Publications

Research outputs from members of the Centre, and other relevant publications

2024

March

Title	Authors	Summary	Reference
Outdoor air pollution and near-fatal/fatal asthma attacks in children: A systematic review.	Varghese D, Ferris K, Lee B, Grigg J, Pinnock H, Cunningham S.	Globally, observational studies have demonstrated an association between high levels of air pollution and asthma attacks in children, however it remains unclear to what extent exposure may be associated with increased near-fatal and fatal attacks.	Pediatr Pulmonol. 2024 Mar 13. doi: 10.1002/ppul.26932. Online ahead of print.PMID: 38477643 Review.
Level of Education Modifies Asthma Mortality in Norway and Sweden. The Nordic EpiLung Study.	Backman H, Bhatta L, Hedman L, Brumpton B, Vähätalo I, Lassmann-Klee PG, Nwaru BI, Ekerljung L, Krokstad S, Aalberg Vikjord SA, Lindberg A, Kankaanranta H, Rönmark E, Langhammer A.	Several studies have found that individuals with lower levels of education are more likely to have asthma than those with higher levels of education, which can be explained by work related exposure to asthma triggers, access to healthcare or medical treatment unaffordability.	J Asthma Allergy. 2024 Mar 18;17:209-218. doi: 10.2147/JAA.S450103. eCollection 2024.PMID: 38524102 Free PMC article.
High-Flow Humidified Oxygen as an Early Intervention in Children With Acute Severe Asthma: Protocol for a Feasibility Randomized Controlled Trial.	Rojas-Anaya H, Kapur A, Roberts G, Roland D, Gupta A, Lazner M, Bayreuther J, Pappachan J, Jones C, Bremner S, Cantle F, Seddon P.	"High-flow humidified oxygen (HiFlo) is widely used in respiratory conditions and is increasingly being used in ASA, but with little evidence for its effectiveness.”	JMIR Res Protoc. 2024 Mar 28;13:e54081. doi: 10.2196/54081.PMID: 38546733
Dupilumab reduces exacerbations independent of changes in biomarkers in moderate-to-severe asthma.	Pavord ID, Casale TB, Corren J, FitzGerald MJ, Deniz Y, Altincatal A, Gall R, Pandit-Abid N, Radwan A, Jacob-Nara JA, Rowe PJ, Busse WW.	“Changes from baseline in fractional exhaled nitric oxide and blood eosinophil count may be related to efficacy outcomes in dupilumab-treated patients with moderate-to-severe asthma.”	J Allergy Clin Immunol Pract. 2024 Mar 28:S2213-2198(24)00306-4. doi: 10.1016/j.jaip.2024.03.031. Online ahead of print.PMID: 38555079
Medication Adherence in Children with Asthma.	McCrossan P, Shields MD, McElnay JC.	“Treatment adherence in children’s asthma involves three measures: frequency of inhaler use, quality of inhaler technique and prescriber’s compliance with national guidelines. “	Patient Prefer Adherence. 2024 Mar 5;18:555-564. doi: 10.2147/PPA.S445534. eCollection 2024.PMID: 38476591 Free PMC article. Review.
Primary Care Asthma Attack Prediction Models for Adults: A Systematic Review of Reported Methodologies and Outcomes.	Ma L, Tibble H.	“The predictive performance is heavily influenced by the study design, including the population, the outcome definition, the algorithm, and the model validation procedures. Identifying the most clinically meaningful model characteristics is necessary to enable a “best” model to be identified and highlight routes for future development. “	J Asthma Allergy. 2024 Mar 14;17:181-194. doi: 10.2147/JAA.S445450. eCollection 2024.PMID: 38505397
Lung-function trajectories: relevance and implementation in clinical practice.	Melén E, Faner R, Allinson JP, Bui D, Bush A, Custovic A, Garcia-Aymerich J, Guerra S, Breyer-Kohansal R, Hallberg J, Lahousse L, Martinez FD, Merid SK, Powell P, Pinnock H, Stanojevic S, Vanfleteren LEGW, Wang G, Dharmage SC, Wedzicha J, Agusti A; CADSET Investigators	“This Review presents progressive research into lung-function trajectories and assists the implementation of this knowledge in clinical practice as an innovative approach to detect poor lung health early, monitor respiratory disease progression, and promote lung health.”	Lancet. 2024 Mar 12:S0140-6736(24)00016-3. doi: 10.1016/S0140-6736(24)00016-3. Online ahead of print.PMID:
Efficacy of oral corticosteroids for acute preschool wheeze: a systematic review and individual participant data meta-analysis of randomised clinical trials.	Lee B, Turner S, Borland M, Csonka P, Grigg J, Guilbert TW, Jartti T, Oommen A, Twynam-Perkins J, Lewis S, Cunningham S	Oral corticosteroids are beneficial in treating acute wheeze associated with asthma. Study shows that children with acute preschool wheeze who received oral corticosteroids had statistically significant improvement in wheezing severity score	Lancet Respir Med. 2024 Mar 22:S2213-2600(24)00041-9. doi: 10.1016/S2213-2600(24)00041-9. Online ahead of print.PMID: 38527486
Mast cell activation disrupts interactions between endothelial cells and pericytes during early life allergic asthma.	Joulia R, Puttur F, Stölting H, Traves WJ, Entwistle LJ, Voitovich A, Garcia Martín M, Al-Sahaf M, Bonner K, Scotney E, Molyneaux PL, Hewitt RJ, Walker SA, Yates L, Saglani S, Lloyd CM.	Study demonstrated that tissue remodeling, induced by inhaled allergen, affects blood vessel organization during early life with a reduction of the pulmonary microcirculation that precedes other structural changes, and loss of blood vessels in specific areas may negatively affect gas exchange.	J Clin Invest. 2024 Mar 15;134(6):e173676. doi: 10.1172/JCI173676.PMID: 38487999
Assessing catastrophic health expenditure and impoverishment in adult asthma care: a cross-sectional study of patients attending six public health clinics in Klang District, Malaysia.	Hussein N, Ng CW, Ramli R, Liew SM, Hanafi NS, Lee PY, Cheong AT, Ghazali SS, Pinnock H, Stoddart A, Schwarze J, Khoo EM.	Malaysian patients benefited from the heavily subsidised public health services, however this study highlighted those in the lowest income quintile still experienced financial catastrophe and impoverishment.	BMC Health Serv Res. 2024 Mar 12;24(1):327. doi: 10.1186/s12913-024-10731-8.PMID: 38475801

February

Title	Authors	Summary	Reference
Greenhouse gas emissions associated with suboptimal asthma care in the UK: the SABINA healthCARe-Based envirONmental cost of treatment (CARBON) study.	Wilkinson AJK, Maslova E, Janson C, Radhakrishnan V, Quint JK, Budgen N, Tran TN, Xu Y, Menzies-Gow A, Bell JP.	“Findings of the study suggest that addressing the high burden of poorly controlled asthma, including curbing high SABA use and its associated risk of exacerbations, may significantly alleviate asthma care-related carbon emissions.”	Thorax. 2024 Feb 27:thorax-2023-220259. doi: 10.1136/thorax-2023-220259. Online ahead of print.PMID: 38413192
Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma.	Wechsler ME, Scelo G, Larenas-Linnemann DES, et.al.	Findings of the study highlight the importance of systematic comorbidity evaluation.	Am J Respir Crit Care Med. 2024 Feb 1;209(3):262-272. doi: 10.1164/rccm.202305-0808OC.PMID: 38016003
Effect of Individual Patient Characteristics and Treatment Choices on Reliever Medication Use in Moderate-Severe Asthma: A Poisson Analysis of Randomised Clinical Trials.	van Dijkman SC, Yorgancıoğlu A, Pavord I, Brusselle G, Pitrez PM, Oosterholt S, Fumali S, Majumdar A, Della Pasqua O	Individual demographic and clinical characteristics, as well as exacerbation history can be considered an indicator of the degree of asthma control.	Adv Ther. 2024 Mar;41(3):1201-1225. doi: 10.1007/s12325-023-02774-w. Epub 2024 Feb 1.PMID: 38296921 Free PMC article. Clinical Trial.
Predictors of persistent poor control and validation of ASSESS score: Longitudinal 5-year follow-up of severe asthma cohort.	Tiew PY, Tay TR, Chen W, Price DB, Ong KY, Chotirmall SH, Koh MS.	“Bronchiectasis and gastroesophageal reflux disease are predictors for persistent poor asthma control and targeted traits for precision medicine in severe asthma. The ASSESS score has a good prediction for persistent poor asthma control over 5 years.”	J Allergy Clin Immunol Glob. 2023 Nov 20;3(1):100188. doi: 10.1016/j.jacig.2023.100188. eCollection 2024 Feb.PMID: 38173699
The Association Between Short-Acting β₂-Agonist Over-Prescription, and Patient-Reported Acquisition and Use on Asthma Control and Exacerbations: Data from Australia.	Price D, Jenkins C, Hancock K, Vella R, Heraud F, Le Cheng P, Murray R, Beekman M, Bosnic-Anticevich S, Botini F, Carter V, Catanzariti A, Doan J, Fletton K, Kichkin A, Le T, Le Lievre C, Lau CM, Novic D, Pakos J, Ranasinghe K, Roussos A, Samuel-King J, Sharma A, Stewart D, Willet B, Bateman E; OPCA Improving Asthma Outcomes in Australia Research Group.	In Australia, short-acting β₂-agonists (SABA) are available both over the counter and on prescription, and the ease of access may impact SABA use in the Australian population.	Adv Ther. 2024 Mar;41(3):1262-1283. doi: 10.1007/s12325-023-02746-0. Epub 2024 Feb 4.PMID: 38310584
Type-2 inflammation: a key treatable trait associated with lung function decline in chronic airways disease.	Petousi N, Pavord ID, Kent BD.	“Phenotyping all patients with asthma and COPD by measuring their type-2 biomarkers is essential for identifying those at risk of lung function decline, exacerbations, people remodelling and death, and will allow earlier targeting of treatment.”	Thorax. 2024 Feb 19:thorax-2023-221329. doi: 10.1136/thorax-2023-221329. Online ahead of print.PMID: 38373823
Biomarkers Associated with Lung Function Decline and Dupilumab Response in Patients with Asthma.	Pavord ID, de Prado Gómez L, Brusselle G, Jackson DJ, Brightling CE, Papi A, Maspero JF, Rabe KF, Korn S, Zhang M, Soler X, Jacob-Nara JA, Hardin M; QUEST Lung Function Decline Study Group.	“The analysis provides robust data supporting FeNO as a clinically viable prognostic biomarker for accelerated Lung Function Decline and predictive of the treatment response to dupilumab. Additional research is needed to establish patterns of LFD in patients with moderate-to-severe asthma, as well as the prognostic and predictive role of FeNO.”	Am J Respir Crit Care Med. 2024 Feb 8. doi: 10.1164/rccm.202310-1751LE. Online ahead of print.PMID: 38329781
Can We Test the Function of the Small Airways in Children Outside the Laboratory?	Makrinioti H, Bush A.	Cohort studies pinpoint associations between early life lung function impairment and the development of asthma and COPD. DTG-SBW test is a measure of the uniformity of lung ventilation and gas mixing efficiency, feasible in a pediatric field setting.	Chest. 2024 Feb;165(2):241-242. doi: 10.1016/j.chest.2023.10.004.PMID: 38336434
A simple and effective evidence-based approach to asthma management: ICS-formoterol reliever therapy.	Levy ML, Beasley R, Bostock B, Capstick TG, Crooks MG, Fleming L, Freeman D, Marsh V, Rupani H, Whittamore A, Barnes PJ, Bush A.	Traditionally, SABA inhalers are prescribed as the first step in managing asthma, however SABA monotherapy fails to alleviate inflammation. ICS-formoterol reliever alone reduces severe exacerbations compared with SABA monotherapy in mild asthma.	Br J Gen Pract. 2024 Jan 25;74(739):86-89. doi: 10.3399/bjgp24X736353. Print 2024 Feb.PMID: 38272684
International variation in severe exacerbation rates in patients with severe asthma.	Lee TY, Price D, Yadav CP, Roy R, Mien LLH, Wang E, Wechsler ME, Jackson DJ, Busby J, Heaney LG, Pfeffer PE, Mahboub B, Perng Steve DW, Cosio BG, Perez-de-Llano L, Al-Lehebi R, Larenas-Linnemann D, Al-Ahmad M, Rhee CK, Iwanaga T, Heffler E, Canonica GW, Costello R, Papadopoulos NG, Papaioannou AI, Porsbjerg CM, Torres-Duque CA, Christoff GC, Popov TA, Hew M, Peters M, Gibson PG, Maspero J, Bergeron C, Cerda S, Contreras Contreras EA, Chen W, Sadatsafavi M.	Study shows a large between-country variation in observed severe exacerbation rate, suggesting adapted clinical recommendations for severe asthma.	Chest. 2024 Feb 21:S0012-3692(24)00264-2. doi: 10.1016/j.chest.2024.02.029. Online ahead of print.PMID: 38395297
How have we measured trial outcomes of asthma attack treatment? A systematic review.	Howell I, Howell A, Ramakrishnan S, Bafadhel M, Pavord I.	“Outcomes in randomised controlled trials of asthma attack treatment focus on short-term changes in lung function and may not capture patient-centred and economically important longer-term measures.”	ERJ Open Res. 2024 Feb 26;10(1):00660-2023. doi: 10.1183/23120541.00660-2023. eCollection 2024 Jan.PMID: 38410715
Long-term air pollution exposure and risk of SARS-CoV-2 infection: A UK-wide cohort study.	Hajmohammadi H, Talaei M, Fecht D, Wang W, Vivaldi G, Faustini SE, Richter AG, Shaheen SO, Martineau AR, Sheikh A, Mudway IS, Griffiths CJ.	Findings of the study suggest that the long-term burden of air pollution increased the risks of SARS-CoV-2 infection and has important implications for future pandemic preparedness.	Respir Med. 2024 Feb 27:107567. doi: 10.1016/j.rmed.2024.107567. Online ahead of print.PMID: 38423343
Evaluating the Feasibility of a Community Pharmacy-Delivered Behaviour Change Intervention to Reduce Reliever Reliance in Asthma.	Foot H, Beyene K, Horne R, Fingleton J, Harrison J, Chan AHY.	Brief pharmacy-delivered intervention is feasible and acceptable to patients and pharmacy staff, changing patients’ beliefs about SABA, as well as making pharmacists aware of SABA overuse.	Patient Prefer Adherence. 2024 Feb 7;18:361-371. doi: 10.2147/PPA.S445763. eCollection 2024.PMID: 38344153
Challenges in diagnosing asthma in children.	Chisholm K, Daines L, Turner S.	“Asthma can be diagnosed in children under 5, but is unlikely to explain recurrent respiratory symptoms in children under 2”.	BMJ. 2024 Feb 13;384:e075924. doi: 10.1136/bmj-2023-075924.PMID: 38350681
Time-dependent gene-environment interactions are essential drivers of asthma initiation and persistence.	Chatziparasidis G, Chatziparasidi MR, Kantar A, Bush A.	Study introduces the importance of the time variant in asthma pathogenesis and emphasize the long-term clinical significance of the time-dependent gene-environment interactions in childhood.	Pediatr Pulmonol. 2024 Feb 21. doi: 10.1002/ppul.26935. Online ahead of print.PMID: 38380964

January

Title	Authors	Summary	Reference
Obstructive and restrictive spirometry from school age to adulthood: three birth cohort studies.	Ullah A, Granell R, Haider S, Lowe L, Fontanella S, Arshad H, Murray CS, Turner S, Holloway JW, Simpson A, Roberts G, Custovic A; STELAR/UNICORN Investigators.	Maternal smoking during pregnancy, early wheeze, higher BMI, current wheeze, current asthma diagnosis, current sensitization, and current parental smoking are associated with higher prevalence of obstructive phenotype.	EClinicalMedicine. 2023 Dec 12;67:102355. doi: 10.1016/j.eclinm.2023.102355. eCollection 2024 Jan.PMID: 38169936 Free PMC article.
Psychological interventions for asthma in children and adolescents.	Sharrad KJ, Sanwo O, Cuevas-Asturias S, Kew KM, Carson-Chahhoud KV, Pike KC.	Main objective of the protocol is to determine the efficacy of psychological interventions in modifying health and behavioural outcomes in children with asthma, compared with usual treatment.	Cochrane Database Syst Rev. 2024 Jan 11;1(1):CD013420. doi: 10.1002/14651858.CD013420.pub2.PMID: 38205864 Review.
Analysis of comorbidities and multimorbidity in adult patients in the International Severe Asthma Registry.	Scelo G, Torres-Duque CA, Maspero J, et.al.	First global analysis of comorbidity burden in patients with severe asthma, in terms of both prevalence and association with asthma clinical characteristics and outcomes.	Ann Allergy Asthma Immunol. 2024 Jan;132(1):42-53. doi: 10.1016/j.anai.2023.08.021. Epub 2023 Aug 26.PMID: 37640263 Free article.
What trials do and do not tell us about treatments for severe asthma.	Quint JK, Shah PL.	"As we learn more about long-term risks and benefits of asthma treatments and think in terms of disease phenotypes and personalised medicine, clinicians increasingly tailor treatment, focusing on subgroups of people with disease and targeting minutia within inflammatory pathways."	Lancet. 2024 Jan 20;403(10423):224-226. doi: 10.1016/S0140-6736(23)02409-1.PMID: 38245238 No abstract available.
Dupilumab sustains lung function improvements in patients with moderate-to-severe asthma.	Papi A, Castro M, Corren J, Pavord ID, Tohda Y, Altincatal A, Pandit-Abid N, Laws E, Akinlade B, Mannent LP, Gall R, Jacob-Nara JA, Deniz Y, Rowe PJ, Lederer DJ, Hardin M.	“Dupilumab improves lung function outcomes, including large and small airway measurements and fixed airway obstruction, in patients with uncontrolled, moderate-to-severe asthma; particularly in patients with elevated biomarkers of type 2 inflammation.”	Respir Med. 2024 Jan 23:107535. doi: 10.1016/j.rmed.2024.107535. Online ahead of print.PMID: 38272376 Free article.
From treatable traits to GETomics in airway disease: moving towards clinical practice.	Papi A, Faner R, Pavord I, Baraldi F, McDonald VM, Thomas M, Miravitlles M, Roche N, Agustí A.	“The concept of GETomics provides a new dynamic and integrated understanding of the pathogenesis of human diseases in general, and respiratory diseases in particular.”	Eur Respir Rev. 2024 Jan 17;33(171):230143. doi: 10.1183/16000617.0143-2023. Print 2024 Jan 31.PMID: 38232989 Free PMC article. Review.
Impact of indoor environment on children's pulmonary health.	Murphy J, Tharumakunarajah R, Holden KA, King C, Lee AR, Rose K, Hawcutt DB, Sinha IP.	“Children are particularly susceptible to the effects of environmental insults, and children living in socioeconomic deprivation globally are more likely to breathe air both indoors and outdoors, which poses an acute and long-term risk to their health”	Expert Rev Respir Med. 2024 Jan 19:1-11. doi: 10.1080/17476348.2024.2307561. Online ahead of print.PMID: 38240133 Review.
The infant gut virome is associated with preschool asthma risk independently of bacteria.	Leal Rodríguez C, Shah SA, Rasmussen MA, Thorsen J, Boulund U, Pedersen CT, Castro-Mejía JL, Poulsen CE, Poulsen CS, Deng L, Larsen FAN, Widdowson M, Zhang Y, Sørensen SJ, Moineau S, Petit MA, Chawes B, Bønnelykke K, Nielsen DS, Stokholm J.	A healthy infant virome is dominated by a rich temperate phage community, whereas perturbed core temperate virome lacking particular viral families may be a risk factor for the development of preschool asthma independent of the bacterial community.	Nat Med. 2024 Jan;30(1):138-148. doi: 10.1038/s41591-023-02685-x. Epub 2023 Dec 15.PMID: 38102298
Reduction of daily maintenance inhaled corticosteroids in patients with severe eosinophilic asthma treated with benralizumab (SHAMAL): a randomised, multicentre, open-label, phase 4 study.	Jackson DJ, Heaney LG, Humbert M, Kent BD, Shavit A, Hiljemark L, Olinger L, Cohen D, Menzies-Gow A, Korn S; SHAMAL Investigators.	Study shows that 92% of patients were able to successfully reduce their high-dose ICS and more than 87% of patients remained exacerbation-free by week 48 in the treatment-reduction group.	Lancet. 2024 Jan 20;403(10423):271-281. doi: 10.1016/S0140-6736(23)02284-5. Epub 2023 Dec 7.PMID: 38071986 Free article. Clinical Trial.
Phenotyping of Severe Asthma in the Era of Broad-acting Anti-asthma Biologics.	Bourdin A, Brusselle G, Couillard S, Fajt ML, Heaney LG, Israel E, McDowell PJ, Menzies-Gow A, Martin N, Mitchell PD, Petousi N, Quirce S, Schleich F, Pavord ID	”Effective management of severe asthma requires consideration of clinical heterogeneity that is driven by varying clinical and inflammatory phenotypes, which are reflective of distinct underlying disease mechanisms.”	J Allergy Clin Immunol Pract. 2024 Jan 25:S2213-2198(24)00075-8. doi: 10.1016/j.jaip.2024.01.023. Online ahead of print.PMID: 38280454 Free article.
Strategies to Classify Lung Function: It's Not Black and White.	Baugh A, Buhr RG, Bush A, Foreman M, Mannino DM.	“Lung function is determined by both genetic and environmental influences, but quantifying the role of each in population-level racial differences is difficult. Environmental influences, especially in early life, can influence gene expression in both individuals and their unexposed descendants”	Am J Respir Crit Care Med. 2024 Jan 1;209(1):19-20. doi: 10.1164/rccm.202305-0807VP.PMID: 37878872 No abstract available.
Blood eosinophils and FeNO are prognostic and predictive biomarkers in childhood asthma.	Bacharier LB, Pavord ID, Maspero JF, Jackson DJ, Fiocchi AG, Mao X, Jacob-Nara JA, Deniz Y, Laws E, Mannent LP, Amin N, Akinlade B, Staudinger HW, Lederer DJ, Hardin M.	“In children with uncontrolled moderate-to-severe asthma, blood eosinophil counts and FeNO are clinically relevant biomarkers to identify those at risk for asthma exacerbations, as well as those who will demonstrate a clinical response to dupilumab.”	J Allergy Clin Immunol. 2024 Jan 23:S0091-6749(24)00043-5. doi: 10.1016/j.jaci.2023.09.044. Online ahead of print.PMID: 38272375 Free article.

2023

December

Title	Authors	Summary	Reference
Impact of pre-biologic impairment on meeting domain-specific biologic responder definitions in patients with severe asthma.	Perez-de-Llano L, Scelo G, Canonica GW, Chen W, Henley W, Larenas-Linnemann D, Peters MJ, Pfeffer PE, Tran TN, Ulrik CS, Popov TA, Sadatsafavi M, Hew M, Maspero J, Gibson PG, Christoff GC, Fitzgerald JM, Torres-Duque CA, Porsbjerg CM, Papadopoulos NG, Papaioannou AI, Heffler E, Iwanaga T, Al-Ahmad M, Kuna P, Fonseca JA, Al-Lehebi R, Rhee CK, Koh MS, Cosio BG, Perng Steve DW, Mahboub B, Menzies-Gow AN, Jackson DJ, Busby J, Heaney LG, Patel PH, Wang E, Wechsler ME, Altraja A, Lehtimäki L, Bourdin A, Bjermer L, Bulathsinhala L, Carter V, Murray R, Beastall A, Denton E, Price DB.	Percentage of biologic responders varied by domain and increased with greater pre-biologic impairment, increasing from 70.2 to 90.0% for exacerbation rate and 46.3 to 52.3% for asthma control.	Ann Allergy Asthma Immunol. 2023 Dec 25:S1081-1206(23)01508-9. doi: 10.1016/j.anai.2023.12.023. Online ahead of print.PMID: 38151100
An examination of factorial invariance of the Asthma Control Questionnaire among adults with severe asthma.	McDowell R, Heaney L, Brown T, Bunting B, Burhan H, Chaudhuri R, Dennison P, Faruqi S, Gore R, Jackson DJ, Menzies-Gow A, Pantin T, Patel M, Pfeffer P, Siddiqui S, Busby J; UK Severe Asthma Registry.	The Asthma Control Questionnaire showed to be very informative in comparing levels of symptom control between severe asthmatic patients of different ethnicities, sexes and ages.	PLoS One. 2023 Dec 7;18(12):e0295493. doi: 10.1371/journal.pone.0295493. eCollection 2023.PMID: 38060586
Pioneering a paradigm shift in asthma management: remission as a treatment goal.	Lommatzsch M, Buhl R, Canonica GW, Ribas CD, Nagase H, Brusselle GG, Jackson DJ, Pavord ID, Korn S, Milger K, Taube C, Virchow JC	Phenotyping is an essential prerequisite to establish individually effective treatment as the new concept of disease modification does not warrant the simple addition of one drug to another, but the identification of the right anti-inflammatory disease-modifying anti-asthmatic drugs for the right patient at the right time.	Lancet Respir Med. 2023 Dec 7:S2213-2600(23)00415-0. doi:10.1016/S2213-2600(23)00415-0.
Impact of sex on severe asthma: a cross-sectional retrospective analysis of UK primary and specialist care.	Loewenthal L, Busby J, McDowell R, Brown T, Burhan H, Chaudhuri R, Dennison P, Dodd JW, Doe S, Faruqi S, Gore R, Idris E, Jackson DJ, Patel M, Pantin T, Pavord I, Pfeffer PE, Price DB, Rupani H, Siddiqui S, Heaney LG, Menzies-Gow A; UK Severe Asthma Registry.	“After puberty, females are more likely to develop asthma and in a more severe form than males. The associations between asthma and sex are complex with multiple intrinsic and external factors.”	Thorax. 2023 Dec 16:thorax-2023-220512. doi: 10.1136/thorax-2023-220512. Online ahead of print.PMID: 38124220
Influence of age on clinical characteristics, pharmacological management and exacerbations in children with asthma.	Khalaf Z, Bush A, Saglani S, Bloom CI.	"Children’s baseline characteristics and exacerbation rates varied according to their age group. Clinical guidelines should consider age at time of diagnosis more discretely than the broad range, 5–16 years, as this appears to impact on asthma severity and management."	Thorax. 2023 Dec 7:thorax-2023-220603. doi: 10.1136/thorax-2023-220603. Online ahead of print.PMID: 38071524
Recent trends in asthma diagnosis, preschool wheeze diagnosis and asthma exacerbations in English children and adolescents: a SABINA Jr study.	Kallis C, Maslova E, Morgan AD, Sinha I, Roberts G, van der Valk RJP, Quint JK, Tran TN.	Data shows that preschool wheeze and paediatric asthma incidence decreased in the UK since 2008, particularly in 1–5-year-olds, however exacerbation rates have been increasing.	Thorax. 2023 Dec;78(12):1175-1180. doi: 10.1136/thorax-2022-219757. Epub 2023 Jul 31.PMID: 37524391
Perceptions surrounding the possible interaction between physical activity, pollution and asthma in children and adolescents with and without asthma.	Jordan KA, Mackintosh KA, Davies GA, Griffiths CJ, Lewis PD, McNarry MA.	The primary aim of the study was to elicit the views of children and adolescents regarding physical activity, asthma and pollution and to explore any potential interaction between them. Overall, the participants understood the concept and importance of PA for health, and those with asthma were well aware of its role within the management of the disease.	BMC Public Health. 2023 Dec 5;23(1):2416. doi: 10.1186/s12889-023-17174-6.PMID: 38053057
Strong and graded associations between level of asthma severity and all-cause hospital care use and costs in the UK.	Jacobs A, Wu R, Tomini F, De Simoni A, Mihaylova B.	“The study reports that adults with asthma experience on average more hospital admissions, more days in hospital and incur greater hospital costs than those without asthma, the extent of which varies significantly according to disease severity.”	BMJ Open Respir Res. 2023 Dec 14;10(1):e002003. doi: 10.1136/bmjresp-2023-002003.PMID: 38101812
Reduction of daily maintenance inhaled corticosteroids in patients with severe eosinophilic asthma treated with benralizumab (SHAMAL): a randomised, multicentre, open-label, phase 4 study.	Jackson DJ, Heaney LG, Humbert M, Kent BD, Shavit A, Hiljemark L, Olinger L, Cohen D, Menzies-Gow A, Korn S; SHAMAL Investigators.	The key finding of the study is that 92% of patients were able to successfully reduce their high-dose ICS, with more than 60% reducing to anti-inflammatory reliever only without a change in asthma control.	Lancet. 2023 Dec 7:S0140-6736(23)02284-5. doi: 10.1016/S0140-6736(23)02284-5. Online ahead of print.PMID: 38071986
Use of exhaled nitric oxide in the diagnosis and monitoring of childhood asthma: myth or maxim?	Fraser A, Simpson R, Turner S.	There is insufficient evidence to recommend F_ENO for routine diagnosis and monitoring of asthma in children, and clinical decisions should not be made solely on a F_ENO result.	Breathe (Sheff). 2023 Dec;19(4):220236. doi: 10.1183/20734735.0236-2022. Epub 2023 Dec 19.PMID: 38125803
Spirometry services in England post-pandemic and the potential role of AI support software: a qualitative study of challenges and opportunities.	Doe G, Taylor SJ, Topalovic M, Russell R, Evans RA, Maes J, Van Orshovon K, Sunjaya A, Scott D, Prevost AT, El-Emir E, Harvey J, Hopkinson NS, Kon SS, Patel S, Jarrold I, Spain N, Man WD, Hutchinson A.	Performing quality spirometry is a recognised challenge in primary care, and there is evidence for the use of artificial intelligence in improving the quality of both test conduct and interpretation, as well as support of GPs who are less experienced in spirometry.	Br J Gen Pract. 2023 Nov 30;73(737):e915-e923. doi: 10.3399/BJGP.2022.0608. Print 2023 Dec.PMID: 37903639
Best step-up treatments for children with uncontrolled asthma: a systematic review and network meta-analysis of individual participant data.	Cividini S, Sinha I, Donegan S, Maden M, Rose K, Fulton O, Culeddu G, Hughes DA, Turner S, Tudur Smith C; EINSTEIN Collaborative Group.	“The network meta-analysis results suggest that for a child with uncontrolled asthma despite ICS treatment, the odds of an exacerbation are reduced by stepping up to medium-dose ICS in combination with LABA compared with low-dose ICS. “	Eur Respir J. 2023 Dec 21;62(6):2301011. doi: 10.1183/13993003.01011-2023. Print 2023 Dec.PMID: 37945034
Tezepelumab in patients with allergic and eosinophilic asthma.	Caminati M, Buhl R, Corren J, Hanania NA, Kim H, Korn S, Lommatzsch M, Martin N, Matucci A, Nasser SM, Pavord ID, Domingo C.	By targeting TSLP at the top of and throughout the inflammatory cascade, tezepelumab has an impact on multiple inflammatory pathways and therefore can affect disease pathobiology more broadly than biologics that only target specific downstream type 2 pathways.	Allergy. 2023 Dec 26. doi: 10.1111/all.15986. Online ahead of print.PMID: 38146651 Review.
Ethnic variation in asthma phenotypic presentation and outcomes: a cross-sectional analysis of the UK Biobank.	Busby J, McDowell PJ, Pfeffer PE, Mansur AH, Heaney LG.	To date, several studies have highlighted potential ethnic disparities in asthma, including within the UK where patients from ethnic minority groups report higher emergency department attendances and hospitalisations.	Thorax. 2023 Dec 7:thorax-2023-221101. doi: 10.1136/thorax-2023-221101. Online ahead of print.PMID: 38071553

