Dr Fergus Doubal
Honorary Senior Lecturer & Consultant Stroke Physician
Research summary
Dementia and some type of strokes are caused by disease of the small blood vessels in the brain but the exact nature of this disease is unknown. We use new scanning techniques of the brain (MRI) and the back of the eye (retinal photography) to work out what happens to these blood vessels to cause dementia and stroke. By doing this we will be able to find new treatments to try to prevent both diseases.
Research aims and interests
- Understanding the pathophysiology of cerebral small vessel disease causing stroke and dementia
- Developing novel markers to predict dementia and stroke
- Developing surrogate markers to use in trials of cerebral small vessel disease
- Using advanced neuroimaging – MRI and retinal photography to delineate the pathophysiology of cerebral small vessel disease
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The association between CT biomarkers of cerebral small vessel diseases and long‐term outcome after spontaneous intracerebral hemorrhage
In:
Annals of Neurology
DOI: https://doi.org/10.1002/ana.25949
Research output: Contribution to Journal › Article (E-pub ahead of print) -
The Application of Optical Coherence Tomography Angiography in Cerebral Small Vessel Disease, Ischemic Stroke, and Dementia: A Systematic Review
In:
Frontiers in Neurology, vol. 11
DOI: https://doi.org/10.3389/fneur.2020.01009
Research output: Contribution to Journal › Article (Published) -
Quantitative measurements of enlarged perivascular spaces in the brain are associated with retinal microvascular parameters in older community-dwelling subjects
In:
Cerebral Circulation—Cognition and Behavior
Research output: Contribution to Journal › Article (Accepted/In press) -
Cilostazol for Secondary Prevention of Stroke and Cognitive Decline: Systematic Review and Meta-Analysis
In:
Stroke, vol. 51, pp. 2374-2385
DOI: https://doi.org/10.1161/STROKEAHA.120.029454
Research output: Contribution to Journal › Article (Published) -
Retinal Biomarkers Discovery for Cerebral Small Vessel Disease in an Older Population
DOI: https://doi.org/10.1007/978-3-030-52791-4_31
Research output: › Chapter (Published)