MRC Human Genetics Unit
Medical Research Council Human Genetics Unit

Chris Ponting Research Group

Causal variants and mechanisms in complex traits and diseases

 

Professor Chris Ponting - Section Head: Biomedical Genomics, Chair of Medical Bioinformatics
Professor Chris Ponting - Section Head: Biomedical Genomics, Chair of Medical Bioinformatics

Research in a Nutshell 

The challenge in genomics is to pinpoint DNA variants that alter individuals’ risk to common disease; the challenge in genetics is to determine how these changes alter genetic mechanisms; and, the challenge in cell biology is to find out how these altered mechanisms affect development, cells and organs. Our research uses cutting-edge analytical approaches in genomics, transcriptomics, and cell biology to trace the causal links relating DNA variation to physiological outcome. Our research intersects disease genomics, computational biology, machine learning and molecular mechanism.

We are currently pursuing two major research projects:

  1. Disease and trait genomics. Blending single cell and functional genomics analysis, and machine learning, we predict molecular mechanisms by cell type and developmental stage. We then determine whether DNA variants altering these mechanisms influence human traits, including diseases. This research contributes to MRC’s strategy to investigate biological complexity in real life and at different scales and UKRI’s Delivery Plan to understand today’s greatest challenges that span society and cross disciplinary boundaries. This project is providing a vibrant and eclectic training environment for PhDs and postdocs from diverse backgrounds.  
  2. ME/CFS Genetics.  Funded by MRC and NIHR, we are part of DecodeME, the world’s biggest genetic study of the causes of ME/CFS. This project is a co-production between academics, people with ME and carers. We have also received PhD funds to investigate whether people with ME differ in their T-cell repertoire from healthy controls (funded by Action for M.E. and the Scottish Government’s Chief Scientist’s Office) and to follow-up leads from the DecodeME study (funded by ME Research UK). We support Action for ME’s vision to establish ME/CFS’s first Genetics Centre of Excellence.

 

Research Programme

People

 
Professor Chris Ponting Group Leader
Tom Baker Data Manager, DecodeME
Thibaud Boutin DecodeME Research Fellow

Diana Garcia

DecodeME Project Manager
Shona Kerr DecodeME Co-Investigator
Cristina Martin X-net Project Manager
Gosia Clyde DecodeME Admin Manager
Anne Connolly DecodeME Communications and Engagement Manager
Breeshey Roskams-Hieter

PhD Student

Gemma Samms PhD Student
Veronique Vitart DecodeME Co-Investigator
Jareth Wolfe Research Fellow
Audrey Ryback Action for M.E. Research Fellow
Alina Kumukova Cross-disciplinary Fellow
Andrii Iakovliev Cross-disciplinary Fellow
Yavor Novev Cross-disciplinary Fellow

Contact

Chris.Ponting@ed.ac.uk

Publications

  1. Baran-Gale J, Morgan MD, Maio S, Dhalla F, Calvo-Asensio I, Deadman ME, Handel AE, Maynard A, Chen S, Green F, Sit RV, Neff NF, Darmanis S, Tan W, May AP, Marioni JC, Ponting CP*, Holländer GA*. (2020) Ageing compromises mouse thymus function and remodels epithelial cell differentiation. eLife 9:e56221
  2. Dhalla F, Baran-Gale J, Maio S, Chappell L, Holländer GA*, Ponting CP*. (2020) Biologically indeterminate yet ordered promiscuous gene expression in single medullary thymic epithelial cells. EMBO J 39:e101828
  3. Sirey TM*, Roberts K, Haerty W, Bedoya-Reina O, Rogatti-Granados S, Tan JY, Li N, Heather LC, Carter RN, Cooper S, Finch AJ, Wills J, Morton NM, Marques AC, Ponting CP*. (2019) The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity. eLife 8:e45051
  4. Bretherick, A.D., Canela-Xandri, O., Joshi, P.K., Clark, D.W., Rawlik, K., Boutin, T.S., Zeng, Y., Amador, C., Navarro, P., Rudan, I., Wright, A.F., Campbell, H., Vitart, V., Hayward, C., Wilson, J.F., Tenesa, A., Ponting, C.P., Baillie, J.K., Haley, C. (2020) Linking protein to phenotype with Mendelian Randomisation detects 38 proteins with causal roles in human diseases and traits. PLoS Genet. 16: e1008785.
  5. Kousathanas, A., Pairo-Castineira, E. et al. (including Ponting, C.P.) Caulfield, M.J., Baillie, J.K. Whole-genome sequencing reveals host factors underlying critical COVID-19. (2022) Nature

Full publication list can be found on Research Explorer: Chris Ponting — University of Edinburgh Research Explorer

Collaborations

  • Professor Georg Hollander, University of Oxford
  • Dr Ava Khamseh & Dr Sjoerd Beentjes, University of Edinburgh

Partners and Funders

  • MRC
  • Wellcome
  • NIHR
  • Action for ME/ Chief Scientist's Office, Scotland
  • ME Research UK

Scientific Themes

Population genomics, ME/CFS genetics, molecular mechanisms in complex disease.

Technology Expertise

Single cell biology