Neil Carragher (Affiliate)
Advancing drug discovery through high-content phenotypic and pathway profiling technologies
Research in a Nutshell
Our research is focussed on innovating the drug discovery process through the advancement of cell-based assay screening technologies including development and application of automated multiparametric high content imaging integrated with machine learning workflows to classify cell phenotypes and drug mechanisms of action. Our lab also utilises transcriptomic and post-translational pathway profiling technologies such as NanoString and Reverse Phase Protein Array to understand disease evolution and drug mechanism of action at the dynamic pathway network level. Working in close collaboration with several pharmaceutical industry partners and academic groups we apply these approaches across several stages of the drug discovery process to: elucidate new therapeutic targets, identify hit molecules, advance small-molecule lead generation, classify compound mechanism of action (MOA), identify biomarker and drug combination hypotheses to inform clinical trial design.
People |
|
|
Professor of Drug Discovery/Group Leader |
|
| John Dawson | Deputy Leader of Phenotypic Screening |
|
Richard Elliott |
Senior Research Fellow |
| Alison Munro | Senior Research Assistant HTPU |
| Jayne Culley | Research Assistant |
| Edwin Carter | Research Assistant |
| Martin Lee | Imaging Engineer (joint with Val Brunton) |
|
Alex Loftus |
Post Doc (joint with Margaret Frame) |
|
Mitch Foster |
ECAT Fellow |
|
Becka Hughes |
Post Doc |
| Mungo Harvey | PhD Student |
|
Vanessa Smer-Barreto |
XDF Fellow |
|
Nhan Pham |
Senior Drug Screening Scientist (joint with Siddharthan Chandran) |
|
Rod Carter |
Research Scientist (joint with Siddharthan Chandran) |
|
Steve Shave |
Research Fellow |
Contact
PA : jan.irvine@ed.ac.uk
Collaborations
- GlaxoSmithKline, Gunnels Wood Road, Stevenage, Herts, SG1 2NY, United Kingdom.
- Nuvectis Pharma, Inc. Fort Lee, New Jersey, USA.
- PhenoTherapeutics Ltd, Citypoint, 65 Haymarket Terrace, Edinburgh EH12 5HD, United Kingdom.
- National Phenotypic Screening Centre: www.npsc.org
- UK Regenerative Medicine Platform (UKRMP) Engineered Cell Environment Hub: https://www.ukrmp.org.uk/hubs/engineered-cell-environment/
- The Euan Macdonald Centre: http://www.euanmacdonaldcentre.org/
- The Centre for Inflammation Research STOPCOVID team: https://www.ed.ac.uk/inflammation-research/stopcovid
- MRC Centre for Reproductive Health: https://www.ed.ac.uk/centre-reproductive-health/staff/associates
- Asier Unciti-Broceta: Innovative Therapeutics Group
- Steve Pollard: Neural Stem Cells and Brain Cancer Group
- Margaret Frame: Cancer Biology Group
- Val Brunton: Cancer Therapeutics Group
- Siddharthan Chandran: Centre for Clinical Brain Sciences
- Kathryn Evans: Centre for Genomics and Experimental Medicine
- Hilary Critchley Group: MRC Centre for Reproductive Health
- Takanori Kitamura Group: MRC Centre for Reproductive Health
- Achim Schnauffer: School of Biological Sciences, Institute of Immunology & Infection Research
Scientific Themes
Drug Discovery, target validation, network pharmacology, drug combinations, biomarkers
Technology Expertise
High throughput screening; 2D and 3D cell-based models of disease, high content imaging, reverse phase protein array, multivariate statistics and machine learning.