Kathy Evans Research Group
Genetic and Functional Analysis of Neuropsychiatric Illness
Section: Medical Genetics
Research in a Nutshell
My goal is to uncover biological mechanisms underlying neurodegenerative disorders (such as Alzheimer’s disease), psychiatric disorders and related traits, identifying biomarkers and therapeutic targets. My group takes a multi-faceted approach, utilising data analytic, bioinformatic and wet lab techniques to improve understanding of psychiatric disorders at the level of the genotype, epigenome and cellular phenotype. A common aspect to all of these research strands is the use of various ‘omics techniques, that is, characterisation of the epigenome, transcriptome and proteome, in order to facilitate an unbiased assessment of potential pathogenic mechanisms. These approaches are complemented by functional analyses of cellular phenotype, e.g., investigation of candidate genes by genome editing.
Current examples include:
- DNA methylation in Generation Scotland: analysis of ~5,000 samples as part of the STRADL project.
- Sortilins-Investigation of the function of these important brain signalling and trafficking molecules through analysis of samples from knock out mice and production of mutant neuronal lines and iPSCs through genome editing.
- Involvement of CNVs in DLG2 in schizophrenia and related disorders
|Dr Kathy Evans||Group Leader|
|Susan Anderson||Research Assistant|
|Mairead Bermingham||Research Associate|
|Panos Giannopolous||PhD Student|
|Sophie Glen||PhD Student|
|Katerina Gospodinova||PhD Student|
|Jonathan Phillips||Research Associate|
|Rosie Walker||Research Associate|
• Prof Cathy Abbott, Prof Neil Carragher, Dr Mandy Jonstone, Dr Kirsty Millar, Dr Kristin Nicodemus; Prof David Porteous, Dr Pippa Thomson, IGMM, University of Edinburgh • Prof Siddharthan Chandran, Prof Ian Deary, Prof Tilo Kunath, Dr Riccardo Marioni, Prof Andrew McIntosh, Prof Tara Spires-Jones, University of Edinburgh • Dr Simon Gerup, Prof Anders Nykjaer, Aarhus University, Denmark • Dr Dick McCombie, Cold Spring Harbor labs, USA
Partners and Funders
Current • Bequest from Eva Lester • The Sackler Foundation. • The Wellcome Trust Past • The Brain and Behavior Research Foundation (NARSAD) • The Medical Research Council • The National Centre for the Replacement, Refinement and Reduction of Animals in Research • The National Institute of Mental Health, USA • The Scottish Executive Chief Scientist Office
Psychiatric Illness; Alzheimer’s Disease, Parkinsons Disease, Epigenetics
CRISPR/Cas9 gene editing, DNA methylation, expression analysis, bioinformatics, production and analysis of neuronal derivatives of induced pluripotent stem cells (iPSCs)