Edinburgh Clinical Trials
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Get Involved

If you have Osteogenesis Imperfecta (brittle bone disease) and you are aged 18 years or over you may be eligible to take part in the TOPaZ trial.

The trial is being carried out across the UK and Ireland and aims to determine if a two year spell of treatment with a drug called Teriparatide (TPTD) following by treatment with another drug called Zoledronic acid (ZA) reduces the risk of broken bones occurring in people with Osteogenesis Imperfecta. If you are interested in reading more about this study download the current patient information leaflet here.


Even if you are not attending one of the participating centre, it is still possible for you to take part in the trial by contacting the co-ordinating centre by telephone, post or email.

TOPaZ Trial Office

  • Edinburgh Clinical Trials Unit
  • University of Edinburgh

Contact details



Edinburgh Clinical Trials Unit
Usher Institute
University of Edinburgh
Level 2, Nine Edinburgh BioQuarter
9 Little France Road

Post Code
EH16 4UX

We will ask for your permission to contact your GP or hospital specialist to check that you are suitable for the study and, if you are, we will give you a choice of the most convenient study centre to attend.  

There is a form we will ask you to fill in to confirm that you give us permission to contact your GP or specialist about you.  Download the TOPaZ form here: