Edinburgh Clinical Trials

UKCRC Studies

ECTU has a portfolio of adopted trials, which fall under the UK Clinical Research Collaboration registration number.

List of UKCRC studies

For further information please click on the study name.

Rheumatology / Orthopaedic:

DENS  (duration of external neck stabilisation)

MOTION  (osteoarthritis)

LASER (assisted Staphylococcal eradication)

OPPORTUNITY (osteoarthritis in knees)

SLEx (lupus)

TOPaZ (Osteogenesis Imperfecta)

TRIO-Physio (physiotherapy vs knee replacement)

ZiPP (Paget's disease)


Perioperative Medicine:

RESULT-HIP (effect of haemoglobin transfusion threshold after hip fracture surgery on cardiac injury and death)

Health Economics:



4AT (triage tool for delirium)

AGS-RTI(reverse transcriptase inhibitors + interferon signalling)

CARE (symptomatic brain cavernoma)

MS-SMART (multiple sclerosis)

RESTART (spontaneous intracerebral haemorrhage)

MND-SMART (Motor Neurone Disease Systematic Multi-Arm Adaptive Randomised Trial)






Cardiac CARE (high-sensitivity cardiac troponin I)

DIAMOND (coronary atherosclerosis and PET CT)

DUAL ACS  (acute coronary syndrome)

EVoLVeD (early valve replacement)

HighSTEACS (high sensitivity Troponin)

HiSTORIC (high sensitivity Troponin)

PRE18FFIR (PET CT and myocardial infarction)

SALTIRE II (aortic stenosis)

SCOT-HEART 2 (computer tomography coronary angiography for the prevention of myocardial infarction)

TARGET-CTCA (using troponin to guide CTCA)


GEM (Crohn's disease)

MARVEL (ulcerative colitis)

SPARE (Crohn's disease)

Mini MARVEL (ulcerative colitis)

MUSIC(ulcerative colitis and crohn's disease)



Clinical Toxicology:

MAIL(macrophage therapy for acute liver injury)

Emergency/Critical Care:

A2B (alpha 2 agonists sedation agents)

ASPIRED (enhanced ambulatory ECG monitoring)

HiSNAP (paracetamol overdose)

The RUFUS Study (repurposing flumazenil for intramuscular treatment of coma due to         unintentional drug overdose - a dose-finding safety and efficacy phase II/III study)



PIB CAP (personalised antibiotic treatment for pneumonia) 

MucAct  (COPD)

TEMPESTAS (effect of inhaled steroids in severe COPD patients) 


HOT2 (renal transport - delayed graft function)




ELVIS Kids (upper respiratory tract infection)


BRIDGE-IT  (emergency contraception)

CHOICE (cervical ripening at home or in hospital)

METAFOR (gestational diabetes)

Further information:

How to get your trial adopted and access support    
All current studies Commercial Partnerships Data Linkage Studies
Health Services Research Studies Completed Studies