MRC Human Genetics Unit
Medical Research Council Human Genetics Unit

Luke Boulter Research Group

Signalling in Tissue Repair and Cancer

Dr Luke Boulter - IGMM Chancellor's Fellow
Dr Luke Boulter - IGMM Chancellor's Fellow

Section: Disease Mechanisms

Research in a Nutshell 

During tissue homeostasis and regeneration epithelial cells must balance proliferation, cell death and differentiation to maintain a functional organ. In the liver, this regulation requires the constant integration of signals by epithelial cells from non-epithelial, niche cells, which includes inflammatory cells and fibroblasts. In cancer, these interactions become deregulated and epithelial cells can either be regulated independent of their microenvironment or the niche becomes permissive to tumour formation. 

Our lab is interested in how the signals, which come from the regenerative microenvironment drive tissue repair following injury and how these signals are co-opted by the tumour to support cancer growth. We are particularly interested in the role of the Wnt pathway in these processes and are currently working on both canonical and non-canonical Wnt signalling to define how these pathways regulate tissue architecture, using the adult liver and cancers of the adult liver as a models for these studies.

 

Research Programme

Luke Boulter lab 9.2018

People

 
Luke Boulter IGMM Chancellor’s Fellow and Principal Investigator
Edward Jarman Postdoctoral Research Fellow
David Wilson Senior Research Assistant

Nicholas Younger

PhD Student

Scott Waddell

PhD Student (with Pleasantine Mill)
Mollie Wilson PhD Student
John Connelly Clinical Research Fellow

Contact

 luke.boulter@igmm.ed.ac.uk

Scientific Themes

Cholangiocarcinoma, liver, intestine, Wnt signalling

Technology Expertise

Cancer Models, Organoids, Quantitative Imaging, Pathologist