Centre for Genomic & Experimental Medicine
Centre for Genomic & Experimental Medicine

Yanick Crow (Affiliate)

Genetic disorders of Human Neurological and Immune Function

Professor Yanick Crow
Professor Yanick Crow

Section:  Disease Mechanisms

Research in a Nutshell

Yanick Crow is a clinician scientist, with the work of the Crow group driven by an interest in human diseases and a determination to improve their diagnosis and treatment.

The laboratory works across two themes: one relating to Aicardi-Goutières syndrome (AGS) and other disorders associated with enhanced type I interferon signalling (the so-called type I interferonopathies); and the second dedicated to an understanding of the causes of calcium in the brain (intracranial calcification), with a particular focus on two rare genetic conditions - leukoencephalopathy with calcifications and cysts (LCC) and Coats plus.

More information about these projects can be found by following the links below.

 

Aicardi-Goutières syndrome and the type I interferonopathies

 

LCC and Coats plus

Yanick Crow group

 

People

 
Yanick Crow Group Leader
Carolina Uggenti Post-doctoral Research Associate
Andrew Badrock Post-doctoral Research Associate
Marie-Therese El-Daher Post-doctoral Research Associate
Erisa Nita Post-doctoral Research Associate
Gaofeng Zhu PhD Student (Marie-Curie INFLANET consortium)
Katie Livingstone Research Assistant

Contact

yanick.crow@ed.ac.uk

Publications

  1. Crow YJ *, Stetson DB. The type I interferonopathies: 10 years on. Nature Reviews Immunology 2021;20:1-13.
  2. Uggenti C, Lepelley, A, Depp M, Badrock AP, Rodero MP, El-Daher MT, Rice GI, Dhir S, Wheeler AP, Dhir A, Albawardi W, Frémond ML, Seabra L, Doig J, Blair N, Martin-Niclos MJ, Della Mina E, Rubio-Roldán A, Garcia-Pérez J, Sproul D, Rehwinkel J, Hertzog J, Boland-Auge A, Olaso R, Deleuze J-F, Baruteau J, Brochard K, Buckley J, Cavallera V, Cereda C, De Waele LMH, Dobbie A, Doummar D, Elmslie F, Koch-Hogrebe M, Kumar R, Lamb K, Livingston JH, Majumdar A, Marques Lorenço C, Orcesi S, Peudenier S, Rostasy K, Salmon CA, Scott C, Tonduti D, Touati G, Valente M, van der Linden H, Van Esch H, Vermelle M, Webb K, Jackson AP, Reijns MAM, Gilbert N, Crow YJ. * cGAS-mediated induction of type I interferon due to inborn errors of histone pre-mRNA processing Nature Genetics 52, 1364-1372 (2020).
  3. Lepelley A, Martin-Niclós MJ, Le Bihan M, Marsh JA, Uggenti C, Rice GI, Bondet V, Duffy D, Hertzog J, Rehwinkel J, Amselem S, Boulisfane-El Khalifi S, Brennan M, Carter E, Chatenoud L, Chhun S, Coulomb l'Hermine A, Depp M, Legendre M, Mackenzie KJ, Marey J, McDougall C, McKenzie KJ, Molina TJ, Neven B, Seabra L, Thumerelle C, Wislez M, Nathan N, Manel N, Crow YJ, * Frémond ML. Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signalling. Journal of Experimental Medicine 217, e20200600 (2020).
  4. Badrock AP, Uggenti C, Wacheul L, Crilly S, Jenkinson EM, Rice GI, Kasher PR, Lafontaine DLJ, Crow YJ, O'Keefe RT. Analysis of U8 snoRNA Variants in Zebrafish Reveals How Bi-allelic Variants Cause Leukoencephalopathy With Calcifications and Cysts. American Journal of Human Genetics 106, 694-706 (2020).
  5. Rice GI, Meyzer C, Bouazza N, Hully M, Boddaert N, Semeraro M, Zeef LAH, Rozenberg F, Bondet V, Duffy D, Llibre A, Baek J, Sambe MN, Henry E, Jolaine V, Barnerias C, Barth M, Belot A, Cances C, Debray FG, Doummar D, Frémond ML, Kitabayashi N, Lepelley A, Levrat V, Melki I, Meyer P, Nougues MC, Renaldo F, Rodero MP, Rodriguez D, Roubertie A, Seabra L, Uggenti C, Abdoul H, Treluyer JM, Desguerre I, Blanche S, Crow YJ. * Reverse transcriptase inhibitors in Aicardi-Goutières syndrome. New England Journal of Medicine 379, 2275-7 (2018).

Full publication list can be found on Research Explorer: Yanick Crow — University of Edinburgh Research Explorer

Collaborations

  • Dr David Hunt, University of Edinburgh 
  • Professor Colin Smith, University of Edinburgh
  • Professor Adrian Hayday, King’s College, London 
  • Dr Gillian Rice, University of Manchester
  • Dr Darragh Duffy, Institut Pasteur, Paris
  • Professor Bénédicte Neven, Hôpital Necker Enfants Malades, Paris
  • Professor Stéphane Blanche, Hôpital Necker Enfants Malades, Paris
  • Dr Brigitte Bader-Meunier, Hôpital Necker Enfants Malades, Paris
  • Dr Marie-Louise Frémond, Institut Imagine, Paris
  • Dr Isabelle Melki, Institut Imagine, Paris

Partners and Funders

  • European Research Council
  • European Leukodystrophy Association
  • MRC

Scientific Themes

Genetics, Neurology, Immunology

Technology Expertise

Mendelian gene identification, Biomarker development, Clinical trials