Dr Sandrine Prost
I am interested in the cellular reactions to injury and their role in determining pathogenesis and disease outcome. Our current translational research aims to identify within the diseased tissue new biomarker combinations to improve the recognition and management of inflammatory renal and hepatic disease and of cancer of various etiologies. We are using Nanostring technology and multiplex immunofluorescence coupled with multispectral imaging (Nuance Perkin Elmer) in clinical biopsy samples to phenotype individual cells of interest with 5-6 specific markers and their environment with an additional 5 to 6 markers. Recent work includes a detailed comparative in situ phenotyping study of macrophages in clinical inflammatory and allo-immune conditions affecting the liver and kidney, while new studies are interrogating macrophages phenotypes and immune environment in bladder cancer ( Melville Trust for the Care & Cure of Cancer) and ANCA vasculitis (Kidney Research UK).
Dr Marie O'Donnell, Consultant Pathologist, Uropathology specialist
Mr Param Mariappan, Consultant Urological Surgeon and Honorary Clinical Senior Lecturer
Dr Duncan McLaren, Consultant Clinical Oncologist
Dr Bin-Zhi Qian, University of Edinburgh
Dr Stefan Symeonides, University of Edinburgh
Prost S, Crossan CL, Dalton HR, De Man RA, Kamar N, Selves J, Dhaliwal C, Scobie L, Bellamy COC. Detection of viral hepatitis E in clinical liver biopsies. Histopathology. 2017 Oct;71(4):580-590. doi: 10.1111/his.13266. Epub 2017 Aug 7.
Prost S, Kishen RE, Kluth DC, Bellamy CO. Working with Commercially Available Quantum Dots for Immunofluorescence on Tissue Sections. PLoS One. 2016 Sep 29;11(9):e0163856. doi: 10.1371/journal.pone.0163856. eCollection 2016.
Prost S, Kishen RE, Kluth DC, Bellamy CO. Choice of Illumination System & Fluorophore for Multiplex Immunofluorescence on FFPE Tissue Sections. PLoS One. 2016 Sep 15;11(9):e0162419. doi: 10.1371/journal.pone.0162419. eCollection 2016.
Demetris AJ, Bellamy CO, Gandhi CR, Prost S, Nakanuma Y, Stolz DB. Functional Immune Anatomy of the Liver-As an Allograft. Am J Transplant. 2016 Jun;16(6):1653-80. doi: 10.1111/ajt.13749. Epub 2016 Mar 21.
Bellamy CO, Maxwell RS, Prost S, Azodo IA, Powell JJ, Manning JR. The value of immunophenotyping hepatocellular adenomas: consecutive resections at one UK centre. Histopathology. 2013 Feb;62 (3):431-45. doi: 10.1111/his.12011. Epub 2012 Sep 28.