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Genetic clues of TB spread revealed

Tuberculosis in cattle and badgers passes between members of the same species at least twice as often than between cow and badger.

Cows
Scientists performed whole genome sequencing of the bacteria from 230 badgers and 189 cattle.

Disease spread within badger populations and within cattle herds happens at least twice as frequently as transmission from one species to the other, according to a study at a site where infections occur frequently.

Researchers analysing genetic data from the bacteria that causes the disease also found that cattle are approximately ten times more likely to catch tuberculosis (TB) from badgers than badgers are to catch it from cattle.

Scientists say the findings of the research – which was conducted in Gloucestershire over a 15-year period – could improve control strategies, reduce disease transmission and cut associated costs.

Transmission

Bovine TB is an infectious respiratory disease of cattle that is mainly spread through inhaling infectious particles in the air. It is caused by the bacterium Mycobacterium bovis, which can also infect and cause disease in other mammals, including humans, deer, goats, pigs, cats and dogs.

Using data from an undisturbed population of badgers in Woodchester Park in Gloucestershire and nearby cattle farms, this study provides the first direct evidence of transmission between badgers and cattle. It is an area where tuberculosis is known to occur frequently in both cattle and badgers.

Genetic study

The researchers analysed the entire genetic make-up of the bacteria from 230 badgers and 189 cattle, a process known as whole genome sequencing.

They combined this with detailed information on where the cattle and badgers lived, when they were infected, and whether they could have had contact with one another.

Scientists were then able to estimate how often the two species spread TB. They found that badgers play an important role in the maintenance of the disease in this area.

The work was led by experts from the Roslin Institute, with collaborators from institutions including the Animal and Plant Health Agency, the University of Glasgow and University College Dublin.

Control strategies

Current approaches to controlling bovine tuberculosis only discriminate at a very coarse, regional level between areas where badgers are more likely to be involved in infecting cattle from areas where they are not. This work identifies genetic signatures that could guide the interpretation of similar data if collected in other, less-intensively studied areas.

This would allow for a more targeted control of tuberculosis in cattle and badgers, aiding efforts to control the disease and reduce the impact on the badger population.

Professor Rowland KaoChair of Veterinary Epidemiology and Data Science, the Roslin Institute, University of Edinburgh

The study, published in the journal eLife, was funded by the Biotechnology and Biological Sciences Research Council, Defra and the Wellcome Trust.

Contact

Shane Canning, Press and PR Office, 0755 782 0266, shane.canning@ed.ac.uk

Related links

Scientific publication

Breeding for tuberculosis resistant cattle

Propensity to transmit diseases depends on genes

 

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