TOPaZ
Treatment of Osteogenesis Imperfecta with Parathyroid hormone and Zoledronic acid
TOPaZ is a randomised open-label clinical trial for people with osteogenesis imperfecta (OI). The study aims to investigate whether a two-year spell of treatment with a drug called teriparatide (TPTD) followed by treatment with another drug called Zoledronic acid (ZA) reduces the risk of broken bones occurring in people with OI.
Chief Investigator: Prof. Stuart Ralston
Number and location of participating sites (by region/ country): 25 UK, Republic of Ireland, France, Netherlands, Denmark
EudraCT number: 2016-003228-22
ISRCTN number: 15313991
Funder: NIHR Efficacy and Mechanism Evaluation Programme
Start and End date:
Of grant award - Nov 2016-April 2025
Of recruitment - Oct 2022
Current Status: In follow up
Trial Website: The TOPaZ Trial
UK GDPR Privacy Statement: If you have participated in this study and would like to read how it complies with UK GDPR, please read this document.
Sponsor: ACCORD http://www.accord.ed.ac.uk/
Chief Investigator: Professor Stuart Ralston, Molecular Medicine Centre, Institute of Genetics and Cancer, Western General Hospital, Edinburgh, EH4 2XU
Trial manager: topaz.trial@ed.ac.uk
ECTU Involvement: Trial management / Statistics / Database and randomisation service provision.
(UKCRC)
