06 Feb 20. Featured Paper
Manganese-enhanced T1 mapping to quantify myocardial viability: validation with 18F-fluorodeoxyglucose positron emission tomography.
Gadolinium chelates are widely used in cardiovascular magnetic resonance imaging (MRI) as passive intravascular & extracellular space markers.
Manganese, a biologically active paramagnetic calcium analogue, provides novel intracellular myocardial tissue characterisation.
MEMRI was achieved with unchelated (EVP1001-1) or chelated (mangafodipir) manganese.
MEMRI & PET demonstrated good agreement with histology but native T1 underestimated infarct size.
Quantification of viability by MEMRI, PET & MTC were similar, irrespective of manganese agent.
MEMRI showed superior agreement with PET than native T1.
MEMRI showed excellent agreement with PET & MTC viability.
Myocardial MEMRI T1 correlated with 18F-FDG standard uptake values & influx constant but not native T1.
Our findings indicate that MEMRI identifies & quantifies myocardial viability & has major potential for clinical application in myocardial disease & regenerative therapies.