Publications
Publications from the Edinburgh Imaging community.
2022 publications |
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| Machine learning with 18F-sodium fluoride PET and quantitative plaque analysis on CT angiography for the future risk of myocardial infarction | |
2021 publications |
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| 22 Nov 21. Featured Paper | Tracer kinetic assessment of blood–brain barrier leakage & blood volume in cerebral small vessel disease: Associations with disease burden & vascular risk factors |
| 17 Nov 21. Featured Paper | Prevalence of dementia in ischaemic or mixed stroke populations: systematic review & meta-analysis |
| 10 Nov 21. Featured Paper | MRI-derived g-ratio & lesion severity in newly diagnosed multiple sclerosis |
| 05 Nov 21. Featured Paper | Early lowering of blood pressure after acute intracerebral haemorrhage: a systematic review & meta-analysis of individual patient data |
| 01 Nov 21. Featured Paper | Rim lesions are demonstrated in early relapsing–remitting multiple sclerosis using 3 T-based susceptibility-weighted imaging in a multi-institutional setting. |
| 21 Oct 21. Featured Paper | MRI & CT coronary angiography in survivors of COVID-19 |
| 06 Oct 21. Featured Paper | Predicting post-stroke cognitive impairment using acute CT neuroimaging: A systematic review & meta-analysis |
| Early life predictors of late life cerebral small vessel disease in four prospective cohort studies | |
| 01 Oct 21. Featured Paper | Probabilistic deep learning with adversarial training & volume interval estimation - better ways to perform & evaluate predictive models for white matter hyperintensities evolution. |
| 28 Sep 21. Featured Paper | Identification of plasma proteins relating to brain neurodegeneration & vascular pathology in cognitively normal individuals |
| 14 Sep 21. Featured Paper | Fixel-based analysis effectively identifies white matter tract degeneration in huntington’s disease |
| The prevalence of paramagnetic rim lesions in multiple sclerosis: A systematic review & meta-analysis | |
| 01 Sep 21. Featured Paper | Native aortic valve disease progression & bioprosthetic valve degeneration in patients with transcatheter aortic valve implantation |
| 19 Aug 21. Featured Paper | Positron emission tomography techniques to measure active inflammation, fibrosis & angiogenesis: potential for non-invasive imaging of hypertensive heart failure |
| 17 Aug 21. Featured Paper | Pericoronary & periaortic adipose tissue density are associated with inflammatory disease activity in Takayasu arteritis & atherosclerosis |
| Integrated cardiopulmonary MRI assessment of pulmonary hypertension | |
| 11 Aug 21. Featured Paper | Impact of COVID-19 on the imaging diagnosis of cardiac disease in Europe |
| Roadmap consensus on carotid artery plaque imaging & impact on therapy strategies & guidelines: an international, multispecialty, expert review & position statement | |
| Reproducibility of retinal vascular phenotypes obtained with optical coherence tomography angiography: importance of vessel segmentation | |
| Selective motion artefact reduction via radiomics & k-space reconstruction for improving perivascular space quantification in brain magnetic resonance imaging. | |
| Improved identification of abdominal aortic aneurysm using the Kernelized Expectation Maximization algorithm. | |
| First-phase ejection fraction by cardiovascular magnetic resonance predicts outcomes in aortic stenosis. | |
| Cerebral small vessel disease burden & longitudinal cognitive decline from age 73 to 82: the Lothian Birth Cohort 1936 | |
| 30 Jun 21. Featured Paper | Imaging NeuroVascular, Endothelial & STructural Integrity in prepAration to TrEat Small Vessel Diseases. The INVESTIGATE-SVDs study Protocol. Part of the SVDs@Target Project. |
| Relationship between inferior frontal sulcal hyperintensities on brain MRI, ageing & cerebral small vessel disease. | |
| Diffusion-weighted imaging lesions & risk of recurrent stroke after intracerebral haemorrhage. | |
| Assessment of stunned & viable myocardium using manganese-enhanced MRI. | |
| A comparison of CVR magnitude & delay assessed at 1.5 & 3T in patients with cerebral small vessel disease. | |
| Correlations in post-mortem imaging-histopathology studies of sporadic human cerebral small vessel disease: a systematic review | |
