Sara Brown Research Group
Molecular and genetic mechanisms in atopic eczema
Section: Experimental Medicine
Research in a Nutshell
Sara is a clinical academic dermatologist, caring for patients of all ages with a wide range of skin diseases. Her research focusses on increasing the understanding of how a person’s genetic make-up predisposes to the inflammatory skin disease atopic eczema and associated systemic conditions. Sara is also an associate member of the Centre for Inflammatory Research https://www.ed.ac.uk/inflammation-research/people/associate-members/prof-sara-brown.
The Brown Lab uses a human skin cells to create a skin organoid model which can be precisely manipulated to investigate specific molecular genetic effects. These studies are informed by genome-wide and population-based research with international collaboration. Current and future work tests gene-environment interactions, to address an important question regarding why eczema has increased in prevalence in recent decades.
The ultimate aim of Sara’s work is to define targets for the development of new and better treatments for people affected by eczema, dry skin (ichthyoses) and related allergic conditions.
|Prof Sara Brown||Group Leader|
|Dr Martina Elias||Postdoctoral Research Associate|
- eSkIN – the Skin Interest Network, University of Edinburgh
- Tim Aitman, University of Edinburgh
- Wendy Bickmore, University of Edinburgh
- Stuart Forbes, University of Edinburgh
- Andrew Baker, University of Edinburgh
- Lavinia Paternoster, University of Bristol
- Catherine Smith, Kings College London
- Angus Lamond – University of Dundee
- National Phenotypic Screening Centre – University of Dundee
Partners and Funders
Wellcome Trust - Senior Research Fellowship in Clinical Science
British Skin Foundation
Anonymous and philanthropic donors
BIOMAP consortium (Biomarkers in Atopic Dermatitis and Psoriasis) – funded by the EU Innovative Medicines Initiative
Genetics, genomics, dermatology, atopic eczema/atopic dermatitis, genetic epidemiology, environment, organoid model, transcriptomics, proteomics.