November

Title	Authors	Summary	Reference
Survey-identified experiences of prediagnosis and diagnosis process among patients with COPD, asthma, interstitial lung disease and bronchiectasis.	Zhang X, Ellis A, Quint JK, Bottle A.	Diagnosis of asthma, COPD, bronchiectasis and interstitial lung disease can be convoluted, therefore identification of reasons for diagnostic delay and promoting patients’ knowledge of respiratory diseases can promote early diagnosis and management.	BMJ Open Respir Res. 2023 Nov 22;10(1):e001588. doi: 10.1136/bmjresp-2022-001588.PMID: 37993278 Free PMC article.
Fractional exhaled nitric oxide (FeNO): the future of asthma care?	Wang K, Stonham C, Rutherford C, Pavord ID.	"FeNO testing can potentially provide a non-invasive, feasible way of delivering more personalised asthma management in the community using a ‘treatable traits’ approach."	Br J Gen Pract. 2023 Nov 30;73(737):565-568. doi: 10.3399/bjgp23X735813. Print 2023 Dec.PMID: 38035806 Free PMC article. No abstract available.
Near-fatal and fatal asthma and air pollution: are we missing an opportunity to ask key questions?	Varghese D, Clemens T, McMurray A, Pinnock H, Grigg J, Cunningham S.	There is an increasing body of evidence supporting the link between asthma attacks and air pollution in children, however fatal and near-fatal asthma events are rare and not yet well understood, and measurements of air pollution are challenging.	Arch Dis Child. 2023 Nov 10:archdischild-2023-325548. doi: 10.1136/archdischild-2023-325548. Online ahead of print.PMID: 37949644 Review.
ERS "CONNECT" Clinical Research Collaboration - moving multiple digital innovations towards connected respiratory care: addressing the over-arching challenges of whole systems implementation.	van Boven JFM, Drummond D, Chan AHY, Hew M, Hui CY, Adejumo I, Cano I, Hansen K, Poberezhets V, Costello RW, Pinnock H.	"CONNECT's long-term vision is of a cross-border, interoperable connected digital ecosystem, centred around the needs and preferences of the individual with respiratory disease who, in discussion with their healthcare professional, can choose the digital health and environmental data they record and share."	Eur Respir J. 2023 Nov 9;62(5):2301680. doi: 10.1183/13993003.01680-2023. Print 2023 Nov.PMID: 37945041 No abstract available.
Investigating the impact of London's ultra low emission zone on children's health: children's health in London and Luton (CHILL) protocol for a prospective parallel cohort study.	Tsocheva I, Scales J, Dove R, Chavda J, Kalsi H, Wood HE, Colligan G, Cross L, Newby C, Hall A, Keating M, Sartori L, Moon J, Thomson A, Tomini F, Murray A, Hamad W, Tijm S, Hirst A, Vincent BP, Kotala P, Balkwill F, Mihaylova B, Grigg J, Quint JK, Fletcher M, Mon-Williams M, Wright J, van Sluijs E, Beevers S, Randhawa G, Eldridge S, Sheikh A, Gauderman W, Kelly F, Mudway IS, Griffiths CJ.	CHILL study provides the most reliable results on exposure-response functions and causal relationships between pollutant exposures and children’s health and lung development, and has important implications for the design and implementation of LEZs and Clean Air Zones in the UK, Europe and beyond.	BMC Pediatr. 2023 Nov 4;23(1):556. doi: 10.1186/s12887-023-04384-5.PMID: 37925402 Free PMC article.
IMP²ART: development of a multi-level programme theory integrating the COM-B model and the iPARIHS framework, to enhance implementation of supported self-management of asthma in primary care.	Steed L, Sheringham J, McClatchey K, Hammersley V, Marsh V, Morgan N, Jackson T, Holmes S, Taylor S, Pinnock H.	IMP²ART model is based on extensive use of theory (including from multiple disciplines), the evidence base and lived experience. It follows guidance for development of interventions and described this in line with recommendations for both intervention development and implementation research.	Implement Sci Commun. 2023 Nov 13;4(1):136. doi: 10.1186/s43058-023-00515-2.PMID: 37957778 Free PMC article.
Management of asthma in primary care in the changing context of the COVID-19 pandemic: a qualitative longitudinal study with patients.	Santillo M, Tonkin-Crine S, Wang K, Butler CC, Wanat M.	Forty-six interviews showed that in general patients felt less vulnerable as the pandemic subsided, and mostly relied on self-management strategies, but felt that routine asthma reviews should still have been conducted during the pandemic.	Br J Gen Pract. 2023 Nov 30;73(737):e903-e914. doi: 10.3399/BJGP.2022.0581. Print 2023 Dec.PMID: 37429732 Free PMC article.
Tezepelumab reduces exacerbations across all seasons in patients with severe, uncontrolled asthma (NAVIGATOR).	Pavord ID, Hoyte FCL, Lindsley AW, Ambrose CS, Spahn JD, Roseti SL, Cook B, Griffiths JM, Hellqvist Å, Martin N, Llanos JP, Martin N, Colice G, Corren J.	" Tezepelumab reduced exacerbations across all seasons vs placebo in patients with severe, uncontrolled asthma, including patients with seasonal and perennial allergies. "	Ann Allergy Asthma Immunol. 2023 Nov;131(5):587-597.e3. doi: 10.1016/j.anai.2023.08.015. Epub 2023 Aug 23.PMID: 37619779 Free article. Clinical Trial.
Dupilumab: VOYAGE of discovery leading to a further EXCURSION.	Paraskakis E, Bush A.	" VOYAGE study of more than 400 children showed that dupilumab reduced asthma attacks and improved spirometry and disease control over 52 weeks compared with placebo".	Lancet Respir Med. 2023 Nov 10:S2213-2600(23)00337-5. doi: 10.1016/S2213-2600(23)00337-5. Online ahead of print.PMID: 37956681 No abstract available.
Dupilumab efficacy in high sleep disturbance management among patients with type 2 asthma.	Maspero JF, Shafazand S, Cole J, Pavord ID, Busse WW, Msihid J, Gall R, Soler X, Radwan A, Khan AH, de Prado Gómez L, Jacob-Nara JA.	Study shows the effectiveness of dupilumab and its potential benefits in improving asthma control, including sleep-related symptoms in the patient population with type 2 asthma.	Respir Med. 2023 Nov;218:107344. doi: 10.1016/j.rmed.2023.107344. Epub 2023 Sep 1.PMID: 37659435 Free article.
ERS technical standard: Global Lung Function Initiative reference values for exhaled nitric oxide (F_ENO).	Högman M, Bowerman C, Chavez L, Dressel H, Malinovschi A, Radtke T, Stanojevic S, Steenbruggen I, Turner S, Dinh-Xuan AT; GLI FENO working group.	"Elevated levels of exhaled F_ENO₅₀ are an important indicator of Th2 airway inflammation and may aid clinicians in the diagnosis and monitoring of asthma. "	Eur Respir J. 2023 Nov 16:2300370. doi: 10.1183/13993003.00370-2023. Online ahead of print.PMID: 37973177
Asthma control and associated risk factors among adults with current asthma: Findings from 2019 behavioral risk factor surveillance system asthma call-back survey.	Freels L, Herman A, Lukas S, Chan AHY, Pearce CJ, Arackal J, Beyene K.	Study shows that uncontrolled asthma is common among adults (62%) and can be impacted by several factors such as cost barriers, alternative medicine use, smoking or poor general health.	Respir Med. 2023 Nov 25:107479. doi: 10.1016/j.rmed.2023.107479. Online ahead of print.PMID: 38013060
Long-term efficacy of dupilumab in severe asthma by baseline oral corticosteroid dose.	Domingo C, Rabe KF, Price D, Brusselle G, Wechsler ME, Xia C, Pandit-Abid N, Gall R, Rowe PJ, Deniz Y, Jacob-Nara JA, Radwan A.	"Dupilumab has been shown to improve clinical outcomes long term while reducing oral corticosteroid (OCS) dose in patients with severe OCS-dependent asthma".	ERJ Open Res. 2023 Nov 13;9(6):00056-2023. doi: 10.1183/23120541.00056-2023. eCollection 2023 Nov.PMID: 38020559 Free PMC article.
EUFOREA pocket guide on the diagnosis and management of asthma: An educational and practical tool for general practitioners, non-respiratory physicians, paramedics and patients.	Diamant Z, Jesenak M, Hanania NA, Heaney LG, Djukanovic R, Ryan D, Quirce S, Backer V, Gaga M, Pavord I, Antolín-Amérigo D, Assaf S, Bakakos P, Bobcakova A, Busse W, Kappen J, Loukides S, van Maaren M, Panzner P, Pite H, Spanevello A, Stenberg H, Striz I, Thio B, Vasakova MK, Conti D, Fokkens W, Lau S, Scadding GK, Van Staeyen E, Hellings PW, Bjermer L.	EUFOREA asthma pocket guide is an educational and practical tool for non-respiratory physicians, paramedics and patients.	Respir Med. 2023 Nov;218:107361. doi: 10.1016/j.rmed.2023.107361. Epub 2023 Jul 28.PMID: 37517623 Free article. No abstract available.
Clinician views on how clinical decision support systems can help diagnose asthma in primary care: a qualitative study.	Daines L, Donaghy E, Canny A, Murray V, Campbell L, Stonham C, Bush A, McKinstry B, Milne H, Price D, Sheikh A, Pinnock H.	To be adopted into clinical practice and be useful for trainees or less experienced clinicians, CDSS should be validated, integrated with existing software for a quick and easy use.	J Asthma. 2023 Nov 7:1-9. doi: 10.1080/02770903.2023.2280839. Online ahead of print.PMID: 37934476
Effect of the COVID-19 pandemic on asthma exacerbations in New Zealand: An interrupted time series analysis.	Chan AHY, Tomlin A, Chan E, Harrison J, Beyene KA.	"The first COVID-19 lockdown in 2020 in NZ significantly reduced asthma exacerbation rates across all sociodemographic groups. Whether these reductions are sustained requires further investigation."	J Allergy Clin Immunol Glob. 2023 Jul 26;2(4):100157. doi: 10.1016/j.jacig.2023.100157. eCollection 2023 Nov.PMID: 37781646 Free PMC article.
Prevalence and clinical implications of respiratory viruses in asthma during stable disease state and acute attacks: Protocol for a meta-analysis.	Alimani GS, Ananth S, Boccabella C, Khaleva E, Roberts G, Papadopoulos NG, Kosmidis C, Vestbo J, Papageorgiou E, Beloukas A, Mathioudakis AG.	The study helps to clarify if antivirals should have a more important role in the management of asthma attacks.	PLoS One. 2023 Nov 15;18(11):e0294416. doi: 10.1371/journal.pone.0294416. eCollection 2023.PMID: 37967134 Free PMC article.

October

Title	Authors	Summary	Reference
Use of routine healthcare data in randomised implementation trials: a methodological mixed-methods systematic review.	Xie CX, Sun L, Ingram E, De Simoni A, Eldridge S, Pinnock H, Relton C.	Harmonisation of the language and adherence to the guidance on designing and reporting implementation studies are needed and frequently employed in assessing implementation outcomes.	Implement Sci. 2023 Oct 2;18(1):47. doi: 10.1186/s13012-023-01300-4.PMID: 37784099 Free PMC article. Review.
The treatable traits approach to adults with obstructive airways disease in primary and secondary care.	Thomas M, Beasley R.	Identification and treatment of the specific clinical features or traits facilitates a personalised approach to management.	Respirology. 2023 Oct 25. doi: 10.1111/resp.14610. Online ahead of print.PMID: 37877554 Review.
Parents underestimate fatigue in younger children aged 5-7 years with asthma but not in older children.	Taminskiene V, Vaitkaitienene E, Turner S, Valiulis A, Stukas R, Kostiuk O, Prokopciuk N, Juskiene I, Valiulis A.	"Poor asthma control and severe asthma were associated with higher fatigue, which might be ex-plained by a night time cough that interrupts sleep."	Acta Paediatr. 2023 Oct 19. doi: 10.1111/apa.17005. Online ahead of print.PMID: 37855195
European Respiratory Society short guidelines for the use of as-needed ICS/formoterol in mild asthma.	Papi A, Ferreira DS, Agache I, Baraldi E, Beasley R, Brusselle G, Coleman C, Gaga M, Gotera Rivera CM, Melén E, Pavord ID, Peñate Gómez D, Schuermans D, Spanevello A, Tonia T, Schleich F.	"Recent clinical trials of as-needed fixed-dose combination of ICS/formoterol have provided new evidence that may warrant a reconsideration of current practice."	Eur Respir J. 2023 Oct 12;62(4):2300047. doi: 10.1183/13993003.00047-2023. Print 2023 Oct.PMID: 37678955
Clinical remission in severe asthma with Biologic Therapy: an analysis from the UK Severe Asthma Registry.	McDowell PJ, McDowell R, Busby J, Eastwood MC, Patel PH, Jackson DJ, Mansur A, Patel M, Burhan H, Doe S, Chaudhuri R, Gore R, Dodd JW, Subramanian D, Brown T, Heaney LG; UK Severe Asthma Registry.	Novel biologic therapies have revolutionised the management of severe asthma with 18.3% of patients achieving the primary definition of remission.	Eur Respir J. 2023 Oct 19:2300819. doi: 10.1183/13993003.00819-2023. Online ahead of print.PMID: 37857423
Difficult-to-treat asthma patients from ethnic minority groups in central England are at an enhanced risk of house dust mite sensitisation.	Mansur AH, Marsh J, Bahron A, Thomas M, Walters G, Busby J, Heaney LG, Krishna MT.	Ethnicity‐based disparities in immune‐mediated disorders including asthma have been reported in several countries on 6 million patients of primary care.	Clin Transl Allergy. 2023 Oct;13(10):e12303. doi: 10.1002/clt2.12303.PMID: 37876034
Development of an Asthma Exacerbation Risk Prediction Model for Conversational Use by Adults in England.	Kallis C, Calvo RA, Schuller B, Quint JK.	Researchers developed a simple personalised risk prediction model for asthma exacerbations using factors collected in routine healthcare data for use in a risk modelling feature for automated conversational systems.	Pragmat Obs Res. 2023 Oct 4;14:111-125. doi: 10.2147/POR.S424098. eCollection 2023.PMID: 37817913
Prevalence of Poorly Controlled Asthma and Factors Associated with Specialist Referral in Those with Poorly Controlled Asthma in a Paediatric Asthma Population.	Kallis C, Morgan A, Fleming L, Quint JK.	"Around 1 in 6 children and adolescents with active asthma are not achieving adequate control of their symptoms. "	J Asthma Allergy. 2023 Oct 3;16:1065-1075. doi: 10.2147/JAA.S428623. eCollection 2023.PMID: 37808460
Adult Severe Asthma Registries: A Global and Growing Inventory.	Cushen B, Koh MS, Tran TN, Martin N, Murray R, et al.	"The International Severe Asthma Registry uses standardised variables to enable multi-country and adequately powered research in severe asthma. This study aims to look at the data countries within ISAR and non-ISAR countries reported collecting that enable global research that support individual country interests."	Pragmat Obs Res. 2023 Oct 20;14:127-147. doi: 10.2147/POR.S399879. eCollection 2023.PMID: 37881411
Asthma exacerbations in New Zealand 2010-2019: A national population-based study.	Chan AHY, Tomlin A, Beyene K, Harrison	"Asthma is one of the most common long-term conditions in the world, with New Zealand (NZ) having one of the highest rates of asthma symptoms. Despite the significant burden of asthma in NZ, there is a lack of data on asthma exacerbation rates in NZ and how these have varied over time. "	J.Respir Med. 2023 Oct;217:107365. doi: 10.1016/j.rmed.2023.107365. Epub 2023 Jul 21.PMID: 37481169

September

Title	Authors	Summary	Reference
Online Survey to Investigate Asthma Medication Prescription and Adherence from the Perspective of Patients and Healthcare Practitioners in England.	Zhang X, Quint JK.	The use of short-acting β₂-agonist (SABA) medications significantly increased in the UKduring a 6-year period (2007–2013). Prolonged high use of SABAs is recognized as a marker for poor symptom control and is associated with exacerbations and hospitalization, therefore better targeted education for both patients and HCPs is needed.	J Asthma Allergy. 2023 Sep 18;16:987-996. doi: 10.2147/JAA.S426227. eCollection 2023.PMID: 37745901 Free PMC article.
Exogenous female sex steroid hormones and new-onset asthma in women: a matched case-control study.	Zhang G, Basna R, Mathur MB, Lässer C, Mincheva R, Ekerljung L, Wennergren G, Rådinger M, Lundbäck B, Kankaanranta H, Nwaru BI	Studies show that the use of hormonal contraceptives may decrease asthma risk in women, however use of menopausal hormone therapy (MHT) may increase asthma risk in menopausal women.	BMC Med. 2023 Sep 4;21(1):337. doi: 10.1186/s12916-023-03038-8.PMID: 37667254 Free PMC article.
Association of asthma exacerbations with paper mulberry (Broussenetia papyrifera) pollen in Islamabad: An observational study.	Yusuf OM, Rextin AT, Ahmed B, Aman R, Anjum T, Mustafa S, Nasim M, Yusuf SO, Lin C, Zahra S, Pinnock H, Schwarze J.	Studies show that the rise in pollen concentration of paper mulberry is linked to asthma exacerbations. Predicting pollen peaks could enable alerts and mobilise strategies to proactively manage these peaks of asthma exacerbations.	J Glob Health. 2023 Sep 1;13:04091. doi: 10.7189/jogh.13.04091.PMID: 37651635 Free PMC article.
Effect of Tezepelumab on Lung Function in Patients With Severe, Uncontrolled Asthma in the Phase 3 NAVIGATOR Study.	Menzies-Gow A, Ambrose CS, Colice G, Hunter G, Cook B, Molfino NA, Llanos JP, Israel E.	“Tezepelumab treatment was associated with rapid and sustained improvements in lung function compared with placebo in patients with severe, uncontrolled asthma."	Adv Ther. 2023 Sep 19. doi: 10.1007/s12325-023-02659-y. Online ahead of print.PMID: 37723356
Effect of tezepelumab on healthcare utilization in patients with severe, uncontrolled asthma: The NAVIGATOR study.	Menzies-Gow A, Bourdin A, Chupp G, Israel E, Hellqvist Å, Hunter G, Roseti SL, Ambrose CS, Llanos JP, Cook B, Corren J, Colice G.	“Tezepelumab substantially reduced healthcare utilization across all outcomes measured compared with placebo, in addition to the severity of asthma exacerbations requiring hospitalization. Tezepelumab can reduce the overall burden of disease of severe, uncontrolled asthma.”	Ann Allergy Asthma Immunol. 2023 Sep;131(3):343-348.e2. doi: 10.1016/j.anai.2023.05.028. Epub 2023 May 30.PMID: 37263380 Free article. Clinical Trial.
Preterm birth, birth weight, infant weight gain and their associations with childhood asthma and spirometry: a cross-sectional observational study in Nairobi, Kenya.	Meme H, Amukoye E, Bowyer C, Chakaya J, Dobson R, Fuld J, Gray CM, Kiplimo R, Lesosky M, Mortimer K, Ndombi A, Obasi A, Orina F, Quint JK, Semple S, West SE, Zurba L, Devereux G	“Preterm birth is associated with increased likelihood of the symptoms ‘current wheeze’, ‘trouble breathing’, ‘dry nocturnal cough’ and that birth weight is positively associated with FEV₁ and FVC and reduced likelihood of restricted spirometry.”	BMJ Open Respir Res. 2023 Sep;10(1):e001895. doi: 10.1136/bmjresp-2023-001895.PMID: 37735103 Free PMC article.
Global access and patient safety in the transition to environmentally friendly respiratory inhalers: the Global Initiative for Asthma perspective.	Levy ML, Bateman ED, Allan K, Bacharier LB, Bonini M, Boulet LP, Bourdin A, Brightling C, Brusselle G, Buhl R, Chakaya MJ, Cruz AA, Drazen J, Ducharme FM, Duijts L, Fleming L, Inoue H, Ko FWS, Krishnan JA, Masekela R, Mortimer K, Pitrez P, Salvi S, Sheikh A, Reddel HK, Yorgancıoğlu A.	Inhalation remains the optimal mode of medication delivery for most patients with asthma, however gases used in medical devices contribute to <0∙1% of global greenhouse gas emissions.	Lancet. 2023 Sep 16;402(10406):1012-1016. doi: 10.1016/S0140-6736(23)01358-2. Epub 2023 Jul 19.PMID: 37480934 Review. No abstract available.
Tezepelumab Efficacy in Patients with Severe, Uncontrolled Asthma with Comorbid Nasal Polyps in NAVIGATOR.	Laidlaw TM, Menzies-Gow A, Caveney S, Han JK, Martin N, Israel E, Lee JK, Llanos JP, Martin N, Megally A, Parikh B, Vong S, Welte T, Corren J.	Tezepelumab treatment improved sino-nasal symptoms, including nasal polyps, as well as lung function, asthma control and health related quality of life compared with placebo.	J Asthma Allergy. 2023 Sep 4;16:915-932. doi: 10.2147/JAA.S413064. eCollection 2023.PMID: 37692126 Free PMC article.
Psychological impact of the COVID-19 pandemic on people with asthma: a co-produced mixed-methods study.	Jackson T, McClatchey K, Chan AHY, Morgan N, Kinley E, Pinnock H.	COVID-19 pandemic was having a psychological impact on those living with respiratory conditions, and resulted in increased levels of anxiety and depression.	Psychol Health. 2023 Sep 11:1-21. doi: 10.1080/08870446.2023.2256784. Online ahead of print.PMID: 37695020
Observational UK cohort study to describe intermittent oral corticosteroid prescribing patterns and their association with adverse outcomes in asthma.	Heatley H, Tran TN, Bourdin A, Menzies-Gow A, Jackson DJ, Maslova E, Chapaneri J, Skinner D, Carter V, Chan JSK, Ariti C, Haughney J, Price DB.	Oral corticosteroids for asthma are associated with increased risks of developing adverse outcomes and its use, even intermittently, in the management of asthma should be minimised whenever possible.	Thorax. 2023 Sep;78(9):860-867. doi: 10.1136/thorax-2022-219642. Epub 2022 Dec 27.PMID: 36575040 Free PMC article.
Defining trajectory in severe asthma: can it be changed?	Farinha I, Heaney LG.	“Four trajectories towards developing severe asthma have been identified, suggesting different patterns of progression of severity. This may support the need for targeting patients at high risk of progression and to provide early management strategies.”	Eur Respir J. 2023 Sep 9;62(3):2301281. doi: 10.1183/13993003.01281-2023. Print 2023 Sep.PMID: 37690788 No abstract available.
Prediction of adult asthma risk in early childhood using novel adult asthma predictive risk scores.	Farhan AJ, Kothalawala DM, Kurukulaaratchy RJ, Granell R, Simpson A, Murray C, Custovic A, Roberts G, Zhang H, Arshad SH.	“Adolescent and adult persistent asthma can be predicted early in life using two or three factors that can be collected routinely at clinic visits with relatively high sensitivity and specificity”	Allergy. 2023 Sep 3. doi: 10.1111/all.15876. Online ahead of print.PMID: 37661293
Tezepelumab for the treatment of severe asthma: a plain language summary of the PATHWAY and NAVIGATOR studies.	Corren J, Menzies-Gow A, Bimmel J, McGuinness A, Almqvist G, Bowen K, Griffiths JM, Ponnarambil S, Bourdin A, Israel E, Colice G, Brightling CE, Wechsler ME; PATHWAY and NAVIGATOR study investigators.	“In both studies, tezepelumab reduced the number of severe asthma attacks that the participants had per year compared with placebo”	Immunotherapy. 2023 Sep 29. doi: 10.2217/imt-2023-0109. Online ahead of print.PMID: 37772607 Free article. Review.
Impact of Initiating Biologics in Patients With Severe Asthma on Long-Term Oral Corticosteroids or Frequent Rescue Steroids (GLITTER): Data From the International Severe Asthma Registry.	Chen W, Tran TN, Sadatsafavi M, Murray R, et.al.	“Initiation of biologics is associated with reduced exacerbation rate, OCS exposure, and HCRU in patients with severe asthma and HOCS.”	J Allergy Clin Immunol Pract. 2023 Sep;11(9):2732-2747. doi: 10.1016/j.jaip.2023.05.044. Epub 2023 Jun 8.PMID: 37301430.
The Anti-Inflammatory Reliever (AIR) Algorithm Study: a protocol for a single-group study of an AIR stepwise approach to the treatment of adult asthma.	Bruce P, Hatter L, Houghton C, Kearns C, Holliday M, Anderson AJ, Eathorne A, Martindale J, Semprini A, Weatherall M, Pavord I, Harrison T, Papi A, Horne R, Beasley R.	Study results are providing knowledge to guide the clinical use of Anti-Inflammatory Reliever approach.	ERJ Open Res. 2023 Sep 25;9(5):00239-2023. doi: 10.1183/23120541.00239-2023. eCollection 2023 Sep.PMID: 37753283 Free PMC article.
Healthcare costs associated with short-acting β₂-agonists in asthma: observational UK SABINA study.	Attar-Zadeh D, Capstick T, Leese D, Arnetorp S, Rapsomaniki E, Da Costa KP, Maslova E, Xu Y, Gibson D, Quint JK.	Total annual average costs (HCRU and medication) were 52% higher in the high- versus low-SABA group, and medication accounted for the majority of asthma-related costs.	BJGP Open. 2023 Sep 19;7(3):BJGPO.2023.0015. doi: 10.3399/BJGPO.2023.0015. Print 2023 Sep.PMID: 36759020 Free article.

