Institute of Genetics and Cancer

Cancer immune evasion research on the cover of Science Signaling

The Cancer Biology group at the Cancer Research UK Edinburgh Centre has just published new research that sheds light on how tumours evade the immune system. Their research article was selected as the cover story of the December 5 issue of the journal Science Signaling: December 2017

Cancer imaging

Congratulations to the members of the Cancer Biology group at the Cancer Research UK Edinburgh Centre, whose work entitled “IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks” has recently been published in Science Signaling, a journal of the American Association for the Advancement of Science (AAAS).

This publication has also been selected by the journal editors as the “cover story” for the 5th of December 2017 issue, a testimony to the quality and significance of the study. The project, led by Prof Margaret Frame from the Cancer Centre (and also involving the IGMM Mass Spectrometry Facility and collaborators in Edinburgh), demonstrated how nuclear activity of Focal Adhesion Kinase (FAK) and the cytokine IL-33 drives tumour immune evasion.  The work not only provides important new insights into intricate interactions between FAK activity and the immune system, but it might also directly impact ongoing clinical trials testing the feasibility of FAK inhibitors as anticancer therapeutics.     

Relevant Links

Cancer Biology Lab website

Article in Science Signaling

Science Signaling 5th of December 2017 issue and cover