MRC Human Genetics Unit
Medical Research Council Human Genetics Unit

Colin Semple Research Group

Medical and Regulatory Genomics

C.Semple group
Professor Colin Semple

Section: Biomedical Genomics

Research in a Nutshell 

The genes embedded in your genome have complex patterns of activity and particular constellations of genes must be active at particular times for biological processes, such as embryonic development, to conclude successfully. I am interested in the fundamental biology of gene regulation: when, how and why genes are turned on and off. We try to understand the mechanisms underlying gene regulation, using computational analyses of genomic datasets. This can provide new insights into human evolution and help us interpret disease processes with aberrant regulation, such as cancers and developmental disorders.


Research Programme


C.Semple group



Professor Colin Semple Group Leader
Dr Stuart Aitken    Bioinformatician
Dr Jose Campos Parada IGMM Staff Bioinformatician

Dr Kevin Donnelly 

Bioinformatician (SGP)

Dr Philippe Gautier  Bioinformatician
Mr Graeme Grimes Bioinformatician
Dr Vera Kaiser  Bioinformatician
Dr Alison Meynert Bioinformatician
Dr Tracy Ballinger Bioinformatician
Dr Mihail Halachev  Bioinformatician
Dr Ailith Ewing Bioinformatician
Annalaura Vacca  PhD student
Toby Gurran PhD student



  • Professor Wendy Bickmore, MRC Human Genetics Unit
  • Professor Malcolm Dunlop, MRC Human Genetics Unit
  • Professor David Fitzpatrick, MRC Human Genetics Unit
  • Professor Chris Haley, MRC Human Genetics Unit
  • Professor Martin Taylor, MRC Human Genetics Unit
  • Professor Tim Aitman, Centre for Genomic & Experimental Medicine, University of Edinburgh
  • Professor Ana Pombo, Berlin Institute for Medical Systems Biology, Germany
  • Professor Piero Carninci, RIKEN  Center for Life Science Technologies, Japan

Partners and Funders

Scientific Themes

Medical Genomics, Bioinformatics, Transcriptomics, Epigenomics

Technology Expertise

Computational Biology