16 Nov 20. Featured preprint
Automatic segmentation of white matter hyperintensities from brain magnetic resonance images in the era of deep learning & big data – a systematic review.
Link to paper on Preprints
Authors
Ramya Balakrishnan, Maria Valdes Hernandez, Andrew Farrall
Abstract
Background:
White matter hyperintensities (WMH), of presumed vascular origin, are visible & quantifiable neuroradiological markers of brain parenchymal change.
These changes may range from damage secondary to inflammation & other neurological conditions, through to healthy ageing.
Fully automatic WMH quantification methods are promising, but still, traditional semi-automatic methods seem to be preferred in clinical research.
We systematically reviewed the literature for fully automatic methods developed in the last five years, to assess what are considered state-of-the-art techniques, as well as trends in the analysis of WMH of presumed vascular origin.
Method:
We registered the systematic review protocol with the International Prospective Register of Systematic Reviews (PROSPERO), registration number - CRD42019132200.
We conducted the search for fully automatic methods developed from 2015 to July 2020 on Medline, Science direct, IEE Explore, & Web of Science.
We assessed risk of bias & applicability of the studies using QUADAS 2.
Results:
The search yielded 2327 papers after removing 104 duplicates.
After screening titles, abstracts & full text, 37 were selected for detailed analysis.
Of these, 16 proposed a supervised segmentation method, 10 proposed an unsupervised segmentation method, & 11 proposed a deep learning segmentation method.
Average DSC values ranged from 0.538 to 0.93, being the highest value obtained from a deep learning segmentation method.
Only four studies validated their method in longitudinal samples, & eight performed an additional validation using clinical parameters.
Only 8/37 studies made available their method in public repositories.
Conclusions:
Although deep learning methods reported highly accurate results, we found no evidence that favours them over the more established k-NN, linear regression & unsupervised methods in this task.
Data & code availability, bias in study design & ground truth generation influence the wider validation & applicability of these methods in clinical research.
Keywords
- Deep learning
- FLAIR hyperintensities
- Supervised segmentation
- Unsupervised segmentation
- White matter lesions
- White matter hyperintensities
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Featured paper: Automatic segmentation of white matter hyperintensities from brain magnetic resonance images in the era of deep learning & big data – a systematic review. @drajfarrall @wmsgISMRM @SVDs_at_target #WMH #DeepLearning