Dr Fergus Doubal
Honorary Senior Lecturer & Consultant Stroke Physician
Research summary
Dementia and some type of strokes are caused by disease of the small blood vessels in the brain but the exact nature of this disease is unknown. We use new scanning techniques of the brain (MRI) and the back of the eye (retinal photography) to work out what happens to these blood vessels to cause dementia and stroke. By doing this we will be able to find new treatments to try to prevent both diseases.
Research aims and interests
- Understanding the pathophysiology of cerebral small vessel disease causing stroke and dementia
- Developing novel markers to predict dementia and stroke
- Developing surrogate markers to use in trials of cerebral small vessel disease
- Using advanced neuroimaging – MRI and retinal photography to delineate the pathophysiology of cerebral small vessel disease
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Effects of Isosorbide Mononitrate and/or Cilostazol on Hematological Markers, Platelet Function, and Hemodynamics in Patients With Lacunar Ischaemic Stroke: Safety Data From the Lacunar Intervention-1 (LACI-1) Trial
In:
Frontiers in Neurology, vol. 10
DOI: https://doi.org/10.3389/fneur.2019.00723
Contribution to journal › Article (Published) -
Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial
In:
Lancet Neurology
DOI: https://doi.org/10.1016/S1474-4422(19)30184-X
Contribution to journal › Article (E-pub ahead of print) -
Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial
In:
The Lancet
DOI: https://doi.org/10.1016/S0140-6736(19)30840-2
Contribution to journal › Article (Published) -
Tolerability, safety and intermediary pharmacological effects of cilostazol and isosorbide mononitrate, alone and combined, in patients with lacunar ischaemic stroke: The LACunar Intervention-1 (LACI-1) trial, a randomised clinical trial
In:
EClinicalMedicine
DOI: https://doi.org/10.1016/j.eclinm.2019.04.001
Contribution to journal › Article (E-pub ahead of print) -
Retinal microvasculature and cerebral small vessel disease in the Lothian Birth Cohort 1936 and Mild Stroke Study
In:
Scientific Reports, vol. 9, no. 1
DOI: https://doi.org/10.1038/s41598-019-42534-x
Contribution to journal › Article (Published)