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Brain development requires the precise coordination of billions of neurons, each guided by proteins acting as ‘chemical signals’. These proteins, known as guidance receptors, bind to other proteins in the cell's environment ('ligands') to trigger signalling pathways that direct cell movement. Our research focuses on unravelling the complex interactions between three emerging receptor families: Teneurins, Latrophilins, and Fibronectin-Leucine-Rich-Transmembrane proteins (FLRTs). Depending on the cellular context, these proteins come together in different combinations, giving rise to a structure-based “combinatorial code”. We use structural biology methods in combination with cell biology and in vivo experiments to decipher the many functions of these proteins in brain development, especially in cortical cell migration. Our lab is very collaborative and integrates orthogonal techniques to gather information and understand processes at the molecular, cellular and tissue levels.