David Newby
Personal Chair - BHF Duke of Edinbugh Chair of Cardiology
Address
- Street
-
Chancellor's Building
49 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4SB
Research summary
Professor Newby has major interests in experimental medicine and the advanced imaging of cardiovascular disease including coronary heart disease, aortic stenosis and heart failure. He has held British Heart Foundation Programme Grants exploring the atherothrombotic effects of air pollution, and has interests in the interaction between cardiac and respiratory diseases. He has been involved in several multicentre trials and has played a major role in the conduct of the SALTIRE (Scottish Aortic stenosis Lipid lowering Trial, Impact on REgression) and 3CPO (Health Technology Assessment trial of non-invasive ventilation for acute cardiogenic pulmonary oedema) trials. He currently holds a BHF Programme Grant exploring non-invasive coronary atherothrombosis imaging. He is Chief Investigator for the SCOT-HEART trial funded by the Chief Scientist Office; a national multicentre randomised controlled trial of computed tomography coronary angiography in patients attending the Rapid Access Chest Pain Clinic. He is also Chief Investigator of the National Institute for Health Research Efficacy and Mechanism Evaluation-funded MA3RS study: a multicentre trial of magnetic resonance imaging in abdominal aortic aneurysms. He is Chief Investigator of the Wellcome Trust-funded multicentre trial:Prediction of Recurrent Events with 18F-Fluoride to Identify Ruptured and High-risk Coronary Artery Plaques in Patients with Myocardial Infarction (PRE18FFIR) trial, and the British Heart Foundation funded Dual Antiplatelet Therapy in Acute Coronary Syndromes in Scotland Trial.
-
A Machine-Learning Framework to Identify Distinct Phenotypes of Aortic Q1 Stenosis Severity
In:
JACC: Cardiovascular Imaging
DOI: https://doi.org/10.1016/j.jcmg.2021.03.020
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Improved Identification of Abdominal Aortic Aneurysm using the Kernelised Expectation Maximisation Algorithm
In:
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
DOI: https://doi.org/10.1098/rsta.2020.0201
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Effect of hypoglycaemia on measures of myocardial blood flow and myocardial injury in adults with and without type 1 diabetes: a prospective, randomised, open-label, blinded endpoint, cross-over study
In:
Endocrinology, Diabetes and Metabolism Case Reports
DOI: https://doi.org/10.1002/edm2.258 Funding information:
Research output: Contribution to Journal › Article (E-pub ahead of print) -
CARMN loss regulates smooth muscle cells and accelerates atherosclerosis in mice
In:
Circulation Research
DOI: https://doi.org/10.1161/CIRCRESAHA.120.318688
Research output: Contribution to Journal › Article (Published) -
Effect of denosumab or alendronic acid on the progression of aortic stenosis. A double-blind randomized controlled trial
In:
Circulation
DOI: https://doi.org/10.1161/CIRCULATIONAHA.121.053708
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Machine-learning with 18F-sodium fluoride PET and quantitative plaque analysis on CT angiography for the future risk of myocardial infarction
In:
Journal of Nuclear Medicine
DOI: https://doi.org/10.2967/jnumed.121.262283
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Sex-specific CT coronary plaque characterization and risk of myocardial infarction
In:
Journal of the American College of Cardiology
DOI: https://doi.org/10.1016/j.jcmg.2021.03.004
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Coronary computed tomography angiography to triage patients with non-ST elevation acute coronary syndrome
In:
Journal of the American College of Cardiology
DOI: https://doi.org/10.1016/j.jacc.2020.12.050
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Sodium-glucose co-transporter 2 inhibitor therapy – mechanisms of action in heart failure
In:
Heart
DOI: https://doi.org/10.1136/heartjnl-2020-318060
Research output: Contribution to Journal › Review article (E-pub ahead of print) -
Role of shear stress and tPA concentration in the fibrinolytic potential of thrombi
In:
International Journal of Molecular Sciences
DOI: https://doi.org/10.3390/ijms22042115
Research output: Contribution to Journal › Article (Published) -
MINOCA: A heterogenous group of conditions associated with myocardial damage
In:
Heart
DOI: https://doi.org/10.1136/heartjnl-2020-318269
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Quality assurance of quantitative cardiac T1-mapping in multicenter clinical trials – A T1 phantom program from the hypertrophic cardiomyopathy registry (HCMR) study
In:
International Journal of Cardiology
DOI: https://doi.org/10.1016/j.ijcard.2021.01.026
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Contrast-enhanced computed tomography assessment of aortic stenosis
In:
Heart
DOI: https://doi.org/10.1136/heartjnl-2020-318556
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Quantifying Microcalcification Activity in the Thoracic Aorta
In:
Journal of Nuclear Cardiology
DOI: https://doi.org/10.1007/s12350-020-02458-w
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Activated neutrophil fluorescent imaging technique for human lungs
In:
Scientific Reports, vol. 11
DOI: https://doi.org/10.1038/s41598-020-80083-w
Research output: Contribution to Journal › Article (Published) -
Vascular effects of serelaxin in patients with stable coronary artery disease: a randomised placebo-controlled trial
In:
Cardiovascular Research, vol. 117, pp. 320–329
DOI: https://doi.org/10.1093/cvr/cvz345
Research output: Contribution to Journal › Article (Published) -
Reproducibility of quantitative plaque measurement in advanced coronary artery disease
In:
Journal of Cardiovascular Computed Tomography
DOI: https://doi.org/10.1016/j.jcct.2020.12.008
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Machine learning to predict cardiac events in asymptomatic individuals
In:
Atherosclerosis
DOI: https://doi.org/10.1016/j.atherosclerosis.2020.12.006
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Prevalence and clinical implications of valvular calcification on coronary computed tomography angiography
In:
European Heart Journal - Cardiovascular Imaging
DOI: https://doi.org/10.1093/ehjci/jeaa263
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Coronary 18F-Fluoride Uptake and Progression of Coronary Artery Calcification
In:
Circulation: Cardiovascular Imaging
DOI: https://doi.org/10.1161/CIRCIMAGING.120.011438
Research output: Contribution to Journal › Article (E-pub ahead of print)