August

Title	Authors	Summary	Reference
ERS International Congress 2022: highlights from the Respiratory Clinical Care and Physiology Assembly.	Vontetsianos A, Karadeniz Güven D, Betka S, Souto-Miranda S, Marillier M, Price OJ, Hui CY, Sivapalan P, Jácome C, Aliverti A, Kaltsakas G, Kolekar SB, Evans RA, Vagheggini G, Vicente C, Poberezhets V, Bayat S, Pinnock H, Franssen FME, Vogiatzis I, Chaabouni M, Gille T.	This article contains an overview of the laboratory-based science, clinical trials and qualitative research that were presented during the 2022 European Respiratory Society International Congress.	ERJ Open Res. 2023 Aug 14;9(4):00194-2023. doi: 10.1183/23120541.00194-2023. eCollection 2023 Jul.PMID: 37583963.
Inhaled corticosteroids to improve lung function in children (aged 6-12 years) who were born very preterm (PICSI): a randomised, double-blind, placebo-controlled trial.	Urs RC, Evans DJ, Bradshaw TK, Gibbons JTD, Smith EF, Foong RE, Wilson AC, Simpson SJ.	To date, little work has been undertaken to understand the mechanisms underpinning prematurity-associated lung disease.	Lancet Child Adolesc Health. 2023 Aug;7(8):567-576. doi: 10.1016/S2352-4642(23)00128-1. Epub 2023 Jun 26.PMID: 37385269 Clinical Trial.
Rebound in asthma exacerbations following relaxation of COVID-19 restrictions: a longitudinal population-based study (COVIDENCE UK).	Tydeman F, Pfeffer PE, Vivaldi G, Holt H, Talaei M, Jolliffe D, Davies G, Lyons RA, Griffiths C, Kee F, Sheikh A, Shaheen SO, Martineau AR.	"Relaxation of COVID-19 restrictions in the UK from April 2021 coincided with reduced use of face coverings, increased social mixing and increases in COVID-19, non-COVID-19 ARI and severe asthma exacerbations".	Thorax. 2023 Aug;78(8):752-759. doi: 10.1136/thorax-2022-219591. Epub 2022 Nov 23.PMID: 36423925 Free PMC article.
Antenatal size, early childhood growth, and asthma within a cohort created by data linkage.	Turner S, Chapman A, Aucott L.	There are associations between anthropometric measurements and asthma risk, showing that Increasing length in the first trimester and at 5 years of age were independently associated with more favorable asthma outcomes, whereas the relationship between weight and asthma outcomes was less clear.	Pediatr Pulmonol. 2023 Aug;58(8):2364-2374. doi: 10.1002/ppul.26499. Epub 2023 May 26.PMID: 37232335.
Understanding interventions delivered in the emergency department targeting improved asthma outcomes beyond the emergency department: an integrative review.	Skene I, Kinley E, Pike K, Griffiths C, Pfeffer P, Steed L.	ED-based asthma interventions may be capable of improving long-term outcomes, however, there are significant variations in the range of interventions, reported outcomes and duration of follow-up.	BMJ Open. 2023 Aug 7;13(8):e069208. doi: 10.1136/bmjopen-2022-069208.PMID: 37550032 Free PMC article.
Understanding the Clinical Implications of Individual Patient Characteristics and Treatment Choice on the Risk of Exacerbation in Asthma Patients with Moderate-Severe Symptoms.	Singh D, Oosterholt S, Pavord I, Garcia G, Abhijith Pg, Della Pasqua O.	"Individual baseline characteristics and treatment choices affect future risk. Achieving comparable levels of symptom control whilst on treatment does not imply comparable risk reduction".	Adv Ther. 2023 Aug 17. doi: 10.1007/s12325-023-02590-2. Online ahead of print.PMID: 37589831.
Analysis of comorbidities and multimorbidity in adult patients in the International Severe Asthma Registry.	Scelo G, Torres-Duque CA, Maspero J, et.al.	There is a a differential association between comorbidities and asthma biomarkers, a comorbidity-specific association across multiple asthma outcomes and a clear relationship between number of comorbidities and extent of outcome impairment.	Allergy Asthma Immunol. 2023 Aug 26:S1081-1206(23)00630-0. doi: 10.1016/j.anai.2023.08.021. Online ahead of print.PMID: 37640263.
Immunoregulation of asthma by type 2 cytokine therapies: Treatments for all ages?	Saglani S, Yates L, Lloyd CM.	"The range of treatments for severe asthma has increased over the last few years with the introduction of biological agents that suppress the activity of type 2 cytokines".	Eur J Immunol. 2023 Aug;53(8):e2249919. doi: 10.1002/eji.202249919. Epub 2023 Apr 3.PMID: 36932669 Review.
Clinical Remission in Severe Asthma: How to Move From Theory to Practice.	Menzies-Gow AN, Price DB.	There are challenges with applying extant definitions of asthma remission to patients with SA, however studies and clinical observations suggest that clinicians should consider treating certain asthma phenotypes with targeted therapies earlier in the disease course, to increase the likelihood of achieving and maintaining asthma remission.	Chest. 2023 Aug;164(2):296-298. doi: 10.1016/j.chest.2023.03.001.PMID: 37558327
Experiences of Diagnosis, Symptoms, and Use of Reliever Inhalers in Patients With Asthma and Concurrent Inducible Laryngeal Obstruction or Breathing Pattern Disorder: Qualitative Analysis of a UK Asthma Online Community.	Byrne C, Pfeffer PE, De Simoni A.	Study shows that patients experiencing BPD and ILO, conditions with an estimated prevalence of one-third to one-fifth of all patients with asthma, have unmet needs.	J Med Internet Res. 2023 Aug 14;25:e44453. doi: 10.2196/44453.PMID: 37578820
Prescribing patterns of budesonide/formoterol maintenance and reliever therapy in patients with asthma in Sweden.	Janson C, Melén E, de Fine Licht S, Telg G, Maslova E, Tran TN, Surmont F, Wiklund F, Olsson U, Nwaru BI, Ekström M.	"Consistent with previous studies from the UK,^6, 7 our analysis reported inadequate BUD/FORM prescription claims in the follow-up period."	Allergy. 2023 Aug;78(8):2311-2314. doi: 10.1111/all.15710. Epub 2023 Apr 11.PMID: 36919650 No abstract available.

July

Title	Authors	Summary	Reference
Effective respiratory management of asthma and COPD and the environmental impacts of inhalers.	Usmani OS, Levy ML.	Detrimental effect of inhalers on the environment has recently been highlighted in both the media and the scientific community, and is beginning to be reflected in treatment strategies for asthma and COPD.	NPJ Prim Care Respir Med. 2023 Jul 1;33(1):24. doi: 10.1038/s41533-023-00346-7.PMID: 37393273 Free PMC article.
Asthma exacerbations are associated with a decline in lung function: a longitudinal population-based study.	Soremekun S, Heaney LG, Skinner D, Bulathsinhala L, Carter V, Chaudhry I, Hosseini N, Eleangovan N, Murray R, Tran TN, Emmanuel B, Garcia Gil E, Menzies-Gow A, Peters M, Lugogo N, Jones R, Price DB.	The largest nationwide cohort demonstrating that asthma exacerbations are associated with faster lung function decline.	Thorax. 2023 Jul;78(7):643-652. doi: 10.1136/thorax-2021-217032. Epub 2022 Aug 3.PMID: 35922128 Free PMC article.
Device-Measured Change in Physical Activity in Primary School Children During the UK COVID-19 Pandemic Lockdown: A Longitudinal Study.	Scales J, Chavda J, Ikeda E, Tsocheva I, Dove RE, Wood HE, Kalsi H, Colligan G, Griffiths L, Day B, Crichlow C, Keighley A, Fletcher M, Newby C, Tomini F, Balkwill F, Mihaylova B, Grigg J, Beevers S, Eldridge S, Sheikh A, Gauderman J, Kelly F, Randhawa G, Mudway IS, van Sluijs E, Griffiths CJ.	Physical activity has been associated with numerous health benefits in children, including a reduction in early-life risk factors for cardiovascular disease and obesity.	J Phys Act Health. 2023 May 4;20(7):639-647. doi: 10.1123/jpah.2022-0434. Print 2023 Jul 1.PMID: 37142406
Implementation of digital home monitoring and management of respiratory disease.	Pinnock H, Hui CY, van Boven JFM.	"Digital respiratory monitoring interventions (e.g. smart inhalers and digital spirometers) can improve clinical outcomes and/or organizational efficiency, and the focus is shifting to sustainable implementation as an approach to delivering respiratory care".	Curr Opin Pulm Med. 2023 Jul 1;29(4):302-312. doi: 10.1097/MCP.0000000000000965. Epub 2023 May 2.PMID: 37132298 Free PMC article. Review.
Changes in exhaled volatile organic compounds following indirect bronchial challenge in suspected asthma.	Peel A, Wang R, Ahmed W, White I, Wilkinson M, Loke YK, Wilson AM, Fowler SJ.	Inhalation of mannitol was associated with changes in breath VOCs, that are associated with acute airway inflammation and/or bronchoconstriction and merit further investigation as potential biomarkers in asthma.	Thorax. 2023 Jul 26:thorax-2022-219708. doi: 10.1136/thorax-2022-219708. Online ahead of print.PMID: 37495368
Dupilumab sustains efficacy in patients with moderate-to-severe type 2 asthma regardless of ICS dose.	Pavord ID, Bourdin A, Papi A, Domingo C, Corren J, Altincatal A, Radwan A, Pandit-Abid N, Jacob-Nara JA, Deniz Y, Rowe PJ, Laws E, Lederer DJ, Hardin M.	"Dupilumab shows- sustained efficacy for up to 3 years in patients with uncontrolled, moderate-to-severe type 2 asthma on high- or medium-dose inhaled corticosteroid ."	Allergy. 2023 Jul 11. doi: 10.1111/all.15792. Online ahead of print.PMID: 37431558
Development of theoretically informed audit and feedback: An exemplar from a complex implementation strategy to improve asthma self-management in UK primary care.	McClatchey K, Sheldon A, Steed L, Sheringham J, Holmes S, Preston M, Appiagyei F, Price D, Taylor SJC, Pinnock H; IMP2ART Programme Group.	"A recent meta-review confirmed that supported asthma self-management can reduce hospitalisations, accident and emergency attendances and unscheduled care consultations. However, despite the ‘overwhelming’ evidence, supported self-management is poorly implemented in primary care."	J Eval Clin Pract. 2023 Jul 12. doi: 10.1111/jep.13895. Online ahead of print.PMID: 37438918
Early-life respiratory infections and developmental immunity determine lifelong lung health.	Lloyd CM, Saglani S.	Better understanding of the molecular mechanisms underlying the path to a healthy respiratory ecosystem prevents progression of childhood wheezing disorders and chronic asthma.	Nat Immunol. 2023 Aug;24(8):1234-1243. doi: 10.1038/s41590-023-01550-w. Epub 2023 Jul 6.PMID: 37414905 Review.
Global access and patient safety in the transition to environmentally friendly respiratory inhalers: the Global Initiative for Asthma perspective.	Levy ML, Bateman ED, Allan K, Bacharier LB, Bonini M, Boulet LP, Bourdin A, Brightling C, Brusselle G, Buhl R, Chakaya MJ, Cruz AA, Drazen J, Ducharme FM, Duijts L, Fleming L, Inoue H, Ko FWS, Krishnan JA, Masekela R, Mortimer K, Pitrez P, Salvi S, Sheikh A, Reddel HK, Yorgancıoğlu A.	Many countries have developed policies to reduce the carbon footprint of inhalers and replace harmful propellants with safer alternatives that are under development.	Lancet. 2023 Jul 19:S0140-6736(23)01358-2. doi: 10.1016/S0140-6736(23)01358-2. Online ahead of print.PMID: 37480934 Review. No abstract available.
Definitions of non-response and response to biological therapy for severe asthma: a systematic review.	Khaleva E, Rattu A, Brightling C, Bush A, Bourdin A, Bossios A, Chung KF, Chaudhuri R, Coleman C, Djukanovic R, Dahlén SE, Exley A, Fleming L, Fowler SJ, Gupta A, Hamelmann E, Koppelman GH, Melén E, Mahler V, Seddon P, Singer F, Porsbjerg C, Ramiconi V, Rusconi F, Yasinska V, Roberts G.	"Although many studies have measured responses to different biologics, there are no universally accepted criteria for what constitutes response, and the absence of guidance on criteria is reported as a high-priority research gap in both children and adults".	ERJ Open Res. 2023 May 2;9(3):00444-2022. doi: 10.1183/23120541.00444-2022. eCollection 2023 Jul.PMID: 37143849 Free PMC article. Review.
Non-randomised feasibility study testing a primary care intervention to promote engagement in an online health community for adults with troublesome asthma: protocol.	Karampatakis GD, Wood HE, Griffiths CJ, Taylor SJC, Toffolutti V, Bird VJ, Lea NC, Ashcroft RE, Day B, Coulson NS, Panzarasa P, Li X, Sheikh A, Relton C, Sastry N, Watson JS, Marsh V, Mant J, Mihaylova B, Walker N, De Simoni A.	"In the UK, approximately 4.3 million adults have asthma, with one-third experiencing poor asthma control, affecting their quality of life, and increasing their healthcare use. Interventions promoting self-management can improve asthma control and reduce comorbidities and mortality."	BMJ Open. 2023 Jul 11;13(7):e073503. doi: 10.1136/bmjopen-2023-073503.PMID: 37433727 Free PMC article. Clinical Trial.
Recent trends in asthma diagnosis, preschool wheeze diagnosis and asthma exacerbations in English children and adolescents: a SABINA Jr study.	Kallis C, Maslova E, Morgan AD, Sinha I, Roberts G, van der Valk RJP, Quint JK, Tran TN.	Routinely collected primary care data, showed that the incidence of asthma decreased steadily by 51% from 2008 to 2018; the rate of decline was similar in boys and girls, with the most pronounced decrease observed in the 1–5-year-olds.	Thorax. 2023 Jul 31:thorax-2022-219757. doi: 10.1136/thorax-2022-219757. Online ahead of print.PMID: 37524391
Patient financial incentives to improve asthma management: a systematic review.	Hine J, Lee B, Bush A, De Simoni A, Griffiths C, Judah G, Fleming L.	The objectives of this review are to identify studies that assess the effectiveness of patient-directed financial incentive interventions to improve asthma management behaviours, determine overall effectiveness of financial incentives, identify design characteristics of effective interventions and assess the impact on longer-term outcomes in the context of asthma.	BMJ Open. 2023 Jul 30;13(7):e070761. doi: 10.1136/bmjopen-2022-070761.PMID: 37518086 Free PMC article.
Use of digital measurement of medication adherence and lung function to guide the management of uncontrolled asthma (INCA Sun): a multicentre, single-blinded, randomised clinical trial.	Hale EM, Greene G, Mulvey C, Mokoka MC, van Boven JFM, Cushen B, Sulaiman I, Brennan V, Lombard L, Walsh J, Plunkett S, McCartan TA, Kerr PJ, Reilly RB, Hughes C, Kent BD, Jackson DJ, Butler M, Counihan I, Hayes J, Faul J, Kelly M, Convery R, Nanzer AM, Fitzgerald JM, Murphy DM, Heaney LG, Costello RW; INCA Research Team.	"Implementation of evidence-based asthma management strategies by use of objective digital data led to significant reductions in high-dose asthma treatments and less escalation to biological agents compared to more traditional methods."	Lancet Respir Med. 2023 Jul;11(7):591-601. doi: 10.1016/S2213-2600(22)00534-3. Epub 2023 Mar 21.PMID: 36963417 Clinical Trial.
Asthma exacerbations in New Zealand 2010-2019: A national population-based study.	Chan AHY, Tomlin A, Beyene K, Harrison J.	"Asthma exacerbation rates in NZ have increased over 2010-2019, however hospitalisation rates have decreased. This potentially suggests a move away from secondary to primary care management of exacerbations and provides important information for asthma care planning."	Respir Med. 2023 Jul 21;217:107365. doi: 10.1016/j.rmed.2023.107365. Online ahead of print.PMID: 37481169
Ethnic variation in asthma healthcare utilisation and exacerbation: systematic review and meta-analysis.	Akin-Imran A, Bajpai A, McCartan D, Heaney LG, Kee F, Redmond C, Busby J.	Patients from ethnic minority groups frequently report poorer asthma outcomes; however, a broad synthesis summarising ethnic disparities is yet to be undertaken.	ERJ Open Res. 2023 May 2;9(3):00591-2022. doi: 10.1183/23120541.00591-2022. eCollection 2023 Jul.PMID: 37143831 Free PMC article. Review.

June

Title	Authors	Summary	Reference
Blood transcriptomic signature in type-2 biomarker low severe asthma and asthma control.	Zeng X, Qing J, Li CM, Lu J, Yamawaki T, Hsu YH, Lugt BV, Hsu H, Busby J, McDowell PJ, Jackson DJ, Djukanovic R, Matthews JG, Arron JR, Bradding P, Brightling CE, Chaudhuri R, Choy DF, Cowan D, Fowler SJ, Hardman TC, Harrison T, Howarth P, Lordan J, Mansur AH, Menzies-Gow A, Pavord ID, Walker S, Woodcock A, Heaney LG; investigators for the UK MRC Refractory Asthma Stratification Program (RASP-UK)*.	"Patients with Type-2 (T2) cytokine-low severe asthma often have persistent symptoms despite suppression of T2-inflammation with corticosteroids ."	J Allergy Clin Immunol. 2023 Jun 12:S0091-6749(23)00751-0. doi: 10.1016/j.jaci.2023.05.023. Online ahead of print.PMID: 37315813 Free article.
Home monitoring with connected mobile devices for asthma attack prediction with machine learning.	Tsang KCH, Pinnock H, Wilson AM, Salvi D, Shah SA.	Passive monitoring of asthma by mobile-health devices combined with machine-learning can provide an avenue to reduce management burden.	Sci Data. 2023 Jun 8;10(1):370. doi: 10.1038/s41597-023-02241-9.PMID: 37291158 Free PMC article.
Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls.	Zheng B, Vivaldi G, Daines L, Leavy OC, Richardson M, Elneima O, McAuley HJC, Shikotra A, Singapuri A, Sereno M, Saunders RM, Harris VC, Houchen-Wolloff L, Greening NJ, Pfeffer PE, Hurst JR, Brown JS, Shankar-Hari M, Echevarria C, De Soyza A, Harrison EM, Docherty AB, Lone N, Quint JK, Chalmers JD, Ho LP, Horsley A, Marks M, Poinasamy K, Raman B, Heaney LG, Wain LV, Evans RA, Brightling CE, Martineau A, Sheikh A; PHOSP-COVID Study Collaborative Group.	Investigated determinants of recovery from dyspnoea in adults with COVID-19 and compared these to determinants of recovery from non-COVID-19 dyspnoea.	Lancet Reg Health Eur. 2023 Apr 28;29:100635. doi: 10.1016/j.lanepe.2023.100635. eCollection 2023 Jun.PMID: 37261214 Free PMC article.
Questions in Mild Asthma: An Official American Thoracic Society Research Statement.	Mohan A, Lugogo NL, Hanania NA, Reddel HK, Akuthota P, O'Byrne PM, Guilbert T, Papi A, Price D, Jenkins CR, Kraft M, Bacharier LB, Boulet LP, Yawn BP, Pleasants R, Lazarus SC, Beasley R, Gauvreau G, Israel E, Schneider-Futschik EK, Yorgancioglu A, Martinez F, Moore W, Sumino K.	There is an immediate need for a robust mild asthma definition and an improved understanding of its pathophysiology and management strategies across all age groups.	Am J Respir Crit Care Med. 2023 Jun 1;207(11):e77-e96. doi: 10.1164/rccm.202304-0642ST.PMID: 37260227 Free PMC article.
Asthma symptoms, spirometry and air pollution exposure in schoolchildren in an informal settlement and an affluent area of Nairobi, Kenya.	Meme H, Amukoye E, Bowyer C, Chakaya J, Das D, Dobson R, Dragosits U, Fuld J, Gray C, Hahn M, Kiplimo R, Lesosky M, Loh MM, McKendree J, Mortimer K, Ndombi A, Netter L, Obasi A, Orina F, Pearson C, Price H, Quint JK, Semple S, Twigg M, Waelde C, Walnycki A, Warwick M, Wendler J, West SE, Wilson M, Zurba L, Devereux G.	"Children living in informal settlements are more likely to develop wheezing symptoms consistent with asthma that are more severe but less likely to be diagnosed as asthma. Self-reported but not objectively measured air pollution exposure was associated with increased risk of asthma symptoms."	Thorax. 2023 Jun 6:thorax-2023-220057. doi: 10.1136/thorax-2023-220057. Online ahead of print.PMID: 37280096 Free article.
A²BCD: a concise guide for asthma management.	Lommatzsch M, Brusselle GG, Levy ML, Canonica GW, Pavord ID, Schatz M, Virchow JC.	" Precise assessment and phenotyping are required to establish individually targeted treatment with disease-modifying anti-asthmatic drugs".	Lancet Respir Med. 2023 Jun;11(6):573-576. doi: 10.1016/S2213-2600(22)00490-8. Epub 2023 Jan 27.PMID: 36716752 Review.
Recovery of Breakthrough Asthma Attacks Treated With Oral Steroids While on Monoclonal Antibody Therapy: Protocol for a Prospective Observational Study (BOOST).	Howell I, Mahdi M, Bafadhel M, Hinks TSC, Ramakrishnan S, Melhorn J, Jabeen M, Pavord ID.	Testing the hypothesis that there is a difference in the rate of recovery of clinical and inflammatory measures between high-FeNO and low-FeNO asthma attacks that occur in patients on Monoclonal Antibody therapy.	JMIR Res Protoc. 2023 Jun 23;12:e46741. doi: 10.2196/46741.PMID: 37351918 Free article.
Type 2 inflammation and biological therapies in asthma: Targeted medicine taking flight.	Howell I, Howell A, Pavord ID.	Nowadays, patients have access to highly effective and safe treatments in the form of biological therapies, thanks to better understanding of type 2 inflammation and its interplay with pathophysiology in asthma.	J Exp Med. 2023 Jul 3;220(7):e20221212. doi: 10.1084/jem.20221212. Epub 2023 Jun 2.PMID: 37265457 Free PMC article. Review.
Clinically accessible biomarkers to assess the modifiable risk of asthma/wheezing attacks in toddlers.	Couillard S, Ducharme FM, Pavord ID.	Response to "Blood eosinophils for prediction of exacerbation in preschool children with recurrent wheezing" publication.	J Allergy Clin Immunol Pract. 2023 Jun;11(6):1984-1985. doi: 10.1016/j.jaip.2023.02.042.PMID: 37295867 No abstract available.
The benefits, challenges, and best practice for patient and public involvement in evidence synthesis: A systematic review and thematic synthesis.	Agyei-Manu E, Atkins N, Lee B, Rostron J, Dozier M, Smith M, McQuillan R.	This study aimed to synthesise qualitative evidence on the benefits, challenges, and best practices for PPI in ES/SR projects from the perspectives of patients/public and researchers.	Health Expect. 2023 Jun 1. doi: 10.1111/hex.13787. Online ahead of print.PMID: 37260191 Free article. Review.

May

Title	Authors	Summary	Reference
Implementation of digital home monitoring and management of respiratory disease.	Pinnock H, Hui CY, van Boven JFM.	"Understanding and addressing the implementation challenges posed by gaps in policy, regulatory, financial, and technical infrastructure is essential to support delivery of equitable respiratory care that is acceptable to patients and professionals."	Curr Opin Pulm Med. 2023 Jul 1;29(4):302-312. doi: 10.1097/MCP.0000000000000965. Epub 2023 May 2.PMID: 37132298 Review.
Cluster analyses from the real-world NOVELTY study: six clusters across the asthma-COPD spectrum.	Hughes R, Rapsomaniki E, Bansal AT, Vestbo J, Price D, Agustí A, Beasley R, Fagerås M, Alacqua M, Papi A, Müllerová H, Reddel HK.	The objective of the study is to investigate clustering of clinical and physiological features and readily available biomarkers in patients with physician-assigned diagnoses of asthma and/or COPD.	NOVELTY Scientific Community and the NOVELTY study investigators.J Allergy Clin Immunol Pract. 2023 May 23:S2213-2198(23)00549-4. doi: 10.1016/j.jaip.2023.05.013. Online ahead of print.PMID: 37230383.
Ethnic variation in asthma healthcare utilisation and exacerbation: systematic review and meta-analysis.	Akin-Imran A, Bajpai A, McCartan D, Heaney LG, Kee F, Redmond C, Busby J.	Patients from ethnic minority groups had higher secondary healthcare utilisation, increased rates of exacerbation, and, when restricting to good-quality studies, reduced primary care attendance.	ERJ Open Res. 2023 May 2;9(3):00591-2022. doi: 10.1183/23120541.00591-2022. eCollection 2023 Jul.PMID: 37143831 Free PMC article. ReviewDefinitions of non-response and response to biological therapy for severe asthma: a systematic review
Definitions of non-response and response to biological therapy for severe asthma: a systematic review.	Khaleva E, Rattu A, Brightling C, Bush A, Bourdin A, Bossios A, Chung KF, Chaudhuri R, Coleman C, Djukanovic R, Dahlén SE, Exley A, Fleming L, Fowler SJ, Gupta A, Hamelmann E, Koppelman GH, Melén E, Mahler V, Seddon P, Singer F, Porsbjerg C, Ramiconi V, Rusconi F, Yasinska V, Roberts G.	This study aimed to review the literature on definitions of response and non-response to biological therapy for severe asthma. The full text of 35 papers was assessed for eligibility, including 20 articles identified through review of citations. 13 papers were included in the systematic review, of which three were about development of the outcome measures.	ERJ Open Res. 2023 May 2;9(3):00444-2022. doi: 10.1183/23120541.00444-2022. eCollection 2023 Jul.PMID: 37143849 Free PMC article. Review.
Diagnostic Performance of a Machine Learning Algorithm (Asthma/Chronic Obstructive Pulmonary Disease [COPD] Differentiation Classification) Tool Versus Primary Care Physicians and Pulmonologists in Asthma, COPD, and Asthma/COPD Overlap.	Kocks JWH, Cao H, Holzhauer B, Kaplan A, FitzGerald JM, Kostikas K, Price D, Reddel HK, Tsiligianni I, Vogelmeier CF, Bostel S, Mastoridis P.	"The AC/DC tool has the potential to aid in the differential diagnosis for patients aged 35 years and older who have asthma and COPD and provide a valuable additional source of information to supplement final decision-making by practicing physicians".	J Allergy Clin Immunol Pract. 2023 May;11(5):1463-1474.e3. doi: 10.1016/j.jaip.2023.01.017. Epub 2023 Jan 28.PMID: 36716998 Free article.
Risk factors for poorer respiratory outcomes in adolescents and young adults born preterm.	Smith EF, Hemy NR, Hall GL, Wilson AC, Murray CP, Simpson SJ.	"Preterm birth survivors are at increased risk of early-onset COPD and should be more closely monitored in the clinical setting and provided with anticipatory guidance on smoking, vaping and employment. "	Thorax. 2023 May 19:thorax-2022-219634. doi: 10.1136/thorax-2022-219634. Online ahead of print.PMID: 37208189 Free article.
Medication Adherence in People with Asthma: A Qualitative Systematic Review of Patient and Health Professional Perspectives.	Zhang X, Ding R, Zhang Z, Chen M, Yin Y, Quint JK.	Findings suggest that the relationship and communication with/between healthcare professionals and patients play an important role in medication adherence. This is consistent with previous studies that indicate communication between clinicians and patients was associated with medication adherence.	J Asthma Allergy. 2023 May 9;16:515-527. doi: 10.2147/JAA.S407552. eCollection 2023.PMID: 37193110 Free PMC article. Review.
Modelling Asthma TrEatment Responses (MASTER): Effect of individual patient characteristics on the risk of exacerbation in moderate or severe asthma: a time-to-event analysis of randomised clinical trials.	Oosterholt S, Pavord ID, Brusselle G, Yorgancıoğlu A, Pitrez PM, Abhijith PG, Teli C, Pasqua OD.	" Interindividual differences at baseline and seasonal variation affect the exacerbation risk independently from drug treatment. Moreover, it appears that even when comparable level of symptom control is achieved in a group of patients, each individual may have a different exacerbation risk, depending on their baseline characteristics and time of the year."	Br J Clin Pharmacol. 2023 May 23. doi: 10.1111/bcp.15801. Online ahead of print.PMID: 37221636
Dupilumab long-term efficacy in patients with non-OCS-dependent asthma with and without evidence of allergic asthma.	Sher LD, Corren J, Pavord ID, Daizadeh N, Altincatal A, Soler X, Djandji M, Radwan A, Jacob-Nara JA, Deniz Y, Rowe PJ.	"Dupilumab efficacy was sustained for up to 3 years in patients with uncontrolled, moderate-to-severe type 2 inflammatory asthma, with or without evidence of allergic asthma"	J Asthma. 2023 May 31:1-8. doi: 10.1080/02770903.2023.2185895. Online ahead of print.PMID: 36876957
Implementation of a primary care asthma management quality improvement programme across 68 general practice sites.	Gilchrist FJ, Carroll WD, Clayton S, Price D, Jarrold I, Small I, Sutton EJ, Lenney W.	Asthma Management Quality Improvement Programme met its primary objective to improve asthma control in a large cohort of adults and children.	NPJ Prim Care Respir Med. 2023 May 13;33(1):21. doi: 10.1038/s41533-023-00341-y.PMID: 37179388 Free PMC article.
Oropharyngeal Microbiota Clusters in Children with Asthma/Wheeze Associate with Allergy, Blood Transcriptomic Immune Pathways and Exacerbations Risk.	Abdel-Aziz MI, Thorsen J, Hashimoto S, Vijverberg SJH. et.al.	"The analysis of the oropharyngeal microbiota of children with asthma/wheezing identified four clusters with distinct clinical characteristics (phenotypes) that associate with exacerbations' risk and transcriptomic pathways involved in airway remodeling."	Am J Respir Crit Care Med. 2023 May 10. doi: 10.1164/rccm.202211-2107OC. Online ahead of print.PMID: 37163754
Trends in Long-Term Ventilation Care in U.K. Children and Young People-Further Consideration Required for Pediatric Critical Care Services.	Wilkinson K, Freeth H, Mahoney N, Iles R, Juniper M.	"The increased numbers and changing characteristics of babies and children requiring LTV over the last 3 decades in the United Kingdom have implications for all healthcare sectors but particularly for providers of critical care services."	Pediatr Crit Care Med. 2023 May 1. doi: 10.1097/PCC.0000000000003253. Online ahead of print.PMID: 37125802
Asthma control and care among six public health clinic attenders in Malaysia: A cross-sectional study.	Hussein N, Liew SM, Hanafi NS, Lee PY, Cheong AT, Ghazali SS, Chinna K, Pang YK, Kassim A, Parker RA, Schwarze J, Sheikh A, Pinnock H, Khoo EM; RESPIRE Collaborators.	A cross-sectional study collecting patients' sociodemographic characteristics, asthma control, trigger factors, healthcare use, asthma treatment, and monitoring and use of asthma action plan.	Health Sci Rep. 2023 May 2;6(5):e1021. doi: 10.1002/hsr2.1021. eCollection 2023 May.PMID: 37152232 Free PMC article.

