Colin Semple Research Group

The genes embedded in your genome have complex patterns of activity and particular constellations of genes must be active at particular times for biological processes, such as embryonic development, to conclude successfully. I am interested in the fundamental biology of gene regulation: when, how and why genes are turned on and off. We try to understand the mechanisms underlying gene regulation, using computational analyses of genomic datasets. This can provide new insights into human evolution and help us interpret disease processes with aberrant regulation, such as cancers and developmental disorders.