| Sources of systematic error in DCE-MRI estimation of low-level blood-brain barrier leakage. | |
| Comparison of structural MRI brain measures between 1.5 & 3 T: Data from the Lothian Birth Cohort 1936 | |
| ESO Guideline on covert cerebral small vessel disease. | |
| Effect of denosumab or alendronic acid on the progression of aortic stenosis: a double-blind randomized controlled trial. | |
| Zooming in on cerebral small vessel function in small vessel diseases with 7T MRI: Rationale & design of the “ZOOM@SVDs” study. | |
| Application of the ATN classification scheme in a population without dementia: Findings from the EPAD cohort. | |
| Quantification of macrophage-driven inflammation during myocardial infarction with 18F-LW223, a novel TSPO radiotracer with binding independent of the rs6971 human polymorphism. | |
| Kinetic modeling & parameter estimation of TSPO PET imaging in the human brain. | |
| Lacunar stroke lesion extent & location & white matter hyperintensities evolution 1 year post-lacunar stroke. | |
| The application of optical coherence tomography angiography in Alzheimer's disease: A systematic review. | |
| Post-stroke cognition at 1 & 3 years is influenced by the location of white matter hyperintensities in patients with lacunar stroke. | |
| Cerebrovascular reactivity measurement using magnetic resonance imaging: a systematic review. | |
| Contrast-enhanced computed tomography assessment of aortic stenosis. | |
| Sonographic bridging callus at six weeks following displaced midshaft clavicle fracture can accurately predict healing. | |
| 11 Feb 21. Featured Paper | Neuropsychiatric symptoms associated with cerebral small vessel disease: a systematic review & meta-analysis. |
| Low- versus standard-dose alteplase in acute lacunar ischemic stroke: The ENCHANTED Trial | |
| Multi-national survey of current practice from imaging to treatment of atherosclerotic carotid stenosis. | |
| Automatic segmentation of white matter hyperintensities from brain magnetic resonance images in the era of deep learning & big data – A systematic review. | |
| A four-dimensional computational model of dynamic contrast-enhanced magnetic resonance imaging measurement of subtle blood-brain barrier leakage. | |
| Quantifying microcalcification activity in the thoracic aorta. | |
| International impact of COVID-19 on the diagnosis of heart disease. | |
| Dietary patterns, cognitive function, & structural neuroimaging measures of brain aging. | |
| Three major dimensions of human brain cortical ageing in relation to cognitive decline across the eighth decade of life. | |
2020 publications |
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| Reproducibility of quantitative plaque measurement in advanced coronary artery disease. | |
| Clinical management of cerebral small vessel disease: a call for a holistic approach | |
| Brain network reorganisation & spatial lesion distribution in systemic lupus erythematosus. | |
| Coronary 18F-fluoride uptake & progression of coronary artery calcification. | |
| Automated segmentation of optical coherence tomography angiography images: benchmark data & clinically relevant metrics. | |
| Hyperdense artery sign, symptomatic infarct swelling & effect of alteplase in acute ischaemic stroke. | |
| Structural brain correlates of serum & epigenetic markers of inflammation in major depressive disorder. | |
| Intensive versus guideline‐recommended blood pressure reduction in acute lacunar stroke with intravenous thrombolysis therapy: The ENCHANTED trial. | |
| Association of baseline hematoma & edema volumes with one-year outcome & long-term survival after spontaneous intracerebral hemorrhage: A community-based inception cohort study. | |
| Ex vivo 18F-fluoride uptake & hydroxyapatite deposition in human coronary atherosclerosis. | |
| Pharmacokinetic modelling for the simultaneous assessment of perfusion & 18F-flutemetamol uptake in cerebral amyloid angiopathy using a reduced PET-MR acquisition time: Proof of concept | |
| Feasibility & diagnostic accuracy of using brain attenuation changes on CT to estimate time of ischemic stroke onset. | |
| Association between computed tomographic biomarkers of cerebral small vessel diseases & long‐term outcome after spontaneous intracerebral hemorrhage. | |
