Genome Stability and Genome Editing
In order to maintain a stable genome through cell division, chromosomes must undergo replication and then condense before segregating equally into daughter cells during mitosis. My laboratory uses blood cell development to understand how effectively these processes operate during the course of normal tissue development and homeostasis, and the consequences of their malfunction on mutagenesis and malignancy.
Several other projects in the lab make use of genome editing technologies. We are using CRISPR/Cas9 to study fundamental mechanisms of DNA repair, and to develop novel genome engineering strategies that expand the genetic toolbox.
|Dr Andrew Wood||Group Leader|
|Dr Gillian Taylor||Postdoctoral Scientist|
|Martijn Kelder||PhD Student|
genome stability, mutagenesis, chromosome structure, cell proliferation
Genome editing, flow cytometry, in vivo modelling