David Newby
Personal Chair - BHF Duke of Edinbugh Chair of Cardiology
Address
- Street
-
Chancellor's Building
49 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4SB
Research summary
Professor Newby has major interests in experimental medicine and the advanced imaging of cardiovascular disease including coronary heart disease, aortic stenosis and heart failure. He has held British Heart Foundation Programme Grants exploring the atherothrombotic effects of air pollution, and has interests in the interaction between cardiac and respiratory diseases. He has been involved in several multicentre trials and has played a major role in the conduct of the SALTIRE (Scottish Aortic stenosis Lipid lowering Trial, Impact on REgression) and 3CPO (Health Technology Assessment trial of non-invasive ventilation for acute cardiogenic pulmonary oedema) trials. He currently holds a BHF Programme Grant exploring non-invasive coronary atherothrombosis imaging. He is Chief Investigator for the SCOT-HEART trial funded by the Chief Scientist Office; a national multicentre randomised controlled trial of computed tomography coronary angiography in patients attending the Rapid Access Chest Pain Clinic. He is also Chief Investigator of the National Institute for Health Research Efficacy and Mechanism Evaluation-funded MA3RS study: a multicentre trial of magnetic resonance imaging in abdominal aortic aneurysms. He is Chief Investigator of the Wellcome Trust-funded multicentre trial:Prediction of Recurrent Events with 18F-Fluoride to Identify Ruptured and High-risk Coronary Artery Plaques in Patients with Myocardial Infarction (PRE18FFIR) trial, and the British Heart Foundation funded Dual Antiplatelet Therapy in Acute Coronary Syndromes in Scotland Trial.
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Prevalence and clinical implications of valvular calcification on coronary computed tomography angiography
In:
European Heart Journal - Cardiovascular Imaging
DOI: https://doi.org/10.1093/ehjci/jeaa263
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Coronary 18F-Fluoride Uptake and Progression of Coronary Artery Calcification
In:
Circulation: Cardiovascular Imaging
DOI: https://doi.org/10.1161/CIRCIMAGING.120.011438
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Cardiopulmonary Impact of Particulate Air Pollution in High-Risk Populations: JACC State-of-the-Art Review
In:
Journal of the American College of Cardiology
DOI: https://doi.org/10.1016/j.jacc.2020.10.020
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Ex vivo 18F-fluoride uptake and hydroxyapatite deposition in human coronary atherosclerosis
In:
Scientific Reports
DOI: https://doi.org/10.1038/s41598-020-77391-6
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Manganese-enhancedmagnetic resonance imaging in dilated cardiomyopathy and hypertrophic cardiomyopathy
In:
European Heart Journal - Cardiovascular Imaging
DOI: https://doi.org/10.1093/ehjci/jeaa273
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Characterisation of an atherosclerotic micro-calcification model using ApoE-/- mice and PET/CT
In:
International Journal of Cardiology Heart & Vasculature
DOI: https://doi.org/10.1016/j.ijcha.2020.100672
Research output: Contribution to Journal › Article (E-pub ahead of print) -
EACVI survey on investigations and imaging modalities in chronic coronary syndromes
In:
European Heart Journal - Cardiovascular Imaging
DOI: https://doi.org/10.1093/ehjci/jeaa300
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Disentangle, align and fuse for multimodal and semi-supervised image segmentation
In:
IEEE Transactions on Medical Imaging
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Disentangle, align and fuse for multimodal and semi-supervised image segmentation
(10 pages)
In:
IEEE Transactions on Medical Imaging, pp. 1-10
DOI: https://doi.org/10.1109/TMI.2020.3036584
Research output: Contribution to Journal › Article (E-pub ahead of print) -
DiCyc: GAN-based deformation invariant cross-domain information fusion for medical image synthesis
In:
International Journal of Information Fusion
DOI: https://doi.org/10.1016/j.inffus.2020.10.015
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Preclinical dosimetry models and the prediction of clinical doses of novel Positron Emission Tomography radiotracers
In:
Scientific Reports
DOI: https://doi.org/10.1038/s41598-020-72830-w
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Nonculprit Lesion Severity and Outcome of Revascularization in Patients With STEMI and Multivessel Coronary Disease
In:
Journal of the American College of Cardiology, vol. 76, pp. 1277-1286
DOI: https://doi.org/10.1016/j.jacc.2020.07.034
Research output: Contribution to Journal › Article (Published) -
Quantification of macrophage-driven inflammation during myocardial infarction with 18F-LW223, a novel TSPO radiotracer with binding independent of the rs6971 human polymorphism
In:
Journal of Nuclear Medicine
DOI: https://doi.org/10.2967/jnumed.120.243600
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Antithrombotic effects of combined protease-activated receptor-4 antagonism and factor Xa inhibition
In:
Arteriosclerosis, Thrombosis, and Vascular Biology
Research output: Contribution to Journal › Article (Published) -
Progression and regression of left ventricular hypertrophy and myocardial fibrosis in a mouse model of hypertension and concomitant cardiomyopathy
In:
Journal of Cardiovascular Magnetic Resonance
DOI: https://doi.org/10.1186/s12968-020-00655-7
Research output: Contribution to Journal › Article (Published) -
Mir-96 and miR-183 differentially regulate neonatal and adult post-infarct neovascularisation
In:
JCI Insight, vol. 5
DOI: https://doi.org/10.1172/jci.insight.134888
Research output: Contribution to Journal › Article (Published) -
Eosinophil deficiency promotes aberrant repair and adverse remodelling following acute myocardial infarction
In:
JACC: Basic to Translational Science
DOI: https://doi.org/10.1016/j.jacbts.2020.05.005
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Respiration-averaged CT versus standard CT attenuation maps for correction of the 18F-NaF uptake in hybrid PET/CT
In:
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
DOI: https://doi.org/10.1007/s12350-020-02245-7
Research output: Contribution to Journal › Article (Published) -
Understanding quantitative CT coronary artery plaque assessment using machine learning
In:
JACC. Cardiovascular imaging
DOI: https://doi.org/10.1016/j.jcmg.2020.04.027
Research output: Contribution to Journal › Editorial (Published) -
Coronary 18F-Sodium Fluoride Uptake Predicts Outcomes in Patients With Coronary Artery Disease
In:
Journal of the American College of Cardiology, vol. 75, pp. 3061-3074
DOI: https://doi.org/10.1016/j.jacc.2020.04.046
Research output: Contribution to Journal › Article (Published)