Mr James Loan (MRCS, MSc)

Thesis title: Non-cell autonomous effects of microglial nuclear factor erythroid 2-related factor 2 signalling after intracerebral haemorrhage

Edinburgh Clinical Academic Track (ECAT)

Year of study: 1

  • Translational Neurosurgery, Centre for Clinical Brain Sciences
  • Centre for Discovery Brain Sciences
  • Dementia Research Institute

Contact details

Address

Street

Centre for Clinical Brain Sciences
Chancellor's Building
49 Little France Crescent

City
Edinburgh
Post code
EH16 4SB
Street

Centre for Discovery Brain Sciences
Hugh Robson Building
George Square

City
Edinburgh
Post code
EH8 9XD

Background

  • 2014-2016: Academic Foundation Medical Training in Critical Care, NHS Grampian
  • 2016-2017: Supernumerary Neurosurgical Registrar, Groote Schuur Hospital, Cape Town, South Africa. Visiting Scientist at University of Cape Town.
  • 2017-2018: Honorary Specialty Registrar in Neurosurgery, NHS Greater Glasgow and Clyde.
  • 2017-present ECAT Clinical Lecturer, University of Edinburgh and Honorary Specialty Registrar in Neurosurgery, NHS Lothian
  • 2018-present PhD student. UK Dementia Research Institute, Centre for Discovery Brain Sciences and Centre for Clinical Brain Sciences

Qualifications

  • Bachelor of Medicine and Bachelor of Surgery, with honours (MBChB hons), University of Edinburgh
  • Bachelor of Medical Sciences with first class honours (Neuroscience) (BMedSci Hons) and first in class, University of Edinburgh
  • Membership of the Royal College of Surgeons of Edinburgh (MRCS Ed)
  • Master of Science (MSc Surgical Sciences), with distinction and Lister Medal, Royal College of Surgeons of Edinburgh and University of Edinburgh, 

Responsibilities & affiliations

Member of the Royal College of Surgeons of Edinburgh 

Associate member of the Society of British Neurological Surgeons

Research summary

I am a doctor training in neurosurgery. Broadly, I am interested in understanding why inflammatory responses to acute brain injury vary between people and how these impact on long-term clinical outcome. This is important to inform patient selection for surgery and may allow targeted therapeutic development. 

Current research interests

Towards my PhD, I am developing in vitro and in vivo models of brain haemorrhage to investigate how microglia, the resident immune cells of the brain, modulate astrocyte and neuronal responses to haemorrhage. By accessing brain tissue and clinical data kindly donated by patients who have died following haemorrhage we will identify which disease modifying factors are translatable to human disease. My PhD is supervised by Prof. Giles Hardingham, Dr. Barry McColl and Prof. Rustam Salman and is funded by the Wellcome Trust.

View all 19 publications on Research Explorer