Edinburgh Pathology

Dr Chris Bellamy

Reader in Hepatic and Renal Pathology

+44 (0)131 242 7510

 

Department of Pathology

Royal Infirmary of Edinburgh

Edinburgh BioQuarter

51 Little France Crescent

Edinburgh EH16 4SA

 

Current Research

I specialise in kidney and liver histopathology, including transplantation pathology and developments thereof. Present interests cover a variety of topics including recognition of antibody mediated rejection in liver transplants, and the phenotypes of macrophages in kidney and liver allografts, together with new approaches to evaluating such multiplex data.

Aims:

•To identify biomarkers important in the development of liver cancer.

•To identify biomarkers important for liver & kidney allograft disease.

•To develop multispectral imaging technology to improve prognosis & diagnosis by allowing multicomponent analysis on clinical biopsy material.

Group Members

Members Name   Role Telephone Email

Dr Sandrine Prost    

Senior Lecturer     Email Sandrine Prost

Web Links

Selected Publications

Neil D, Bellamy C, Smith M, Haga H, Zen Y, Sebagh M, Lunz J, Ruppert K, Hubscher S, Demetris AJ Global quality assessment of liver allograft C4d staining during acute antibody mediated rejection in formalin-fixed paraffin-embedded tissue. Human Pathology 2018 Mar; 73:144-155.

Bellamy COC, Burt AD 'The Liver in Systemic Disease. Chapter in MacSween’s Pathology of the Liver, 7th edition (2018). pp966-1017. Editors Burt AD, Ferrell LD, Hubscher SG. Elsevier, Philadelphia, PA

Prost S, Crossan CL, Dalton HR, De Man RA, Kamar N, Selves J, Dhaliwal C, Scobie L, Bellamy COC Detection of viral hepatitis E in clinical liver biopsies Histopathology. 2017 Oct;71(4):580-590 

Demetris AJ, Bellamy COC, Gandhi CR, Prost S, Nakanuma Y, Stolz DB Functional immune anatomy of the liver – as an allograft American Journal of Transplantation, 2016, Jun; 16(6): 1653-80

Buckley C, Dun A, Peter A, Bellamy C, Gross K, Duncan R, Mullins J Bimodal dynamics of granular organelles in primary renin-expressing cells revealed using TIRF microscopy  Am J Physiol Renal Physiol (2017) 312(1): F200-209 

Thomas RA, Czopek A, McNally S, Bellamy C, Kluth DC, Marson LP Hemin pre-conditioning upregulates heme-oxygenase 1 in deceased donor renal transplant recipients and may offer protection: a randomised, controlled, phase IIB trial Transplantation (2016), 100(1): 176-83

Kavanagh D, McGlasson S, Jury A, Williams J, Scolding N, Bellamy C, Guenther C, Ritchie D, et al Type I interferon causes thrombotic microangiopathy by a dose-dependent toxic effect on the microvasculature Blood (2016), 128(24): 2824-2833

Prost S, Kishen REB, Kluth DC, Bellamy COC Choice of Illumination system & fluorophore for multiplex immunofluorescence on FFPE tissue sections PLoS ONE (2016), Sep 15; 11(9):e0162419, PMID: 27632367

Prost S, Kishen REB, Kluth DC, Bellamy COC Working with commercially available Quantum dots for immunofluorescence on tissue sections PLoS ONE (2016), Sep 29; 11(9): e0163856, PMID: 27685858

Dhaun N, Saunders A, Bellamy CO, Martinez-Gallardo R, Manson L, Kluth DC Benefits of an expanded use of plasma exchange for anti-neutrophil cytoplasmic antibody-associated vasculitis within a dedicated clinical service BMC Musculoskeletal Disorders (2015) 16:343