| DiCyc: GAN-based deformation invariant cross-domain information fusion for medical image synthesis. | |
| 4D flow MRI for non-invasive measurement of blood flow in the brain: A systematic review | |
| Computed tomography aortic valve calcium scoring for the assessment of aortic stenosis progression. | |
| Brain imaging abnormalities & outcome after acute ischaemic stroke: the ENCHANTED trial | |
| Rates, risks & routes to reduce vascular dementia (R4vad), a UK-wide multicentre prospective observational cohort study of cognition after stroke: Protocol | |
| Issues & recommendations from the OHBM COBIDAS MEEG committee for reproducible EEG & MEG research | |
| 18F-fluoride PET/MR in cardiac amyloid: a comparison study with aortic stenosis & age- & sex-matched controls | |
| 23 Sep 20. Featured Paper | Quantitative measurements of enlarged perivascular spaces in the brain are associated with retinal microvascular parameters in older community-dwelling subjects |
| 22 Sep 20. Featured Paper | Association of common genetic variants with brain microbleeds: A Genome-wide Association Study |
| 10 Sep 20. Featured Paper | The application of optical coherence tomography angiography in cerebral small vessel disease, ischemic stroke, & dementia: a systematic review |
| 20 Aug 20. Featured editorial | Imaging patients with stable chest pain special feature: introductory editorial |
| 20 Aug 20. Featured Paper | Progression & regression of left ventricular hypertrophy & myocardial fibrosis in a mouse model of hypertension & concomitant cardiomyopathy |
| 11 Aug 20. Featured Paper | Cilostazol for secondary prevention of stroke & cognitive decline: systematic review & meta-analysis |
| 03 Aug 20. Featured Paper | Eye‐tracking for longitudinal assessment of social cognition in children born preterm |
| 31 Jul 20. Featured Paper | The vascular nature of COVID-19 |
| 24 Jul 20. Featured Paper | Retinal biomarkers discovery for cerebral small vessel disease in an older population |
| 20 Jul 20. Featured Paper | Automatic spatial estimation of white matter hyperintensities evolution in brain MRI using disease evolution predictor deep neural networks |
| 22 Jun 20. Featured Paper | Coronary 18F-sodium fluoride uptake predicts outcomes in patients with coronary artery disease |
| 18 Jun 20. Featured Paper | Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis |
| 17 Jun 20. Featured Paper | Thrombolysis outcomes in acute ischemic stroke by fluid-attenuated inversion recovery hyperintense arteries |
| 08 Jun 20. Featured Paper | Examining the relationship between semiquantitative methods analysing concentration-time & enhancement-time curves from dynamic-contrast enhanced magnetic resonance imaging & cerebrovascular dysfunction in small vessel disease |
| 05 Jun 20. Featured Paper | Rationale & design of a longitudinal study of cerebral small vessel diseases, clinical & imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3 |
| 03 Jun 20. Featured Paper | Exercise electrocardiography & computed tomography coronary angiography for patients with suspected stable angina pectoris. A post hoc analysis of the randomized SCOT-HEART trial |
| 05 May 20. Featured Paper | Intracranial hemodynamic relationships in patients with cerebral small vessel disease |
| 23 Apr 20. Featured Paper | Diagnosis, prevention, & treatment of thromboembolic complications in COVID-19: report of the National Institute for Public Health of the Netherlands |
| 21 Apr 20. Featured Paper | Protocol: The Lacunar Intervention Trial 2 (LACI-2). A trial of two repurposed licenced drugs to prevent progression of cerebral small vessel disease |
| 14 Apr 20. Featured Paper | Improving clinical detection of acute lacunar stroke: analysis from the IST-3 |
| 08 Apr 20. Featured Paper | Relationship between venules & perivascular spaces in sporadic small vessel diseases |
| 16 Mar 20. Featured Paper | Low-attenuation noncalcified plaque on coronary computed tomography angiography predicts myocardial infarction: results from the multicenter SCOT-HEART Trial (Scottish computed tomography of the heart) |
| 06 Mar 20. Featured Paper | DNA methylation & brain structure & function across the life course: a systematic review |
