Dr Fergus Doubal
Honorary Senior Lecturer & Consultant Stroke Physician
Research summary
Dementia and some type of strokes are caused by disease of the small blood vessels in the brain but the exact nature of this disease is unknown. We use new scanning techniques of the brain (MRI) and the back of the eye (retinal photography) to work out what happens to these blood vessels to cause dementia and stroke. By doing this we will be able to find new treatments to try to prevent both diseases.
Research aims and interests
- Understanding the pathophysiology of cerebral small vessel disease causing stroke and dementia
- Developing novel markers to predict dementia and stroke
- Developing surrogate markers to use in trials of cerebral small vessel disease
- Using advanced neuroimaging – MRI and retinal photography to delineate the pathophysiology of cerebral small vessel disease
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ESO Guideline on covert cerebral small vessel disease
In:
European Stroke Journal, vol. 6, pp. IV-IV
DOI: https://doi.org/10.1177/23969873211027002
Research output: Contribution to Journal › Article (Published) -
Consensus on core outcome measures for palliative or end-of-life research after severe stroke: mixed-method Delphi study
In:
Stroke
Research output: Contribution to Journal › Article (Accepted/In press) -
A Comparison of CVR Magnitude and Delay Assessed at 1.5 and 3T in Patients With Cerebral Small Vessel Disease
In:
Frontiers in physiology, vol. 12
DOI: https://doi.org/10.3389/fphys.2021.644837
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Sources of systematic error in DCE‐MRI estimation of low‐level blood‐brain barrier leakage
In:
Magnetic Resonance in Medicine
DOI: https://doi.org/10.1002/mrm.28833
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Neuropsychiatric symptoms associated with cerebral small vessel disease: a systematic review and meta-analysis
In:
The Lancet Psychiatry
DOI: https://doi.org/10.1016/S2215-0366(20)30431-4
Research output: Contribution to Journal › Article (E-pub ahead of print)