David Newby
Personal Chair - BHF Duke of Edinbugh Chair of Cardiology
Address
- Street
-
Chancellor's Building
49 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4SB
Research summary
Professor Newby has major interests in experimental medicine and the advanced imaging of cardiovascular disease including coronary heart disease, aortic stenosis and heart failure. He has held British Heart Foundation Programme Grants exploring the atherothrombotic effects of air pollution, and has interests in the interaction between cardiac and respiratory diseases. He has been involved in several multicentre trials and has played a major role in the conduct of the SALTIRE (Scottish Aortic stenosis Lipid lowering Trial, Impact on REgression) and 3CPO (Health Technology Assessment trial of non-invasive ventilation for acute cardiogenic pulmonary oedema) trials. He currently holds a BHF Programme Grant exploring non-invasive coronary atherothrombosis imaging. He is Chief Investigator for the SCOT-HEART trial funded by the Chief Scientist Office; a national multicentre randomised controlled trial of computed tomography coronary angiography in patients attending the Rapid Access Chest Pain Clinic. He is also Chief Investigator of the National Institute for Health Research Efficacy and Mechanism Evaluation-funded MA3RS study: a multicentre trial of magnetic resonance imaging in abdominal aortic aneurysms. He is Chief Investigator of the Wellcome Trust-funded multicentre trial:Prediction of Recurrent Events with 18F-Fluoride to Identify Ruptured and High-risk Coronary Artery Plaques in Patients with Myocardial Infarction (PRE18FFIR) trial, and the British Heart Foundation funded Dual Antiplatelet Therapy in Acute Coronary Syndromes in Scotland Trial.
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Antithrombotic effects of combined protease-activated receptor-4 antagonism and factor Xa inhibition
In:
Arteriosclerosis, Thrombosis, and Vascular Biology
Research output: Contribution to Journal › Article (Published) -
Progression and regression of left ventricular hypertrophy and myocardial fibrosis in a mouse model of hypertension and concomitant cardiomyopathy
In:
Journal of Cardiovascular Magnetic Resonance
DOI: https://doi.org/10.1186/s12968-020-00655-7
Research output: Contribution to Journal › Article (Published) -
Eosinophil deficiency promotes aberrant repair and adverse remodelling following acute myocardial infarction
In:
JACC: Basic to Translational Science
DOI: https://doi.org/10.1016/j.jacbts.2020.05.005
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Respiration-averaged CT versus standard CT attenuation maps for correction of the 18F-NaF uptake in hybrid PET/CT
In:
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
DOI: https://doi.org/10.1007/s12350-020-02245-7
Research output: Contribution to Journal › Article (Published) -
Understanding quantitative CT coronary artery plaque assessment using machine learning
In:
JACC. Cardiovascular imaging
DOI: https://doi.org/10.1016/j.jcmg.2020.04.027
Research output: Contribution to Journal › Editorial (Published) -
Coronary 18F-Sodium Fluoride Uptake Predicts Outcomes in Patients With Coronary Artery Disease
In:
Journal of the American College of Cardiology, vol. 75, pp. 3061-3074
DOI: https://doi.org/10.1016/j.jacc.2020.04.046
Research output: Contribution to Journal › Article (Published) -
Global Evaluation of Echocardiography in Patients with COVID-19
In:
European Heart Journal - Cardiovascular Imaging
DOI: https://doi.org/10.1093/ehjci/jeaa178
Research output: Contribution to Journal › Article (Published) -
Assessment of different quantification metrics of [18F]-NaF PET/CT images of patients with abdominal aortic aneurysm
In:
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
DOI: https://doi.org/10.1007/s12350-020-02220-2
Research output: Contribution to Journal › Article (Published) -
Time to look deeper into the plaque
In:
European Heart Journal - Cardiovascular Imaging
DOI: https://doi.org/10.1093/ehjci/jeaa081
Research output: Contribution to Journal › Editorial (E-pub ahead of print) -
CLINICAL ENDPOINT ADJUDICATION
In:
The Lancet
DOI: https://doi.org/10.1016/S0140-6736(20)30635-8
Research output: Contribution to Journal › Comment/debate (Published) -
Cold feet, warm heart
In:
Heart
DOI: https://doi.org/10.1136/heartjnl-2020-316815
Research output: Contribution to Journal › Editorial (Published) -
Observer repeatability and interscan reproducibility of 18F-sodium fluoride coronary microcalcification activity
In:
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
DOI: https://doi.org/10.1007/s12350-020-02221-1
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Exercise ECG and CT Coronary Angiography in Patients with Suspected Stable Angina Pectoris A post-hoc analysis of the randomised SCOTHEART trial.
In:
JAMA cardiology
DOI: https://doi.org/10.1001/jamacardio.2020.1567
Research output: Contribution to Journal › Article (Published) -
Sex differences in valve calcification activity and calcification progression in aortic stenosis
In:
JACC. Cardiovascular imaging
DOI: https://doi.org/10.1016/j.jcmg.2020.02.034
Research output: Contribution to Journal › Letter (E-pub ahead of print) -
Getting to the heart of the matter of COVID-19
In:
Heart
DOI: https://doi.org/10.1136/heartjnl-2020-317118
Research output: Contribution to Journal › Editorial (Published) -
CARDIOVASCULAR IMAGING TO GUIDE PRIMARY PREVENTION
In:
Heart
DOI: https://doi.org/10.1136/heartjnl-2019-316217
Research output: Contribution to Journal › Article (Published) -
FEV1 is a stronger mortality predictor than FVC in mild-to-moderate patients with COPD and an increased risk for cardiovascular disease
In:
International Journal of Chronic Obstructive Pulmonary Disease
DOI: https://doi.org/10.2147/COPD.S242809
Research output: Contribution to Journal › Article (Published) -
We all breathe the same air …. and we are all mortal
In:
Cardiovascular Research
DOI: https://doi.org/10.1093/cvr/cvaa126
Research output: Contribution to Journal › Article (Published) -
Incidence, microbiology and outcomes in patient hospitalized with infective endocarditis
In:
Circulation
DOI: https://doi.org/10.1161/CIRCULATIONAHA.119.044913
Research output: Contribution to Journal › Article (Published) -
Inherited Thoracic Aortic Disease: New Insights and Translational Targets Running Title: Translational Targets in Hereditary Aortopathy
In:
Circulation
DOI: https://doi.org/10.1161/CIRCULATIONAHA.119.043756
Research output: Contribution to Journal › Article (Published)