Andrew Jackson Research Group
Growth, Inflammation and the Brain
Section: Disease Mechanisms
Research in a Nutshell
My research programme identifies new genes for inherited disorders affecting the human brain. We also study how these genes function using cells and model organisms. Aicardi-Goutières syndrome is a genetic condition in which faults in genes encoding enzymes called nucleases, mimic viral infection of the brain. These nucleases may normally clean up naturally produced ‘waste’ DNA and RNA, with failure of this process leading to the body mounting an immune reaction against itself. This immune response mechanism is relevant to common autoimmune diseases such as lupus and so we are studying these enzymes to understand their normal roles in cells and to establish what happens when these enzymes fail.
Secondly, we are identifying genes that cause extreme growth failure of the brain and body. Individuals with primordial dwarfism are often described as the 'smallest people in the world'. These genes are components of the core cell machinery which controls cell duplication and mutations likely result in fewer cells being made, leading to a smaller person. Identifying these genes will help diagnosis and management of these rare conditions. It may also help us better understand how the body regulates growth, perhaps shedding light into why humans are bigger than mice and how our brains evolved to be so large.
People |
|
|---|---|
| Professor Andrew Jackson | Group Leader |
| Patricia Heyn |
Postdoctoral scientist |
| Clare Logan |
Postdoctoral scientist |
| Karen Mackenzie |
Postdoctoral scientist |
| Carol-Anne Martin |
Postdoctoral scientist |
| Olga Murina |
Postdoctoral scientist |
| David Parry | Postdoctoral scientist |
| Kaalak Reddy |
Postdoctoral scientist |
| Martin Reijns |
Postdoctoral scientist |
| Adeline Fluteau | Research Support |
| Andrea Robertson | Area Supervisor and Research Support |
| Zygimate Tarnaukaite |
PhD student |
| Thomas Williams |
ECAT PhD student |
| Jennie Murray | Clinical lecturer |
| David Hunt | Intermediate Fellow |
| Rachel Challis | Translational Postdoctoral scientist (Shared) |
Contact
Collaborations
- Dr Martin Taylor, MRC HGU
- Dr Andrew Wood, MRC HGU
- Professor Bob Hill, MRC HGU
- Professor Wendy Bickmore, MRC HGU
- Dr Garcia-Perez, MRC HGU
- Professor Chris Ponting, MRC HGU
- Dr Alexander von Kriegsheim, IGMM
- Professor Grant Stewart, University of Birmingham
- Professor Dan Durocher, University of Toronto
- Dr Jan Rehwinkel, WIMM, Oxford
- Dr Ian Holt, NIMR
- Dr Mike Bober, Delaware
- Dr Carol Wise, Dallas
- Professor Bernd Wollnik, Gottingen
- Professor Valerie Cormier-Daire, Paris
- Walking with Giants Foundation, UK
- Potentials Foundation, USA
Partners and Funders
- Medical Research Council
- Lister Institute for Preventative Medicine
- European Research Council
Scientific Themes
Microcephaly, Aicardi-Goutieres syndrome, Ribonuclease H2, genome stability, inflammation