Centre for Genomic & Experimental Medicine
Centre for Genomic & Experimental Medicine

Neil Carragher (Affiliate)

Advancing drug discovery through high-content phenotypic and pathway profiling technologies

Research in a Nutshell 

Portrait of Neil Carragher
Professor Neil Carragher - Professor of Drug Discovery

Our research is focussed on innovating the drug discovery process through the advancement of cell-based assay screening technologies including development and application of automated multiparametric high content imaging integrated with machine learning workflows to classify cell phenotypes and drug mechanisms of action. Our lab also utilises transcriptomic and post-translational pathway profiling technologies such as NanoString and Reverse Phase Protein Array to understand disease evolution and drug mechanism of action at the dynamic pathway network level. Working in close collaboration with several pharmaceutical industry partners and academic groups we apply these approaches across several stages of the drug discovery process to: elucidate new therapeutic targets, identify hit molecules, advance small-molecule lead generation, classify compound mechanism of action (MOA), identify biomarker and drug combination hypotheses to inform clinical trial design.


Neil Carragher

Professor of Drug Discovery/Group Leader

John Dawson Deputy Leader of Phenotypic Screening

Richard Elliott

Senior Research Fellow

Alison Munro Senior Research Assistant HTPU
Jayne Culley Research Assistant
Edwin Carter Research Assistant
Martin Lee Imaging Engineer (joint with Val Brunton)

Alex Loftus

Post Doc (joint with Margaret Frame)

Mitch Foster

ECAT Fellow

Becka Hughes

Post Doc

Mungo Harvey PhD Student

Vanessa Smer-Barreto

XDF Fellow

Nhan Pham

Senior Drug Screening Scientist (joint with Siddharthan Chandran)

Rod Carter

Research Scientist (joint with Siddharthan Chandran)

Steve Shave

Research Fellow


PA : jan.irvine@ed.ac.uk


  • GlaxoSmithKline, Gunnels Wood Road, Stevenage, Herts, SG1 2NY, United Kingdom.
  • Nuvectis Pharma, Inc. Fort Lee, New Jersey, USA.
  • PhenoTherapeutics Ltd, Citypoint, 65 Haymarket Terrace, Edinburgh EH12 5HD, United Kingdom.
  • National Phenotypic Screening Centre: www.npsc.org
  • UK Regenerative Medicine Platform (UKRMP) Engineered Cell Environment Hub: https://www.ukrmp.org.uk/hubs/engineered-cell-environment/
  • The Euan Macdonald Centre: http://www.euanmacdonaldcentre.org/
  • The Centre for Inflammation Research STOPCOVID team: https://www.ed.ac.uk/inflammation-research/stopcovid
  • MRC Centre for Reproductive Health: https://www.ed.ac.uk/centre-reproductive-health/staff/associates
  • Asier Unciti-Broceta: Innovative Therapeutics Group
  • Steve Pollard:  Neural Stem Cells and Brain Cancer Group
  • Margaret Frame: Cancer Biology Group
  • Val Brunton: Cancer Therapeutics Group
  • Siddharthan Chandran: Centre for Clinical Brain Sciences
  • Kathryn Evans: Centre for Genomics and Experimental Medicine
  • Hilary Critchley Group: MRC Centre for Reproductive Health
  • Takanori Kitamura Group: MRC Centre for Reproductive Health
  • Achim Schnauffer: School of Biological Sciences, Institute of Immunology & Infection Research


Scientific Themes

Drug Discovery, target validation, network pharmacology, drug combinations, biomarkers

Technology Expertise

High throughput screening; 2D and 3D cell-based models of disease, high content imaging, reverse phase protein array, multivariate statistics and machine learning.