Edinburgh Clinical Trials

About the Trial

TOPaZ is a non-commercial trial sponsored by a partnership of the University of Edinburgh and NHS Lothian called ACCORD and funded by the UK National Institute for Health Research (NIHR).

It is a multicentre, parallel arm, randomised open-label clinical trial. These types of trial aim to make a fair comparison between a new treatment and an existing treatment to see which one works best. The decision about who gets one treatment or another is random – made by chance rather than by a doctor or a participant. This means that researchers can be sure that any differences between the groups are due to the treatment and not to any other factor.

'Open-label' means that participants are randomised at the beginning of the trial and they will know straightaway which treatment group they are part of.

Both treatment groups are equally important: we want to know which treatment is best but we will only know this by carrying out the trial!


UK GDPR Privacy Statement

If you have already joined the TOPaZ Trial, or are considering participating, and would like to read how the study complies with UK GDPR, please click on this link:

UK GDPR UK Statement: