24 Jul 20. Featured Paper
Retinal biomarkers discovery for cerebral small vessel disease in an older population.
The retinal & cerebral microvasculatures share many morphological & physiological properties.
In this pilot we study the strength of the associations between morphological measurements of the retinal vasculature, obtained from fundus camera images, & of features of Small Vessel Disease (SVD), as white matter hyperintensities (WMH) & perivascular spaces (PVS), obtained from MRI brain scans.
We performed a 500-trial bootstrap analysis with Regularized Gaussian linear regression on a cohort of older community-dwelling subjects (Lothian Birth Cohort 1936, N = 866) in their eighth decade.
Arteriolar bifurcation coefficients, vessel tortuosity & fractal dimension predicted WMH volume in 23% of the trials.
Arteriolar widths, venular bifurcation coefficients, & venular tortuosity predicted PVS in up to 99.6% of the trials.
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Featured paper: Retinal biomarkers discovery for cerebral small vessel disease in an older population. @lucia_ballerini @EdinUniLBC #SmallVesselDisease #Retina