Aortic stenosis is a problem whereby the exit from the heart’s left ventricle into the aorta, is narrowed & may affect the valve separating the two structures, or the tissues above or below the valve.
In patients with aortic stenosis, we demonstrated that the electrocardiographic strain pattern associated with left ventricular hypertrophy is indicative of myocardial fibrosis. We described a risk prediction model for patients with aortic stenosis demonstrating the important role of myocardial fibrosis imaging in determining future events.
This formed the basis of the Sir Jules Thorn Award for Biomedical Research 2015 to Dr Marc Dweck, which has funded a multi-centre clinical trial of early surgery in patients with advanced asymptomatic aortic stenosis using MR-based T1-mapping techniques, to characterise the fibrosis progression associated with this disease.
Lead aortic stenosis researcher
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Relevant Edinburgh Imaging publications
12 Jul 21. Featured Paper. First-phase ejection fraction by cardiovascular magnetic resonance predicts outcomes in aortic stenosis.
03 May 21. Featured Paper. Effect of denosumab or alendronic acid on the progression of aortic stenosis: a double-blind randomized controlled trial.
18 Feb 21. Featured Paper. Contrast-enhanced computed tomography assessment of aortic stenosis.
21 Oct 20. Featured Paper. Computed tomography aortic valve calcium scoring for the assessment of aortic stenosis progression.
01 Oct 20. Featured Paper. 18F-fluoride PET/MR in cardiac amyloid: a comparison study with aortic stenosis & age- & sex-matched controls.
20 Aug 20. Featured Paper. Progression & regression of left ventricular hypertrophy & myocardial fibrosis in a mouse model of hypertension & concomitant cardiomyopathy.
13 Feb 19. Featured Paper. Imaging & impact of myocardial fibrosis in aortic stenosis.
21 Aug 18. Featured Paper. Cardiac CT in prosthetic aortic valve complications.
- 04 Apr 18. Featured Paper. Computed tomography aortic valve calcium scoring in patients with aortic stenosis.
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