04 Nov 20. Featured Paper
Association between computed tomographic biomarkers of cerebral small vessel diseases & long‐term outcome after spontaneous intracerebral hemorrhage.
Mark A. Rodrigues FRCR, PhD, Neshika E. Samarasekera MRCP, PhD, Christine Lerpiniere RGN, Luke A. Perry MBBS, Tom J. Moullaali MBBS, MRCP, James J.M. Loan MRCS, MSc, Joanna M. Wardlaw FRCR, MD, Rustam Al‐Shahi Salman MA PhD FRCPEdin FESO for the Lothian Audit of the Treatment of Cerebral Haemorrhage Collaborators
Methods: We performed a prospective, community‐based cohort study of adults diagnosed with spontaneous intracerebral hemorrhage between June 1, 2010 & May 31, 2013.
We assessed the association between CT SVD biomarkers & either death, or death or dependence (modified Rankin Scale scores = 4–6) 1 year after first‐ever intracerebral hemorrhage using logistic regression, adjusting for known predictors of outcome.
Results: Within 1 year of intracerebral hemorrhage, 224 (56%) of 402 patients died.
In separate models, 1‐year death was associated with severe atrophy (adjusted odds ratio [aOR] = 2.54, 95% confidence interval [CI] = 1.44–4.49, p = 0.001) but not lacunes or severe white matter lucencies, & CT SVD sum score ≥ 1 (aOR = 2.50, 95% CI = 1.40–4.45, p = 0.002).
Two hundred seventy‐seven (73%) of 378 patients with modified Rankin Scale data were dead or dependent at 1 year.
In separate models, 1‐year death or dependence was associated with severe atrophy (aOR = 3.67, 95% CI = 1.71–7.89, p = 0.001) & severe white matter lucencies (aOR = 2.18, 95% CI = 1.06–4.51, p = 0.035) but not lacunes, & CT SVD sum score ≥ 1 (aOR = 2.81, 95% CI = 1.45–5.46, p = 0.002).
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Featured paper: Association between computed tomographic biomarkers of cerebral small vessel diseases & long‐term outcome after spontaneous intracerebral hemorrhage. @EdinUniBrainSci @BleedingStroke