Centre for Clinical Brain Sciences

Research to Understand Stroke due to Haemorrhage (RUSH)

The RUSH programme is dedicated to better understanding the causes and outcome of spontaneous (non-traumatic) intracerebral haemorrhage in adults, leading to randomised controlled clinical trials of interventions to improve outcome.

The Arthur Fonville Award for Stroke Research: competition now open!

Arthur Fonville

This is an award for a 1,500 word dissertation summarising a research project into any aspect of stroke, conducted by a medical student in year 3 to 6 at the University of Edinburgh or the University of Amsterdam . There is a prize of £100 for the best entry plus the opportunity of a further award of up to £750 contributing to a to support conference attendance in the forthcoming year.

This posthumous award was established in memory of Arthur Fonville, a medical student from the University of Amsterdam, who worked with the Research to Understand Stroke due to Haemorrhage (RUSH) team in Edinburgh 2011-2013, and died in September 2014.

The best dissertation is chosen by a panel of members of the RUSH group

The 2019 competition is now open.  The closing date for submissions will be 13th September 2019. Entries should be sent to Rosemary.Anderson@ed.ac.uk. The award presentation will take place in November 2019.


Components of the programme

RUSH programme logo
  • Clinico-radio-pathological case control study of the causes of intracerebral haemorrhage, based on a community-based inception cohort study in Lothian (LINCHPIN) in collaboration with the Medical Research Council Cognitive Function and Ageing Study (CFAS)
  • RESTART (REstart or STop Antithrombotics Randomised Trial), which is funded by the British Heart Foundation, started in the UK in 2013. At least one quarter of adults with a stroke due to intracerebral haemorrhage are on drugs like aspirin at the time of the bleed because they had previously suffered vaso-occlusive disease. For 720 people like this who survive the brain haemorrhage, RESTART will test whether more brain haemorrhages occur after starting drugs like aspirin than after avoiding them, and it will investigate whether brain microbleeds on brain MRI are important effect modifiers. If starting antiplatelet drugs does not raise the risk of further brain haemorrhage, continuing them could allow survivors to continue to benefit from them
  • Clinical epidemiological analyses of a prospective population-based study of intracranial vascular malformations in Scotland (SAIVMs)
  • Studies of the genetic influences on intracranial vascular malformations
  • Systematic reviews and meta-analyses of intervention, genetic association, neuropathological, and prognostic studies
  • Community- and population-based clinical audits of the care of patients with intracerebral haemorrhage (LATCH) and its various causes (SAIVMs)
  • Participation in major randomised controlled trials in stroke in the present (ARUBA – intervention versus conservative management of unruptured AVMs, funded by NIH; PATCH – platelet transfusion for cerebral haemorrhage, funded by Chest Heart and Stroke Scotland;) and in the past (MASH II – magnesium for the prevention of poor outcome after aneurysmal SAH; STICH2 – surgical trial in lobar intracerebral haemorrhage, funded by MRC).
  • Participation in observational studies (CROMIS, funded by British Heart Foundation and UK Stroke Association)

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Brain haemorrhage clinic

We conduct a weekly specialist clinic for survivors of brain haemorrhage at the Anne Rowling Regenerative Neurology Clinic.


Arthur Fonville Award Winners 2016

Congratulations to the joint winners of this year's prize, Vhinoth Sivakumaran & Henry Millar. This prize is given to the best dissertation on stroke research written by a University of Edinburgh medical student in the clinical years. For more information see: Arthur Fonville Award winners 2016

Public Lecture: 30th May 2016

Professor Rustam Al-Shahi Salman, Lead of the RUSH programme, delivered his Inaugural Lecture on 30th May 2016 . The lecture was entitled "What's the RUSH? (Research to Understand Stroke due to Haemorrhage)".

Latest news in the RUSH flyer

Arthur Fonville Awardees 2015

Arthur Fonville Awardees 2015

Congratulations to the winners of the inaugural year of the Arthur Fonville Award for Stroke Research. The standard of applications was so high that there was not just one, but three, winners:

  • Francesca Wright, for “Psychological associations of post-stroke anxiety: A systematic review and meta-analysis”
  • Scott Osborne, for “Confirmation and Sub-classification of Stroke Cases in UK Biobank”
  • Pheng Toh, for, “Radiographic features of intracerebral haemorrhage associated with pathologically-proven cerebral amyloid angiopathy: systematic review and meta-analysis”

Make a single donation to the Arthur Fonville fund

Make a regular gift to the Arthur Fonville fund

Project grant awarded to boost trial recruitment

The RUSH team has been awarded a British Heart Foundation BHF project grant for Promoting Recruitment using Information Management Efficiently (PRIME), to study a method of boosting recruitment to our RESTART trial.

Stroke Association Fellowship for Katie McGoohan

Katie McGoohan

Congratulations to Katie McGoohan (Masters of Nursing in Clinical Research student at the University of Edinburgh), who has been awarded a prestigious Stroke Association Postgraduate Fellowship for nurses to do a PhD. Katie will be co-supervised by Rustam Al-Shahi Salman and Sheila Rodgers (Nursing Studies). Her clinical research project will be based with the Stroke Research Group and will focus on the participants in LINCHPIN, a clinico-radio-pathological case control study of the causes of intracerebral haemorrhage.


Study websites



  • UK Medical Research Council senior clinical fellowship and clinical research training fellowship
  • British Heart Foundation special project grant
  • Chest Heart and Stroke Scotland
  • Donations from generous benefactors

Patient reference group

The RUSH team has an active patient reference group, who meet to discuss the research and its implications. Find out more about the members of the group.

Clinical research training opportunities

We encourage keen clinical academics to work with us, and help them obtain clinical research training fellowships.


Name Role
Professor Rustam Al-Shahi Salman Professor of Clinical Neurology
Miss Rosemary Anderson Project Co-ordinator
Mr Aidan Hutchison Database Designer, Developer and Consultant
Mrs Chris Lerpiniere Senior Research Nurse
Mr James Loan Wellcome Trust/Edinburgh Clinical Academic Track (ECAT)
Miss Katie McGoohan Stroke Association Postgraduate Fellow
Dr Tom Moullaali British Heart Foundation Clinical Research Fellow
Dr Mark Rodrigues Wellcome Trust/Edinburgh Clinical Academic Track (ECAT)
Dr Neshika Samarasekera Consultant neurologist, NHS Lothian and NRS Research Fellow