MRC Human Genetics Unit
Medical Research Council Human Genetics Unit

Neil Henderson Group (Affiliate)

Cellular and Molecular Mechanisms of Tissue Repair and Regeneration

Research in a Nutshell 

N. Henderson
Professor Neil Henderson, Chair of Tissue Repair and Regeneration, Wellcome Trust Senior Research Fellow in Clinical Science, Honorary Consultant Hepatologist

Organ fibrosis (scarring) is a major cause of morbidity and mortality worldwide, and as yet there are no effective anti-fibrotic treatments. My lab is interested in the cellular and molecular mechanisms that drive organ fibrosis, and also the molecular pathways which are responsible for efficient wound healing and healthy tissue regeneration following injury. By understanding more about how organs scar, heal and regenerate we hope to develop new treatments for patients with organ fibrosis.

Single-cell genomics approaches are transforming our understanding of disease pathogenesis, allowing interrogation of homeostatic and pathogenic cell populations at unprecedented resolution, and adding an illuminating dimension to transcriptomic information relative to traditional methods that profile bulk cell populations. The single cell genomics field has developed rapidly over the last few years, chiefly because these approaches allow powerful, unbiased exploration of cell states and types at single-cell resolution, resulting in unexpected novel insights into tissue biology and disease mechanisms.  

The convergence of these multi-modal single-cell technologies represent a remarkable opportunity to de-code the molecular mechanisms regulating human tissue fibrosis and regeneration at single cell resolution, which we hope will inform and accelerate the development of effective new therapies for patients with fibrotic diseases.

People

Professor Neil Henderson Group Leader
Mariana Beltran Research Assistant
Madara Brice Research Assistant

Ross Dobie

Postdoctoral Researcher
Laura Kitto Wellcome Trust ECAT PhD student
Andreas Kapourani MRC Cross-Disciplinary (XDF) Postdoctoral Research Fellow
Dyana Markose Postdoctoral Researcher
Kylie Matchett Postdoctoral Researcher
Prasad Palani Velu Wellcome Trust ECAT PhD student
Jordan Portman MRC Precision Medicine PhD student
Prakash Ramachandran MRC Clinician Scientist
Sebastian Wallace Clinical Research Fellow / PhD student
Chris West SCREDS Clinical Lecturer
John Wilson-Kanamori Postdoctoral Researcher

Contact

Neil.Henderson@ed.ac.uk

Collaborations

  • Chris Ponting, MRC Human Genetics Unit, University of Edinburgh  
  • John Marioni, EMBL-EBI, Wellcome Genome Campus, Cambridge
  • Sarah Teichmann, Wellcome Trust Sanger Institute, University of Cambridge  
  • Dean Sheppard, University of California, San Francisco

Partners and Funders

  • Wellcome Trust
  • Medical Research Council
  • Chan Zuckerberg Initiative
  • Guts UK
  • Children's Liver Disease Foundation
  • British Heart Foundation
  • Tenovus Scotland
  • William Rooney Research Trust
  • Kidney Research UK
  • Medical Research Scotland

Scientific Themes

Tissue fibrosis and regeneration

Technology Expertise

Single-cell technologies, modelling of tissue fibrosis and regeneration.