David Newby
Personal Chair - BHF Duke of Edinbugh Chair of Cardiology
Address
- Street
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Chancellor's Building
49 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4SB
Research summary
Professor Newby has major interests in experimental medicine and the advanced imaging of cardiovascular disease including coronary heart disease, aortic stenosis and heart failure. He has held British Heart Foundation Programme Grants exploring the atherothrombotic effects of air pollution, and has interests in the interaction between cardiac and respiratory diseases. He has been involved in several multicentre trials and has played a major role in the conduct of the SALTIRE (Scottish Aortic stenosis Lipid lowering Trial, Impact on REgression) and 3CPO (Health Technology Assessment trial of non-invasive ventilation for acute cardiogenic pulmonary oedema) trials. He currently holds a BHF Programme Grant exploring non-invasive coronary atherothrombosis imaging. He is Chief Investigator for the SCOT-HEART trial funded by the Chief Scientist Office; a national multicentre randomised controlled trial of computed tomography coronary angiography in patients attending the Rapid Access Chest Pain Clinic. He is also Chief Investigator of the National Institute for Health Research Efficacy and Mechanism Evaluation-funded MA3RS study: a multicentre trial of magnetic resonance imaging in abdominal aortic aneurysms. He is Chief Investigator of the Wellcome Trust-funded multicentre trial:Prediction of Recurrent Events with 18F-Fluoride to Identify Ruptured and High-risk Coronary Artery Plaques in Patients with Myocardial Infarction (PRE18FFIR) trial, and the British Heart Foundation funded Dual Antiplatelet Therapy in Acute Coronary Syndromes in Scotland Trial.
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In vivo thrombosis imaging in patients recovering from COVID-19 and pulmonary embolism
In:
American Journal of Respiratory and Critical Care Medicine
Research output: Contribution to Journal › Article (Accepted/In press) -
Modelling [18F]LW223 PET data using simplified imaging protocols for quantification of TSPO expression in the rat heart and brain
In:
European Journal of Nuclear Medicine and Molecular Imaging
Research output: Contribution to Journal › Article (Accepted/In press) -
The therapeutic potential of apelin in kidney disease
In:
Nature Reviews Nephrology
Research output: Contribution to Journal › Article (Accepted/In press) -
Association of coronary artery calcium score with qualitatively and quantitatively assessed adverse plaque on coronary CT angiography in the SCOT-HEART trial
In:
European Heart Journal - Cardiovascular Imaging
Research output: Contribution to Journal › Article (Accepted/In press) -
Challenging the obesity paradox: Extreme obesity and COPD mortality in the SUMMIT Trial
In:
ERJ Open Research
DOI: https://doi.org/10.1183/23120541.00902-2020
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Clinical burden, risk factor impact and outcomes following myocardial infarction and stroke: a 25-year individual patient level linkage study
In:
The Lancet regional health. Europe
DOI: https://doi.org/10.1016/j.lanepe.2021.100141
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Influence of Heart Rate on Image Quality and Radiation Dose Exposure in Coronary CT Angiography
In:
Radiology
DOI: https://doi.org/10.1148/radiol.2021210245
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Acute Cardiovascular Effects of Controlled Exposure to Dilute Petrodiesel and Biodiesel Exhaust in Healthy Volunteers: A Crossover Study
In:
Particle and Fibre Toxicology
DOI: https://doi.org/10.1186/s12989-021-00412-3
Research output: Contribution to Journal › Article (E-pub ahead of print) -
First-phase ejection fraction by CMR predicts outcomes in aortic stenosis
In:
Journal of Cardiovascular Magnetic Resonance
DOI: https://doi.org/10.1186/s12968-021-00756-x
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Assessment of Stunned and Viable Myocardium Using Manganese-Enhanced Magnetic Resonance Imaging
In:
Open heart
DOI: https://doi.org/10.1136/openhrt-2021-001646
Research output: Contribution to Journal › Article (E-pub ahead of print) -
A Machine-Learning Framework to Identify Distinct Phenotypes of Aortic Q1 Stenosis Severity
In:
JACC: Cardiovascular Imaging
DOI: https://doi.org/10.1016/j.jcmg.2021.03.020
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Forget ischemia, it’s all about the plaque
In:
Circulation
Research output: Contribution to Journal › Article (Accepted/In press) -
Improved Identification of Abdominal Aortic Aneurysm using the Kernelised Expectation Maximisation Algorithm
In:
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
DOI: https://doi.org/10.1098/rsta.2020.0201
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Markers of Myocardial Damage Predict Mortality in Patients with Aortic Stenosis
In:
Journal of the American College of Cardiology
Research output: Contribution to Journal › Article (Accepted/In press) -
Effect of hypoglycaemia on measures of myocardial blood flow and myocardial injury in adults with and without type 1 diabetes: a prospective, randomised, open-label, blinded endpoint, cross-over study
In:
Endocrinology, Diabetes and Metabolism Case Reports
DOI: https://doi.org/10.1002/edm2.258 Funding information:
Research output: Contribution to Journal › Article (E-pub ahead of print) -
CARMN loss regulates smooth muscle cells and accelerates atherosclerosis in mice
In:
Circulation Research
DOI: https://doi.org/10.1161/CIRCRESAHA.120.318688
Research output: Contribution to Journal › Article (Published) -
Effect of denosumab or alendronic acid on the progression of aortic stenosis. A double-blind randomized controlled trial
In:
Circulation
DOI: https://doi.org/10.1161/CIRCULATIONAHA.121.053708
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Machine-learning with 18F-sodium fluoride PET and quantitative plaque analysis on CT angiography for the future risk of myocardial infarction
In:
Journal of Nuclear Medicine
DOI: https://doi.org/10.2967/jnumed.121.262283
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Sex-specific CT coronary plaque characterization and risk of myocardial infarction
In:
Journal of the American College of Cardiology
DOI: https://doi.org/10.1016/j.jcmg.2021.03.004
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Coronary computed tomography angiography to triage patients with non-ST elevation acute coronary syndrome
In:
Journal of the American College of Cardiology
DOI: https://doi.org/10.1016/j.jacc.2020.12.050
Research output: Contribution to Journal › Article (E-pub ahead of print)