David Newby
Personal Chair - BHF Duke of Edinbugh Chair of Cardiology
Address
- Street
-
Chancellor's Building
49 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4SB
Research summary
Professor Newby has major interests in experimental medicine and the advanced imaging of cardiovascular disease including coronary heart disease, aortic stenosis and heart failure. He has held British Heart Foundation Programme Grants exploring the atherothrombotic effects of air pollution, and has interests in the interaction between cardiac and respiratory diseases. He has been involved in several multicentre trials and has played a major role in the conduct of the SALTIRE (Scottish Aortic stenosis Lipid lowering Trial, Impact on REgression) and 3CPO (Health Technology Assessment trial of non-invasive ventilation for acute cardiogenic pulmonary oedema) trials. He currently holds a BHF Programme Grant exploring non-invasive coronary atherothrombosis imaging. He is Chief Investigator for the SCOT-HEART trial funded by the Chief Scientist Office; a national multicentre randomised controlled trial of computed tomography coronary angiography in patients attending the Rapid Access Chest Pain Clinic. He is also Chief Investigator of the National Institute for Health Research Efficacy and Mechanism Evaluation-funded MA3RS study: a multicentre trial of magnetic resonance imaging in abdominal aortic aneurysms. He is Chief Investigator of the Wellcome Trust-funded multicentre trial:Prediction of Recurrent Events with 18F-Fluoride to Identify Ruptured and High-risk Coronary Artery Plaques in Patients with Myocardial Infarction (PRE18FFIR) trial, and the British Heart Foundation funded Dual Antiplatelet Therapy in Acute Coronary Syndromes in Scotland Trial.
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A novel CT-based radiotranscriptomic signature of perivascular fat improves cardiac risk prediction
In:
European Heart Journal
DOI: https://doi.org/10.1093/eurheartj/ehz592
Contribution to journal › Article (Published) -
Standardization of preclinical PET/CT imaging to improve quantitative accuracy, precision and reproducibility: a multi-center study
In:
Journal of Nuclear Medicine
DOI: https://doi.org/10.2967/jnumed.119.231308
Contribution to journal › Article (Published) -
From Subclinical Atherosclerosis to Plaque Progression and Acute Coronary Events : JACC State-of-the-Art Review
(10 pages)
In:
Journal of the American College of Cardiology, vol. 74, no. 12, pp. 1608-1617
DOI: https://doi.org/10.1016/j.jacc.2019.08.012
Contribution to journal › Review article (Published) -
Emerging techniques in atherosclerosis imaging
In:
British Journal of Radiology, pp. 20180309
DOI: https://doi.org/10.1259/bjr.20180309
Contribution to journal › Review article (E-pub ahead of print) -
High-sensitivity troponin and the application of risk stratification thresholds in patients with suspected acute coronary syndrome
In:
Circulation
DOI: https://doi.org/10.1161/CIRCULATIONAHA.119.042866
Contribution to journal › Article (E-pub ahead of print) -
Multimodal cardiac segmentation using disentangled representations
Chapter in Book/Report/Conference proceeding › Conference contribution (Accepted/In press) -
Molecular coronary plaque imaging using 18F-fluoride
In:
Circulation: Cardiovascular Imaging
DOI: https://doi.org/10.1161/CIRCIMAGING.118.008574
Contribution to journal › Article (Published) -
Triple-gated motion and blood pool clearance corrections improve reproducibility of coronary 18F-NaF PET
In:
European Journal of Nuclear Medicine and Molecular Imaging
DOI: https://doi.org/10.1007/s00259-019-04437-x
Contribution to journal › Article (Published) -
Acute Vascular Effects of Vascular Endothelial Growth Factor Inhibition in the Forearm Arterial Circulation
In:
Journal of Hypertension
DOI: https://doi.org/10.1097/HJH.0000000000002230,
Contribution to journal › Article (Published) -
In Vivo Alpha-V Beta-3 Integrin Expression in Human Aortic Atherosclerosis
In:
Heart
DOI: https://doi.org/10.1136/heartjnl-2019-315103
Contribution to journal › Article (E-pub ahead of print) -
Sex-Related Differences in the Extent of Myocardial Fibrosis in Patients with Aortic Valve Stenosis
In:
JACC. Cardiovascular imaging
DOI: https://doi.org/10.1016/j.jcmg.2019.06.014
Contribution to journal › Article (Published) -
Ticagrelor to reduce myocardial injury in patients with high-risk coronary artery plaque
In:
Journal of the American College of Cardiology
DOI: https://doi.org/10.1016/j.jcmg.2019.05.023
Contribution to journal › Article (E-pub ahead of print) -
Non-invasive in vivo imaging of acute thrombosis: development of a novel factor XIIIa radiotracer
In:
European Heart Journal - Cardiovascular Imaging
DOI: https://doi.org/10.1093/ehjci/jez207
Contribution to journal › Article (Published) -
Global burden of atherosclerotic cardiovascular disease in people with hepatitis C virus infection: a systematic review, meta-analysis, and modelling study
In:
Lancet Gastroenterology and Hepatology
DOI: https://doi.org/10.1016/S2468-1253(19)30227-4
Contribution to journal › Article (Published) -
Standardized reporting systems for computed tomography coronary angiography and calcium scoring: A real-world validation of CAD-RADS and CAC-DRS in patients with stable chest pain
In:
Journal of Cardiovascular Computed Tomography
DOI: https://doi.org/10.1016/j.jcct.2019.07.010
Contribution to journal › Article (Published) -
The Human-Specific and Smooth Muscle Cell-Enriched LncRNA SMILR Promotes Proliferation by Regulating Mitotic CENPF mRNA and Drives Cell-Cycle Progression Which Can Be Targeted to Limit Vascular Remodeling.
In:
Circulation Research
DOI: https://doi.org/10.1161/CIRCRESAHA.119.314876
Contribution to journal › Article (Published) -
Convalescent troponin and cardiovascular death following acute coronary syndrome
In:
Heart
DOI: https://doi.org/10.1136/heartjnl-2019-315084
Contribution to journal › Article (Published) -
Manganese-enhanced MRI of the myocardium
In:
Heart
DOI: https://doi.org/10.1136/heartjnl-2019-315227
Contribution to journal › Review article (Published) -
Disentangled representation learning in cardiac image analysis
(1 page)
In:
Medical image analysis
DOI: https://doi.org/10.1016/j.media.2019.101535
Contribution to journal › Article (E-pub ahead of print) -
Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases : subgroup analyses of the RESTART randomised, open-label trial
(10 pages)
In:
Lancet Neurology, vol. 18, no. 7, pp. 643-652
DOI: https://doi.org/10.1016/S1474-4422(19)30184-X
Contribution to journal › Article (Published)