Dr Stuart Aitken
I am a staff bioinformatician and research scientist in medical and regulatory genomics. Both activities involve the processing and interpretation of next generation sequencing data (RNA Seq, ChIP Seq and HiC) to understand transcriptomic and regulatory processes in model systems and in disease. I am also interested in single cell data, analysis and modelling. In many of these analyses I have applied maximum likelihood, expectation maximisation and Bayesian methods to the problems of fitting models to data, and have have previously studied kinetic modelling in systems biology, parameter optimisation and parameter inference.
Finding Diagnostically Useful Patterns in Quantitative Phenotypic Data
Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1
A slow transcription rate causes embryonic lethality and perturbs kinetic coupling of neuronal genes
Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia
Conserved temporal ordering of promoter activation implicates common mechanisms governing the immediate early response across cell types and stimuli