MRC Human Genetics Unit
Medical Research Council Human Genetics Unit

Research

We seek to understand how DNA changes impact on human health and disease, and how genes and the genome act in normal development and physiology.

Our four research sections enhance collaboration, sharing and mutual feedback on our work. Section meetings are open to all and collaboration between sections is widespread and fruitful.

Ian Adams Research Group

Ian Adams: meiosis
Genetic and Chromosomal Stability in Mammalian Germ Cells

Wendy Bickmore Research Group

W.Bickmore research
Spatial Organisation of the Human Genome

Luke Boulter Research Group

L.Boulter - Research Image
Signalling in Tissue Repair and Cancer

Javier Caceres Research Group

J.Caceres_RNA Processing in Eukaryotes
RNA processing and gene regulation

Oriol Canela-Xandri Research Group

High performance algorithms to analyse large and distributed datasets

Tamir Chandra Research Group

T.Chandra - Research Image
Systems Biology of Ageing and Disease

Helen Colhoun Research Group

Diabetes
Diabetes Medical Informatics and Epidemiology

Yanick Crow Research Group

Yanick-Crow-research
Genetic disorders of Human Neurological and Immune Function

Tom Deegan Research Group

Mechanism and Regulation of Chromosome Replication

Malcolm Dunlop Research Group

M.Dunlop research
Colorectal Cancer, Genetic Susceptibility, Prevention

Ailith Ewing Research Group

Evolutionary trajectories of structural variation in cancer

David FitzPatrick Research Group

D.FitzPatrick - Research Image
Genetic Causes of Developmental Disorders

Nick Gilbert Research Group

Nick Gilbert research 2019
Chromatin Structure and Genome Integrity

Chris Haley Research Group

C.Haley research
Complex Trait Genetics: Dissecting the genetic architecture of health and disease traits

Caroline Hayward Research Group

C.Hayward Research Image
Quantitative Traits in Health and Disease

Robert Hill Research Group

sdrnt1bio-2014_chart
Chromatin Organisation and the Regulation of Gene Expression

Andrew Jackson Research Group

Andrew Jackson research montage 2019
Mechanisms for Microcephaly, Cancer and Autoinflammation

Ian Jackson Research Group

I.Jackson - Research Image
Molecular Genetics and Development of Melanocytes, Genetic Models for Human Disease

Ava Khamseh Research Group

Causal Quantitative Cancer Biology and Population Genomics

Grzegorz Kudla Research Group

G.Kudla - Research Image
RNA Synthetic Biology

Hannah Long Research Group

Gene Regulation in Human Craniofacial Development and Disease

Joe Marsh Research Group

J.Marsh - Research Image
Protein Variant Interpretation

Richard Meehan Research Group

Richard Meehan research
Epigenetic Mechanisms in Development and Disease

Pleasantine Mill Research Group

P.Mill research image
Genetics of Cilia Biology

Jenny Nichols Research Group

Mechanisms of establishment, regulation and differentiation of early mammalian lineages in vivo and in vitro

Liz Patton Research Group

L.Patton research
Targeting developmental cell states in melanoma

Chris Ponting Research Group

C.Ponting research
Causal variants and mechanisms in complex traits and diseases

Colin Semple Research Group

C.Semple research
Origins and Impacts of Regulatory Mutations

Duncan Sproul Research Group

D.Sproul research
Epigenetics in Human Disease

Martin Taylor Research Group

Mutagenesis and its Biomedical Impact

Quantitative Trait Loci Research Group

QTL
Quantitative Traits in Health and Disease

Veronique Vitart Research Group

From GWAS to Function

Catalina Vallejos Research Group

Biomedical Data Science

Andrew Wood Research Group

Genome editing and targeted protein degradation

Sjoerd Beentjes (Affiliate)

Targeted Causal Machine Learning for Population Biomedicine

Simon Biddie (Affiliate)

Genome regulation of lung inflammation, injury and repair

Neil Henderson Group (Affiliate)

Cellular and Molecular Mechanisms of Tissue Repair and Regeneration

Davide Michieletto Research Group (Affiliate)

Topology and Viscoelasticity of DNA and Genomes

Robert Semple Research Group (Affiliate)

Human Genetic Disorders of Insulin Action

Albert Tenesa Research Group (Affiliate)

complex traits, statistical genetics, prediction
Understanding Human Complex Trait Variation

Ian Tomlinson (Affiliate)

Ian Tomlinson research
Cancer Genetics and Evolution

Jim Wilson Research Group (Affiliate)

J.Wilson research
Quantitative traits in health and disease