MRC Human Genetics Unit
Medical Research Council Human Genetics Unit

Colin Semple Research Group

Origins and Impacts of Regulatory Mutations

C.Semple group
Professor Colin Semple - Group leader and Head of Bioinformatics

Section: Biomedical Genomics

Research in a Nutshell 

The genes embedded in your genome have complex patterns of activity and particular constellations of genes must be active at particular times for biological processes, such as embryonic development, to conclude successfully. I am interested in the fundamental biology of gene regulation: when, how and why genes are turned on and off. We try to understand the mechanisms underlying gene regulation, using computational analyses of genomic datasets. This can provide new insights into human evolution and help us interpret disease processes with aberrant regulation, such as cancers and developmental disorders. We focus on relatively poorly studied cancers, such as ovarian cancer and the brain cancer glioblastoma, where the tumour genomes become dramatically rearranged as they evolve during disease progression. With our clinical and experimental collaborators we explore the consequences of these rearrangements for gene functions, and for cancer patient outcomes. The aim is to better understand tumour biology, to reveal new vulnerabilities that can be targeted in cancer treatments.

Group External Website


Professor Colin Semple Group leader and Head of Bioinformatics
Dr Stuart Aitken    Bioinformatician
Dr Vera Kaiser  Bioinformatician
Dr Devin Bendixsen Bioinformatician

Stuart Brown

PhD student
Neil Robertson PhD student
Thomas Parry PhD student
Ryan Silk PhD student
Alhafidz Hamdan ECAT fellow
Mitchell Foster ECAT fellow

Bioinformatics Analysis Core

Dr Alison Meynert Institute of Genetics and Cancer Bioinformatics Analysis Core Manager
Dr Philippe Gautier  Bioinformatician
Mr Graeme Grimes Bioinformatician
Dr Mihail Halachev  NHS/Institute of Genetics and Cancer Translational Bioinformatician
Dr Elvina Gountouna Institute of Genetics and Cancer Research Data Manager
Hannes Becher Institute of Genetics and Cancer Statistician
Murray Wham Bioinformatician



  • Professor Wendy Bickmore, MRC Human Genetics Unit
  • Professor Malcolm Dunlop, MRC Human Genetics Unit
  • Professor David Fitzpatrick, MRC Human Genetics Unit
  • Professor Chris Haley, MRC Human Genetics Unit
  • Professor Martin Taylor, MRC Human Genetics Unit
  • Dr Nicola Crosetto, Karolinska Institute, Sweden
  • Professor Charlie Gourley, Cancer Research UK Edinburgh Centre
  • Professor Piero Carninci, RIKEN  Center for Life Science Technologies, Japan

Partners and Funders

Scientific Themes

Medical Genomics, Bioinformatics, Transcriptomics, Epigenomics

Technology Expertise

Computational Biology