Dr Neshika Samarasekera

Dr Neshika Samarasekera (BMedSci MRCP PhD)

Consultant neurologist, NHS Lothian and NRS Research Fellow

Tel: 01315372944
Email: neshika.samarasekera@ed.ac.uk

Street: Fu303a, Centre for Clinical Brain Sciences
Chancellors Building
49 Little France Crescent
City: Edinburgh
Post code: EH16 4SB

Biography

Background

I am a clinical neurologist and stroke doctor. My research interest is in the epidemiology, causes and the effects of intracerebral haemorrhage on patients and on the brain.

Qualifications

BMedSci (University of Newcastle-upon-Tyne, 2000)

MBBS (University of Newcastle-upon-Tyne, 2003)

MRCP (RCP Edinburgh, 2006)

PhD (University of Edinburgh, 2015)

Teaching & PhD supervision

Undergraduate teaching

I regularly teach University of Edinburgh undergraduate medical students using bedside teaching, small group sessions and teaching students who attend TIA and general neurology out-patient clinics.

Postgraduate teaching

I have contributed to the Neuroscience PhD teaching programme and the teaching of junior doctors prior to their MRCP exams.

Areas of interest for supervision

I have supervised medical students undertaking research projects in intracerebral haemorrhage both as part of their SSC5 block and at other stages of their degree.

Current PhD students supervised

Laura Cunningham, SSC5 medical student, University of Edinburgh

Past PhD students supervised

Arthur Fonville, University of Amsterdam

Pheng Toh, University of Edinburgh

Luke Perry, Monash University, Australia

Intracerebral haemorrhage affects 10 000 adults annually in the UK and 4 out of every 10 sufferers die in the first month after their bleed. As yet, there is no effective medical treatment for this condition. My PhD, examined the underlying causes of ICH (particularly looking at the role of cerebral amyloid angiopathy). My work is part of the Research to Understand Haemorrhage programme(RUSH; https://www.ed.ac.uk/clinical-brain-sciences/research/diagnoses-disease-targets/rush). I am looking at the long term outcomes for adults who have had a spontaneous intracerebral haemorrhage and the effect that bleeding has on brain tissue. The long term aim is to be able to develop an effective treatment for this condition.

Projects

Current project grants

2017 The Stroke Association Haemorrhagic Stroke Priority Programme Award, Co-lead applicant £449,482

Past project grants

2009 UK MRC / The Stroke Association Clinical Research Training Fellowship, £163,316

Publications

The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI–neuropathology diagnostic accuracy study 1 Aug 2022 In: Lancet Neurology, vol. 21, pp. 714-725
DOI: https://doi.org/10.1016/S1474-4422(22)00208-3
Research output: Contribution to Journal › Article (Published)
Profiling of human perihaematomal tissue identifies two pathological brain states following intracerebral haemorrhage 29 May 2022 In: Journal of Cerebral Blood Flow and Metabolism, vol. 42, pp. 64-64
DOI: https://doi.org/10.1177/0271678X221096356
Research output: Contribution to Journal › Meeting abstract (Published)
Nrf2 activation in the human brain after stroke due to supratentorial intracerebral haemorrhage: a case–control study 19 Feb 2022 In: BMJ Neurology Open, vol. 4, pp. e000238
DOI: https://doi.org/10.1136/bmjno-2021-000238
Research output: Contribution to Journal › Article (E-pub ahead of print)
Secondary injury and inflammation after intracerebral haemorrhage: a systematic review and meta-analysis of molecular markers in patient brain tissue 6 Aug 2021 In: Journal of Neurology, Neurosurgery & Psychiatry, pp. jnnp-2021-327098
DOI: https://doi.org/10.1136/jnnp-2021-327098
Research output: Contribution to Journal › Article (E-pub ahead of print)
Risks of recurrent stroke and all serious vascular events after spontaneous intracerebral haemorrhage: pooled analyses of two population-based studies 1 Jun 2021 In: Lancet Neurology, vol. 20, pp. 437-447
DOI: https://doi.org/10.1016/S1474-4422(21)00075-2
Research output: Contribution to Journal › Article (Published)
Rare missense functional variants at COL4A1 and COL4A2 in sporadic intracerebral Hhmorrhage 24 May 2021 In: Neurology
DOI: https://doi.org/10.1212/WNL.0000000000012227
Research output: Contribution to Journal › Article (Published)
Association of baseline hematoma and edema volumes with one-year outcome and long-term survival after spontaneous intracerebral hemorrhage: A community-based inception cohort study 25 Nov 2020 In: International Journal of Stroke, pp. 174749302097428
DOI: https://doi.org/10.1177/1747493020974282
Research output: Contribution to Journal › Article (Published)
Association between Computed Tomographic Biomarkers of Cerebral Small Vessel Diseases and Long-Term Outcome after Spontaneous Intracerebral Hemorrhage 3 Nov 2020 In: Annals of Neurology
DOI: https://doi.org/10.1002/ana.25949
Research output: Contribution to Journal › Article (E-pub ahead of print)
Accuracy of identifying incident stroke cases from linked healthcare data in UK Biobank 2 Jul 2020 In: Neurology
DOI: https://doi.org/10.1212/WNL.0000000000009924
Research output: Contribution to Journal › Article (E-pub ahead of print)
Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study 25 Jun 2020 In: The Lancet Psychiatry
DOI: https://doi.org/10.1016/S2215-0366(20)30287-X
Research output: Contribution to Journal › Article (Published)
Elderly woman with subacute lower limb weakness and rapid systemic decline 30 Jan 2020 In: Practical Neurology, pp. practneurol-2019-002476
DOI: https://doi.org/10.1136/practneurol-2019-002476
Research output: Contribution to Journal › Article (Published)
Incident Cerebral Microbleeds After Intracerebral Hemorrhage: Systematic Review and Meta-Analysis 17 Jun 2019 In: Stroke
DOI: https://doi.org/10.1161/STROKEAHA.118.023746
Research output: Contribution to Journal › Article (E-pub ahead of print)
Association of apolipoprotein E with intracerebral hemorrhage risk by race/ethnicity: A meta-analysis 1 Apr 2019 In: JAMA Neurology, pp. 480-491
DOI: https://doi.org/10.1001/jamaneurol.2018.4519
Research output: Contribution to Journal › Article (Published)
The Edinburgh CT and genetic diagnostic criteria for lobar intracerebral haemorrhage with cerebral amyloid angiopathy: model development and diagnostic test accuracy study (9 pages) 1 Mar 2018 In: Lancet Neurology, vol. 17, pp. 232-240
DOI: https://doi.org/10.1016/S1474-4422(18)30006-1
Research output: Contribution to Journal › Article (Published)
Brain hemorrhage recurrence, small vessel disease type and cerebral microbleeds: a meta-analysis 26 Jul 2017 In: Neurology
DOI: https://doi.org/10.1212/WNL.0000000000004259
Research output: Contribution to Journal › Article (E-pub ahead of print)
Imaging features of intracerebral hemorrhage with cerebral amyloid angiopathy: Systematic review and meta-analysis 10 Jul 2017 In: PLoS ONE, vol. 12
DOI: https://doi.org/10.1371/journal.pone.0180923
Research output: Contribution to Journal › Article (E-pub ahead of print)
Genetic Variants in CETP Increase Risk of Intracerebral Hemorrhage (11 pages) Nov 2016 In: Annals of Neurology, vol. 80, pp. 730–740
DOI: https://doi.org/10.1002/ana.24780
Research output: Contribution to Journal › Article (Published)

View all 29 publications on Research Explorer

This article was published on 2 Feb, 2023