April

Title	Authors	Summary	Reference
Short-acting β₂-agonists and exacerbations in children with asthma in England: SABINA Junior.	Morgan A, Maslova E, Kallis C, Sinha I, Roberts G, Tran TN, van der Valk RJP, Quint JK.	Higher SABA prescriptions in children were associated with increased future exacerbation rates,which requires prescription monitoring of three or more SABA canisters per year.	ERJ Open Res. 2023 Apr 24;9(2):00571-2022. doi: 10.1183/23120541.00571-2022. eCollection 2023 Mar.PMID: 37101737
Dupilumab Improves Long-term Outcomes in Patients With Uncontrolled, Moderate-to-Severe GINA-Based Type 2 Asthma, Irrespective of Allergic Status.	Rabe KF, Pavord ID, Busse WW, Chupp GL, Izuhara K, Altincatal A, Gall R, Pandit-Abid N, Deniz Y, Rowe PJ, Jacob-Nara JA, Radwan A	"Long-term treatment with dupilumab reduced exacerbation rates, and improved lung function and asthma control in patients with asthma with type 2 inflammation".	Allergy. 2023 Apr 19. doi: 10.1111/all.15747. Online ahead of print.PMID: 37073882
Dupilumab Improves Outcomes in Patients with Chronic Rhinosinusitis with Nasal Polyps and Coexisting Asthma Irrespective of Baseline Asthma Characteristics.	Busse WW, Pavord ID, Siddiqui S, Khan AH, Praestgaard A, Nash S, Jacob-Nara JA, Rowe PJ, Deniz Y.J	Dupilumab, which is a fully human monoclonal antibody that blocks the shared receptor component for interleukin-4 and -13, (key and central drivers of type 2 inflammation), can significantly improve both CRSwNP and asthma outcomes.	Asthma Allergy. 2023 Apr 18;16:411-419. doi: 10.2147/JAA.S391896. eCollection 2023.PMID: 37096015
Remission outcomes in severe eosinophilic asthma with mepolizumab therapy: Analysis of the REDES study.	Pavord I, Gardiner F, Heaney LG, Domingo C, Price RG, Pullan A, Oppenheimer J, Brusselle G, Nagase H, Chupp G, Pizzichini E, Bañas-Conejero D, Howarth P.	"In daily clinical practice, mepolizumab treatment enables a subset of patients with severe eosinophilic asthma to achieve the proposed composite definitions of clinical remission, with more than one-third meeting the three-component definition."	Front Immunol. 2023 Apr 12;14:1150162. doi: 10.3389/fimmu.2023.1150162. eCollection 2023.PMID: 37122713
Patient-centred digital biomarkers for allergic respiratory diseases and asthma: the ARIA-EAACI approach.	Bousquet J, Shamji MH, Anto JM, Schünemann HJ, et.al	"Although some biomarkers exist in specialist care for asthma, they cannot be largely used in primary care, and there are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice".	Allergy. 2023 Apr 11. doi: 10.1111/all.15740. Online ahead of print.PMID: 37042071
Chronic Airways Assessment Test: psychometric properties in patients with asthma and/or COPD.	Tomaszewski EL, Atkinson MJ, Janson C, Karlsson N, Make B, Price D, Reddel HK, Vogelmeier CF, Müllerová H, Jones PW.	CAAT demonstrated good cross-sectional psychometric properties and moderate-strong correlations with other health status measures, making it a suitable PRO instrument to assess the impact of obstructive lung disease in broad populations of patients with airways disease. It might be relevant for routine clinical practice and ‘real-world’ effectiveness studies performed in patients in a routine care setting.	NOVELTY Scientific Community; and the NOVELTY study investigators.Respir Res. 2023 Apr 8;24(1):106. doi: 10.1186/s12931-023-02394-6.PMID: 37031164
Identifying and appraising outcome measures for severe asthma: a systematic review.	Rattu A, Khaleva E, Brightling C, Dahlén SE, Bossios A, Fleming L, Chung KF, Melén E, Djukanovic R, Chaudhuri R, Exley A, Koppelman GH, Bourdin A, Rusconi F, Porsbjerg C, Coleman C, Williams C, Nielsen H, Davin E, Taverner P, Romagosa Vilarnau S, Roberts G.	"This review identified 96 ‘candidate’ outcome measures and used a multi-stakeholder consensus process to select 24 ‘priority’ outcome measures for adult and paediatric severe asthma."	3TR Consortium Respiratory Work Package.Eur Respir J. 2023 Apr 3;61(4):2201231. doi: 10.1183/13993003.01231-2022. Print 2023 Apr.PMID: 36549712
Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA).	Khaleva E, Rattu A, Brightling C, Bush A, Bossios A, Bourdin A, Chung KF, Chaudhuri R, Coleman C, Dahlén SE, Djukanovic R, Deschildre A, Fleming L, Fowler SJ, Gupta A, Hamelmann E, Hashimoto S, Hedlin G, Koppelman GH, Melén E, Murray CS, Pilette C, Porsbjerg C, Pike KC, Rusconi F, Williams C, Ahrens B, Alter P, Anckers F, van den Berge M, Blumchen K, Brusselle G, Clarke GW, Cunoosamy D, Dahlén B, Dixey P, Exley A, Frey U, Gaillard EA, Giovannini-Chami L, Grigg J, Hartenstein D, Heaney LG, Karadag B, Kaul S, Kull I, Licari A, Maitland-van der Zee AH, Mahler V, Schoos AM, Nagakumar P, Negus J, Nielsen H, Paton J, Pijnenburg M, Ramiconi V, Romagosa Vilarnau S, Principe S, Rutjes N, Saglani S, Seddon P, Singer F, Staudinger H, Turner S, Vijverberg S, Winders T, Yasinska V, Roberts G	"This patient-centred collaboration has produced two COM sets for paediatric and adult severe asthma. It is expected that they will inform the methodology of future clinical trials, enhance comparability of efficacy and effectiveness of biological therapies, and help assess their socioeconomic value. COMSA will inform definitions of non-response and response to biological therapy for severe asthma."	; COMSA Working Group in the 3TR Consortium.Eur Respir J. 2023 Apr 3;61(4):2200606. doi: 10.1183/13993003.00606-2022. Print 2023 Apr.PMID: 36229046
Development and validation of an electronic daily control score for asthma (e-DASTHMA): a real-world direct patient data study.	Sousa-Pinto B, Jácome C, Pereira AM, Regateiro FS, Almeida R, Czarlewski W, Kulus M, Shamji MH, Boulet LP, Bonini M, Brussino L, Canonica GW, Cruz AA, Gemicioglu B, Haahtela T, Kupczyk M, Kvedariene V, Larenas-Linnemann D, Louis R, Niedoszytko M, Pham-Thi N, Puggioni F, Romantowski J, Sastre J, Scichilone N, Taborda-Barata L, Ventura MT, Vieira RJ, Agache I, Bedbrook A, Bergmann KC, Amaral R, Azevedo LF, Bosnic-Anticevich S, Brusselle G, Buhl R, Cecchi L, Charpin D, Loureiro CC, de Blay F, Del Giacco S, Devillier P, Jassem E, Joos G, Jutel M, Klimek L, Kuna P, Laune D, Luna Pech J, Makela M, Morais-Almeida M, Nadif R, Neffen HE, Ohta K, Papadopoulos NG, Papi A, Pétré B, Pfaar O, Yeverino DR, Cordeiro CR, Roche N, Sá-Sousa A, Samolinski B, Sheikh A, Ulrik CS, Usmani OS, Valiulis A, Vandenplas O, Vieira-Marques P, Yorgancioglu A, Zuberbier T, Anto JM, Fonseca JA, Bousquet J.	"e-DASTHMA is a good tool for the daily assessment of asthma control. This tool can be used as an endpoint in clinical trials as well as in clinical practice to assess fluctuations in asthma control and guide treatment optimisation."	Lancet Digit Health. 2023 Apr;5(4):e227-e238. doi: 10.1016/S2589-7500(23)00020-1. Epub 2023 Mar 3.PMID: 36872189
Baseline FeNO Independently Predicts the Dupilumab Response in Patients With Moderate-to-Severe Asthma.	Pavord ID, Deniz Y, Corren J, Casale TB, FitzGerald JM, Izuhara K, Daizadeh N, Ortiz B, Johnson RR, Harel S, Djandji M, Goga L, Crikelair N, Rowe PJ, Busse WW.	"Increased baseline FeNO was associated with greater clinical effects in dupilumab versus placebo independently of eosinophil levels and other clinical characteristics."	J Allergy Clin Immunol Pract. 2023 Apr;11(4):1213-1220.e2. doi: 10.1016/j.jaip.2022.11.043. Epub 2022 Dec 16.PMID: 36535524

March

Title	Authors	Summary	Reference
International consensus statement on allergy and rhinology: Allergic rhinitis - 2023	Wise SK, Damask C, Roland LT, et.al.	The ICAR-Allergic Rhinitis 2023 update provides a comprehensive evaluation of Allergic Rhinitis and the currently available evidence.	2023 Apr;13(4):293-859. doi: 10.1002/alr.23090. Epub 2023 Mar 6.PMID: 36878860 Review
Dietary patterns, lung function and asthma in childhood: a longitudinal study.	Talaei M, Emmett PM, Granell R, Tabatabaeian H, Northstone K, Bergström A, Shaheen SO.	"A 'health-conscious' diet in mid-childhood was associated with higher subsequent lung function, while a diet high in processed food was associated with lower lung function."	Respir Res. 2023 Mar 16;24(1):82. doi: 10.1186/s12931-023-02383-9.PMID: 36927379 Free PMC article.
Asthma medication adherence and exacerbations and lung function in children managed in Leicester primary care.	Paracha R, Lo DKH, Montgomery U, Ryan L, Varakantam V, Gaillard EA.	Investigating the link between inhaled corticosteroid adherence and spirometry, fraction of exhaled nitric oxide and asthma control in asthmatic school-age children.	NPJ Prim Care Respir Med. 2023 Mar 25;33(1):12. doi: 10.1038/s41533-022-00323-6.PMID: 36966170
Development of a patient-centred electronic review template to support self-management in primary care.	McClatchey K, Sheldon A, Steed L, Sheringham J, Appiagyei F, Price D, Hammersley V, Taylor S, Pinnock H.	The aim of the study is to IMPlement IMProved Asthma self-management as RouTine (IMP²ART) programme to develop a patient-centred asthma review template that encourages supported self-management.	BJGP Open. 2023 Mar 3:BJGPO.2022.0165. doi: 10.3399/BJGPO
Challenges and Opportunities in Asthma Prevention and Treatment.	Gern JE, Pavord ID.	The study focuses on advances in asthma assessment, pathogenesis, and treatment, as well as new insights into type-2 and epithelial mechanisms of asthma that have led to the development of potent biologics, which can markedly reduce exacerbation rates for children and adults with severe asthma.	.J Allergy Clin Immunol Pract. 2023 Mar;11(3):748-749. doi: 10.1016/j.jaip.2022.12.032.PMID: 36894276
Immunoregulation of asthma by type2 cytokine therapies - treatments for all ages?	Saglani S, Yates L, Lloyd CM	"The range of treatments for severe asthma has increased over the last few years with the introduction of biological agents that suppress the activity of type 2 cytokines."	Eur J Immunol. 2023 Mar 17:e2249919. doi: 10.1002/eji.202249919. Online ahead of print.PMID: 36932669
Students' and staffs' views and experiences of asymptomatic testing on a university campus during the COVID-19 pandemic in Scotland: a mixed methods study.	Bauld L, Street A, Connelly R, Bevan I, Morlet Corti Y, Baxter MS, Stagg HR, Christison S, Mulherin T, Sinclair L, Aitman T.	"Despite alternative testing options being available in the community at the time of the research, our results indicate that an asymptomatic SARS-CoV-2 testing programme designed specifically for university staff and students was acceptable and was positively received by those who took part."	BMJ Open. 2023 Mar 20;13(3):e065021. doi: 10.1136/bmjopen-2022-065021.PMID: 36940944
Re-analysis of ventilator-free days (VFD) in acute respiratory distress syndrome (ARDS) studies.	Verghis RM, McDowell C, Blackwood B, Lee B, McAuley DF, Clarke M.	" In critical care research, “ventilator-free days” combines mortality and duration of mechanical ventilation into a single continuous measure, which can be analysed in a variety of ways, which is investigated in this study".	Trials. 2023 Mar 13;24(1):183. doi: 10.1186/s13063-023-07190-7.PMID: 36907882
Patient and public involvement in research: the need for budgeting PPI staff costs in funding applications.	De Simoni A, Jackson T, Inglis Humphrey W, Preston J, Mah H, Wood HE, Kinley E, Gonzalez Rienda L, Porteous C.	The article shows the importance of Patient and Public Involvement for the best outcomes of high-quality research, making it more relevant to patients and useful for the healthcare.	Res Involv Engagem. 2023 Mar 25;9(1):16. doi: 10.1186/s40900-023-00424-7.PMID: 36966346
Randomised controlled trial for the titration of oral corticosteroids using markers of inflammation in severe asthma.	Ramsahai JM, Simpson JL, Cook A, Gibson PG, McDonald V, Grainge C, Heaney LG, Wark PA	Studying the efficacy of an algorithm to guide the titration of oral corticosteroids using blood eosinophil count and fraction of exhaled nitric oxide (FeNO) levels.	Thorax. 2023 Mar 22:thoraxjnl-2021-217865. doi: 10.1136/thorax-2021-217865.
Development and validation of an electronic daily control score for asthma (e-DASTHMA): a real-world direct patient data study.	Sousa-Pinto B, Jácome C, Pereira AM, et.al.	Using MASK-air data to develop and assess different daily control scores for asthma.	Lancet Digit Health. 2023 Apr;5(4):e227-e238. doi: 10.1016/S2589-7500(23)00020-1. Epub 2023 Mar 3.PMID: 368721
Post-consultation acute respiratory tract infection recovery: a latent class-informed analysis of individual patient data.	Hounkpatin H, Stuart B, Zhu S, Yao G, Moore M, Löffler C, Little P, Kenealy T, Gillespie D, Francis NA, Bostock J, Becque T, Arroll B, Altiner A, Alonso-Coello P, Hay AD.	"The study found that older age, greater baseline severity, longer prior duration of illness, and presence of lung disease predicted membership to trajectories with slower symptom recovery. Immediate antibiotic prescribing was associated with lower odds of slower recovery."	Br J Gen Pract. 2023 Feb 23;73(728):e196-e203. doi: 10.3399/BJGP.2022.0229. Print 2023 Mar.PMID: 36823057
Cost-effectiveness of fractional exhaled nitric oxide suppression testing as an adherence screening tool among patients with difficult-to-control asthma.	Barry LE, O'Neill C, Butler C, Chaudhuri R, Heaney LG.	"Fractional exhaled nitric oxide suppression testing has demonstrated clinical effectiveness as an adherence screening tool to detect poor adherence to inhaled corticosteroids in difficult-to-control asthma prior to initiation of expensive biologic therapy."	J Allergy Clin Immunol Pract. 2023 Mar 18:S2213-2198(23)00292-1. doi: 10.1016/j.jaip.2023.03.008. Online ahead of print.PMID: 36940864
Antibiotic effectiveness for children with lower respiratory infections: prospective cohort and trial in primary care.	Little P, Becque T, Hay AD, Francis NA, Stuart B, O'Reilly G, Thompson N, Hood K, Moore M, Verheij T.	"Antibiotics for uncomplicated chest infections, even in a sample of more unwell children, are unlikely to be clinically very effective."	Br J Gen Pract. 2023 Feb 23;73(728):e156-e163. doi: 10.3399/BJGP.2022.0239. Print 2023 Mar.PMID: 36823052
Prevalence of childhood cough in epidemiological studies depends on the question used: findings from two population-based studies.	Mallet MC, Mozun R, Pedersen ESL, Ardura-Garcia C, Gaillard EA, Latzin P, Moelller A, Kuehni CE.	" Epidemiological studies use different questions to assess recurrent cough in children. In two independent population-based studies, we assessed how prevalence estimates of cough vary depending on the questions parents are asked about their child’s cough and how answers to the different questions overlap."	LUIS study group.Swiss Med Wkly. 2023 Mar 8;153:40044. doi: 10.57187/smw.2023.40044.PMID: 36912371
Comparative effectiveness of Anti-IL5 and Anti-IgE biologic classes in patients with severe asthma eligible for both.	Pfeffer PE, Ali N, Murray R, et.al.	"In real life, both anti-IgE and anti-IL5/5R improve asthma outcomes in patients eligible for both biologic classes; however, anti-IL5/5R was superior in terms of reducing asthma exacerbations and long-term oral corticosteroid use".	Allergy. 2023 Mar 17. doi: 10.1111/all.15711. Online ahead of print.PMID: 36929509
Stratification of asthma by lipidomic profiling of induced sputum supernatant.	Brandsma J, Schofield JPR, Yang X, Strazzeri F, Barber C, Goss VM, Koster G, Bakke PS, Caruso M, Chanez P, Dahlén SE, Fowler SJ, Horváth I, Krug N, Montuschi P, Sanak M, Sandström T, Shaw DE, Chung KF, Singer F, Fleming LJ, Adcock IM, Pandis I, Bansal AT, Corfield J, Sousa AR, Sterk PJ, Sánchez-García RJ, Skipp PJ, Postle AD, Djukanović R.	" Lipidomics of induced sputum supernatant revealed a spectrum of nine molecular phenotypes, highlighting not just significant differences between the sputum lipidomes of asthmatics and healthy controls, but within the asthmatic population as well."	U-BIOPRED Study Group.J Allergy Clin Immunol. 2023 Mar 12:S0091-6749(23)00293-2. doi: 10.1016/j.jaci.2023.02.032. Online ahead of print.PMID: 36918039
Individualised risk prediction model for exacerbations in patients with severe asthma: protocol for a multicentre real-world risk modelling study.	Lee TY, Sadatsafavi M, Yadav CP, Price DB, Beasley R, Janson C, Koh MS, Roy R, Chen W.	"Accurate prediction of the risk of severe exacerbations may enable clinicians to tailor treatment plans to an individual patient. This study aims to develop and validate a novel risk prediction model for severe exacerbations in patients with severe asthma, and to examine the potential clinical utility of this tool."	BMJ Open. 2023 Mar 9;13(3):e070459. doi: 10.1136/bmjopen-2022-070459.PMID: 36894199
Characteristics of asthma patients overprescribed short-acting beta-agonist (SABA) reliever inhalers stratified by blood eosinophil count in North East London - a cross-sectional observational study.	Pfeffer P, Hajmohammadi H, Cole J, Griffiths C, Hull S, De Simoni A.	"Eosinophilia was significantly less likely in female patients, those with multiple mental health comorbidities and those with SABA on repeat prescription. "	BJGP Open. 2023 Mar 15:BJGPO.2023.0020. doi: 10.3399/BJGPO.2023.0020. Online ahead of print.PMID: 36921995
General practice wide adaptations to support patients affected by DVA during the COVID-19 pandemic: a rapid qualitative study.	Dixon S, De Simoni A, Szilassy E, Emsley E, Wileman V, Feder G, Downes L, Barbosa EC, Panovska-Griffiths J, Griffiths C, Dowrick A.	"Disruption caused by pandemic restrictions revealed how team dynamics and interactions before, during and after clinical consultations contribute to identifying and supporting patients experiencing DVA. "	BMC Prim Care. 2023 Mar 23;24(1):78. doi: 10.1186/s12875-023-02008-6.PMID: 36959527
Is sibship composition a risk factor for childhood asthma? Systematic review and meta-analysis.	Lisik D, Ermis SSÖ, Ioannidou A, Milani GP, Nyassi S, Spolidoro GCI, Kankaanranta H, Goksör E, Wennergren G, Nwaru BI.	"Being second-born or later and having at least one sibling is associated with a slightly increased risk of temporary wheezing in infancy. In contrast, being second-born or later is associated with marginal protection against asthma. These associations appear to have weakened since the turn of the millennium, possibly due to lifestyle changes and socioeconomic development."	World J Pediatr. 2023 Mar 30. doi: 10.1007/s12519-023-00706-w. Online ahead of print.PMID: 36997765 Review
Estimating the contribution of respiratory pathogens to acute exacerbations of COPD using routine data.	Sivakumaran S, Alsallakh MA, Lyons RA, Quint JK, Davies GA.	"In people admitted to hospital with Acute exacerbation of COPD increased testing for respiratory viruses could enable more effective antibiotic stewardship and isolation of cases. Linkage with microbiology data achieves more accurate and reliable case definitions."	J Infect. 2023 Mar;86(3):233-238. doi: 10.1016/j.jinf.2023.01.012. Epub 2023 Jan 24.PMID: 36706962
Application of an algorithm to analyze patterns of intermittent oral corticosteroid use in asthma.	Haughney J, Tran TN, Heatley H, Bourdin A, Menzies-Gow A, Jackson DJ, Maslova E, Chapaneri J, Skinner D, Carter V, Chan JSK, Price D.	"Initial data showed that almost a third of patients with asthma who receive only intermittent OCS had a frequent pattern of use at some point, including those with mild asthma; patients with more severe asthma have a more frequent pattern of OCS use"	NPJ Prim Care Respir Med. 2023 Mar 4;33(1):9. doi: 10.1038/s41533-023-003310.PMID: 36871120
Long-term effect of dupilumab on prevention of lung function decline in patients with uncontrolled moderate-to-severe asthma: ATLAS trial design.	De Prado Gomez L, Pavord I, Busse W, Brightling CE, Wechsler ME, Rabe KF, Zhang M, Xing J, Jacob-Nara JA, Rowe PJ.	Many patients with asthma experience loss of lung function over time, and in certain patients this can lead to progressive obstructive patterns similar to COPD. Patients with severe asthma may experience accelerated lung function decline (LFD),however, Dupilumab may prevent or slow the rate of LFD in patients with uncontrolled, moderate-to-severe asthma.	ERJ Open Res. 2023 Mar 6;9(2):00417-2022. doi: 10.1183/23120541.00417-2022. eCollection 2023 Mar.PMID: 36891077 Editorial: Difficult and severe asthma in children, volume II.
Editorial: Difficult and severe asthma in children, volume II.	Ullmann N, Bush A, Piacentini G, Santamaria F, Cutrera R.	A summary giving a perspective on severe asthma in children with useful practical articles.	Front Pediatr. 2023 Mar 16;11:1158309. doi: 10.3389/fped.2023.1158309. eCollection 2023.PMID: 37009299

February

Title	Authors	Summary	Reference
Vitamin D for the management of asthma.	Williamson A, Martineau AR, Sheikh A, Jolliffe D, Griffiths CJ.	"In contrast to previous findings, this updated review does not find evidence to support a role for vitamin D supplementation or its hydroxylated metabolites to reduce risk of asthma exacerbations or improve asthma control."	Cochrane Database Syst Rev. 2023 Feb 6;2(2):CD011511. doi: 10.1002/14651858.CD011511.pub3.PMID: 36744416
Environmental influences on childhood asthma: Allergens.	Custovic A, de Moira AP, Murray CS, Simpson A.	"High allergen exposure among sensitized patients with asthma diagnosis can increase airway inflammation, trigger symptoms, and increase the risk of asthma attacks."	Pediatr Allergy Immunol. 2023 Feb;34(2):e13915. doi: 10.1111/pai.13915.PMID: 36825741
Pediatric obesity and severe asthma: Targeting pathways driving inflammation.	Di Cicco M, Ghezzi M, Kantar A, Song WJ, Bush A, Peroni D, D'Auria E.	"Obesity is both a major risk factor and a disease modifier of asthma in children and adults".	Pharmacol Res. 2023 Feb;188:106658. doi: 10.1016/j.phrs.2023.106658. Epub 2023 Jan 12.PMID: 36642111
Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDALL hypothesis.	Bousquet J, Melén E, Haahtela T, Koppelman GH, et al.	"Asthma, rhinitis and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome."	.Allergy. 2023 Feb 17. doi: 10.1111/all.15679. Online ahead of print.PMID: 36799120 Review.
Patient views on asthma diagnosis and how a clinical decision support system could help: A qualitative study.	Canny A, Donaghy E, Murray V, Campbell L, Stonham C, Bush A, McKinstry B, Milne H, Pinnock H, Daines L.	A clinical decision support system could improve the diagnostic process, communication relating to the nature of the condition and its management, including the patient's role in self‐management.	Health Expect. 2023 Feb;26(1):307-317. doi: 10.1111/hex.13657. Epub 2022 Nov 12.PMID: 36370457
Asynchronous digital health interventions for reviewing asthma: A mixed-methods systematic review protocol.	Uzzaman MN, Hammersley V, McClatchey K, Sheringham J, Habib GMM, Pinnock H.	"The findings of this review are expected to provide valuable insight into organising routine care for people living with asthma in the context of multiple modes of consulting in a way that benefits both patients and healthcare professionals."	PLoS One. 2023 Feb 9;18(2):e0281538. doi: 10.1371/journal.pone.0281538. eCollection 2023.PMID: 36758039
Key recommendations for primary care from the 2022 Global Initiative for Asthma (GINA) update.	Levy ML, Bacharier LB, Bateman E, Boulet LP, Brightling C, Buhl R, Brusselle G, Cruz AA, Drazen JM, Duijts L, Fleming L, Inoue H, Ko FWS, Krishnan JA, Mortimer K, Pitrez PM, Sheikh A, Yorgancıoğlu A, Reddel HK.	The diagnosis of asthma should be confirmed with lung function testing before initiating controller treatment, which should be assessed in two domains: current symptom control and risk factors for future asthma flare-ups.	NPJ Prim Care Respir Med. 2023 Feb 8;33(1):7. doi: 10.1038/s41533-023-00330-1.PMID: 36754956
Dog ownership in infancy is protective for persistent wheeze in 17q21 asthma-risk carriers.	Tutino M, Granell R, Curtin JA, Haider S, Fontanella S, Murray CS, Roberts G, Arshad SH, Turner S, Morris AP, Custovic A, Simpson A.	"There was no evidence of an association between dog or cat ownership and wheeze. The attenuating effect of dog ownership on persistent wheeze for those with the asthma-risk allele observed in the current study is likely due to an environmental exposure for which dogs are a proxy (ie, microbiota, endotoxin levels). "	STELAR/UNICORN investigators.J Allergy Clin Immunol. 2023 Feb;151(2):423-430. doi: 10.1016/j.jaci.2022.10.012. Epub 2022 Oct 20.PMID: 36273658
Incidence determinants and serological correlates of reactive symptoms following SARS-CoV-2 vaccination.	Holt H, Jolliffe DA, Talaei M, Faustini S, Vivaldi G, Greenig M, Richter AG, Lyons RA, Griffiths CJ, Kee F, Sheikh A, Davies GA, Shaheen SO, Martineau AR.	"Factors that associate with lower risk of systemic post-vaccination symptoms include greater age, male sex, and receipt of an mRNA vaccine. Factors that associate with a higher risk of systemic post-vaccination symptoms include history of symptomatic SARS-CoV-2 infection prior to vaccination, presence of self-rated anxiety or depression and use of a multivitamin supplement."	NPJ Vaccines. 2023 Feb 25;8(1):26. doi: 10.1038/s41541-023-00614-0.PMID: 36841835
Remodeling Phenotypes Take Center Stage in the Prediction of Preschool Wheeze Attacks.	Saglani S, Baraldo S.	"Airway inflammation and structural wall abnormalities (remodeling) are considered the two hallmark pathological features of asthma."	Am J Respir Crit Care Med. 2023 Feb 15;207(4):381-382. doi: 10.1164/rccm.202209-1833ED.PMID: 36170640
Influences on indoor environmental trigger remediation uptake for children and young people with asthma: A scoping review.	Lewis G, Milnes L, Adams A, Schwarze J, Duff A.	"Children and young people (CYP) with asthma can benefit from reduced exposure to indoor environmental allergens and triggers but may not consistently have avoidance strategies implemented."	Health Expect. 2023 Feb;26(1):87-97. doi: 10.1111/hex.13670. Epub 2022 Dec 7.PMID: 36478049
Cohort Profile: Longitudinal population-based study of COVID-19 in UK adults (COVIDENCE UK).	Holt H, Relton C, Talaei M, Symons J, Davies MR, Jolliffe DA, Vivaldi G, Tydeman F, Williamson AE, Pfeffer PE, Orton C, Ford DV, Davies GA, Lyons RA, Griffiths CJ, Kee F, Sheikh A, Breen G, Shaheen SO, Martineau AR.	"A population-based longitudinal studies to complement research conducted in secondary and tertiary care by identifying risk factors for developing predominantly mild/moderate COVID-19 that did not present to hospital. "	Int J Epidemiol. 2023 Feb 8;52(1):e46-e56. doi: 10.1093/ije/dyac189.PMID: 36174228

January

Title	Authors	Summary	Reference
Diagnosis and Assessment of the Asthmas	Pavord ID, Barnes PJ, Lemière C, Gibson PG.	New understanding about how to address the complexity and heterogeneity of the different forms of asthma.	J Allergy Clin Immunol Pract. 2023 Jan;11(1):1-8. doi: 10.1016/j.jaip.2022.09.034. Epub 2022 Oct 3.PMID: 36195258
A²BCD: a concise guide for asthma management	Lommatzsch M, Brusselle GG, Levy ML, Canonica GW, Pavord ID, Schatz M, Virchow JC.	A practical guide for asthma management with four components: dual assessment of asthma, basic measures, identification and treatment of comorbidities, phenotype-specific, individually targeted treatment.	Lancet Respir Med. 2023 Jan 27:S2213-2600(22)00490-8. doi: 10.1016/S2213-2600(22)00490-8. Online ahead of print.PMID: 36716752
Pediatric obesity and severe asthma: Targeting pathways driving inflammation	Di Cicco M, Ghezzi M, Kantar A, Song WJ, Bush A, Peroni D, D'Auria E.	"This review outlines the most recent findings on Severe Asthma in obese children, particularly focusing on inflammatory pathways, which are becoming of pivotal importance in order to identify selective targets for specific treatments, such as biological agents."	Pharmacol Res. 2023 Jan 12;188:106658. doi: 10.1016/j.phrs.2023.106658. Online ahead of print.PMID: 36642111
Reducing oral steroid intolerability and drug costs for acute wheezers: A retrospective evaluation of a clinical management algorithm in a Pediatric Emergency Department	Davison G, Ruddell J, Trouton M, McDonald R, Kennedy B, O'Neill V, McCann J, Bartholome B, Steen H, Shields MD, Mullen S.	"Acute wheezing attacks are a leading cause of PED attendances and inpatient admissions. Prednisolone, a routine treatment, is intolerable in almost one-third of children, requiring repeated dosing, which may prolong length of stay".	Pediatr Pulmonol. 2023 Jan 4. doi: 10.1002/ppul.26286. Online ahead of print.PMID: 36598127
A qualitative process evaluation within a clinical trial that used healthcare technologies for children with asthma-insights and implications.	Lawrie L, Turner S, Cotton SC, Wood J, Morgan HM.	Investigating clinical and patient perspectives regarding the use of technology in the management of childhood asthma.	PLoS One. 2023 Jan 5;18(1):e0280086. doi: 10.1371/journal.pone.0280086. eCollection 2023.PMID: 36603013
A practical toolbox for the effective transition of adolescents and young adults with asthma and allergies: An EAACI position paper.	Vazquez-Ortiz M, Gore C, Alviani C, Angier E, Blumchen K, Comberiati P, Duca B, DunnGalvin A, Garriga-Baraut T, Gowland MH, Egmose B, Knibb R, Khaleva E, Mortz CG, Pfaar O, Pite H, Podesta M, Santos AF, Sanchez-Garcia S, Timmermans F, Roberts G.	Practical resource to support effective transitional care for adolescents and young adults with asthma and allergies.	Allergy. 2023 Jan;78(1):20-46. doi: 10.1111/all.15533. Epub 2022 Oct 18.PMID: 36176045
Diagnostic performance of a machine-learning algorithm (Asthma/COPD Differentiation Classification; AC/DC) tool versus primary care physicians and pulmonologists in asthma, COPD and ACO	Kocks JWH, Cao H, Holzhauer B, Kaplan A, FitzGerald JM, Kostikas K, Price D, Reddel HK, Tsiligianni I, Vogelmeier CF, Bostel S, Mastoridis P.	Investigating the diagnostic accuracy of the Asthma/COPD Differentiation Classification (AC/DC) tool compared with primary care physicians and pulmonologists.	J Allergy Clin Immunol Pract. 2023 Jan 27:S2213-2198(23)00081-8. doi: 10.1016/j.jaip.2023.01.017. Online ahead of print.PMID: 36716998
Differences in respiratory oscillometry measurements using mouthpiece, mouth, and nasal mask in healthy adults	Alshlowi M, Hakizimana A, Alraimi A, Devani P, Lundblad LKA, Beardsmore CS, Gaillard EA.	First study to compare the use of mouthpiece, mouth mask, and nasal mask for oscillometry.	J Appl Physiol (1985). 2023 Jan 1;134(1):142-146. doi: 10.1152/japplphysiol.00491.2022. Epub 2022 Dec 8.PMID: 36476160
Too Little, Too Late: Adult Lung Disease Cannot Be Prevented by Interventions in Adult Life	Bush A.	"Early adverse life events can increase the risk of occupational asthma".	Am J Respir Crit Care Med. 2023 Jan 15;207(2):124-126. doi: 10.1164/rccm.202208-1537ED.PMID: 35972758
Narrative review to capture patients' perceptions and opinions about non-response and response to biological therapy for severe asthma	Coleman C, Khaleva E, Rattu A, Frankemölle B, Nielsen H, Roberts G, Williams C; 3TR Respiratory Work Package.	"Biological therapies have revolutionised the treatment landscape for severe asthma and improved the lives of many patients, although questions remain around how treatment success has been defined."	Eur Respir J. 2023 Jan 19;61(1):2200837. doi: 10.1183/13993003.00837-2022. Print 2023 Jan.PMID: 36104293
Differing effects of mepolizumab across the life course	Bush A.	"Large studies showed that asthma attacks in adults with asthma were substantially reduced by mepolizumab."	Lancet Respir Med. 2023 Feb;11(2):123-125. doi: 10.1016/S2213-2600(23)00004-8. Epub 2023 Jan 12.PMID: 36642076
Asthma: Closing in on the Biology of a Complex Life-Course Disease.	Bush A, Holguin F, Porsbjerg C, Saglani S.A.	The roots of asthma definition.	Am J Respir Crit Care Med. 2023 Jan 4. doi: 10.1164/rccm.202212-2302ED. Online ahead of print.PMID: 36598866
Implementing the Patient Needs in Asthma Treatment (NEAT) questionnaire in routine care: a qualitative study among patients and health professionals	Salandi J, Vu-Eickmann P, Apfelbacher C, Sheikh A, Loerbroks A.	"Many patients with asthma report unmet health care needs. The Patient Needs in Asthma Treatment (NEAT) questionnaire is a validated instrument to quantify these unmet needs. "	BMC Pulm Med. 2023 Jan 17;23(1):21. doi: 10.1186/s12890-022-02293-4.PMID: 36650461
Adverse perception of cough in patients with severe asthma: a discrete choice experiment	Holmes J, O'Neill V, McGarvey LP, Heaney LG.	" This study aims to improve our understanding of how patients with asthma perceive cough to better understand its clinical impact."	ERJ Open Res. 2023 Jan 3;9(1):00442-2022. doi: 10.1183/23120541.00442-2022. eCollection 2023 Jan.PMID: 36605903

2022

December

Title	Authors	Summary	Reference
Asthma and Wheeze Severity and the Oropharyngeal Microbiota in Children and Adolescents	Thorsen J, Stokholm J, Rasmussen MA, Roggenbuck-Wedemeyer M, Vissing NH, Mortensen MS, Brejnrod AD, Fleming L, Bush A, Roberts G, Singer F, Frey U, Hedlin G, Nordlund B, Murray CS, Abdel-Aziz MI, Hashimoto S, van Aalderen W, Maitland-van der Zee AH, Shaw D, Fowler SJ, Sousa A, Sterk PJ, Chung KF, Adcock IM, Djukanovic R, Auffray C, Bansal AT, Wagers S, Chawes B, Bønnelykke K, Sørensen SJ, Bisgaard H. Ann.	Authors are identifying factors, such as airway microbiota, that can contribute to disease severity and may lead to improved diagnostics, biomarkers, or therapies.	Am Thorac Soc. 2022 Dec;19(12):2031-2043. doi: 10.1513/AnnalsATS.202110-1152OC. PMID: 35904980
How to interpret spirometry in a child with suspected asthma	Brown A, McNaughten B, Russell C, Watters P, O'Donoghue D.	This article outlines some of the technical aspects of spirometry together with how the forced expiration manoeuver and bronchodilator responsiveness testing can be performed and interpreted in a child with suspected asthma.	Arch Dis Child Educ Pract Ed. 2022 Dec;107(6):435-441. doi: 10.1136/archdischild-2022-324308. Epub 2022 Aug 25. PMID: 36008112
Risk of serious COVID-19 outcomes among adults and children with moderate-to-severe asthma: a systematic review and meta-analysis	Lee B, Lewis G, Agyei-Manu E, Atkins N, Bhattacharyya U, Dozier M, Rostron J, Sheikh A, McQuillan R, Theodoratou E.	High-quality evidence demonstrated that severe asthma requiring high-dose ICS or OCS was associated with a higher risk of COVID-19 hospitalisation compared to mild asthmatics and/or nonasthmatic controls.	Usher Network for COVID-19 Evidence Reviews (UNCOVER) group. Eur Respir Rev. 2022 Nov 2;31(166):220066. doi: 10.1183/16000617.0066-2022. Print 2022 Dec 31. PMID: 36323417
Influences on indoor environmental trigger remediation uptake for children and young people with asthma: A scoping review	Lewis G, Milnes L, Adams A, Schwarze J, Duff A.	This review sought to provide a high-level overview of what was known about beliefs, and other factors influencing avoidance of indoor environmental asthma triggers.	Health Expect. 2022 Dec 7. doi: 10.1111/hex.13670. Epub ahead of print. PMID: 36478049
Assessing the technical feasibility of a flexible, integrated Internet-of-things connected for asthma (C4A) system to support self-management: a mixed method study exploring patients and healthcare professionals perspectives	Hui CY, McKinstry B, Mclean S, Buchner M, Pinnock H.	A connected system could facilitate digital approaches to care by linking data from several devices to provide on-going self-monitoring to support remote consultations	JAMIA Open. 2022 Dec 30;5(4):ooac110. doi: 10.1093/jamiaopen/ooac110. eCollection 2022 Dec. PMID: 36601366
Defining clinical subtypes of adult asthma using electronic health records: Analysis of a large UK primary care database with external validation	Horne EMF, McLean S, Alsallakh MA, Davies GA, Price DB, Sheikh A, Tsanas A.	This study provides evidence that subtypes of asthma are identifiable from primary care EHRs database	Int J Med Inform. 2022 Dec 7;170:104942. doi: 10.1016/j.ijmedinf.2022.104942. Online ahead of print. PMID: 36529028
SARS-CoV-2 infection risk among 77,587 healthcare workers: a national observational longitudinal cohort study in Wales, United Kingdom, April to November 2020	Hollinghurst J, North L, Szakmany T, Pugh R, Davies GA, Sivakumaran S, Jarvis R, Rolles M, Pickrell WO, Akbari A, Davies G, Griffiths R, Lyons J, Torabi F, Fry R, Gravenor MB, Lyons RA.	Patient-facing healthcare worker roles were at the highest risk of SARS-CoV-2 infection, which has important policy implications for PPE provision and the prioritisation of vaccination	J R Soc Med. 2022 Dec;115(12):467-478. doi: 10.1177/01410768221107119. Epub 2022 Jul 7. PMID: 35796183

November

Title	Authors	Summary	Reference
Urinary Leukotriene E4 as a Biomarker in NSAID-Exacerbated Respiratory Disease (N-ERD): a Systematic Review and Meta-analysis.	Marquette M, Tailor BV, Calder PC, Curtis PJ, Loke Y, Wilson AM.	"Researchers sought to determine if uLTE₄ was a effective biomarker in Non-steroidal exacerbated respiratory disease (N-ERD)."	Curr Allergy Asthma Rep. 2022 Dec;22(12):209-229. doi: 10.1007/s11882-022-01049-8. Epub 2022 Nov 14. PMID: 36374376; PMCID: PMC9732072.
Risk factors for SARS-CoV-2 infection after primary vaccination with ChAdOx1 nCoV-19 or BNT162b2 and after booster vaccination with BNT162b2 or mRNA-1273: A population-based cohort study (COVIDENCE UK).	Vivaldi G, Jolliffe DA, Holt H, Tydeman F, Talaei M, Davies GA, Lyons RA, Griffiths CJ, Kee F, Sheikh A, Shaheen SO, Martineau AR.	This study investigates whether SARS-CoV-2 infection risk factors which emerge after primary or booster vaccinations can differ to those observed in unvaccinated populations.	Lancet Reg Health Eur. 2022 Sep 23;22:100501. doi: 10.1016/j.lanepe.2022.100501. PMID: 36168404; PMCID: PMC9499825.
Patient views on asthma diagnosis and how a clinical decision support system could help: A qualitative study. Health Expect.	Canny A, Donaghy E, Murray V, Campbell L, Stonham C, Bush A, McKinstry B, Milne H, Pinnock H, Daines L.	"Participants diagnosed with asthma within the last 5 years were recruited from general practices across four UK regions. In-depth interviews were used to explore patient experiences relating to their asthma diagnosis and to understand how a CDSS could be used to improve the diagnostic process for patients."	2022 Nov 12. doi: 10.1111/hex.13657. Epub ahead of print. PMID: 36370457.
Risk of serious COVID-19 outcomes among adults and children with moderate-to-severe asthma: a systematic review and meta-analysis.	Lee B, Lewis G, Agyei-Manu E, Atkins N, Bhattacharyya U, Dozier M, Rostron J, Sheikh A, McQuillan R, Theodoratou E; Usher Network for COVID-19 Evidence Reviews (UNCOVER) group.	Findings from this analysis indicate that adults with severe asthma face increased COVID-19 hospitalisation risks. The study also notes the lack of similar studies regarding children with asthma.	Eur Respir Rev. 2022 Nov 2;31(166):220066. doi: 10.1183/16000617.0066-2022. PMID: 36323417; PMCID: PMC9724896.
Rebound in asthma exacerbations following relaxation of COVID-19 restrictions: a longitudinal population-based study (COVIDENCE UK).	Tydeman F, Pfeffer PE, Vivaldi G, Holt H, Talaei M, Jolliffe D, Davies G, Lyons RA, Griffiths C, Kee F, Sheikh A, Shaheen SO, Martineau AR.	This study indicates that the relaxation of COVID-19 restrictions correlates to factors which contributed to ARI and asthma exacerbations, which has further implications given the associations between incident ARI and severe asthma exacerbation risk.	Thorax. 2022 Nov 23:thorax-2022-219591. doi: 10.1136/thorax-2022-219591. Epub ahead of print. PMID: 36423925.
Risk factors for community-acquired respiratory infections in a non-pandemic context: Secondary analysis of the PRIMIT study.	Hammond A, Stuart B, Little P, Hay AD.	After conducting a secondary analysis of the PRIMIT study, this publication concludes that chronic lung conditions, skin conditions preventing handwashing, prior RTIs, and occupying a household with children can all be predispositions to RTI acquisition.	PLoS One. 2022 Nov 17;17(11):e0277201. doi: 10.1371/journal.pone.0277201. PMID: 36395249; PMCID: PMC9671441.
Correlation Between Postvaccination Anti-Spike Antibody Titers and Protection Against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Population-Based Longitudinal Study.	Vivaldi G, Jolliffe DA, Faustini S, Shields AM, Holt H, Perdek N, Talaei M, Tydeman F, Chambers ES, Cai W, Li W, Gibbons JM, Pade C, McKnight Á, Shaheen SO, Richter AG, Martineau AR.	"Our combined measure of anti-spike IgG/A/M was only modestly predictive of breakthrough infection in vaccinated individuals, with performance significantly improved by incorporating factors reflecting postvaccination SARS-CoV-2 exposure."	J Infect Dis. 2022 Nov 28;226(11):1903-1908. doi: 10.1093/infdis/jiac321. PMID: 35906930.

October

Title	Authors	Summary	Reference
Diagnosis and assessment of the asthmas.	Pavord ID, Barnes PJ, Lemiere C, Gibson PG.	This paper documents the ways in which optimising asthma diagnosis can reduce excessive illness burden from asthma, not just in the UK, but globally.	J Allergy Clin Immunol Pract. 2022 Oct 1:S2213-2198(22)00972-2. doi: 10.1016/j.jaip.2022.09.034. Epub ahead of print. PMID: 36195258.
Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA).	Khaleva E, Rattu A, Brightling C, Bush A, Bossios A, Bourdin A, Chung KF, Chaudhuri R, Coleman C, Dahlén SE, Djukanovic R, Deschildre A, Fleming L, Fowler SJ, Gupta A, Hamelmann E, Hashimoto S, Hedlin G, Koppelman GH, Melén E, Murray CS, Pilette C, Porsbjerg C, Pike KC, Rusconi F, Williams C, Ahrens B, Alter P, Anckers F, van den Berge M, Blumchen K, Brusselle G, Clarke GW, Cunoosamy D, Dahlén B, Dixey P, Exley A, Frey U, Gaillard EA, Giovannini-Chami L, Grigg J, Hartenstein D, Heaney LG, Karadag B, Kaul S, Kull I, Licari A, Maitland-van der Zee AH, Mahler V, Schoos AM, Nagakumar P, Negus J, Nielsen H, Paton J, Pijnenburg M, Ramiconi V, Vilarnau SR, Principe S, Rutjes N, Saglani S, Seddon P, Singer F, Staudinger H, Turner S, Vijverberg S, Winders T, Yasinska V, Roberts G; COMSA working group in the 3TR consortium.	This multi-stakeholder study produced two COM sets for paediatric and adult severe asthma, which will hopefully inform the methodology in future clinical trials.	Eur Respir J. 2022 Oct 13:2200606. doi: 10.1183/13993003.00606-2022. Epub ahead of print. PMID: 36229046.
Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150,000 European children.	van Meel ER, Mensink-Bout SM, den Dekker HT, Ahluwalia TS, Annesi-Maesano I, Arshad SH, Baïz N, Barros H, von Berg A, Bisgaard H, Bønnelykke K, Carlsson CJ, Casas M, Chatzi L, Chevrier C, Dalmeijer G, Dezateux C, Duchen K, Eggesbø M, van der Ent C, Fantini M, Flexeder C, Frey U, Forastiere F, Gehring U, Gori D, Granell R, Griffiths LJ, Inskip H, Jerzynska J, Karvonen AM, Keil T, Kelleher C, Kogevinas M, Koppen G, Kuehni CE, Lambrechts N, Lau S, Lehmann I, Ludvigsson J, Magnus MC, Mélen E, Mehegan J, Mommers M, Nybo Andersen AM, Nystad W, Pedersen ESL, Pekkanen J, Peltola V, Pike KC, Pinot de Moira A, Pizzi C, Polanska K, Popovic M, Porta D, Roberts G, Santos AC, Schultz ES, Standl M, Sunyer J, Thijs C, Toivonen L, Uphoff E, Usemann J, Vafeidi M, Wright J, de Jongste JC, Jaddoe VWV, Duijts L.	Researchers collated data from the EU Child Cohort Network to examine how respiratory tract infections relate to asthma. Their findings indicate that early-life infections of this kind, particularly lower respiratory tract infections, correlate with respiratory diseases later in life.	Eur Respir J. 2022 Oct 6;60(4):2102395. doi: 10.1183/13993003.02395-2021. PMID: 35487537; PMCID: PMC9535116
Predicting asthma attacks using connected mobile devices and machine learning: the AAMOS-00 observational study protocol.	Tsang KCH, Pinnock H, Wilson AM, Salvi D, Shah SA.	Researchers undertood an observational study on asthma status using smart monitoring devices and questionnaires, working with volunteers from a severe asthma clinic. Monitoring data will be analysed to identify predictors of asthma attacks. Once the monitoring period is complete, contributors will be asked about their perspectives on system utility, from which more conclusions and data will be gleaned.	BMJ Open. 2022 Oct 3;12(10):e064166. doi: 10.1136/bmjopen-2022-064166. PMID: 36192103; PMCID: PMC9535155.
Supplementation with long chain n-3 fatty acids during pregnancy, lactation, or infancy in relation to risk of asthma and atopic disease during childhood: a systematic review and meta-analysis of randomized controlled clinical trials.	Bärebring L, Nwaru BI, Lamberg-Allardt C, Thorisdottir B, Ramel A, Söderlund F, Arnesen EK, Dierkes J, Åkesson A.	"Searches were performed in MEDLINE, Embase, Cochrane Central Register of Controlled Trials, and Scopus up to 2021-09-20, for randomized controlled trials (RCTs) that investigated the effect of supplemental long chain n-3 fatty acids during pregnancy, lactation, or infancy for the prevention of childhood asthma or allergy."	Food Nutr Res. 2022 Oct 11;66. doi: 10.29219/fnr.v66.8842. PMID: 36340915; PMCID: PMC9602204.
Dog ownership in infancy is protective for persistent wheeze in 17q21 asthma-risk carriers.	Tutino M, Granell R, Curtin JA, Haider S, Fontanella S, Murray CS, Roberts G, Arshad SH, Turner S, Morris AP, Custovic A, Simpson A; STELAR/UNICORN investigators.	This study sought to better inform our existing assumptions about a possible correlation between pet ownership and asthma, chiefly by examining asthma-associated SNPs (single nucleotide polymorphisms).	J Allergy Clin Immunol. 2022 Oct 20:S0091-6749(22)01413-0. doi: 10.1016/j.jaci.2022.10.012. Epub ahead of print. PMID: 36273658.
A systematic review of the characteristics of interventions that promote physical activity in adults with asthma.	Tyson L, Hardeman W, Marquette M, Semlyen J, Stratton G, Wilson AM.	Despite evidence that physical activity helps with asthma management, population-based studies indicate many of those living with asthma engage in less physical activity than advised. This systematic review explores the potential reasons for this, including under-referrals and uptake barriers.	J Health Psychol. 2022 Oct;27(12):2777-2796. doi: 10.1177/13591053211059386. Epub 2021 Dec 29. PMID: 34963369; PMCID: PMC9537443
Evolution of Eczema, Wheeze, and Rhinitis from Infancy to Early Adulthood: Four Birth Cohort Studies	Haider S, Fontanella S, Ullah A, Turner S, Simpson A, Roberts G, Murray CS, Holloway JW, Curtin JA, Cullinan P, Arshad SH, Hurault G, Granell R, Custovic A; STELAR/UNICORN investigators.	Researchers used logstic regression to consider whether or not wheeze, eczema, and rhinitis (as well as genetic factors) increase the risk of multimorbidity in birth cohorts.	Am J Respir Crit Care Med. 2022 Oct 15;206(8):950-960. doi: 10.1164/rccm.202110-2418OC. PMID: 35679320.
Determinants of Severe Asthma – A Long-Term Cohort Study in Northern Sweden.	Backman H, Stridsman C, Hedman L, Rönnebjerg L, Nwaru BI, Sandström T, Kankaanranta H, Lindberg A, Rönmark E.	This study works to identify and asthma risk factors in adults through a population-based cohort study.	J Asthma Allergy. 2022 Oct 10;15:1429-1439. doi: 10.2147/JAA.S376806. PMID: 36248343; PMCID: PMC9562796
Generational perspective on asthma self-management in the Bangladeshi and Pakistani community in the United Kingdom: A qualitative study.	Ahmed S, Pinnock H, Dowrick A, Steed L.	Researchers inverviewed 27 participants on the topic of asthma and its management both at the individual and community levels. They determined that individuals raised in the United Kingdom had less acculturative stress than older generations, which impacted asthma self-management in numerous ways.	Health Expect. 2022 Oct;25(5):2534-2547. doi: 10.1111/hex.13579. Epub 2022 Aug 23. PMID: 35999685; PMCID: PMC9615058.
Characterization of Patients in the International Severe Asthma Registry with High Steroid Exposure Who Did or Did Not Initiate Biologic Therapy.	Chen W, Sadatsafavi M, Tran TN, Murray RB, Wong CBN, Ali N, Ariti C, Garcia Gil E, Newell A, Alacqua M, Al-Ahmad M, Altraja A, Al-Lehebi R, Bhutani M, Bjermer L, Bjerrum AS, Bourdin A, Bulathsinhala L, von Bülow A, Busby J, Canonica GW, Carter V, Christoff GC, Cosio BG, Costello RW, FitzGerald JM, Fonseca JA, Yoo KH, Heaney LG, Heffler E, Hew M, Hilberg O, Hoyte F, Iwanaga T, Jackson DJ, Jones RC, Koh MS, Kuna P, Larenas-Linnemann D, Lehmann S, Lehtimäki LA, Lyu J, Mahboub B, Maspero J, Menzies-Gow AN, Sirena C, Papadopoulos N, Papaioannou AI, Pérez de Llano L, Perng DW, Peters M, Pfeffer PE, Porsbjerg CM, Popov TA, Rhee CK, Salvi S, Taillé C, Taube C, Torres-Duque CA, Ulrik CS, Ra SW, Wang E, Wechsler ME, Price DB.	Researchers used the International Severe Asthma Registry (ISAR) to identify 1,412 adult patients with severe asthma from 19 countries so as to identify how biologic initiation varied across geographical regions.	J Asthma Allergy. 2022 Oct 21;15:1491-1510. doi: 10.2147/JAA.S377174. PMID: 36303891; PMCID: PMC9595059.
Heterogeneity in the use of biologics for severe asthma in Europe: a SHARP ERS study.	Frix AN, Heaney LG, Dahlén B, Mihaltan F, Sergejeva S, Popović-Grle S, Sedlak V, Lehtimäki L, Bourdin A, Korn S, Zervas E, Csoma Z, Lúðvíksdóttir D, Butler M, Canonica GW, Grisle I, Bieksiene K, Ten Brinke A, Kuna P, Chaves Loureiro C, Nenasheva NM, Lazic Z, Škrgat S, Ramos-Barbon D, Leuppi J, Gemicioglu B, Bossios A, Porsbjerg CM, Bel EH, Djukanovic R, Louis R.	"The European Respiratory Society (ERS) SHARP Clinical Research Collaboration conducted a three-step survey collecting information on asthma biologics use in Europe [...] selected questions were submitted to a broad group of 263 asthma experts identified by national societies."	ERJ Open Res. 2022 Oct 24; 8(4):00273-2022. doi: 10.1183/23120541.00273-2022. PMID: 36299366; PMCID: PMC9589318.
A rare infective cause for recurrent exacerbations and poor asthma control - Mycobacterium kumamotonense.	Marshall BG, Keyvani P, Martineau AR.	Non-tuberculosis myobacteria (NTM), as this report relates, can complicate asthma (particularly uncontrolled asthma) upon infection.	JRSM Open. 2022 Oct 13;13(10):20542704221124013. doi: 10.1177/20542704221124013. PMID: 36247387; PMCID: PMC9561674.
The use of remote video directly observed therapy to improve both inhaler technique and adherence to asthma medications.	McCrossan P, O'Donoghue D, McElnay JC, Shields MD.	Growing evidence indicates that video directly observed therapy can improve patient's inhaler technique and asthma medication adherence. Remote video directly observed theory has been used to assess and in some cases optimize treatment of poorly controlled asthma in children.	Front Public Health. 2022 Oct 5;10:965629. doi: 10.3389/fpubh.2022.965629. PMID: 36276358; PMCID: PMC9581185.

September

Title	Authors	Summary	Reference
Practical approaches to the diagnosis of asthma in school-age children.	Devani P, Lo DKH, Gaillard EA.	This paper outlines an approach for objectively testing and diagnosing asthma in school-age children, and to do so, it considers the challenges currently facing test implementation.	Expert Rev Respir Med. 2022 Sep 22:1-9. doi: 10.1080/17476348.2022.2126355. Epub ahead of print. PMID: 36125212.
Enigma variations: The multi-faceted problems of pre-school wheeze.	Chatziparasidis G, Bush A.	This paper considers how new asthma studies differ from old ones despite the shared goal of helping identify and manage pre-school wheeze.	Pediatr Pulmonol. 2022 Sep;57(9):1990-1997. doi: 10.1002/ppul.26027. Epub 2022 Jun 10. PMID: 35652262.
Exacerbation Profile and Risk Factors in a Type-2-Low Enriched Severe Asthma Cohort: A Clinical Trial to Assess Asthma Exacerbation Phenotypes.	McDowell PJ, Busby J, Hanratty CE, Djukanovic R, Woodcock A, Walker S, Hardman TC, Arron JR, Choy DF, Bradding P, Brightling CE, Chaudhuri R, Cowan D, Mansur AH, Fowler SJ, Diver SE, Howarth P, Lordan J, Menzies-Gow A, Harrison T, Robinson DS, Holweg CTJ, Matthews JG, Pavord ID, Heaney LG.	This paper addresses the mechanisms which underlie T2-low asthma by exploring differences between T2-high and T2-low exacerbation and the physiological changes which accompany it.	Am J Respir Crit Care Med. 2022 Sep 1;206(5):545-553. doi: 10.1164/rccm.202201-0129OC. PMID: 35549845
A practical toolbox for the effective transition of adolescents and young adults with asthma and allergies - an EAACI Position paper.	Vazquez-Ortiz M, Gore C, Alviani C, Angier E, Blumchen K, Comberiati P, Duca B, DunnGalvin A, Garriga-Baraut T, Gowland MH, Egmose B, Knibb R, Khaleva E, Mortz CG, Pfaar O, Pite H, Podesta M, Santos AF, Sanchez-Garcia S, Timmermans F, Roberts G.	This paper reviews the accessible resources designed to support effective transitional care for AYA with asthma and allergies.	Allergy. 2022 Sep 29. doi: 10.1111/all.15533. Epub ahead of print. PMID: 36176045.
Oral corticosteroids in asthma and beyond: moving forward.	Chan JSK, Murray RB, Price D.	This paper considers the history of corticosertoids as a means of treating asthma and other chronic inflammatory conditions.	Eur Respir J. 2022 Sep 15;60(3):2200776. doi: 10.1183/13993003.00776-2022. PMID: 36109044
Case-finding and diagnosis of obstructive airway diseases: the Dragons' Den experience.	Pavord ID.	This paper works to address concerns about the progress made in obstructive airway disease research, which have accumulated over the past two decades as healthcare systems struggle to meet rising costs and other pressures.	Eur Respir J. 2022 Sep 22;60(3):2200679. doi: 10.1183/13993003.00679-2022. PMID: 36137584.
Narrative Review to capture patients' perceptions and opinions about non-response and response to biological therapy for severe asthma.	Coleman C, Khaleva E, Rattu A, Frankemölle B, Nielsen H, Roberts G, Williams C; 3TR respiratory working group.	This paper seeks to gauge how patients dealing with severe asthma perceive biological therapy as a treatment method.	Eur Respir J. 2022 Sep 14:2200837. doi: 10.1183/13993003.00837-2022. Epub ahead of print. PMID: 36104293.
Perceptions on Home-Administration of Biologics in the Context of Severe Asthma: An International Qualitative Study.	Flokstra-de Blok B, Kocks J, Wouters H, Arling C, Chatelier J, Douglass J, Heaney LG, Holmes J, Humbert M, Kolanowski M, Landsman JJA, Lugogo N, Malpass A, Meijer J, Metz B, de Mul B, Postma F, Leving M.	This paper asserts that the positives of using biologics in severe asthma treatment, particularly with regards to home administration, outweigh the negatives.	J Allergy Clin Immunol Pract. 2022 Sep;10(9):2312-2323.e2. doi: 10.1016/j.jaip.2022.04.015. Epub 2022 Apr 27. PMID: 35487370.
Breathing Exercises for Patients with Asthma in Specialist Care: A Multicenter Randomized Clinical Trial.	Andreasson KH, Skou ST, Ulrik CS, Madsen H, Sidenius K, Assing KD, Porsbjerg C, Bloch-Nielsen J, Thomas M, Bodtger U.	This paper investigates the effectiveness of BrEX when treating moderate to severe asthma--particularly as it relates to patients' quality of life.	Ann Am Thorac Soc. 2022 Sep;19(9):1498-1506. doi: 10.1513/AnnalsATS.202111-1228OC. PMID: 35588357; PMCID: PMC9447391
Risk of COVID-19 hospitalizations among school-aged children in Scotland: A national incident cohort study.	Shi T, Pan J, Moore E, Katikireddi SV, Docherty AB, Fenton L, McCowan C, Agrawal U, Kerr S, Shah SA, Stock SJ, Simpson CR, Robertson C, Sheikh A; Public Health Scotland and the EAVE II Collaborators.	Researchers used Early Pandemic Evaluation to undertake a national incident cohort analysis in order to investigate the risk of hospitalization among 5-17 year olds identified as living within risk groups based in Scotland.	J Glob Health. 2022 Sep 23;12:05044. doi: 10.7189/jogh.12.05044. PMID: 36134546; PMCID: PMC9494196.
Biologic therapy practices in severe asthma; outcomes from the UK Severe Asthma Registry and survey of specialist opinion.	Mansur AH, Gonem S, Brown T, Burhan H, Chaudhuri R, Dodd JW, Pantin T, Gore R, Jackson D, Menzies-Gow A, Patel M, Pavord I, Pfeffer P, Siddiqui S, Busby J, Heaney LG; of UK Severe Asthma Registry.	Researchers analyzed the UK Severe Asthma Registry's findings, as well as the accounts of UK severe asthma specialists, to evaluate how varied biologic treatments are undertaken by experts and assessed by patients.	Clin Exp Allergy. 2022 Sep 3. doi: 10.1111/cea.14222. Epub ahead of print. PMID: 36057784.
Experiences of exercise in patients with asthma: a qualitative analysis of discussions in a UK asthma online community.	Sadek Attalla S, Ow NL, McNarry M, De Simoni A.	This paper asserts that engagement with exercise in adults with asthma is suboptimal and sought to explore experiences of exercise.	BJGP Open. 2022 Sep 28;6(3):BJGPO.2021.0162. doi: 10.3399/BJGPO.2021.0162. PMID: 35487580.
Short-acting β₂-agonist prescription patterns for asthma management in the SABINA III primary care cohort.	Price D, Hancock K, Doan J, Taher SW, Muhwa CJ, Farouk H, Beekman MJHI.	"Short-acting β₂-agonist (SABA) prescriptions and associated outcomes were assessed in 1440 patients with asthma [...] Data on asthma medications were collected, and multivariable regression models analysed the association of SABA prescriptions with clinical outcomes."	NPJ Prim Care Respir Med. 2022 Sep 29;32(1):37. doi: 10.1038/s41533-022-00295-7. PMID: 36175556; PMCID: PMC9522811.
What have we learnt from real-life research in asthma and COPD? Standards and novel designs for the future.	Price D, Uthaman T.	This paper reviews the many different data sources and study designs used to undertake real-life asthma research and many of the conclusions derived from this research, including the prevalence of eosinophilic disease in broad and severe asthma.	Respirology. 2022 Sep 29. doi: 10.1111/resp.14381. Epub ahead of print. PMID: 36172950

August

Title	Authors	Summary	Reference
Planning a digital intervention for adolescents with asthma (BREATHE4T): A theory-, evidence- and Person-Based Approach to identify key behavioural issues.	Easton S, Ainsworth B, Thomas M, Latter S, Knibb R, Cook A, Wilding S, Bahrami-Hessari M, Kennington E, Gibson D, Wilkins H, Yardley L, Roberts G.	Researchers undertook a scoping review and semi-structured interviews with target intervention users to accrue their perspectives on digital intervention in asthma treatment.	Pediatr Pulmonol. 2022 Aug 6. doi: 10.1002/ppul.26099. Epub ahead of print. PMID: 35932183.
Delivery of supported self-management in remote asthma reviews: A systematic rapid realist review.	Kinley E, Skene I, Steed E, Pinnock H, McClatchey K.	Researchers aimed to study the context and mechanisms for clinical effectiveness outcomes (including how to deliver self-management support within remote asthma consultations).	Health Expect. 2022 Aug;25(4):1200-1214. doi: 10.1111/hex.13441. Epub 2022 Apr 11. PMID: 35411670; PMCID: PMC9327809.
Dupilumab Is Effective in Patients With Moderate-to-Severe Uncontrolled GINA-Defined Type 2 Asthma Irrespective of an Allergic Asthma Phenotype.	Rabe KF, FitzGerald JM, Bateman ED, Castro M, Pavord ID, Maspero JF, Busse WW, Izuhara K, Daizadeh N, Ortiz B, Pandit-Abid N, Rowe PJ, Deniz Y.	"The Global Initiative for Asthma report recommends consideration of add-on biologics for patients with type 2 inflammation [...] whose asthma cannot be controlled by high-dose inhaled corticosteroids."	J Allergy Clin Immunol Pract. 2022 Aug 23:S2213-2198(22)00651-1. doi: 10.1016/j.jaip.2022.06.036. Epub ahead of print. PMID: 36028446.
Vaccine effectiveness of two-dose BNT162b2 against symptomatic and severe COVID-19 among adolescents in Brazil and Scotland over time: a test-negative case-control study.	Florentino PTV, Millington T, Cerqueira-Silva T, Robertson C, de Araújo Oliveira V, Júnior JBS, Alves FJO, Penna GO, Vital Katikireddi S, Boaventura VS, Werneck GL, Pearce N, McCowan C, Sullivan C, Agrawal U, Grange Z, Ritchie LD, Simpson CR, Sheikh A, Barreto ML, Rudan I, Barral-Netto M, Paixão ES.	Researchers conduced test-negative case-control studies in adolescents with COVID symptoms in both Brazil and Scotland, and connected these to COVID vaccination and text records where applicable. They found that	Lancet Infect Dis. 2022 Aug 8:S1473-3099(22)00451-0. doi: 10.1016/S1473-3099(22)00451-0. Epub ahead of print. PMID: 35952702; PMCID: PMC9359673.
A Pragmatic Primary Practice Approach to Using Specific IgE in Allergy Testing in Asthma Diagnosis, Management, and Referral.	Demoly P, Liu AH, Rodriguez Del Rio P, Pedersen S, Casale TB, Price D.	This paper concludes that "for selected clinical circumstances of patients with asthma, sIgE testing yields quantifiable results for tested allergens that can help guide asthma management in the context of the patient's clinical presentation, age, and relevant allergen exposures."	J Asthma Allergy. 2022 Aug 16;15:1069-1080. doi: 10.2147/JAA.S362588. PMID: 35996427; PMCID: PMC9392458.
Generational perspective on asthma self-management in the Bangladeshi and Pakistani community in the United Kingdom: A qualitative study.	Ahmed S, Pinnock H, Dowrick A, Steed L.	Researchers conducted semi-structured interviews with Bangladeshi and Pakistani asthma patients and analysed the data from these discussions; they discovered significant generational differences and cultural distinctions impacting asthma treatment.	Health Expect. 2022 Aug 23. doi: 10.1111/hex.13579. Epub ahead of print. PMID: 35999685.
Impact of COVID-19 pandemic on asthma exacerbations: Retrospective cohort study of over 500,000 patients in a national English primary care database.	Shah SA, Quint JK, Sheikh A.	Researchers found over 100,000 asthma patients within England have experienced at least one exacerbation episode; the paper also addresses the drop in reported attacks during the months following the first UK lockdown.	Lancet Reg Health Eur. 2022 Aug;19:100428. doi: 10.1016/j.lanepe.2022.100428. Epub 2022 Jun 15. PMID: 35756853; PMCID: PMC9213032.
Asthma control with ICS-formoterol reliever versus maintenance ICS and SABA reliever therapy: a post hoc analysis of two randomised controlled trials.	Hatter L, Houghton C, Bruce P, Holliday M, Eathorne A, Pavord I, Reddel HK, Hancox RJ, Braithwaite I, Oldfield K, Papi A, Weatherall M, Beasley R; Novel START and PRACTICAL study teams.	In a study undertaken by the researchers behind this paper, results indicated no clinically important differences in proportions of patients of 'well-controlled' or 'partially-controlled' asthma symptoms.	BMJ Open Respir Res. 2022 Aug;9(1):e001271. doi: 10.1136/bmjresp-2022-001271. PMID: 36007980; PMCID: PMC9422833.
Asthma exacerbations are associated with a decline in lung function: a longitudinal population-based study.	Soremekun S, Heaney LG, Skinner D, Bulathsinhala L, Carter V, Chaudhry I, Hosseini N, Eleangovan N, Murray R, Tran TN, Emmanuel B, Garcia Gil E, Menzies-Gow A, Peters M, Lugogo N, Jones R, Price DB.	Researchers undertook the largest nationwide study of its kind and suggest their research shows that asthma exacerbation are associated with faster progressive lung function decline.	Thorax. 2022 Aug 3:thoraxjnl-2021-217032. doi: 10.1136/thorax-2021-217032. Epub ahead of print. PMID: 35922128.
Too Little, Too Late: Adult Lung Disease Cannot Be Prevented by Interventions in Adult Life.	Bush A.	This paper outlines many of the positives behind clean air legislation and highlights the vulnerability of young people to tobacco and other lung health risks.	Am J Respir Crit Care Med. 2022 Aug 16. doi: 10.1164/rccm.202208-1537ED. Epub ahead of print. PMID: 35972758.
Sub-stratification of type-2 high airway disease for therapeutic decision-making: A 'bomb' (blood eosinophils) meets 'magnet' (FeNO) framework.	Couillard S, Pavord ID, Heaney LG, Petousi N, Hinks TSC.	"We suggest that these post hoc studies and new comparative studies are urgently needed to test whether sub-stratification of type-2 high airway disease is a valid means to better match patients and biologics and determine whether this stratification allows us to make other clinically useful predictions."	Respirology. 2022 Aug;27(8):573-577. doi: 10.1111/resp.14294. Epub 2022 May 19. PMID: 35591794.
Association of bronchial steroid inducible methylation quantitative trait loci with asthma and chronic obstructive pulmonary disease treatment response.	Slob EMA, Faiz A, van Nijnatten J, Vijverberg SJH, Longo C, Kutlu M, Chew FT, Sio YY, Herrera-Luis E, Espuela-Ortiz A, Perez-Garcia J, Pino-Yanes M, Burchard EG, Potočnik U, Gorenjak M, Palmer C, Maroteau C, Turner S, Verhamme K, Karimi L, Mukhopadhyay S, Timens W, Hiemstra PS, Pijnenburg MW, Neighbors M, Grimbaldeston MA, Tew GW, Brandsma CA, Berce V, Aliee H, Theis F, Sin DD, Li X, van den Berge M, Maitland-van der Zee AH, Koppelman GH.	Researchers used meQTL analysis to identify SNPs that may prove useful in the future, and their work further elucidates the various treatments for asthma in children.	Clin Transl Allergy. 2022 Aug;12(8):e12173. doi: 10.1002/clt2.12173. PMID: 36036237; PMCID: PMC9421427.

July

Title	Authors	Summary	Reference
Asthma and Wheeze Severity and the Oropharyngeal Microbiota in Children and Adolescents.	Thorsen J, Stokholm J, Rasmussen MA, Roggenbuck-Wedemeyer M, Vissing NH, Mortensen MS, Brejnrod AD, Fleming L, Bush A, Roberts G, Singer F, Frey U, Hedlin G, Nordlund B, Murray CS, Abdel-Aziz MI, Hashimoto S, van Aalderen W, Maitland-van der Zee AH, Shaw D, Fowler SJ, Sousa A, Sterk PJ, Chung KF, Adcock IM, Djukanovic R, Auffray C, Bansal AT, Wagers S, Chawes B, Bønnelykke K, Sørensen SJ, Bisgaard H.	"There was a modest difference in the oropharyngeal airway microbiota between children with severe and mild/moderate asthma/wheeze across all children but not in individual age groups, and a strong association between the microbiota and age."	Ann Am Thorac Soc. 2022 Jul 29. doi: 10.1513/AnnalsATS.202110-1152OC. Epub ahead of print. PMID: 35904980.
Treatable traits in the NOVELTY study.	Agustí A, Rapsomaniki E, Beasley R, Hughes R, Müllerová H, Papi A, Pavord ID, van den Berge M, Faner R; NOVELTY Study Investigators.	"We assessed how the presence/absence of specific TTs relate to the diagnosis and severity of 'asthma', 'COPD' or 'asthma + COPD' [...] These results provide the largest and most granular characterization of TTs in patients with airway diseases in a real-world setting to date."	Respirology. 2022 Jul 21. doi: 10.1111/resp.14325. Epub ahead of print. PMID: 35861464.
Telemedicine and virtual respiratory care in the era of COVID-19.	Pinnock H, Murphie P, Vogiatzis I, Poberezhets V.	"The COVID-19 pandemic has resulted in a major change in perceptions of telemedicine. In many situations, remote consulting has been the only safe option."	ERJ Open Res. 2022 Jul 25;8(3):00111-2022. doi: 10.1183/23120541.00111-2022. PMID: 35891622; PMCID: PMC9131135.
Adrenal function recovery after durable OCS-sparing with benralizumab in the PONENTE study.	Menzies-Gow A, Gurnell M, Heaney LG, Corren J, Bel EH, Maspero J, Harrison T, Jackson DJ, Price D, Lugogo N, Kreindler J, Burden A, de Giorgio-Miller A, Faison S, Padilla K, Martin UJ, Garcia Gil E; PONENTE Study Group.	"PONENTE's oral corticosteroid-reduction phase showed that, following benralizumab initiation, 91.5% of patients eliminated corticosteroids or achieved a final dosage ≤5 mg·day⁻¹[...] Outcomes included changes in daily oral corticosteroid dosage, Asthma Control Questionnaire 6 (ACQ-6), and St. George's Respiratory Questionnaire (SGRQ), as well as adrenal status, asthma exacerbations, and adverse events."	Eur Respir J. 2022 Jul 26:2103226. doi: 10.1183/13993003.03226-2021. Epub ahead of print. PMID: 35896216.
Longitudinal changes in sputum and blood inflammatory mediators during FeNO suppression testing.	Couillard S, Shrimanker R, Lemaire-Paquette S, Hynes GM, Borg C, Connolly C, Thulborn SJ, Moran A, Poole S, Morgan S, Powell T, Pavord I, Hinks T.	"Our longitudinal subgroup support the notion that patients with uncontrolled asthma who fail to suppress FeNO despite monitored high-intensity corticosteroid therapy have distinct clinical, biomarker and inflammatory mediator responses which imply biological corticosteroid resistance."	Thorax. 2022 Jul 8: thoraxjnl-2021-217994. doi: 10.1136/thoraxjnl-2021-217994. Epub ahead of print. PMID: 35803725.
Relationship between inflammatory status and microbial composition in severe asthma and during exacerbation.	Diver S, Haldar K, McDowell PJ, Busby J, Mistry V, Micieli C, Brown V, Cox C, Yang F, Borg C, Shrimanker R, Ramsheh MY, Hardman T, Arron J, Bradding P, Cowan D, Mansur AH, Fowler SJ, Lordan J, Menzies-Gow A, Robinson D, Matthews J, Pavord ID, Chaudhuri R, Heaney LG, Barer MR, Brightling C; Medical Research Council: Refractory Asthma Stratification Programme (RASP-UK Consortium).	"High FeNO could indicate a subgroup of severe asthma less likely to benefit from antimicrobial strategies at exacerbation or in the context of poor control [...] We found no evidence that mepolizumab alters airway microbial composition."	Allergy. 2022 Jul 1. doi: 10.1111/all.15425. Epub ahead of print. PMID: 35778780.
An observational study to determine the relationship between cough frequency and markers of inflammation in severe asthma.	Holmes J, McGarvey LP, Birring SS, Fletcher H, Heaney LG.	"Patients with severe asthma and mild/moderate asthma completed validated asthma and cough-related measurement tools (including ambulatory cough monitoring) and measurement of spirometry and T2-biomarkers (fractional exhaled nitric oxide measurement (FeNO) and peripheral blood eosinophil count (PBE))."	Eur Respir J. 2022 Jul 1:2103205. doi: 10.1183/13993003.03205-2021. Epub ahead of print. PMID: 35777770.
Benefits of specialist severe asthma management: demographic and geographic disparities.	Redmond C, Heaney LG, Chaudhuri R, Jackson DJ, Menzies-Gow A, Pfeffer P, Busby J; UK Severe Asthma Registry.	"1,140 patients were followed-up for 1,370 person-years from twelve specialist centres [...] Specialist assessment and management is associated with substantially improved patient outcomes which are broadly consistent across demographic groups, and are not restricted to those receiving biologic therapy."	Eur Respir J. 2022 Jul 1:2200660. doi: 10.1183/13993003.00660-2022. Epub ahead of print. PMID: 35777771.
Corticosteroid Responsiveness Following Mepolizumab in Severe Eosinophilic Asthma-A Randomized, Placebo-Controlled Crossover Trial (MAPLE).	Yang F, Busby J, Heaney LG, Pavord ID, Brightling CE, Borg K, McDowell JP, Diver SE, Shrimanker R, Bradding P, Shepherd M, Chaudhuri R; Medical Research Council: Refractory Asthma Stratification Programme (RASP-UK Consortium).	"OCS improved small-airway obstruction and reduced biomarkers of type 2 inflammation but had no significant effect on symptoms or quality of life in patients with SEA receiving treatment with mepolizumab."	J Allergy Clin Immunol Pract. 2022 Jul 19:S2213-2198(22)00701-2. doi: 10.1016/j.jaip.2022.06.050. Epub ahead of print. PMID: 35863669.
Community-based asthma assessment in young children: adaptations for a multicentre longitudinal study in South Asia.	Islam MS, Huq S, Cunningham S, Schwarze J, Islam ASMDA, Amin M, Raza F, Satpathy R, Rauta PR, Ahmed S, Mahmood H, Fernandes G, Baloch B, Nisar I, Soofi S, Panigrahi P, Juvekar S, Bavkedar A, Baqui AH, Saha S, Campbell H, Sheikh A, Nair H, Saha SK; RESPIRE.	"This study can be seen as a large-scale feasibility assessment of applying spirometry and exercise challenge tests in community settings of LMICs and provides confidence to build capacity to evaluate children’s respiratory outcomes in future translational research studies."	Ther Adv Infect Dis. 2022 Jul 18;9:20499361221103876. doi: 10.1177/20499361221103876. PMID: 35875810; PMCID: PMC9297457.
Efficacy, safety, and tolerability of lebrikizumab in adolescent patients with uncontrolled asthma (ACOUSTICS).	Szefler SJ, Roberts G, Rubin AS, Zielen S, Kuna P, Alpan O, Anzures-Cabrera J, Chen Q, Holweg CTJ, Kaminski J, Putnam WS, Matthews JG, Kamath N.	"Lebrikizumab 125 mg reduced asthma exacerbation rates in adolescents with uncontrolled asthma. However, the study was prematurely terminated (sponsor's decision) potentially limiting interpretation of results."	Clin Transl Allergy. 2022 Jul 14;12(7):e12176. doi: 10.1002/clt2.12176. PMID: 35846226; PMCID: PMC9281483.
Characterisation of the Australian Adult Population Living with Asthma: Severe - Exacerbation Frequency, Long-Term OCS Use and Adverse Effects.	Hancock KL, Bosnic-Anticevich S, Blakey JD, Hew M, Chung LP, Cvetkovski B, Claxton S, Del Fante P, Denton E, Doan J, Ranasinghe K, Morgan L, Sharma A, Smith PK, Stewart D, Thompson PJ, Wiseman R, Upham JW, Yan KY, Carter V, Dhillon K, Heraud F, Le T, Vella R, Price D; OPCA Improving Asthma outcomes in Australia Research Group.	"Based upon prescriptions or diagnostic codes in EMR, 51,307 adults were identified as potentially having asthma or COPD, representing 6.4% of patients in the database. Of these, 27,230 (53%) had no formal diagnosis recorded; however, 7868 were identified as having active asthma and were included in the current study."	Pragmat Obs Res. 2022 Jul 5;13:43-58. doi: 10.2147/POR.S360044. PMID: 35818499; PMCID: PMC9270906.

June

Title	Authors	Summary	Reference
Global, regional, and national prevalence of asthma in 2019: a systematic analysis and modelling study.	Song P, Adeloye D, Salim H, Dos Santos JP, Campbell H, Sheikh A, Rudan I.	"We aimed to provide global estimates of asthma prevalence and cases in 2019 across four main epidemiological case definitions: current wheezing, ever wheezing, current asthma, and ever asthma."	J Glob Health. 2022 Jun 29;12:04052. doi: 10.7189/jogh.12.04052. PMID: 35765786; PMCID: PMC9239324.
Dupilumab efficacy and safety in patients with asthma and blood eosinophils ≥500 cells.	Rabe KF, Pavord ID, Castro M, Wechsler ME, Daizadeh N, Kapoor U, Ortiz B, Radwan A, Johnson RR, Rowe PJ, Deniz Y, Jacob-Nara JA.	"Dupilumab is a fully human VelocImmune®-derived monoclonal antibody that blocks the shared receptor component for interleukin-4 and interleukin-13 (cytokines that are key and central drivers of type 2 inflammation in multiple diseases)."	Eur Respir J. 2022 Jun 23;59(6):2102577. doi: 10.1183/13993003.02577-2021. PMID: 35487538; PMCID: PMC9218240.
Child poverty and health inequalities in the UK: a guide for paediatricians.	Lee AR, Kingdon CC, Davie M, Hawcutt D, Sinha IP.	"In this review, we discuss drivers for family poverty in the UK, and how this leads to poor child health outcomes. We present a framework for healthcare professionals and institutions to consider interventions and strategies relating to socioeconomic health inequalities."	Arch Dis Child. 2022 Jun 9:archdischild-2021-323671. doi: 10.1136/archdischild-2021-323671. Epub ahead of print. PMID: 35680401.
Multi-ancestry genome-wide association study of asthma exacerbations	Herrera-Luis E, Ortega VE, Ampleford EJ, Sio YY, Granell R, de Roos E, Terzikhan N, Vergara EE, Hernandez-Pacheco N, Perez-Garcia J, Martin-Gonzalez E, Lorenzo-Diaz F, Hashimoto S, Brinkman P; U-BIOPRED Study Group, Jorgensen AL, Yan Q, Forno E, Vijverberg SJ, Lethem R, Espuela-Ortiz A, Gorenjak M, Eng C, González-Pérez R, Hernández-Pérez JM, Poza-Guedes P, Sardón O, Corcuera P, Hawkins GA, Marsico A, Bahmer T, Rabe KF, Hansen G, Kopp MV, Rios R, Cruz MJ, González-Barcala FJ, Olaguibel JM, Plaza V, Quirce S, Canino G, Cloutier M, Del Pozo V, Rodriguez-Santana JR, Korta-Murua J, Villar J, Potočnik U, Figueiredo C, Kabesch M, Mukhopadhyay S, Pirmohamed M, Hawcutt DB, Melén E, Palmer CN, Turner S, Maitland-van der Zee AH, von Mutius E, Celedón JC, Brusselle G, Chew FT, Bleecker E, Meyers D, Burchard EG, Pino-Yanes M.	"We aimed to identify common genetic loci associated with asthma exacerbations across diverse populations and to assess their functional role in regulating DNA methylation and gene expression."	Pediatr Allergy Immunol. 2022 Jun;33(6):e13802. doi: 10.1111/pai.13802. PMID: 35754128.
Digital interventions to improve adherence to maintenance medication in asthma.	Chan A, De Simoni A, Wileman V, Holliday L, Newby CJ, Chisari C, Ali S, Zhu N, Padakanti P, Pinprachanan V, Ting V, Griffiths CJ.	"Pooled results showed that patients receiving digital interventions may have increased adherence (mean difference of 14.66 percentage points, 95% confidence interval (CI) 7.74 to 21.57; low‐certainty evidence); this is likely to be clinically significant in those with poor baseline medication adherence."	Cochrane Database Syst Rev. 2022 Jun 13;6(6):CD013030. doi: 10.1002/14651858.CD013030.pub2. PMID: 35691614; PMCID: PMC9188849.
Evolution of Eczema, Wheeze and Rhinitis fromInfancy to Early Adulthood: Four Birth Cohort Studies	Haider S, Fontanella S, Ullah A, Turner S, Simpson A, Roberts G, Murray CS, Holloway JW, Curtin JA, Cullinan P, Arshad SH, Hurault G, Granell R, Custovic A; STELAR/UNICORN11 investigators.	"We used logistic regression to ascertain if early-life eczema or wheeze, or genetic factors (filaggrin mutations and 17q21 variants), increase the risk of multimorbidity."	Am J Respir Crit Care Med. 2022 Jun 9. doi: 10.1164/rccm.202110-2418OC. Epub ahead of print. PMID: 35679320.
Biologics in severe asthma: the role of real-world evidence from registries	Paoletti G, Pepys J, Casini M, Di Bona D, Heffler E, Goh CYY, Price DB, Canonica GW.	"Understanding the actual effectiveness of the specific drugs in real-life patients is a crucial part of tailoring the right drugs to the right patients."	Eur Respir Rev. 2022 Jun 7;31(164):210278. doi: 10.1183/16000617.0278-2021. PMID: 35675922.
A Response to: Letter to the Editor Regarding "Clinical Remission in Severe Asthma: A Pooled Post Hoc Analysis of the Patient"	Menzies-Gow A, Hoyte FL, Price DB, Cohen D, Barker P, Kreindler J, Jison M, Brooks CL, Papeleu P, Katial R.	"it is critical for experts in the field to develop a widely accepted and rigorously validated consensus definition of clinical remission in severe asthma in the near future. Nevertheless, in the absence of such a validated consensus definition, we believe that post hoc analyses of prior clinical trials in severe asthma will help to advance the notion of clinical remission by stimulating conversations about remission among experts in the field."	Journey with Benralizumab. Adv Ther. 2022 Aug;39(8):3862-3865. doi: 10.1007/s12325-022-02214-1. Epub 2022 Jun 22. PMID: 35731339; PMCID: PMC9309141.
Application of Machine Learning Algorithms for Asthma Management with mHealth: A Clinical Review	Tsang KCH, Pinnock H, Wilson AM, Shah SA.	"We searched PubMed for peer-reviewed studies that applied machine learning to data derived from mHealth for asthma management in the last five years. We selected studies that included some human data other than routinely collected in primary care and used at least one machine learning algorithm."	J Asthma Allergy. 2022 Jun 29; 15:855-873. doi: 10.2147/JAA.S285742. PMID: 35791395; PMCID: PMC9250768.

