David Newby
Personal Chair - BHF Duke of Edinbugh Chair of Cardiology
Address
- Street
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Chancellor's Building
49 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4SB
Research summary
Professor Newby has major interests in experimental medicine and the advanced imaging of cardiovascular disease including coronary heart disease, aortic stenosis and heart failure. He has held British Heart Foundation Programme Grants exploring the atherothrombotic effects of air pollution, and has interests in the interaction between cardiac and respiratory diseases. He has been involved in several multicentre trials and has played a major role in the conduct of the SALTIRE (Scottish Aortic stenosis Lipid lowering Trial, Impact on REgression) and 3CPO (Health Technology Assessment trial of non-invasive ventilation for acute cardiogenic pulmonary oedema) trials. He currently holds a BHF Programme Grant exploring non-invasive coronary atherothrombosis imaging. He is Chief Investigator for the SCOT-HEART trial funded by the Chief Scientist Office; a national multicentre randomised controlled trial of computed tomography coronary angiography in patients attending the Rapid Access Chest Pain Clinic. He is also Chief Investigator of the National Institute for Health Research Efficacy and Mechanism Evaluation-funded MA3RS study: a multicentre trial of magnetic resonance imaging in abdominal aortic aneurysms. He is Chief Investigator of the Wellcome Trust-funded multicentre trial:Prediction of Recurrent Events with 18F-Fluoride to Identify Ruptured and High-risk Coronary Artery Plaques in Patients with Myocardial Infarction (PRE18FFIR) trial, and the British Heart Foundation funded Dual Antiplatelet Therapy in Acute Coronary Syndromes in Scotland Trial.
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CARMN loss regulates smooth muscle cells and accelerates atherosclerosis in mice
In:
Circulation Research
DOI: https://doi.org/10.1161/CIRCRESAHA.120.318688
Research output: Contribution to Journal › Article (E-pub ahead of print) -
MINOCA: A heterogenous group of conditions associated with myocardial damage
In:
Heart
DOI: https://doi.org/10.1136/heartjnl-2020-318269
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Quality assurance of quantitative cardiac T1-mapping in multicenter clinical trials – A T1 phantom program from the hypertrophic cardiomyopathy registry (HCMR) study
In:
International Journal of Cardiology
DOI: https://doi.org/10.1016/j.ijcard.2021.01.026
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Contrast-enhanced computed tomography assessment of aortic stenosis
In:
Heart
DOI: https://doi.org/10.1136/heartjnl-2020-318556
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Quantifying Microcalcification Activity in the Thoracic Aorta
In:
Journal of Nuclear Cardiology
DOI: https://doi.org/10.1007/s12350-020-02458-w
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Activated neutrophil fluorescent imaging technique for human lungs
In:
Scientific Reports, vol. 11
DOI: https://doi.org/10.1038/s41598-020-80083-w
Research output: Contribution to Journal › Article (Published) -
Vascular effects of serelaxin in patients with stable coronary artery disease: a randomised placebo-controlled trial
In:
Cardiovascular Research, vol. 117, pp. 320–329
DOI: https://doi.org/10.1093/cvr/cvz345
Research output: Contribution to Journal › Article (Published) -
Reproducibility of quantitative plaque measurement in advanced coronary artery disease
In:
Journal of Cardiovascular Computed Tomography
DOI: https://doi.org/10.1016/j.jcct.2020.12.008
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Machine learning to predict cardiac events in asymptomatic individuals
In:
Atherosclerosis
DOI: https://doi.org/10.1016/j.atherosclerosis.2020.12.006
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Prevalence and clinical implications of valvular calcification on coronary computed tomography angiography
In:
European Heart Journal - Cardiovascular Imaging
DOI: https://doi.org/10.1093/ehjci/jeaa263
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Coronary 18F-Fluoride Uptake and Progression of Coronary Artery Calcification
In:
Circulation: Cardiovascular Imaging
DOI: https://doi.org/10.1161/CIRCIMAGING.120.011438
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Cardiopulmonary Impact of Particulate Air Pollution in High-Risk Populations: JACC State-of-the-Art Review
In:
Journal of the American College of Cardiology
DOI: https://doi.org/10.1016/j.jacc.2020.10.020
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Ex vivo 18F-fluoride uptake and hydroxyapatite deposition in human coronary atherosclerosis
In:
Scientific Reports
DOI: https://doi.org/10.1038/s41598-020-77391-6
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Manganese-enhancedmagnetic resonance imaging in dilated cardiomyopathy and hypertrophic cardiomyopathy
In:
European Heart Journal - Cardiovascular Imaging
DOI: https://doi.org/10.1093/ehjci/jeaa273
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Characterisation of an atherosclerotic micro-calcification model using ApoE-/- mice and PET/CT
In:
IJC Heart & Vasculature
DOI: https://doi.org/10.1016/j.ijcha.2020.100672
Research output: Contribution to Journal › Article (E-pub ahead of print) -
EACVI survey on investigations and imaging modalities in chronic coronary syndromes
In:
European Heart Journal - Cardiovascular Imaging
DOI: https://doi.org/10.1093/ehjci/jeaa300
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Disentangle, align and fuse for multimodal and semi-supervised image segmentation
(10 pages)
In:
IEEE Transactions on Medical Imaging, pp. 1-10
DOI: https://doi.org/10.1109/TMI.2020.3036584
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Adverse health effects associated with household air pollution: a systematic review, meta-analysis and burden estimation study
In:
The Lancet Global Health
DOI: https://doi.org/10.1016/S2214-109X(20)30343-0
Research output: Contribution to Journal › Article (E-pub ahead of print) -
DiCyc: GAN-based deformation invariant cross-domain information fusion for medical image synthesis
In:
Information Fusion
DOI: https://doi.org/10.1016/j.inffus.2020.10.015
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Improved Identification of Abdominal Aortic Aneurysm using the Kernelised Expectation Maximisation Algorithm
In:
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
Research output: Contribution to Journal › Article (E-pub ahead of print)