Andrew Wood Research Group

Research in a Nutshell 

We develop technologies to manipulate the function of genes and proteins in physiological models of human disease, focusing on CRISPR and targeted protein degradation. Our laboratory applies these technologies to study the mechanisms through which the genome is propagated through cell division. Through collaboration, we also apply them more broadly to study other biological processes relevant to human disease.

Our research is divided into three main themes:

1. Degron Tagging
2. Genome Editing
3. Mitotic Chromosome Condensation

Research Programme

Contact

Andrew.J.Wood@ed.ac.uk

Publications

1. Macdonald L, Taylor G, Brisbane J, Christodoulou E, Scott L, Von Kriegsheim A, Rossant J, Gu B*, Wood AJ* (2022) Rapid and specific degradation of endogenous proteins in mouse models using auxin-inducible degrons. eLife Jun 23, 2022. https://doi.org/10.7554/eLife.77987
2. Kallimasioti-Pazi I, Chathoth K, Taylor G, Meynert A, Ballinger T, Kelder M, Sanli I, Lalevee S, Feil R, Wood AJ. (2018) Heterochromatin impedes CRISPR-Cas9 mutagenesis but does not influence the outcome of mutagenic DNA repair. PLoS Biology 16:e2005595
3. Woodward J, Taylor GC, 12 others, Arends MJ, Kranc KR, Jackson AP, Bickmore WA*, Wood AJ*. (2016) Condensin II mutation causes T cell lymphoma through tissue-specific genome instability. Genes & Development 30:2173-2186.
4. Therizols PT, Illingworth R, Courilleau C, Boyle S, Wood AJ, Bickmore WA. (2014) Chromatin decondensation is sufficient to alter nuclear positioning in embryonic stem cells. Science. 346:1238-1242.
5. *Wood AJ, *Lo TW, *Zeitler B, Pickle CS, Ralston EJ, Lee AH, Amora R, Miller JC, Leung E, Meng X, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Meyer BJ. (2011) Targeted genome editing across species using ZFNs and TALENs. Science. 333:30

Full publication list can be found on Research Explorer: Andrew Wood — University of Edinburgh Research Explorer

Collaborations

• Dr Joe Marsh
• Professor Wendy Bickmore
• Professor Andrew Jackson
• Professor Javier Caceres

Partners and Funders

• The Wellcome Trust
• The Royal Society
• Medical Research Council