May

Title	Authors	Reference
Real-world efficacy of treatment with benralizumab, dupilumab, mepolizumab and reslizumab for severe asthma: A systematic review and meta-analysis.	Charles D, Shanley J, Temple SN, Rattu A, Khaleva E, Roberts G.	Clin Exp Allergy. 2022 May;52(5):616-627. doi: 10.1111/cea.14112. Epub 2022 Mar 9. PMID: 35174566.
Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis.	Vlieg-Boerstra B, de Jong N, Meyer R, Agostoni C, De Cosmi V, Grimshaw K, Milani GP, Muraro A, Oude Elberink H, Pali-Schöll I, Roduit C, Sasaki M, Skypala I, Sokolowska M, van Splunter M, Untersmayr E, Venter C, O'Mahony L, Nwaru BI.	Allergy. 2022 May;77(5):1373-1388. doi: 10.1111/all.15136. Epub 2021 Oct 27. PMID: 34626488.
Socioeconomic disparities in asthma health care utilization, exacerbations, and mortality: A systematic review and meta-analysis.	Redmond C, Akinoso-Imran AQ, Heaney LG, Sheikh A, Kee F, Busby J.	J Allergy Clin Immunol. 2022 May;149(5):1617-1627. doi: 10.1016/j.jaci.2021.10.007. Epub 2021 Oct 18. PMID: 34673047.
Exacerbation Profile and Risk Factors in a T2-Low Severe Asthma Population.	McDowell PJ, Busby J, Hanratty CE, Djukanovic R, Woodcock A, Walker S, Hardman TC, Arron JR, Choy DF, Bradding P, Brightling CE, Chaudhuri R, Cowan D, Mansur AH, Fowler SJ, Diver SE, Howarth P, Lordan J, Menzies-Gow A, Harrison T, Robinson DS, Holweg CTJ, Matthews JG, Pavord ID, Heaney LG; investigators for the MRC Refractory Asthma Stratification Program.	Am J Respir Crit Care Med. 2022 May 12. doi: 10.1164/rccm.202201-0129OC. Epub ahead of print. PMID: 35549845.
Vitamin D replacement in children with acute wheeze: a dose-escalation study.	Stefanidis C, Bush A, Newby C, Nwokoro C, Liebeschuetz S, Skene IP, Griffiths CJ, Martineau AR.	ERJ Open Res. 2022 May 16;8(2):00609-2021. doi: 10.1183/23120541.00609-2021. PMID: 35586451; PMCID: PMC9108968.
Clinical Remission in Severe Asthma: A Pooled Post Hoc Analysis of the Patient Journey with Benralizumab.	Menzies-Gow A, Hoyte FL, Price DB, Cohen D, Barker P, Kreindler J, Jison M, Brooks CL, Papeleu P, Katial R.	Adv Ther. 2022 May;39(5):2065-2084. doi: 10.1007/s12325-022-02098-1. Epub 2022 Mar 14. PMID: 35287231; PMCID: PMC9056458.
Understanding Online and Offline Social Networks in Illness Management of Older Patients With Asthma and Chronic Obstructive Pulmonary Disease: Mixed Methods Study Using Quantitative Social Network Assessment and Qualitative Analysis.	Andreou A, Dhand A, Vassilev I, Griffiths C, Panzarasa P, De Simoni A.	JMIR Form Res. 2022 May 17;6(5):e35244. doi: 10.2196/35244. PMID: 35579933; PMCID: PMC9157321.
Experiences and behaviours of patients with asthma requesting prescriptions from primary care during medication shortages linked to the COVID-19-lockdown: insights from a qualitative analysis of a UK asthma online community.	Ow NL, Sadek Attalla S, Davies G, Griffiths C, De Simoni A.	BJGP Open. 2022 May 30:BJGPO.2021.0222. doi: 10.3399/BJGPO.2021.0222. Epub ahead of print. PMID: 35640963.
Breathing Exercises for Asthma Patients in Specialist Care: A Multicenter Randomized Trial.	Andreasson KH, Skou ST, Ulrik CS, Madsen H, Sidenius K, Assing KD, Porsbjerg C, Bloch-Nielsen J, Thomas M, Bodtger U.	Ann Am Thorac Soc. 2022 May 19. doi: 10.1513/AnnalsATS.202111-1228OC. Epub ahead of print. PMID: 35588357.
Electronic Inhaler Monitoring for Chronic Airway Disease: Development and Application of a Multidimensional Efficacy Framework.	Tay TR, van Boven JFM, Chan A, Hew M.	J Allergy Clin Immunol Pract. 2022 May;10(5):1189-1201.e1. doi: 10.1016/j.jaip.2021.11.027. Epub 2021 Dec 13. PMID: 34915225.
Global Variability in Administrative Approval Prescription Criteria for Biologic Therapy in Severe Asthma.	Porsbjerg CM, Menzies-Gow AN, Tran TN, Murray RB, Unni B, Audrey Ang SL, Alacqua M, Al-Ahmad M, Al-Lehebi R, Altraja A, Belevskiy AS, Björnsdóttir US, Bourdin A, Busby J, Canonica GW, Christoff GC, Cosio BG, Costello RW, FitzGerald JM, Fonseca JA, Hansen S, Heaney LG, Heffler E, Hew M, Iwanaga T, Jackson DJ, Kocks JWH, Kallieri M, Bruce Ko HK, Koh MS, Larenas-Linnemann D, Lehtimäki LA, Loukides S, Lugogo N, Maspero J, Papaioannou AI, Perez-de-Llano L, Pitrez PM, Popov TA, Rasmussen LM, Rhee CK, Sadatsafavi M, Schmid J, Siddiqui S, Taillé C, Taube C, Torres-Duque CA, Ulrik C, Upham JW, Wang E, Wechsler ME, Bulathsinhala L, Carter V, Chaudhry I, Eleangovan N, Hosseini N, Rowlands MA, Price DB, van Boven JFM.	J Allergy Clin Immunol Pract. 2022 May;10(5):1202-1216.e23. doi: 10.1016/j.jaip.2021.12.027. Epub 2022 Jan 3. PMID: 34990866.
Airway remodelling rather than cellular infiltration characterizes both type2 cytokine biomarker-high and -low severe asthma.	Khalfaoui L, Symon FA, Couillard S, Hargadon B, Chaudhuri R, Bicknell S, Mansur AH, Shrimanker R, Hinks TSC, Pavord ID, Fowler SJ, Brown V, McGarvey LP, Heaney LG, Austin CD, Howarth PH, Arron JR, Choy DF, Bradding P.	Allergy. 2022 May 17. doi: 10.1111/all.15376. Epub ahead of print. PMID: 35579040. 10.3310/HLZE0479. PMID: 35639493.
Engaging stakeholders and communities to improve respiratory health in Asia.	Jackson T, Williams S, Fernandes G.	J Glob Health. 2022 May 7;12:01001. doi: 10.7189/jogh.12.01001. PMID: 35524773; PMCID: PMC9078154.
Evaluation of sputum eosinophil count as a predictor of treatment response to mepolizumab.	Pavord ID, Buhl R, Kraft M, Prazma CM, Price RG, Howarth PH, Yancey SW.	ERJ Open Res. 2022 May 3;8(2):00560-2021. doi: 10.1183/23120541.00560-2021. PMID: 35509441; PMCID: PMC9062111.
The effects of social distancing and self-isolation during the COVID-19 pandemic on adults diagnosed with asthma: A qualitative study.	Tyson L, Hardeman W, Stratton G, Wilson AM, Semlyen J.	J Health Psychol. 2022 May;27(6):1408-1420. doi: 10.1177/13591053211012766. Epub 2021 May 4. PMID:33947267; PMCID: PMC9036148.
Sub-stratification of type-2 high airway disease for therapeutic decision-making: A 'bomb' (blood eosinophils) meets 'magnet' (FeNO) framework.	Couillard S, Pavord ID, Heaney LG, Petousi N, Hinks TSC.	Respirology. 2022 May 19. doi: 10.1111/resp.14294. Epub ahead of print. PMID: 35591794.

April

Title	Authors	Reference
Should we apply a treatable traits approach to asthma care?	Melhorn J, Howell I, Pavord ID.	Ann Allergy Asthma Immunol. 2022 Apr;128(4):390-397. doi:10.1016/j.anai.2022.02.005. Epub 2022 Feb 13. PMID: 35172180.
Objective and Subjective Measurement of Cough in Asthma: A Systematic Review of the Literature.	Holmes J, Heaney LG, McGarvey LPA.	Lung. 2022 Apr;200(2):169-178. doi: 10.1007/s00408-022-00527-0. Epub 2022 Apr 13. PMID: 35416544; PMCID: PMC9038879.
Level of education and asthma control in adult-onset asthma.	Ilmarinen P, Stridsman C, Bashir M, Tuomisto LE, Vähätalo I, Goksör E, Kankaanranta H, Backman H, Langhammer A, Piirilä P, Rönmark E, Lundbäck B, Nwaru BI, Wennergren G.	J Asthma. 2022 Apr;59(4):840-849. doi: 10.1080/02770903.2021.1871742. Epub 2021 Mar 10. PMID: 33497270.
Pharmacogenomics and asthma treatment: acceptability to children, families and healthcare professionals.	Parry CM, Seddon G, Rogers N, Sinha IP, Bracken L, King C, Peak M, Hawcutt DB.	Arch Dis Child. 2022 Apr;107(4):394-399. doi: 10.1136/archdischild-2021-322396. Epub 2022 Jan 24. PMID: 35074833.
Vitamin D replacement in children with acute wheeze: a dose-escalation study.	Stefanidis C, Bush A, Newby C, Nwokoro C, Liebeschuetz S, Skene IP, Griffiths CJ, Martineau AR.	ERJ Open Res. 2022 May 16;8(2):00609-2021. doi: 10.1183/23120541.00609-2021. PMID: 35586451; PMCID: PMC9108968.
Perceptions of adolescents and young adults with allergy and/or asthma and their parents on EAACI guideline recommendations about transitional care: A European survey.	Khaleva E, Knibb R, DunnGalvin A, Vazquez-Ortiz M, Comberiati P, Alviani C, Garriga-Baraut T, Gowland MH, Gore C, Angier E, Blumchen K, Duca B, Hox V, Jensen B, Mortz CG, Pite H, Pfaar O, Santos AF, Sanchez-Garcia S, Timmermans F, Roberts G.	Allergy. 2022 Apr;77(4):1094-1104. doi: 10.1111/all.15109. Epub 2021 Nov 1. PMID: 34564855.
Perceptions on Home- Administration of Biologics in the Context of Severe Asthma: An International Qualitative Study.	Flokstra-de Blok B, Kocks J, Wouters H, Arling C, Chatelier J, Douglass J, Heaney LG, Holmes J, Humbert M, Kolanowski M, Landsman JJA, Lugogo N, Malpass A, Meijer J, Metz B, de Mul B, Postma F, Leving M.	J Allergy Clin Immunol Pract. 2022 Apr 27:S2213-2198(22)00363-4. doi: 10.1016/j.jaip.2022.04.015. Epub ahead of print. PMID: 35487370.
Clinical and transcriptomic features of persistent exacerbation-prone severe asthma in U-BIOPRED cohort.	Hoda U, Pavlidis S, Bansal AT, Takahashi K, Hu S, Ng Kee Kwong F, Rossios C, Sun K, Bhavsar P, Loza M, Baribaud F, Chanez P, Fowler SJ, Horvath I, Montuschi P, Singer F, Musial J, Dahlen B, Krug N, Sandstrom T, Shaw DE, Lutter R, Fleming LJ, Howarth PH, Caruso M, Sousa AR, Corfield J, Auffray C, De Meulder B, Lefaudeux D, Dahlen SE, Djukanovic R, Sterk PJ, Guo Y, Adcock IM, Chung KF; U-BIOPRED study group.	Clin Transl Med. 2022 Apr;12(4):e816. doi: 10.1002/ctm2.816. PMID: 35474304; PMCID: PMC9043117.
Airway inflammation in severe asthmatics with acid gastro-oesophageal reflux.	Tanner N, Saglani S, Li AM, Bush A, Fleming L.	Thorax. 2022 Apr;77(4):398-399. doi: 10.1136/thoraxjnl-2020-216304. Epub 2021 Sep 8. PMID: 34497139.
Blood eosinophils, fractional exhaled nitric oxide and the risk of asthma attacks in randomised controlled trials: protocol for a systemic review and control arm patient-level meta-analysis for clinical prediction modelling.	Couillard S, Steyerberg E, Beasley R, Pavord I.	BMJ Open. 2022 Apr 1;12(4):e058215. doi: 10.1136/bmjopen-2021-058215. PMID: 35365539; PMCID: PMC8977743.
Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children.	Van Meel ER, Mensink-Bout SM, den Dekker HT, Ahluwalia TS, Annesi-Maesano I, Arshad SH, Baïz N, Barros H, von Berg A, Bisgaard H, Bønnelykke K, Carlsson CJ, Casas M, Chatzi L, Chevrier C, Dalmeijer G, Dezateux C, Duchen K, Eggesbø M, van der Ent C, Fantini M, Flexeder C, Frey U, Forastiere F, Gehring U, Gori D, Granell R, Griffiths LJ, Inskip H, Jerzynska J, Karvonen AM, Keil T, Kelleher C, Kogevinas M, Koppen G, Kuehni CE, Lambrechts N, Lau S, Lehmann I, Ludvigsson J, Magnus MC, Mélen E, Mehegan J, Mommers M, Andersen AN, Nystad W, Pedersen ESL, Pekkanen J, Peltola V, Pike KC, de Moira AP, Pizzi C, Polanska K, Popovic M, Porta D, Roberts G, Santos AC, Schultz ES, Standl M, Sunyer J, Thijs C, Toivonen L, Uphoff E, Usemann J, Vafeidi M, Wright J, de Jongste JC, Jaddoe VWV, Duijts L.	Eur Respir J. 2022 Apr 29:2102395. doi: 10.1183/13993003.02395-2021. Epub ahead of print. PMID: 35487537.
Delivery of supported self-management in remote asthma reviews: A systematic rapid realist review.	Kinley E, Skene I, Steed E, Pinnock H, McClatchey K.	Health Expect. 2022 Apr 11. doi: 10.1111/hex.13441. Epub ahead of print. PMID: 35411670.
Risk of serious COVID-19 outcomes among adults with asthma in Scotland: a national incident cohort study.	Shi T, Pan J, Vasileiou E, Robertson C, Sheikh A; Public Health Scotland and the EAVE II Collaborators.	Lancet Respir Med. 2022 Apr;10(4):347-354. doi: 10.1016/S2213-2600(21)00543-9. Epub 2022 Jan 13. PMID: 35033224; PMCID: PMC8758152.
The effect of the COVID-19 pandemic on severe asthma care in Europe: will care change for good?	Eger K, Paroczai D, Bacon A, Schleich F, Sergejeva S, Bourdin A, Vachier I, Zervas E, Katsoulis K, Papapetrou D, Kostikas K, Csoma Z, Heffler E, Canonica GW, Grisle I, Bieksiene K, Palacionyte J, Ten Brinke A, Hashimoto S, Smeenk FWJM, Braunstahl GJ, van der Sar S, Mihălţan F, Nenasheva N, Peredelskaya M, Zvezdin B, Čekerevac I, Hromiš S, Ćupurdija V, Lazic Z, Milenkovic B, Dimic- Janjic S, Yasinska V, Dahlén B, Bossios A, Lazarinis N, Aronsson D, Egesten A, Munir AKM, Ahlbeck L, Janson C, Škrgat S, Edelbaher N, Leuppi J, Jaun F, Rüdiger J, Pavlov N, Gianella P, Fischer R, Charbonnier F, Chaudhuri R, Smith SJ, Doe S, Fawdon M, Masoli M, Heaney L, Haitchi HM, Kurukulaaratchy R, Fulton O, Frankemölle B, Gibson T, Needham K, Howarth P, Djukanovic R, Bel E, Hyland M.	ERJ Open Res. 2022 May 16;8(2):00065-2022. doi: 10.1183/23120541.00065-2022. PMID: 35582679; PMCID: PMC8994963.
Reply to "Ethnicity-based differences in asthma diagnostic thresholds".	Busby J, Heaney LG, Pfeffer PE; UK Severe Asthma Registry.	J Allergy Clin Immunol Pract. 2022 Apr;10(4):1124-1125. doi: 10.1016/j.jaip.2022.01.027. PMID: 35397811.
Factors affecting adherence with treatment advice in a clinical trial of patients with severe asthma.	Busby J, Matthews JG, Chaudhuri R, Pavord ID, Hardman TC, Arron JR, Bradding P, Brightling CE, Choy DF, Cowan DC, Djukanovic R, Hanratty CE, Harrison TW, Holweg CT, Howarth PH, Fowler SJ, Lordan JL, Mansur AH, Menzies-Gow A, Niven RM, Robinson DS, Walker SM, Woodcock A, Heaney LG; investigators for the MRC Refractory Asthma Stratification Programme.	Eur Respir J. 2021 Sep 24;59(4):2100768. doi: 10.1183/13993003.00768-2021. PMID: 34561291.
Experiences of exercise in patients with asthma: qualitative analysis of discussions in a UK asthma online community.	Sadek Attalla S, Ow NL, McNarry M, De Simoni A.	BJGP Open. 2022 Apr 29:BJGPO.2021.0162. doi: 10.3399/BJGPO.2021.0162. Epub ahead of print. PMID: 35487580.
Features of successful interventions to improve adherence to inhaled corticosteroids in children with asthma: A narrative systematic review.	Pearce CJ, Chan AHY, Jackson T, Fleming L, Foot H, Bush A, Horne R.	Pediatr Pulmonol. 2022 Apr;57(4):822-847. doi: 10.1002/ppul.25838. Epub 2022 Feb 21. PMID: 35064651.
Developing a theoretically informed education programme within the context of a complex implementation strategy in UK primary care: an exemplar from the IMP<sup>2</sup>ART trial.	McClatchey K, Marsh V, Steed L, Holmes S, Taylor SJC, Wiener-Ogilvie S, Neal J, Last R, Saxon A, Pinnock H; IMP2ART Programme Group.	Trials. 2022 Apr 23;23(1):350. doi: 10.1186/s13063-022-06147-6. PMID: 35461269; PMCID: PMC9034072.
Reply to Baraldi and Piacentini: Global Initiative for Asthma 2021: Asthma in Preschool Children and Short-Acting β<sub>2</sub>-Agonist-Only Treatment.	Duijts L, Fleming LJ, Bacharier LB, Pitrez PM, Reddel HK.	Am J Respir Crit Care Med. 2022 Apr 15;205(8):972-973. doi: 10.1164/rccm.202112-2788LE. PMID: 35202561.
ERS International Congress 2021: highlights from the Respiratory Clinical Care and Physiology Assembly.	Gille T, Sivapalan P, Kaltsakas G, Kolekar SB, Armstrong M, Tuffnell R, Evans RA, Vagheggini G, Degani-Costa LH, Vicente C, Das N, Poberezhets V, Rolland-Debord C, Bayat S, Vogiatzis I, Franssen FME, Pinnock H, Vanfleteren LEGW.	ERJ Open Res. 2022 May 23;8(2):00710-2021. doi: 10.1183/23120541.00710-2021. PMID: 35615417; PMCID: PMC9125042.

March

Title	Authors	Reference
COVID-19 and delivery of difficult asthma services.	Nichols AL, Sonnappa-Naik M, Gardner L, Richardson C, Orr N, Jamalzadeh A, Moore-Crouch R, Makhecha S, Wells C, Hall P, Bush A, Fleming L, Saglani S, Sonnappa S.	Arch Dis Child. 2022 Mar;107(3):e15. doi: 10.1136/archdischild-2021-322335. Epub 2021 Nov 2. PMID: 34728462.
Asthma remission- what is it and how can it be achieved?	Thomas D, McDonald VM, Pavord ID, Gibson PG.	Eur Respir J. 2022 Mar 31:2102583. doi: 10.1183/13993003.02583-2021. Epub ahead of print. PMID: 35361633.
Qualitative study on perceptions of use of Fractional Exhaled Nitric Oxide (FeNO) in asthma reviews.	Santillo M, Ainsworth B, Van Velthoven MH, Yardley L, Thomas M, Wang K, Tonkin-Crine S.	NPJ Prim Care Respir Med. 2022 Mar 21;32(1):13. doi: 10.1038/s41533-022-00272-0. PMID: 35314710.
Effect of electronic adherence monitoring on adherence and outcomes in chronic conditions: A systematic review and meta-analysis.	Chan AHY, Foot H, Pearce CJ, Horne R, Foster JM, Harrison J.	PLoS One. 2022 Mar 21;17(3):e0265715. doi: 10.1371/journal.pone.0265715. PMID: 35312704; PMCID: PMC8936478.
Fluticasone furoate: CAPTAIN of fluticasones in type 2 inflammatory asthma.	Couillard S, Pavord ID.	Respirology. 2022 Mar;27(3):184-186. doi: 10.1111/resp.14213. Epub 2022 Feb 1. PMID: 35104914.
Issues affecting young people with asthma through the transition period to adult care.	Robinson PD, Jayasuriya G, Haggie S, Uluer AZ, Gaffin JM, Fleming L.	Paediatr Respir Rev. 2022 Mar;41:30-39. doi: 10.1016/j.prrv.2021.09.005. Epub 2021 Sep 21. PMID: 34686436.
Relationship between asthma and severe COVID-19: a national cohort study.	Dolby T, Nafilyan V, Morgan A, Kallis C, Sheikh A, Quint JK.	Thorax. 2022 Mar 30:thoraxjnl-2021-218629. doi: 10.1136/thoraxjnl-2021-218629. Epub ahead of print. PMID: 35354646.
The utility of a standardised breath sampler in school age children within a real- world prospective study.	Bhavra KK, Wilde M, Richardson M, Cordell R, Thomas P, Zhao B, Bryant L, Brightling CE, Ibrahim W, Salman D, Siddiqui S, Monks P, Gaillard EA.	J Breath Res. 2022 Mar 3;16(2). doi: 10.1088/1752-7163/ac5526. PMID: 35168217.
Sputum biomarkers during acute severe asthma attacks in children-a case-control study.	Ramphul M, Welsh KG, May RD, Ghebre MA, Rapley L, Cohen ES, Herath A, Monteiro W, Rousseau K, Thornton DJ, Brightling CE, Gaillard EA.	Acta Paediatr. 2022 Mar;111(3):620-627. doi: 10.1111/apa.16186. Epub 2021 Dec 2. PMID: 34773288.
Reply to: Challenging the paradigm.	Bush A, Pavord ID.	Breathe (Sheff). 2022 Mar;18(1):210174. doi: 10.1183/20734735.0174-2021. Epub 2021 Mar 8. PMID: 35284016; PMCID: PMC8908864.
School-based self-management intervention using theatre to improve asthma control in adolescents: a pilot cluster-randomised controlled trial.	Harris K, Newby C, Mosler G, Steed L, Griffiths C, Grigg J.	Pilot Feasibility Stud. 2022 Mar 23;8(1):67. doi: 10.1186/s40814-022-01031-1. PMID: 35321754; PMCID: PMC8941818.
Reply to "'Nothing about us without us' - What matters to patients with severe asthma?".	Upham JW, Le Lievre C, Jackson DJ, Masoli M, Wechsler ME, Price DB.	J Allergy Clin Immunol Pract. 2022 Mar;10(3):891. doi: 10.1016/j.jaip.2021.12.036. PMID: 352727

February

Title	Authors	Reference
Socioeconomic inequalities in asthma and respiratory symptoms in a high-income country: changes from 1996 to 2016. J Asthma.	Schyllert C, Lindberg A, Hedman L, Stridsman C, Andersson M, Andersén H, Piirilä P, Nwaru BI, Krokstad S, Rönmark E, Backman H.	2022 Feb 17:1-10. doi: 10.1080/02770903.2022.2039937. Epub ahead of print. PMID: 35167415.
A clinical review of long- COVID with a focus on the respiratory system.	Daines L, Zheng B, Pfeffer P, Hurst JR, Sheikh A.	Curr Opin Pulm Med. 2022 Feb 7. doi: 10.1097/MCP.0000000000000863. Epub ahead of print. PMID: 35131989.
European Respiratory Society Guidelines for the Diagnosis of Asthma in Adults.	Louis R, Satia I, Ojanguren I, Schleich F, Bonini M, Tonia T, Rigau D, Ten Brinke A, Buhl R, Loukides S, Kocks JWH, Boulet LP, Bourdin A, Coleman C, Needham K, Thomas M, Idzko M, Papi A, Porsbjerg C, Schuermans D, Soriano JB, Usmani OS.	Eur Respir J. 2022 Feb 15:2101585. doi: 10.1183/13993003.01585-2021. Epub ahead of print. PMID: 35169025.
The utility of a standardised breath sampler in school age children within a real-world prospective study.	Bhavra K, Wilde M, Richardson M, Cordell R, Thomas CLP, Zhao B, Bryant L, Brightling CE, Ibrahim W, Salman D, Siddiqui S, Monks P, Gaillard E.	J Breath Res. 2022 Feb 15. doi: 10.1088/1752-7163/ac5526. Epub ahead of print. PMID: 35168217.
Effective Management of Severe Asthma with Biologic Medications in Adult Patients: A Literature Review and International Expert Opinion.	Buhl R, Bel E, Bourdin A, Dávila I, Douglass JA, FitzGerald JM, Jackson DJ, Lugogo NL, Matucci A, Pavord ID, Wechsler ME, Kraft M.	J Allergy Clin Immunol Pract. 2022 Feb;10(2):422-432. doi: 10.1016/j.jaip.2021.10.059. Epub 2021 Nov 8. PMID: 34763123.
Real-World Efficacy of Treatment with Benralizumab, Dupilumab, Mepolizumab and Reslizumab for Severe Asthma: A Systematic Review and Meta-analysis.	Charles D, Shanley J, Temple SN, Rattu A, Khaleva E, Roberts G.	Clin Exp Allergy. 2022 Feb 16. doi: 10.1111/cea.14112. Epub ahead of print. PMID: 35174566.
A feasibility trial of a digital mindfulness-based intervention to improve asthma-related quality of life for primary care patients with asthma.	Ainsworth B, Stanescu S, Stuart B, Russell D, Liddiard M, Djukanovic R, Thomas M.	J Behav Med. 2022 Feb;45(1):133-147. doi: 10.1007/s10865-021-00249-3. Epub 2021 Aug 27. PMID: 34448986; PMCID: PMC8818629.
Insights into how Malaysian adults with limited health literacy self-manage and live with asthma: A Photovoice qualitative study.	Salim H, Young I, Lee PY, Shariff-Ghazali S, Pinnock H; RESPIRE collaboration.	Health Expect. 2022 Feb;25(1):163-176. doi: 10.1111/hex.13360. Epub 2021 Sep 12. PMID: 34514689; PMCID: PMC8849262.
Microbiome-immune interactions and relationship to asthma severity.	Trujillo J, Lunjani N, Ryan D, O'Mahony L.	J Allergy Clin Immunol. 2022 Feb;149(2):533-534. doi: 10.1016/j.jaci.2021.12.774. Epub 2021 Dec 23. PMID: 34953788.
Ethnic Differences in Severe Asthma Clinical Care and Outcomes: An Analysis of United Kingdom Primary and Specialist Care.	Busby J, Heaney LG, Brown T, Chaudhuri R, Dennison P, Gore R, Jackson DJ, Mansur AH, Menzies-Gow A, Message S, Niven R, Patel M, Price D, Siddiqui S, Stone R, Pfeffer PE; UK Severe Asthma Registry.	J Allergy Clin Immunol Pract. 2022 Feb;10(2):495-505.e2. doi: 10.1016/j.jaip.2021.09.034. Epub 2021 Oct 7. PMID: 34626858.
Stakeholders' views of supporting asthma management in schools with a school-based asthma programme for primary school children: a qualitative study in Malaysia.	Ramdzan SN, Khoo EM, Liew SM, Cunningham S, Pinnock H; RESPIRE collaborators.	BMJ Open. 2022 Feb 7;12(2):e052058. doi: 10.1136/bmjopen-2021-052058. PMID: 35131821; PMCID: PMC8823135.
Establishing consensus on key elements and implementation enablers of community-based pain programs to support primary health network decision making: an eDelphi study.	Walker P, De Morgan S, Wilson A, Blyth FM.	Aust J Prim Health. 2022 Feb;28(1):56-62. doi: 10.1071/PY21145. PMID: 34911617.
Determinants of pre-vaccination antibody responses to SARS-CoV-2: a population-based longitudinal study (COVIDENCE UK).	Talaei M, Faustini S, Holt H, Jolliffe DA, Vivaldi G, Greenig M, Perdek N, Maltby S, Bigogno CM, Symons J, Davies GA, Lyons RA, Griffiths CJ, Kee F, Sheikh A, Richter AG, Shaheen SO, Martineau AR.	BMC Med. 2022 Feb 22;20(1):87. doi: 10.1186/s12916-022-02286-4. PMID: 35189888; PMCID: PMC8860623.
Fluticasone furoate: CAPTAIN of fluticasones in type 2 inflammatory asthma.	Couillard S, Pavord ID.	Respirology. 2022 Mar;27(3):184-186. doi: 10.1111/resp.14213. Epub 2022 Feb 1. PMID: 35104914.
Risk of COVID-19 hospital admission among children aged 5-17 years with asthma in Scotland: a national incident cohort study.	Shi T, Pan J, Katikireddi SV, McCowan C, Kerr S, Agrawal U, Shah SA, Simpson CR, Ritchie LD, Robertson C, Sheikh A; Public Health Scotland and the EAVE II Collaborators.	Lancet Respir Med. 2022 Feb;10(2):191-198. doi: 10.1016/S2213-2600(21)00491-4. Epub 2021 Nov 30. PMID: 34861180; PMCID: PMC8631918.
Derivation of a prototype asthma attack risk scale centred on blood eosinophils and exhaled nitric oxide.	Couillard S, Laugerud A, Jabeen M, Ramakrishnan S, Melhorn J, Hinks T, Pavord I.	Thorax. 2022 Feb;77(2):199-202. doi: 10.1136/thoraxjnl-2021-217325. Epub 2021 Aug 6. PMID: 34362839; PMCID: PMC8762000.
Risk of COVID-19 hospital admission among children with asthma.	Harwood R, Sinha IP.	Lancet Respir Med. 2022 Feb;10(2):128-130. doi: 10.1016/S2213-2600(21)00509-9. Epub 2021 Nov 30. PMID: 34861181; PMCID: PMC8631801.
Key considerations when involving children in health intervention design: reflections on working in partnership with South Asian children in the UK on a tailored Management and Intervention for Asthma (MIA) study.	Nixon LS, Hudson N, Culley L, Lakhanpaul M, Robertson N, Johnson MRD, McFeeters M, Johal N, Hamlyn-Williams C, Boo YY, Lakhanpaul M.	Res Involv Engagem. 2022 Feb 28;8(1):9. doi: 10.1186/s40900-022-00342-0. PMID: 35227322.
Early life inter-kingdom interactions shape the immunological environment of the airways.	Pattaroni C, Macowan M, Chatzis R, Daunt C, Custovic A, Shields MD, Power UF, Grigg J, Roberts G, Ghazal P, Schwarze J, Gore M, Turner S, Bush A, Saglani S, Lloyd CM, Marsland BJ.	Microbiome. 2022 Feb 21;10(1):34. doi: 10.1186/s40168-021-01201-y. PMID: 35189979; PMCID: PMC8862481.
Reply to: GINA 2021: Asthma in Pre-School Children and SABA-Only Treatment.	Duijts L, Fleming LJ, Bacharier LB, Pitrez PM, Reddel HK; authors of "Global Initiative for Asthma (GINA) Strategy 2021 – Executive summary and rationale for key changes"..	Am J Respir Crit Care Med. 2022 Feb 24. doi: 10.1164/rccm.202112-2788LE. Epub ahead of print. PMID: 35202561.
Comparison of epidemiologic surveillance and Google Trends data on asthma and allergic rhinitis in England.	Sousa-Pinto B, Antó JM, Sheikh A, de Lusignan S, Haahtela T, Fonseca JA, Bousquet J.	Allergy. 2022 Feb;77(2):675-678. doi: 10.1111/all.15139. Epub 2021 Oct 26. PMID: 34665881.

