We seek to understand how DNA changes impact on human health and disease, and how genes and the genome act in normal development and physiology.
Our research can be described by 2 broad themes:
Generating step-change in understanding how changes to genome sequence, regulation and organisation can impact understanding of normal human biology, health and disease to underpin better disease diagnostics and disease management.
4D cellular medicine
Harnessing state-of-the-art cell, organoid and animal models integrated with the latest advances in genome editing, single cell ‘omics and imaging to understand genetic and molecular basis of disease and identify novel therapeutic strategies
We are also organised into three research sections to enhance collaboration, sharing and mutual feedback on our work. Section meetings are open to all and collaboration between sections is widespread and fruitful.
Our research harnesses the power of large genome-size and population data to reveal the complex nature of disease processes.
Section Head: Professor Chris Ponting
Our research focuses on mechanisms that maintain the stability of the genome between cells and between generations, regulate the expression of genes and how changes to these contribute to disease.
Section Head: Professor Javier Caceres
Our research aims to understand how changes in our genomes cause disease by studying patients and families as well as model organisms.
Section Head: Professor Andrew Jackson