Propensity to transmit diseases depends on genes
A new study from the Roslin Institute shows the genetic propensity of animals to transmit diseases affects survival in populations during epidemics.
Survival in animal populations during an epidemic is partly determined by the genetic propensity of individual animals to transmit it to others, research shows.
It is well known that genetic differences in disease resistance affect mortality rates in populations during an epidemic. A genetic study led by scientists at The Roslin Institute (the research arm of the Royal (Dick) School of Veterinary Studies), in collaboration with researchers in Spain, found that mortality rates also depend on genetic differences in endurance – the propensity of a sick animal to survive infection, and infectivity – the propensity of an infected animal to transmit the disease to others.
This is the first time scientists provide evidence of genetic variation in infectivity of infected animals.
Important aquaculture disease
Scientists looked at how long it took for turbot to become infected and ill with- or die of Scuticociliatosis after being exposed to infected fish. Scuticociliatosis is one of the most important diseases in marine aquaculture worldwide.
They have used novel experimental designs and statistical modelling to investigate whether differences in the genes determined endurance, infectivity and resistance of infected fish and demonstrated how this contributed to survival.
Understanding and controlling epidemics
This study is the first existing evidence that animals differ genetically not only in their resistance to disease, but also in their ability to transmit disease. Our infection model in fish shows that genetic variation in infectivity of infected animals, in addition to variation in resistance and endurance, affects survival in populations. These results have important implications for understanding and controlling epidemics.
The study is published in the journal “Scientific Reports” and has been funded by the EU FP7 Framework project Fishboost and the UK Government’s Biotechnology and Biological Sciences Research Council.
Genetic basis of host resistance
About the Royal Dick School of Veterinary Studies
The Royal (Dick) School of Veterinary Studies is a one-of-a-kind centre of excellence in clinical activity, teaching and research. Our purpose-built campus, set against the backdrop of the beautiful Pentland Hills Regional Park, is home to more than eight hundred staff and almost fourteen hundred students, all of whom contribute to our exceptional community ethos.
The School comprises:
- The Roslin Institute
- The Global Academy of Agriculture and Food Security
- The Roslin Innovation Centre
- The Hospital for Small Animals
- Equine Veterinary Services
- Farm Animal Services
- Easter Bush Pathology
- The Jeanne Marchig International Centre for Animal Welfare Education
We represent the largest concentration of animal science related expertise in Europe, impacting local, regional, national and international communities in terms of economic growth, the provision of clinical services and the advancement of scientific knowledge.