Edinburgh Pathology

Professor C Simon Herrington

Professor of Molecular Cancer Pathology

+44 (0)131 651 8624

 

Cancer Research UK Edinburgh Centre

University of Edinburgh

Western General Hospital

Crewe Road South

Edinburgh, EH4 2XR

 

PA Jan Irvine

Tel +44 (0)131 651 8690

Email Jan.Irvine@igmm.ed.ac.uk

Current Research

My main research focus is the development of optical imaging for the early detection of epithelial neoplasia. I have a long-standing optical imaging collaboration with the School of Physics and Astronomy in St Andrews, which focuses on technology that can discriminate between normal and neoplastic cells and tissues. I am part of the Engineering and Physical Sciences Research Council (EPSRC) and MRC Centre for Doctoral Training in Optical Imaging (OPTIMA), through which I have a collaboration with Strathclyde University, and I am also working with Edinburgh Medical Imaging. These collaborations all aim to develop novel optical approaches to cancer diagnosis. I am also part of the Nicola Murray Centre for Ovarian Cancer Research (Prof Charlie Gourley), with current projects including the molecular investigation of high-grade serous, low grade serous, endometrioid and clear cell ovarian carcinomas. I am Editor in Chief of The Journal of Pathology and The Journal of Pathology: Clinical Research. My research interests are aligned with my clinical practice in gynaecological pathology as a Consultant Pathologist with NHS Lothian.

Group Members

Members Name Role    
Lana Woolford PhD student                                                                     
Amelia Hallas-Potts PhD student    
Barbara Stanley (with Charlie Gourley) MD student    
Sam Benson (with Marc Vendrell) PhD student    

Web Links

Full publication list

The Journal of Pathology Website

The Journal of Pathology: Clinical Research Website

Collaborators

  • Prof Kishan Dholakia, Physics and Astronomy, University of St Andrews
  • Prof Duncan Graham, Chemistry, University of Strathclyde
  • Edinburgh Medical Imaging

Selected Publications

Hollis RL, Churchman M, Michie CO, Rye T, Knight L, McCavigan A, Perren T, Williams A, McCluggage WG, Kaplan RS, Jayson GC, Oza A, Harkin DP, Herrington CS, Kennedy R, Gourley C. High EMSY expression defines a BRCA-like subgroup of high grade serous ovarian carcinomas with superior clinical outcome and hypersensitivity to platinum. Cancer (In press)

Grondin K, Lidang M, Bonnelycke MK, Alvarado-Cabrero I, Herrington CS, McCluggage WG. Neuroendocrine tumors of the Fallopian tube: report of a case series and review of the literature. Int J Gynecol Pathol 2019; 38: 78 – 84.

Cho KR, Cooper K, Croce S, Djordevic B, Herrington CS, Howitt B, Hui PIp PKoebel MLax SQuade BJShaw PVidal AYemelyanova AClarke BHedrick Ellenson LLongacre TAShih IMMcCluggage WGMalpica AOliva EParkash VMatias-Guiu X. International Society of Gynecological Pathologists (ISGyP) Endometrial Cancer Project: Guidelines From the Special Techniques and Ancillary Studies Group. Int J Gynecol Pathol 2019; 38 Suppl 1: S114–22.

Stanley B, Hollis RL, Nunes H, Towler JD, Yan X, Rye T, Dawson C, Mackean MJ, Nussey F, Churchman M, Herrington CS, Gourley C. Endocrine treatment of high-grade serous ovarian carcinoma: quantification of efficacy and identification of response predictors. Gynecol Oncol 2019; 159: 278-285

Escobet-Montalbàn A, Spesyvtsev R, Chen M, Saber WA, Andrews M, Herrington CS, Mazilu M, Dholakia K. Wide-field multiphoton imaging through scattering media. Science Advances 2018; 4: eaau1338

Woolford L, Chen M, Dholakia K, Herrington CS. Towards automated cancer screening: label free classification of fixed cell samples using wavelength modulated Raman spectroscopy. J Biophot 2018; e201700244 – highlighted in Advanced Science News - https://www.advancedsciencenews.com/automated-cancer-screening-using-raman-spectroscopy/

Hollis RL, Meynert A, Churchman M, Rye T, McKean M, Nussey F, Arends M, Semple C, Herrington CS, Gourley C. Enhanced response rate to pegylated liposomal doxorubicin in high grade serous ovarian carcinoma harbouring BRCA1and BRCA2 aberrations. BMC Cancer 2018; 18: 16

Scudamore CL, Soilleux EJ, Karps NA, Smith K, Poulsom R, Herrington CS, Day MJ, Brayton C, Bolon B, Whitelaw B, White ES, Everitt JI, Arends MJ. Recommendations for minimum information for publication of experimental pathology data: MINPEPA guidelines. J Pathol 2016; 238: 359-367.

Kosmeier S, Zolotovskaya S, de Luca AC, Riches A, Herrington CS, Dholakia K, Mazilu M. Non-redundant Raman imaging using optical eigenmodes. Optica 2014; 1: 257-263 3. dx.doi.org/10.1364/OPTICA.1.000257

Ashok PC, Praveen BB, Bellini N, Riches AC, Dholakia K, Herrington CS. Multi-modal approach using Raman spectroscopy and optical coherence tomography for the discrimination of colonic adenocarcinoma from normal colon. Biomed Optics Express 2013; 4: 2179-2186. PMID: 24156073