MRC Human Genetics Unit
Medical Research Council Human Genetics Unit

Andrew Wood Research Group

Genome Stability and Genome Editing

A.Wood
Dr Andrew Wood - IGMM Chancellor's Fellow and Sir Henry Dale Fellow

Section: Genome Regulation

Research in a Nutshell 

In order to maintain a stable genome through cell division, chromosomes must undergo replication and then condense before segregating equally into daughter cells during mitosis.  My laboratory uses blood cell development to understand how effectively these processes operate during the course of normal tissue development and homeostasis, and the consequences of their malfunction on mutagenesis and malignancy.

Several other projects in the lab make use of genome editing technologies. We are using CRISPR/Cas9 to study fundamental mechanisms of DNA repair, and to develop novel genome engineering strategies that expand the genetic toolbox.

 

A.Wood group

People

 

Dr Andrew Wood Group Leader
Dr Gillian Taylor Postdoctoral Scientist
Martijn Kelder PhD Student

Irene Kallimasioti-Pazi

PhD Student

Contact

Andrew.Wood@igmm.ed.ac.uk

Collaborations

  • Dr Ian Adams
  • Professor Wendy Bickmore
  • Professor Andrew Jackson
  • Professor Colin Semple

Partners and Funders

  • The Wellcome Trust
  • The Royal Society

Scientific Themes

genome stability, mutagenesis, chromosome structure, cell proliferation

Technology Expertise

Genome editing, flow cytometry, in vivo modelling