MRC Human Genetics Unit
Medical Research Council Human Genetics Unit

Ian Adams Research Group

Genetic and Chromosomal Stability in Mammalian Germ Cells

I.Adams
Dr Ian Adams - Programme Leader

Section: Genome Regulation

Research in a Nutshell

Our research is trying to find out how the body makes sure that parents pass the right number of chromosomes on to their children. Mistakes in this process are very common in humans and cause miscarriage, infertility, and Down's Syndrome. 

We know that most of the mistakes that cause embryos to inherit the wrong number of chromosomes happen when eggs are being made in the mother, and that these mistakes are very common in older mothers. However the behaviour of the chromosomes in developing eggs is difficult to study in humans because these cells are rare and only found in the ovary deep inside the body.

Mice are much better at passing the right number of chromosomes on to their children than humans, and we have found a new gene that helps mice do this. Female mice that have mutations in this gene make eggs carrying the wrong number of chromosomes. The mistakes happening in these mutant mouse eggs mimic some of the mistakes that happen in human eggs. We hope that by finding the genes that help mouse eggs and sperm carry the right number of chromosomes, we might be able to help humans eggs do the same.

I.Adams research group

People

 

Dr Ian Adams Group Leader

Dr James Crichton 

Postdoctoral scientist

Dr Karen Dobie

Research assistant

Jennifer Lawson Research Assistant 

Isobel MacGregor 

PhD Student

Christopher Playfoot 

PhD Student

Eleanor Raymond

PhD Student

Contact

Ian.Adams@igmm.ed.ac.uk

Partners and Funders

  • Medical Research Council

Scientific Themes

spermatogenesis, oogenesis, meiosis, aneuploidy, retrotransposons.

Technology Expertise

embryonic stem cells, transgenic mouse models, analysis of chromosome behaviour.