Dr Fergus Doubal
Honorary Senior Lecturer & Consultant Stroke Physician
Research summary
Dementia and some type of strokes are caused by disease of the small blood vessels in the brain but the exact nature of this disease is unknown. We use new scanning techniques of the brain (MRI) and the back of the eye (retinal photography) to work out what happens to these blood vessels to cause dementia and stroke. By doing this we will be able to find new treatments to try to prevent both diseases.
Research aims and interests
- Understanding the pathophysiology of cerebral small vessel disease causing stroke and dementia
- Developing novel markers to predict dementia and stroke
- Developing surrogate markers to use in trials of cerebral small vessel disease
- Using advanced neuroimaging – MRI and retinal photography to delineate the pathophysiology of cerebral small vessel disease
-
Longitudinal changes of white matter hyperintensities in sporadic small vessel disease: a systematic review and meta-analysis
In:
medrXiv
DOI: https://doi.org/10.1101/2022.03.22.22272696
Research output: Contribution to Journal › Review article (Published) -
Impact of Small Vessel Disease Progression on Long-term Cognitive and Functional Changes After Stroke
In:
Neurology, pp. 10.1212/WNL.0000000000200005
DOI: https://doi.org/10.1212/WNL.0000000000200005
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Measuring axial length of the eye from magnetic resonance brain imaging
In:
BMC Ophthalmology, vol. 22
DOI: https://doi.org/10.1186/s12886-022-02289-y
Research output: Contribution to Journal › Article (Published) -
Neuropsychiatric symptoms as a sign of small vessel disease progression in cognitive impairment
In:
Cerebral Circulation—Cognition and Behavior, vol. 3, pp. 100041
DOI: https://doi.org/10.1016/j.cccb.2022.100041
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Effects of Cilostazol and Isosorbide Mononitrate on Cerebral Hemodynamics in the LACI-1 Randomized Controlled Trial
In:
Stroke
DOI: https://doi.org/10.1161/STROKEAHA.121.034866
Research output: Contribution to Journal › Article (E-pub ahead of print)