Research to Understand Stroke due to Haemorrhage (RUSH)
The RUSH programme is dedicated to better understanding the causes and outcome of spontaneous (non-traumatic) intracerebral haemorrhage in adults, leading to randomised controlled clinical trials of interventions to improve outcome.
Components of the programme
- Clinico-radio-pathological case control study of the causes of intracerebral haemorrhage, based on a community-based inception cohort study in Lothian (LINCHPIN) in collaboration with the Medical Research Council Cognitive Function and Ageing Study (CFAS)
- RESTART (REstart or STop Antithrombotics Randomised Trial), which is funded by the British Heart Foundation, started in the UK in 2013. At least one quarter of adults with a stroke due to intracerebral haemorrhage are on drugs like aspirin at the time of the bleed because they had previously suffered vaso-occlusive disease. For 720 people like this who survive the brain haemorrhage, RESTART will test whether more brain haemorrhages occur after starting drugs like aspirin than after avoiding them, and it will investigate whether brain microbleeds on brain MRI are important effect modifiers. If starting antiplatelet drugs does not raise the risk of further brain haemorrhage, continuing them could allow survivors to continue to benefit from them
- Clinical epidemiological analyses of a prospective population-based study of intracranial vascular malformations in Scotland (SAIVMs)
- Studies of the genetic influences on intracranial vascular malformations
- Systematic reviews and meta-analyses of intervention, genetic association, neuropathological, and prognostic studies
- Community- and population-based clinical audits of the care of patients with intracerebral haemorrhage (LATCH) and its various causes (SAIVMs)
- Participation in major randomised controlled trials in stroke in the present (ARUBA – intervention versus conservative management of unruptured AVMs, funded by NIH; PATCH – platelet transfusion for cerebral haemorrhage, funded by Chest Heart and Stroke Scotland;) and in the past (MASH II – magnesium for the prevention of poor outcome after aneurysmal SAH; STICH2 – surgical trial in lobar intracerebral haemorrhage, funded by MRC).
- Participation in observational studies (CROMIS, funded by British Heart Foundation and UK Stroke Association)
Brain haemorrhage clinic
We conduct a weekly specialist clinic for survivors of brain haemorrhage at the Anne Rowling Regenerative Neurology Clinic.
The Arthur Fonville Award for Stroke Research: 2018 competition now closed
This is an award for a 1,500 word dissertation summarising a research project into any aspect of stroke, conducted by a medical student in years 3 to 6. There is a prize of £100 for the best entry.
This posthumous award is established in memory of Arthur Fonville, a medical student from the University of Amsterdam, who worked with the RUSH team in Edinburgh 2011-2013 and died in September 2014.
The best dissertation is chosen by Professor Rustam Al-Shahi Salman, Professor of clinical neurology.
The 2018 competition has now closed. The award presentation took place on 26th October 2018.
Arthur Fonville Award Winners 2016
Congratulations to the joint winners of this year's prize, Vhinoth Sivakumaran & Henry Millar. This prize is given to the best dissertation on stroke research written by a University of Edinburgh medical student in the clinical years. For more information see: Arthur Fonville Award winners 2016
Public Lecture: 30th May 2016
Professor Rustam Al-Shahi Salman, Lead of the RUSH programme, delivered his Inaugural Lecture on 30th May 2016 . The lecture was entitled "What's the RUSH? (Research to Understand Stroke due to Haemorrhage)".
Latest news in the RUSH flyer
Arthur Fonville Awardees 2015
Congratulations to the winners of the inaugural year of the Arthur Fonville Award for Stroke Research. The standard of applications was so high that there was not just one, but three, winners:
- Francesca Wright, for “Psychological associations of post-stroke anxiety: A systematic review and meta-analysis”
- Scott Osborne, for “Confirmation and Sub-classification of Stroke Cases in UK Biobank”
- Pheng Toh, for, “Radiographic features of intracerebral haemorrhage associated with pathologically-proven cerebral amyloid angiopathy: systematic review and meta-analysis”
Project grant awarded to boost trial recruitment
The RUSH team has been awarded a British Heart Foundation BHF project grant for Promoting Recruitment using Information Management Efficiently (PRIME), to study a method of boosting recruitment to our RESTART trial.
Stroke Association Fellowship for Katie McGoohan
Congratulations to Katie McGoohan (Masters of Nursing in Clinical Research student at the University of Edinburgh), who has been awarded a prestigious Stroke Association Postgraduate Fellowship for nurses to do a PhD. Katie will be co-supervised by Rustam Al-Shahi Salman and Sheila Rodgers (Nursing Studies). Her clinical research project will be based with the Stroke Research Group and will focus on the participants in LINCHPIN, a clinico-radio-pathological case control study of the causes of intracerebral haemorrhage.
- UK Medical Research Council senior clinical fellowship and clinical research training fellowship
- British Heart Foundation special project grant
- Chest Heart and Stroke Scotland
- Donations from generous benefactors
Patient reference group
The RUSH team has an active patient reference group, who meet to discuss the research and its implications. Find out more about the members of the group.
Clinical research training opportunities
We encourage keen clinical academics to work with us, and help them obtain clinical research training fellowships.
|Professor Rustam Al-Shahi Salman||Professor of Clinical Neurology|
|Miss Rosemary Anderson||Project Co-ordinator|
|Mr Aidan Hutchison||Database Designer, Developer and Consultant|
|Mrs Chris Lerpiniere||Senior Research Nurse|
|Mr James Loan||Wellcome Trust/Edinburgh Clinical Academic Track (ECAT)|
|Miss Katie McGoohan||Stroke Association Postgraduate Fellow|
|Dr Tom Moullaali||British Heart Foundation Clinical Research Fellow|
|Dr Mark Rodrigues||Wellcome Trust/Edinburgh Clinical Academic Track (ECAT)|
|Dr Neshika Samarasekera||Consultant neurologist, NHS Lothian and NRS Research Fellow|