Small Vessel Disease (SVD)
Small vessel disease (SVD) of the brain relates to abnormalities of the tiny vessels known as arterioles, capillaries & venules & encompasses a range of neuroimaging, pathological, & associated clinical features.
Our research aims to determine the pathophysiology of cerebral small vessel disease including lacunar stroke, using medical imaging, particularly magnetic resonance, laboratory methods & clinical research methods in cohort studies & clinical trials.
We have pioneered developments in blood-brain barrier permeability & cerebrovascular reactivity imaging, as well as advanced image analysis methods for SVD, & integration of multi-modality DTI, spectroscopy, structural & blood flow imaging.
Current projects include cross sectional & longitudinal analysis of patients with stroke or cognitive presentations of SVD, to understand more about how & why SVD lesions develop & to develop treatments. These include the mild stroke study I, II & now III, the Foundation Leduq study of Sleep Apnoea, the UK Dementia Research Institute, SVD study (MSS3), the EU H2020 funded SVDs@Target studies of blood brain barriers & CVR (Investigate@SVD’s) & anti-hypertensive treatment (treat@SVD) & EPSRC funded studies of the retina & brain to detect early signs of SVD, & many studies of image analysis methods including developing approaches including industry collaborations funded by Innovative.
We recently completed the AI2 Soc funded Lacunar Intervention Trial – 1 (LACI-1) & are now running the BHF funded LACI-2, which aims to prevent worsening SVD.
The RowFogo centre for research into Aging & the brain recognises this body of work & forms a hub for future SVD research in Edinburgh.
Lead SVD researcher
To discuss new research & collaborative imaging projects with Edinburgh Imaging, please contact:
Enquiries: studies / collaborations / facilities
- Email: email@example.com
Research staff with a SVD focus
- Prof Andrew Farrall
- David Rodriguez
- Ms Eleni Sakka
- Dr Fergus Doubal
- Dr Francesca Chappell
- Prof Ian Marshall
- Ms Iona Hamilton
- Dr Lizzie Hill
- Dr Lucia Ballerini
- Dr Maria Valdés Hernández
- Dr Mark Bastin
- Dr Michael Stringer
- Dr Michael Thrippleton
- Dr Rosalind Brown
- Dr Stewart Wiseman
- Dr Susana Munoz Maniega
- Dr Tom MacGillivray
Funding organisations & research groups
- 05 Jul 18. Drug hope for dementia & stroke
Relevant Edinburgh Imaging publications
02 Sep 22. Featured Paper. Associations of peak-width skeletonized mean diffusivity and post-stroke cognition
26 Aug 22. Featured Paper. Topological relationships between perivascular spaces and progression of white matter hyperintensities: A pilot study in a sample of the Lothian Birth Cohort 1936
16 Aug 22. Featured Paper. Epigenetic and integrative cross-omics analyses of cerebral white matter hyperintensities on MRI
05 Aug 22. Featured Paper. Assessment of perivascular space filtering methods using a three-dimensional computational model
05 Jul 22. Featured Paper. A link between frontal white matter integrity and dizziness in cerebral small vessel disease
27 Jun 22. Featured Paper. Systematic review of cerebral phenotypes associated with monogenic cerebral small‐vessel disease
07 Jun 22. Featured Paper. Loss of the heterogeneous expression of flippase ATP11B leads to cerebral small vessel disease in a normotensive rat model
03 Jun 22. Featured Paper. Prevalence and significance of the vessel-cluster sign on susceptibility-weighted imaging in patients with severe small vessel disease
22 Nov 21. Featured Paper. Tracer kinetic assessment of blood–brain barrier leakage & blood volume in cerebral small vessel disease: Associations with disease burden & vascular risk factors