Catalina Vallejos Research Group
Biomedical Data Science
Section: Biomedical Genomics
Research in a Nutshell
While biomedical data sometimes classifies as “big data” (where the number of samples and/or variables is large), complexity is its most prominent feature. This arises from a combination of different sources of heterogeneity: heterogeneity across individuals in a population (e.g. response to treatment), heterogeneity in terms of the type of data we collect (e.g. health records & genomics) and heterogeneity that is introduced by the data collection process (e.g. measurement error).
We focus on the development of novel statistical methodology to address and study these sources of heterogeneity. This is a highly multidisciplinary task: from the understanding of complex biomedical problems and technologies, to the development of new methodology and the implementation of open-source analysis tools. Our current research focuses on two areas of application. Firstly, single-cell RNA-sequencing, a cutting-edge experimental technique that allows genome-wide quantification of gene expression on a cell-by-cell basis. Secondly, electronic health records research, to develop predictive models based on observational data that is routinely collected by health providers (e.g. NHS). Developing computational tools that can make full advantage of the rich information provided by these data sources is ought to improve our understanding of health and disease, playing an important role in precision medicine initiatives.
|Dr Catalina Vallejos||Group Leader|
|Alan O'Callaghan||PhD student|
|Dr Andreas Kapourani||Cross-Disciplinary Fellow (XDF, rotation project)|
|Christos Maniatis||PhD Student (joint w/ Sanguinetti group, School of Informatics)|
|PhD student (Precision Medicine programme; co-supervised by Charlie Lees)|
|Dr James Liley||Postdoctoral Research Fellow (co-supervised by Louis Aslett, Durham)|
Partners and Funders
- The Alan Turing Institute
- British Heart Foundation
statistical genomics, electronic health records research