Dr Fergus Doubal
Honorary Senior Lecturer & Consultant Stroke Physician
Research summary
Dementia and some type of strokes are caused by disease of the small blood vessels in the brain but the exact nature of this disease is unknown. We use new scanning techniques of the brain (MRI) and the back of the eye (retinal photography) to work out what happens to these blood vessels to cause dementia and stroke. By doing this we will be able to find new treatments to try to prevent both diseases.
Research aims and interests
- Understanding the pathophysiology of cerebral small vessel disease causing stroke and dementia
- Developing novel markers to predict dementia and stroke
- Developing surrogate markers to use in trials of cerebral small vessel disease
- Using advanced neuroimaging – MRI and retinal photography to delineate the pathophysiology of cerebral small vessel disease
-
Quantitative measurements of enlarged perivascular spaces in the brain are associated with retinal microvascular parameters in older community-dwelling subjects
In:
Cerebral Circulation—Cognition and Behavior
Research output: Contribution to Journal › Article (Accepted/In press) -
Cilostazol for Secondary Prevention of Stroke and Cognitive Decline: Systematic Review and Meta-Analysis
In:
Stroke, vol. 51, pp. 2374-2385
DOI: https://doi.org/10.1161/STROKEAHA.120.029454
Research output: Contribution to Journal › Article (Published) -
Retinal Biomarkers Discovery for Cerebral Small Vessel Disease in an Older Population
DOI: https://doi.org/10.1007/978-3-030-52791-4_31
Research output: › Chapter (Published) -
A Framework for Jointly Assessing and Reducing Imaging Artefacts Automatically Using Texture Analysis and Total Variation Optimisation for Improving Perivascular Spaces Quantification in Brain Magnetic Resonance Imaging
DOI: https://doi.org/10.1007/978-3-030-52791-4_14
Research output: › Chapter (Published) -
Accuracy of identifying incident stroke cases from linked healthcare data in UK Biobank
In:
Neurology
DOI: https://doi.org/10.1212/WNL.0000000000009924
Research output: Contribution to Journal › Article (E-pub ahead of print)