Dr Michael Stringer
Research Fellow, Medical Physicist
Address
- Street
-
University of Edinburgh, Centre for Clinical Brain Sciences
Chancellor's Building, 49 Little France Crescent, - City
- Edinburgh
- Post code
- EH16 4SB
Background
Originally from a mathematics background (BSc (Hons) Glasgow, MSc Heriot-Watt) I completed a PhD in medical imaging at the University of Aberdeen in 2016. Thereafter I joined Professor Wardlaw's group at the University of Ediburgh where I am involved with various studies on small vessel disease as well as with with the applications of new sequences and imaging capabilities.
Qualifications
PhD in Medical Sciences, University of Aberdeen
MSc in Applied Mathematical Sciences, Heriot-Watt University
BSc(Hons) in Pure Mathematics, University of Glasgow
Undergraduate teaching
I have previously demonstrated for labs in Biology and Exercise Physiology while pursuing my PhD at the University of Aberdeen.
Postgraduate teaching
I currently tutor for the Applications in Disease Research and Clinical Applications modules for the Edinburgh Imaging MSc programme and Neuroimaging Research for Neuroscience Graduates, part of the Integrative Neuroscience and Stem Cells and Translational Neurology Masters programme.
Current PhD students supervised
I am a co-supervisor for Emily Sleight on the project "Advanced signal processing and MRI to assess cerebrovascular health in small vessel disease and dementia" which aims to implement and assess novel approaches for calculating cerebrovascular reactivity using MRI.
Research summary
My current research primarily revolves around the application of advanced MR imaging techniques to better understand the mechanisms behind small vessel disease. A particular focus of my recent work has been the analysis of cerebrovascular reactivity and phase contrast data from recent studies, including the LACI-1 (LACunar stroke Intervention 1) trial. We are currently working to acquire further imaging data in small vessel disease cohorts, including high resolution DTI, CVR, ASL, DCE and MR spectroscopy data. I am involved with a number of studies, in particular through the collaborative SVDs@Target and Leducq Transatlantic Network on understanding the role of the perivascular space in cerebral small vessel disease.
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Blood-brain barrier leakage hotspots collocating with brain lesions due to sporadic and monogenic small vessel disease
In:
Journal of Cerebral Blood Flow and Metabolism, pp. 0271678X2311734
DOI: https://doi.org/10.1177/0271678X231173444
Research output: Contribution to Journal › Article (Published) -
Cerebrovascular reactivity measurements using 3T BOLD MRI and a fixed inhaled CO2 gas challenge: Repeatability and impact of processing strategy
In:
Frontiers in physiology, vol. 14
DOI: https://doi.org/10.3389/fphys.2023.1070233
Research output: Contribution to Journal › Article (Published) -
Corrigendum: Cerebrovascular reactivity measurement using magnetic resonance imaging: A systematic review
In:
Frontiers in physiology, vol. 13, pp. 1105285
DOI: https://doi.org/10.3389/fphys.2022.1105285
Research output: Contribution to Journal › Article (Published) -
The EffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular FuncTion in Small Vessel Diseases (TREAT-SVDs) trial: Study protocol for a randomised crossover trial
In:
European Stroke Journal, pp. 239698732211435
DOI: https://doi.org/10.1177/23969873221143570
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Retinal capillary microvessel morphology changes are associated with vascular damage and dysfunction in cerebral small vessel disease
In:
Journal of Cerebral Blood Flow and Metabolism
DOI: https://doi.org/10.1177/0271678X221135658
Research output: Contribution to Journal › Article (E-pub ahead of print) -
CADASIL Affects Multiple Aspects of Cerebral Small Vessel Function on 7T-MRI
In:
Annals of Neurology
DOI: https://doi.org/10.1002/ana.26527
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Associations of Peak-Width Skeletonized Mean Diffusivity and Post-Stroke Cognition
In:
Life, vol. 12, pp. 1362
DOI: https://doi.org/10.3390/life12091362
Research output: Contribution to Journal › Article (Published) -
Deep attention super-resolution of brain magnetic resonance images acquired under clinical protocols
(30 pages)
In:
Frontiers in Computational Neuroscience, vol. 16
DOI: https://doi.org/10.3389/fncom.2022.887633
Research output: Contribution to Journal › Article (Published) -
Topological relationships between perivascular spaces and progression of white matter hyperintensities: A pilot study in a sample of the Lothian Birth Cohort 1936
(17 pages)
In:
Frontiers in Neurology, vol. 13
DOI: https://doi.org/10.3389/fneur.2022.889884
Research output: Contribution to Journal › Article (Published) -
Loss of the heterogeneous expression of flippase ATP11B leads to cerebral small vessel disease in a normotensive rat model
In:
Acta Neuropathologica, vol. 144, pp. 283-303
DOI: https://doi.org/10.1007/s00401-022-02441-4
Research output: Contribution to Journal › Article (Published)