12 Oct 20. Featured Paper
Rates, risks & routes to reduce vascular dementia (R4vad), a UK-wide multicentre prospective observational cohort study of cognition after stroke: Protocol
Joanna M Wardlaw, Fergus Doubal, Rosalind Brown, Ellen Backhouse, Lisa Woodhouse, Philip Bath, Terence J Quinn, Thompson Robinson, Hugh S Markus, Richard McManus, John T O’Brien, David J Werring, Nikola Sprigg, Adrian Parry-Jones, Rhian M Touyz, Steven Williams, Yee-Haur Mah, Hedley Emsley, the R4VaD Investigators
However, there are fundamental limitations in our understanding of vascular cognitive impairment, restricting understanding of prevalence, trajectories, mechanisms, prevention, treatment & patient-service needs.
Aims: Rates, Risks & Routes to Reduce Vascular Dementia (R4VaD) is an observational cohort study of post-stroke cognition.
We aim to recruit a wide range of patients with stroke, presenting to geographically diverse UK hospitals, into a longitudinal study to determine rates of, & risk factors for, cognitive & related impairments after stroke, to assess potential mechanisms & improve prediction models.
Methods: We will recruit at least 2000 patients within six weeks of stroke with or without capacity to consent & collect baseline demographic, clinical, socioeconomic, lifestyle, cognitive, neuropsychiatric & informant data using streamlined patient-centred methods appropriate to the stage after stroke.
We will obtain more detailed assessments at four to eight weeks after the baseline assessment & follow-up by phone & post yearly to at least two years.
We will assess diagnostic neuroimaging in all & high-sensitivity inflammatory markers, genetics, blood pressure & diffusion tensor imaging in mechanistic sub-studies.
It will create a platform enabling sharing of data, imaging & samples.
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Featured paper: Rates, risks & routes to reduce vascular dementia (R4vad), a UK-wide multicentre prospective observational cohort study of cognition after stroke: Protocol @fergusdoubal @EdinUniBrainSci #Stroke #Cognition