| 18 Feb 20. Featured editorial | Non-obstructive coronary artery disease can no longer be ignored |
| 06 Feb 20. Featured Paper | Manganese-enhanced T1 mapping to quantify myocardial viability: validation with 18F-fluorodeoxyglucose positron emission tomography |
| 23 Jan 20. Featured Paper | Neonatal morphometric similarity mapping for predicting brain age & characterizing neuroanatomic variation associated with preterm birth |
| 10 Jan 20. Featured Paper | Association between hypertension & retinal vascular features in ultra-widefield fundus imaging |
| 06 Jan 20. Featured Paper | Computational quantification of brain perivascular space morphologies: Associations with vascular risk factors & white matter hyperintensities. A study in the Lothian Birth Cohort 1936 |
| Small vessel disease is associated with altered cerebrovascular pulsatility but not resting cerebral blood flow. | |
2019 publications |
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| 19 Dec 19. Featured Paper | Vulnerable plaque imaging using 18F-sodium fluoride positron emission tomography |
| 18 Dec 19. Featured Paper | Non-invasive imaging of high-risk coronary plaque: the role of computed tomography & positron emission tomography |
| 19 Nov 19. Featured Paper | Predictors of lesion cavitation after recent small subcortical stroke |
| 02 Nov 19. Featured Paper | Aortic valve stenosis—multimodality assessment with PET/CT & PET/MRI |
| 01 Nov 19. Featured Paper | Standardization of preclinical PET/CT imaging to improve quantitative accuracy, precision & reproducibility: a multi-center study |
| 23 Oct 19. Featured Paper | Genetic architecture of subcortical brain structures in 38,851 individuals |
| 15 Oct 19. Featured Paper | 3D angle-independent Doppler & speckle tracking for the myocardium & blood flow |
| 14 Oct 19. Featured Paper | Epigenetic signatures of smoking associate with cognitive function, brain structure, & mental & physical health outcomes in the Lothian Birth Cohort 1936 |
| 09 Oct 19. Featured Paper | Standardization of preclinical PET/CT imaging to improve quantitative accuracy, precision & reproducibility: a multi-center study |
| 29 Sep 19. Featured Paper | Special topic section: linkages among cerebrovascular, cardiovascular, & cognitive disorders: Preventing dementia by preventing stroke: The Berlin Manifesto |
| 12 Aug 19. Featured Paper | Method for measuring disease activity in the coronary arteries |
| 05 Aug 19. Featured Paper | Disentangled representation learning in cardiac image analysis |
| 30 Jul 19. Featured Paper | Associations between vascular risk factors & brain MRI indices in UK Biobank |
| 29 Jul 19. Featured Paper | Manganese-enhanced MRI of the myocardium |
| 24 Jul 19. Featured Paper | Disentangled representation learning in cardiac image analysis |
| 22 Jul 19. Featured Paper | Lowering blood pressure after acute intracerebral haemorrhage: protocol for a systematic review & meta-analysis using individual patient data from randomised controlled trials participating in the Blood Pressure in Acute Stroke Collaboration (BASC) |
| 04 Jul 19. Featured Paper | Effects of isosorbide mononitrate &/or cilostazol on hematological markers, platelet function, & hemodynamics in patients with lacunar ischaemic stroke: safety data from the Lacunar Intervention-1 (LACI-1) trial |
| 06 Jun 19. Featured Paper | Injection-to-scan delay correction improves scan-rescan reproducibility sodium fluoride (18F-NaF) coronary plaque imaging |
| 24 May 19. Featured Paper | Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage & cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial |
| 23 May 19. Featured Paper | Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial |
| 20 May 19. Featured Paper | Small vessel disease: mechanisms & clinical implications |
| 15 May 19. Featured Paper | Breast arterial calcification on mammography & risk of coronary artery disease: a SCOT-HEART sub-study |
| 01 May 19. Featured Paper | Are morphologic features of recent small subcortical infarcts related to specific etiologic aspects? |
| 30 Apr 19. Featured Paper | Quantifying blood-brain barrier leakage in small vessel disease: Review & consensus recommendations |
| 26 Apr 19. Featured Paper | Therapeutic hypothermia for acute ischaemic stroke. Results of a European multicentre, randomised, phase III clinical trial |
