
MRI Relaxometry for Quantitative Analysis of USPIO Uptake in Cerebral Small Vessel Disease 12 Feb 2019 In: International Journal of Molecular Sciences, vol. 20, pp. 776
DOI: https://doi.org/10.3390/ijms20030776
Research output: Contribution to Journal › Article (E-pub ahead of print)
Convolutional Neural Networks for Direct Inference of Pharmacokinetic Parameters: Application to Stroke Dynamic Contrast-Enhanced MRI 8 Jan 2019 In: Frontiers in Neurology, vol. 9
DOI: https://doi.org/10.3389/fneur.2018.01147
Research output: Contribution to Journal › Article (E-pub ahead of print)
MRI measurement of blood-brain barrier leakage: filling the gaps 6 Dec 2018 In: Journal of Physiology
DOI: https://doi.org/10.1113/JP277425
Research output: Contribution to Journal › Article (Published)
Small vessel disease is associated with altered cerebrovascular pulsatility but not resting cerebral blood flow 8 Oct 2018 In: Journal of Cerebral Blood Flow and Metabolism, pp. 0271678X1880395
DOI: https://doi.org/10.1177/0271678X18803956
Research output: Contribution to Journal › Article (Published)
Neonatal Morphometric Similarity Networks Predict Atypical Brain Development Associated with Preterm Birth 15 Sep 2018
DOI: https://doi.org/10.1007/978-3-030-00755-3_6
Research output: › Chapter (Published)
Characterisation of tissue-type metabolic content in Secondary Progressive Multiple Sclerosis: a Magnetic Resonance Spectroscopic Imaging study 30 May 2018 In: Journal of Neurology
DOI: https://doi.org/10.1007/s00415-018-8903-y
Research output: Contribution to Journal › Article (E-pub ahead of print)
How does blood regulate cerebral temperatures during hypothermia? 18 May 2018 In: Scientific Reports
DOI: https://doi.org/10.1038/s41598-018-26063-7
Research output: Contribution to Journal › Article (Published)
Direct Estimation of Pharmacokinetic Parameters from DCE-MRI using Deep CNN with Forward Physical Model Loss 8 Apr 2018
Research output: Contribution to Conference › Paper (Published)
Variance components associated with long-echo-time MR spectroscopic imaging in human brain at 1.5T and 3T 29 Dec 2017 In: PLoS ONE
DOI: https://doi.org/10.1371/journal.pone.0189872
Research output: Contribution to Journal › Article (E-pub ahead of print)

View all 56 publications on Research Explorer

Conferences

Organiser

British Chapter ISMRM 2014 Meeting and Workshop