| 17 Apr 19. Featured Paper | Analysis of PK11195 concentrations in rodent whole blood & tissue samples by rapid & reproducible chromatographic method to support target-occupancy PET studies |
| 16 Apr 19. Featured Paper | The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design & multicenter pilot study |
| 01 Apr 19. Featured Paper | Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration |
| 25 Mar 19. Featured Paper | Clinical diagnosis of TIA or minor stroke & prognosis in patients with neurological symptoms: A rapid access clinic cohort |
| 20 Mar 19. Featured Paper | Detection & prediction of bioprosthetic aortic valve degeneration |
| 13 Mar 19. Featured Paper | A multimodal approach to cardiovascular risk stratification in patients with type 2 diabetes incorporating retinal, genomic & clinical features |
| 12 Mar 19. Featured Paper | Associations between vascular risk factors & brain MRI indices in UK Biobank |
| 13 Feb 19. Featured Paper | Imaging & impact of myocardial fibrosis in aortic stenosis |
| 11 Feb 19. Featured Paper | Disease activity in mitral annular calcification: A multimodality study |
| 22 Jan 19. Featured Paper | Coronary artery plaque characteristics associated with adverse outcomes in the SCOT-HEART study |
| 09 Jan 19. Featured Paper | Longitudinal multi-centre brain imaging studies: guidelines & practical tips for accurate & reproducible imaging endpoints & data sharing |
| 07 Jan 19. Featured Paper | Functional, cognitive & physical outcomes 3 years after minor lacunar or cortical ischaemic stroke |
2018 publications |
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| 06 Nov 18. Featured Paper | Action plan for stroke in Europe 2018–2030 |
| 05 Nov 18. Featured Paper | Manganese-enhanced T1 mapping in the myocardium of normal & infarcted hearts |
| 30 Oct 18. Featured Paper | Effect of IV alteplase on the ischemic brain lesion at 24–48 hours after ischemic stroke |
| 09 Oct 18. Featured Paper | The LKB1–AMPK-α1 signaling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria |
| 18 Sep 18. Featured Paper | Study protocol: HepaT1ca – an observational clinical cohort study to quantify liver health in surgical candidates for liver malignancies |
| 12 Sep 18. Featured Paper | A new map of more than a billion synapses in the brain helps to shed light on how memories are formed & recalled |
| 07 Sep 18. Featured Paper | Polygenic risk score for schizophrenia & structural brain connectivity in older age: A longitudinal connectome & tractography study |
| 01 Sep 18. Featured Paper | Understanding the role of the perivascular space in cerebral small vessel disease |
| 29 Aug 18. Featured Paper | Evaluation of intravascular ultrasound catheter-based transducers using the resolution integral |
| 28 Aug 18. Featured Paper | Coronary CT angiography & 5-year risk of myocardial infarction |
| 21 Aug 18. Featured Paper | Cardiac CT in prosthetic aortic valve complications |
| 15 Aug 18. Featured Paper | Machine learning of neuroimaging for assisted diagnosis of cognitive impairment & dementia: A systematic review |
| 13 Aug 18. Featured Paper | Results from the largest post mortem MRI brain analysis of the fatal disease CJD has been published |
| 06 Jul 18. Featured Paper | Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats |
| 21 Jun 18. Featured Paper | Small vessel disease; a big problem, but fixable |
| 24 May 18. Featured Paper | 18f-fluoride positron emission tomography: computed tomography angiography predicts bioprosthetic valve degeneration |
| 17 May 18. Featured Paper | Artificial intelligence improves stroke & dementia diagnosis in brain scans |
| 10 May 18. Featured Paper | Impact of detecting potentially serious incidental findings during multi-modal imaging |
| 03 May 18. Featured Paper | Small vessels, dementia & chronic disease |
| 06 Apr 18. Featured Paper | Peripheral retinal imaging biomarkers for alzheimer's disease: a pilot study |
| 04 Apr 18. Featured Paper | Computed tomography aortic valve calcium scoring in patients with aortic stenosis |
| 03 Mar 18. Featured Paper | Aortic wall inflammation predicts abdominal aortic aneurysm expansion, rupture, & need for surgical repair |
| 06 Feb 18. Featured Paper | 18F–sodium fluoride uptake in abdominal aortic aneurysms: the SoFIA3 study |