December- January

Title	Authors	Reference
Prioritising primary care respiratory research needs: results from the 2020 International Primary Care Respiratory Group (IPCRG) global e-Delphi exercise.	Abdel-Aal A, Lisspers K, Williams S, Adab P, Adams R, Agarwal D, Barnard A, Bouloukaki I, van Boven JFM, Chavannes N, Dickens AP, van Gemert F, Escarrer M, Haroon S, Kayongo A, Kirenga B, Kocks JWH, Kotz D, Newby C, McNulty C, Metting E, Moral L, Papadakis S, Pinnock H, Price D, Ryan D, Singh SJ, Correia de Sousa J, Ställberg B, Szefler SJ, Taylor SJC, Tsiligianni I, Turner A, Weller D, Yusuf O, Tabyshova AK, Jordan RE.	NPJ Prim Care Respir Med. 2022 Jan 28;32(1):6. doi: 10.1038/s41533-021-00266-4. PMID: 35091570.
The COVID-19 pandemic: Adverse effects on the social determinants of health in children and families.	Abrams EM, Greenhawt M, Shaker M, Pinto AD, Sinha I, Singer A.	Ann Allergy Asthma Immunol. 2022 Jan;128(1):19-25. doi: 10.1016/j.anai.2021.10.022. Epub 2021 Oct 23. PMID: 34699969; PMCID: PMC8539831.
The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease.	Adeloye D, Elneima O, Daines L, Poinasamy K, Quint JK, Walker S, Brightling CE, Siddiqui S, Hurst JR, Chalmers JD, Pfeffer PE, Novotny P, Drake TM, Heaney LG, Rudan I, Sheikh A, De Soyza A; International COVID-19 Airways Diseases Group.	Lancet Respir Med. 2021 Dec;9(12):1467-1478. doi: 10.1016/S2213-2600(21)00286-1. Epub 2021 Aug 17. PMID: 34416191; PMCID: PMC8372501.
Perceptions, attitudes, and behaviors of short-acting beta<sub>2</sub> agonist users: an Australian cross-sectional community pharmacy-based study.	Azzi E, Kritikos V, Peters M, Price D, Cvetkovski B, Alphonse PS, Bosnic- Anticevich S.	J Asthma. 2022 Jan;59(1):178-188. doi: 10.1080/02770903.2020.1841223. Epub 2020 Nov 3. PMID: 33086885.
Eat or heat: fuel poverty and childhood respiratory health.	Barrett C, Lee AR, Abrams EM, Mayell SJ, Hawcutt DB, Sinha IP.	Lancet Respir Med. 2022 Mar;10(3):229. doi: 10.1016/S2213-2600(21)00584-1. Epub 2021 Dec 23. PMID: 34953530.
Pairwise indirect treatment comparison of dupilumab versus other biologics in patients with uncontrolled persistent asthma.	Bateman ED, Khan AH, Xu Y, Guyot P, Chao J, Kamat S, Rowe P, Burnett H, Msihid J, Weinreich D, Pavord ID.	Respir Med. 2022 Jan;191:105991. doi: 10.1016/j.rmed.2020.105991. Epub 2020 Apr 29. PMID: 35090688.
Digital Inhalers for Asthma or Chronic Obstructive Pulmonary Disease: A Scientific Perspective.	Chan AHY, Pleasants RA, Dhand R, Tilley SL, Schworer SA, Costello RW, Merchant R.	Pulm Ther. 2021 Dec;7(2):345-376. doi: 10.1007/s41030-021-00167-4. Epub 2021 Aug 11. PMID: 34379316; PMCID: PMC8589868.
Workup of Severe Asthma.	Couillard S, Jackson DJ, Wechsler ME, Pavord ID.	Chest. 2021 Dec;160(6):2019-2029. doi: 10.1016/j.chest.2021.07.008. Epub 2021 Jul 13. PMID: 34265308.
Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study.	Devereux G, Donaldson GC, Duijts L, Esplugues A, Faner R, Ballester F, Garcia-Aymerich J, Gehring U, Haider S, Hartl S, Backman H, Holloway JW, Koppelman GH, Lertxundi A, Holmen TL, Lowe L, Mensink-Bout SM, Murray CS, Roberts G, Hedman L, Schlünssen V, Sigsgaard T, Simpson A, Sunyer J, Torrent M, Turner S, Van den Berge M, Vermeulen RCH, Vikjord SAA, Wedzicha JA, Maitland van der Zee AH, Melén E.	ERJ Open Res. 2021 Dec 6;7(4):00457-2021. doi: 10.1183/23120541.00457-2021. PMID: 34881328; PMCID: PMC8646001.
Deprescribing montelukast in children with asthma: a systematic review.	Dixon EG, King C, Lilley A, Sinha IP, Hawcutt DB.	BMJ Open. 2022 Jan 31;12(1):e053112. doi: 10.1136/bmjopen-2021-053112. PMID: 35105629.
Perspectives of mild asthma patients on maintenance versus as-needed preventer treatment regimens: a qualitative study.	Foster J, Beasley R, Braithwaite I, Harrison T, Holliday M, Pavord I, Reddel H.	BMJ Open. 2022 Jan 21;12(1):e048537. doi: 10.1136/bmjopen-2020-048537. PMID: 35063953.
Modelling Wheezing Spells Identifies Phenotypes with Different Outcomes and Genetic Associates.	Haider S, Granell R, Curtin J, Fontanella S, Cucco A, Turner S, Simpson A, Roberts G, Murray CS, Holloway JW, Devereux G, Cullinan P, Arshad SH, Custovic A.	Am J Respir Crit Care Med. 2022 Jan 20. doi: 10.1164/rccm.202108-1821OC. Epub ahead of print. PMID: 35050846.
Editorial: COVID-19 and Behavioral Sciences.	Jackson T, Steed L, Pedruzzi R, Beyene K, Chan AHY.	Front Public Health. 2022 Jan 14;9:830797. doi: 10.3389/fpubh.2021.830797. PMID: 35096765; PMCID: PMC8794812.
Asthma Phenotyping in Primary Care: Applying the International Severe Asthma Registry Eosinophil Phenotype Algorithm Across All Asthma Severities.	Kerkhof M, Tran TN, Allehebi R, Canonica GW, Heaney LG, Hew M, Perez de Llano L, Wechsler ME, Bulathsinhala L, Carter VA, Chaudhry I, Eleangovan N, Murray RB, Price CA, Price DB.	J Allergy Clin Immunol Pract. 2021 Dec;9(12):4353-4370. doi: 10.1016/j.jaip.2021.07.056. Epub 2021 Aug 14. PMID: 34403837.
Sociocultural influences on asthma self- management in a multicultural society: A qualitative study amongst Malaysian adults.	Koh WM, Abu Bakar AI, Hussein N, Pinnock H, Liew SM, Hanafi NS, Pang YK, Ho BK, Mohamed Isa S, Sheikh A, Khoo EM.	Health Expect. 2021 Dec;24(6):2078-2086. doi: 10.1111/hex.13352. Epub 2021 Aug 27. PMID: 34449970; PMCID: PMC8628588.
Patient characteristics, biomarkers and exacerbation risk in severe, uncontrolled asthma.	Kraft M, Brusselle G, FitzGerald JM, Pavord ID, Keith M, Fagerås M, Garcia Gil E, Hirsch I, Goldman M, Colice G.	Eur Respir J. 2021 Dec 16;58(6):2100413. doi: 10.1183/13993003.00413-2021. PMID: 34112734.
Risk factors for asthma attacks and poor control in children: a prospective observational study in UK primary care.	Lo D, Beardsmore C, Roland D, Richardson M, Yang Y, Danvers L, Wilson A, Gaillard EA.	Arch Dis Child. 2022 Jan;107(1):26-31. doi: 10.1136/archdischild-2020-320110. Epub 2021 May 20. PMID: 34016593.
Oral corticosteroid elimination via a personalised reduction algorithm in adults with severe, eosinophilic asthma treated with benralizumab (PONENTE): a multicentre, open-label, single-arm study.	Menzies-Gow A, Gurnell M, Heaney LG, Corren J, Bel EH, Maspero J, Harrison T, Jackson DJ, Price D, Lugogo N, Kreindler J, Burden A, de Giorgio-Miller A, Padilla K, Martin UJ, Garcia Gil E.	Lancet Respir Med. 2022 Jan;10(1):47-58. doi: 10.1016/S2213-2600(21)00352-0. Epub 2021 Oct 4. Erratum in: Lancet Respir Med. 2021 Dec;9(12):e114. PMID: 34619104.
Asthma in paediatric intensive care in England residents: observational study.	Mukherjee M, Cunningham S, Bhuia MR, Lo TM, Been JV, Sheikh A.	Sci Rep. 2022 Jan 25;12(1):1315. doi: 10.1038/s41598-022-05414-5. PMID: 35079067; PMCID: PMC8789863.
Controversies in Allergy: Choosing a Biologic for Patients with Severe Asthma.	Pavord ID, Hanania NA, Corren J.	J Allergy Clin Immunol Pract. 2021 Dec 24:S2213-2198(21)01409-4. doi: 10.1016/j.jaip.2021.12.014. Epub ahead of print. PMID: 34958982.
Global Initiative for Asthma Strategy 2021: executive summary and rationale for key changes.	Reddel HK, Bacharier LB, Bateman ED, Brightling CE, Brusselle GG, Buhl R, Cruz AA, Duijts L, Drazen JM, FitzGerald JM, Fleming LJ, Inoue H, Ko FW, Krishnan JA, Levy ML, Lin J, Mortimer K, Pitrez PM, Sheikh A, Yorgancioglu AA, Boulet LP.	Eur Respir J. 2021 Dec 31;59(1):2102730. doi: 10.1183/13993003.02730-2021. PMID: 34667060; PMCID: PMC8719459.
Predicting asthma-related crisis events using routine electronic healthcare data: a quantitative database analysis study.	Noble M, Burden A, Stirling S, Clark AB, Musgrave S, Alsallakh MA, Price D, Davies GA, Pinnock H, Pond M, Sheikh A, Sims EJ, Walker S, Wilson AM.	Br J Gen Pract. 2021 Nov 25;71(713):e948-e957. doi: 10.3399/BJGP.2020.1042. PMID: 34133316; PMCID: PMC8544121.
Pharmacogenomics and asthma treatment: acceptability to children, families and healthcare professionals.	Parry CM, Seddon G, Rogers N, Sinha IP, Bracken L, King C, Peak M, Hawcutt DB.	Arch Dis Child. 2022 Jan 24:archdischild-2021-322396. doi: 10.1136/archdischild-2021-322396. Epub ahead of print. PMID: 35074833.
Features of successful interventions to improve adherence to Inhaled Corticosteroids in children with asthma.	Pearce CJ, Chan AHY, Jackson T, Fleming L, Foot H, Bush A, Horne R.	Pediatr Pulmonol. 2022 Jan 22. doi: 10.1002/ppul.25838. Epub ahead of print. PMID: 35064651.
Global Variability in Administrative Approval Prescription Criteria for Biologic Therapy in Severe Asthma.	Porsbjerg CM, Menzies-Gow AN, Tran TN, Murray RB, Unni B, Audrey Ang SL, Alacqua M, Al-Ahmad M, Al-Lehebi R, Altraja A, Belevskiy AS, Björnsdóttir US, Bourdin A, Busby J, Canonica GW, Christoff GC, Cosio BG, Costello RW, FitzGerald JM, Fonseca JA, Hansen S, Heaney LG, Heffler E, Hew M, Iwanaga T, Jackson DJ, Kocks JWH, Kallieri M, Bruce Ko HK, Koh MS, Larenas-Linnemann D, Lehtimäki LA, Loukides S, Lugogo N, Maspero J, Papaioannou AI, Perez-de-Llano L, Pitrez PM, Popov TA, Rasmussen LM, Rhee CK, Sadatsafavi M, Schmid J, Siddiqui S, Taillé C, Taube C, Torres-Duque CA, Ulrik C, Upham JW, Wang E, Wechsler ME, Bulathsinhala L, Carter V, Chaudhry I, Eleangovan N, Hosseini N, Rowlands MA, Price D, van Boven JF.	J Allergy Clin Immunol Pract. 2022 Jan 3:S2213-2198(21)01454-9. doi: 10.1016/j.jaip.2021.12.027. Epub ahead of print. PMID: 34990866.
Nebulization procedures for children with unknown viral status during the COVID-19 pandemic.	Rodríguez-Martínez CE, Sinha IP, Whittaker E, Nagakumar P, Fernandes RM.	J Asthma. 2021 Dec;58(12):1597-1598. doi: 10.1080/02770903.2020.1827418. Epub 2020 Oct 1. PMID: 32962456.
Identifying and addressing health inequalities in asthma care.	Ryan D, Sabroe I.	Eur Respir J. 2021 Dec 16;58(6):2101829. doi: 10.1183/13993003.01829-2021.PMID: 34916255.
Blood eosinophils in managing preschool wheeze: Lessons learnt from a proof-of-concept trial.	Saglani S, Bingham Y, Balfour-Lynn I, Goldring S, Gupta A, Banya W, Moreiras J, Fleming L, Bush A, Rosenthal M.	Pediatr Allergy Immunol. 2022 Jan;33(1):e13697. doi: 10.1111/pai.13697. Epub 2021 Nov 24. PMID: 34783100.
Risk of serious COVID-19 outcomes among adults with asthma in Scotland: a national incident cohort study.	Shi T, Pan J, Vasileiou E, Robertson C, Sheikh A; Public Health Scotland and the EAVE II Collaborators.	Lancet Respir Med. 2022 Jan 13:S2213-2600(21)00543-9. doi: 10.1016/S2213-2600(21)00543-9. Epub ahead of print. PMID: 35033224; PMCID: PMC8758152.
Microbiome-immune interactions and relationship to asthma severity.	Trujillo J, Lunjani N, Ryan D, O'Mahony L.	J Allergy Clin Immunol. 2021 Dec 22:S0091-6749(21)02684-1. doi: 10.1016/j.jaci.2021.12.774. Epub ahead of print. PMID: 34953788.
Reducing asthma attacks in children using exhaled nitric oxide (RAACENO) as a biomarker to inform treatment strategy: a multicentre, parallel, randomised, controlled,phase 3 trial.	Turner S, Cotton S, Wood J, Bell V, Raja EA, Scott NW, Morgan H, Lawrie L, Emele D, Kennedy C, Scotland G, Fielding S, MacLennan G, Norrie J, Forrest M, Gaillard EA, de Jongste J, Pijnenburg M, Thomas M, Price D.	Lancet Respir Med. 2022 Jan 28:S2213-2600(21)00486-0. doi: 10.1016/S2213-2600(21)00486-0. Epub ahead of print. PMID: 35101183.
A systematic review of the characteristics of interventions that promote physical activity in adults with asthma.	Tyson L, Hardeman W, Marquette M, Semlyen J, Stratton G, Wilson AM.	J Health Psychol. 2021 Dec 29:13591053211059386. doi: 10.1177/13591053211059386. Epub ahead of print. PMID: 34963369.
Implementing spirometry and fractional exhaled nitric oxide testing in childhood asthma management in UK primary care: an observational study to examine training and implementation cost and impact on patient's health use and outcome.	Wang G, Hallberg J, Charalampopoulos D, Sanahuja MC, Breyer-Kohansal R, Langhammer A, Granell R, Vonk JM, Mian A, Olvera N, Laustsen LM, Rönmark E, Abellan A, Agusti A, Arshad SH, Bergström A, Boezen HM, Breyer MK, Burghuber O, Bolund AC, Custovic A, Yang Y, Lo DK, Beardsmore C, Roland D, Richardson M, Danvers L, Wilson A, Gaillard EA.	Arch Dis Child. 2022 Jan;107(1):21-25. doi:10.1136/archdischild-2020-319310. Epub 2021 Jul 9. PMID: 34244168; PMCID:PMC8685621.

2021

November

Title	Authors	Reference
Development and validation of a self-report measure of practical barriers to medication adherence: The medication practical barriers to adherence questionnaire (MPRAQ)	Chan AHY, Vervloet M, Lycett H, Brabers A, van Dijk L, Horne R.	Br J Clin Pharmacol. 2021 Nov;87(11):4197-4211. doi: 10.1111/bcp.14744. Epub 2021 Sep 10. PMID: 33486802.
Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study.	Evans RA, McAuley H, Harrison EM, Shikotra A, Singapuri A, Sereno M, Elneima O, Docherty AB, Lone NI, Leavy OC, Daines L, Baillie JK, Brown JS, Chalder T, De Soyza A, Diar Bakerly N, Easom N, Geddes JR, Greening NJ, Hart N, Heaney LG, Heller S, Howard L, Hurst JR, Jacob J, Jenkins RG, Jolley C, Kerr S, Kon OM, Lewis K, Lord JM, McCann GP, Neubauer S, Openshaw PJM, Parekh D, Pfeffer P, Rahman NM, Raman B, Richardson M, Rowland M, Semple MG, Shah AM, Singh SJ, Sheikh A, Thomas D, Toshner M, Chalmers JD, Ho LP, Horsley A, Marks M, Poinasamy K, Wain LV, Brightling CE; PHOSP-COVID Collaborative Group.	Lancet Respir Med. 2021 Nov;9(11):1275-1287. doi: 10.1016/S2213-2600(21)00383-0. Epub 2021 Oct 7. PMID: 34627560; PMCID: PMC8497028.
Defining a Severe Asthma Super-Responder: Findings from a Delphi Process.	Upham JW, Le Lievre C, Jackson DJ, Masoli M, Wechsler ME, Price DB; Delphi Panel.	J Allergy Clin Immunol Pract. 2021 Nov;9(11):3997-4004. doi: 10.1016/j.jaip.2021.06.041. Epub 2021 Jul 13. PMID: 34271216.
Ventilation heterogeneity in children with severe asthma	Nuttall AG, Beardsmore CS, Gaillard EA.	Eur J Pediatr. 2021 Nov;180(11):3399-3404. doi: 10.1007/s00431-021-04101-3. Epub 2021 May 13. PMID: 33987684; PMCID: PMC8502735.
Predicting asthma-related crisis events using routine electronic healthcare data: a quantitative database analysis study.	Noble M, Burden A, Stirling S, Clark AB, Musgrave S, Alsallakh MA, Price D, Davies GA, Pinnock H, Pond M, Sheikh A, Sims EJ, Walker S, Wilson AM.	Br J Gen Pract. 2021 Nov 25;71(713):e948-e957. doi: 10.3399/BJGP.2020.1042. PMID: 34133316; PMCID: PMC8544121.
Risk factors for developing COVID-19: a population-based longitudinal study (COVIDENCE UK)	Holt H, Talaei M, Greenig M, Zenner D, Symons J, Relton C, Young KS, Davies MR, Thompson KN, Ashman J, Rajpoot SS, Kayyale AA, El Rifai S, Lloyd PJ, Jolliffe D, Timmis O, Finer S, Iliodromiti S, Miners A, Hopkinson NS, Alam B, Lloyd-Jones G, Dietrich T, Chapple I, Pfeffer PE, McCoy D, Davies G, Lyons RA, Griffiths C, Kee F, Sheikh A, Breen G, Shaheen SO, Martineau AR.	Thorax. 2021 Nov 30:thoraxjnl-2021-217487. doi: 10.1136/thoraxjnl-2021-217487. Epub ahead of print. PMID: 34848555.
COVID-19 and delivery of difficult asthma services.	Nichols AL, Sonnappa-Naik M, Gardner L, Richardson C, Orr N, Jamalzadeh A, Moore-Crouch R, Makhecha S, Wells C, Hall P, Bush A, Fleming L, Saglani S, Sonnappa S.	Arch Dis Child. 2021 Nov 2:archdischild-2021-322335. doi: 10.1136/archdischild-2021-322335. Epub ahead of print. PMID: 34728462.
Sputum biomarkers during acute severe asthma attacks in children- a case-control study.	Ramphul M, Welsh KG, May RD, Ghebre MA, Rapley L, Cohen ES, Herath A, Monteiro W, Rousseau K, Thornton DJ, Brightling CE, Gaillard EA.	Acta Paediatr. 2021 Nov 13. doi: 10.1111/apa.16186. Epub ahead of print. PMID: 34773288.
Effective Management of Severe Asthma with Biologic Medications in Adult Patients: A Literature Review and International Expert Opinion.	Buhl R, Bel E, Bourdin A, Dávila I, Douglass JA, FitzGerald JM, Jackson DJ, Lugogo N, Matucci A, Pavord ID, Wechsler ME, Kraft M.	J Allergy Clin Immunol Pract. 2021 Nov 8:S2213-2198(21)01249-6. doi: 10.1016/j.jaip.2021.10.059. Epub ahead of print. PMID: 34763123.
Impact of Socioeconomic Status on Adult Patients with Asthma: A Population-Based Cohort Study from UK Primary Care.	Busby J, Price D, Al-Lehebi R, Bosnic-Anticevich S, van Boven JFM, Emmanuel B, FitzGerald JM, Gaga M, Hansen S, Hew M, Iwanaga T, Larenas Linnemann D, Mahboub B, Mitchell P, Morrone D, Pham J, Porsbjerg C, Roche N, Wang E, Eleangovan N, Heaney LG.	J Asthma Allergy. 2021 Nov 10;14:1375-1388. doi: 10.2147/JAA.S326213. PMID: 34785911; PMCID: PMC8591110.
European Respiratory Society clinical practice guidelines for the diagnosis of asthma in children aged 5-16 years.	Gaillard EA, Kuehni CE, Turner S, Goutaki M, Holden KA, de Jong CCM, Lex C, Lo DKH, Lucas JS, Midulla F, Mozun R, Piacentini G, Rigau D, Rottier B, Thomas M, Tonia T, Usemann J, Yilmaz O, Zacharasiewicz A, Moeller A.	Eur Respir J. 2021 Nov 4;58(5):2004173. doi: 10.1183/13993003.04173-2020. PMID: 33863747.
Effectiveness of mobile health interventions to improve nasal corticosteroid adherence in allergic rhinitis: A systematic review.	Baxter MS, Tibble H, Bush A, Sheikh A, Schwarze J.	Clin Transl Allergy. 2021 Nov;11(9):e12075. doi: 10.1002/clt2.12075. PMID: 34841729.
External validation of the QCovid risk prediction algorithm for risk of COVID-19 hospitalisation and mortality in adults: national validation cohort study in Scotland.	Simpson CR, Robertson C, Kerr S, Shi T, Vasileiou E, Moore E, McCowan C, Agrawal U, Docherty A, Mulholland R, Murray J, Ritchie LD, McMenamin J, Hippisley-Cox J, Sheikh A.	Thorax. 2021 Nov 15:thoraxjnl-2021-217580. doi: 10.1136/thoraxjnl-2021-217580. Epub ahead of print. PMID: 34782484; PMCID: PMC8595052.
Blood eosinophils in managing preschool wheeze: Lessons learnt from a proof-of-concept trial.	Saglani S, Bingham Y, Balfour-Lynn I, Goldring S, Gupta A, Banya W, Moreiras J, Fleming L, Bush A, Rosenthal M.	Pediatr Allergy Immunol. 2021 Nov 16. doi: 10.1111/pai.13697. Epub ahead of print. PMID: 34783100.
Implementing asthma management guidelines in public primary care clinics in Malaysia	Cheong AT, Lee PY, Shariff-Ghazali S, Salim H, Hussein N, Ramli R, Pinnock H, Liew SM, Hanafi NS, Abu Bakar AI, Mohd Ahad A, Pang YK, Chinna K, Khoo EM.	NPJ Prim Care Respir Med. 2021 Nov 29;31(1):47. doi: 10.1038/s41533-021-00257-5. PMID: 34845205.
Expert meeting report: towards a joint European roadmap to address the unmet needs and priorities of paediatric asthma patients on biologic therapy	Golebski K, Dankelman LHM, Björkander S, Bønnelykke K, Brinkman P, Deschildre A, van Dijk YE, Fleming L, Grigg J, Hamelmann E, Hashimoto S, Kabesch M, Klevebro S, Maitland-van der Zee AH, Merid SK, Nieto A, Niggel J, Nilsson C, Potočnik U, Roberts G, Rusconi F, Saglani S, Valente E, van Drunen C, Wang G, Melén E, Vijverberg SJH.	ERJ Open Res. 2021 Nov 1;7(4):00381-2021. doi: 10.1183/23120541.00381-2021. PMID: 34729368; PMCID: PMC8558470.
Developing theory-based asthma self-management interventions for South Asians and African Americans: A systematic review.	Ahmed S, Pinnock H, Steed E.	Br J Health Psychol. 2021 Nov;26(4):1040-1068. doi: 10.1111/bjhp.12518. Epub 2021 Mar 16. PMID: 33724618.
Forthcoming UK asthma guidelines: an opportunity to improve asthma outcomes.	Bush A, Pavord ID.	Lancet. 2021 Nov 20;398(10314):1856-1858. doi: 10.1016/S0140-6736(21)02244-3. Epub 2021 Oct 14. PMID: 34656285.

October

Title	Authors	Reference
Efficacy and Safety of Itepekimab in Patients with Moderate-to-Severe Asthma.	Wechsler ME, Ruddy MK, Pavord ID, Israel E, Rabe KF, Ford LB, Maspero JF, Abdulai RM, Hu CC, Martincova R, Jessel A, Nivens MC, Amin N, Weinreich DM, Yancopoulos GD, Goulaouic H.	N Engl J Med. 2021 Oct 28;385(18):1656-1668. doi: 10.1056/NEJMoa2024257. PMID: 34706171.
Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study.	Evans RA, McAuley H, Harrison EM, Shikotra A, Singapuri A, Sereno M, Elneima O, Docherty AB, Lone NI, Leavy OC, Daines L, Baillie JK, Brown JS, Chalder T, De Soyza A, Diar Bakerly N, Easom N, Geddes JR, Greening NJ, Hart N, Heaney LG, Heller S, Howard L, Hurst JR, Jacob J, Jenkins RG, Jolley C, Kerr S, Kon OM, Lewis K, Lord JM, McCann GP, Neubauer S, Openshaw PJM, Parekh D, Pfeffer P, Rahman NM, Raman B, Richardson M, Rowland M, Semple MG, Shah AM, Singh SJ, Sheikh A, Thomas D, Toshner M, Chalmers JD, Ho LP, Horsley A, Marks M, Poinasamy K, Wain LV, Brightling CE; PHOSP-COVID Collaborative Group.	Lancet Respir Med. 2021 Nov;9(11):1275-1287. doi: 10.1016/S2213-2600(21)00383-0. Epub 2021 Oct 7. PMID: 34627560; PMCID: PMC8497028.
Dietary intake of vitamin A, lung function and incident asthma in childhood.	Talaei M, Hughes DA, Mahmoud O, Emmett PM, Granell R, Guerra S, Shaheen SO.	Eur Respir J. 2021 Oct 28;58(4):2004407. doi: 10.1183/13993003.04407-2020. PMID: 33795317; PMCID: PMC8551559.
Socioeconomic disparities in asthma healthcare utilization, exacerbations and mortality: A systematic review and meta-analysis.	Redmond C, Akinoso-Imran AQ, Heaney LG, Sheikh A, Kee F, Busby J.	J Allergy Clin Immunol. 2021 Oct 18:S0091-6749(21)01560-8. doi: 10.1016/j.jaci.2021.10.007. Epub ahead of print. PMID: 34673047.
Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis.	Vlieg-Boerstra B, de Jong N, Meyer R, Agostoni C, De Cosmi V, Grimshaw K, Milani GP, Muraro A, Oude Elberink H, Pali-Schöll I, Roduit C, Sasaki M, Skypala I, Sokolowska M, van Splunter M, Untersmayr E, Venter C, O'Mahony L, Nwaru BI.	Allergy. 2021 Oct 9. doi: 10.1111/all.15136. Epub ahead of print. PMID: 34626488.
Moving towards a Treatable Traits model of care for the management of obstructive airways diseases.	Agusti A, Barnes N, Cruz AA, Gibson PG, Heaney LG, Inoue H, Leather D, Martinez FJ, McDonald VM, Oppenheimer J, Papi A, Pavord ID, Thomas M, Walker S, Yates L.	Respir Med. 2021 Oct;187:106572. doi: 10.1016/j.rmed.2021.106572. Epub 2021 Aug 13. PMID: 34478992.
Predictors for detecting chronic respiratory diseases in community surveys: A pilot cross-sectional survey in four South and South East Asian low- and middle-income countries.	Agarwal D, Hanafi NS, Khoo EM, Parker RA, Ghorpade D, Salvi S, Abu Bakar AI, Chinna K, Das D, Habib M, Hussein N, Isaac R, Islam MS, Khan MS, Liew SM, Pang YK, Paul B, Saha SK, Wong LP, Yusuf OM, Yusuf SO, Juvekar S, Pinnock H; RESPIRE Collaboration.	J Glob Health. 2021 Oct 30;11:04065. doi: 10.7189/jogh.11.04065. PMID: 34737865; PMCID: PMC8561335.
Baseline FeNO as a prognostic biomarker for subsequent severe asthma exacerbations in patients with uncontrolled, moderate-to-severe asthma receiving placebo in the LIBERTY ASTHMA QUEST study: a post-hoc analysis.	Busse WW, Wenzel SE, Casale TB, FitzGerald JM, Rice MS, Daizadeh N, Deniz Y, Patel N, Harel S, Rowe PJ, Graham NMH, O'Riordan T, Pavord ID.	Lancet Respir Med. 2021 Oct;9(10):1165-1173. doi: 10.1016/S2213-2600(21)00124-7. Epub 2021 Jun 25. PMID: 34181876.
Ethnic Differences in Severe Asthma Clinical Care and Outcomes: An Analysis of United Kingdom Primary and Specialist Care.	Busby J, Heaney LG, Brown T, Chaudhuri R, Dennison P, Gore R, Jackson DJ, Mansur AH, Menzies-Gow A, Message S, Niven R, Patel M, Price D, Siddiqui S, Stone R, Pfeffer PE; UK Severe Asthma Registry.	J Allergy Clin Immunol Pract. 2021 Oct 7:S2213-2198(21)01061-8. doi: 10.1016/j.jaip.2021.09.034. Epub ahead of print. PMID: 34626858.
Global Initiative for Asthma (GINA) Strategy 2021 - Executive summary and rationale for key changes.	Reddel HK, Bacharier LB, Bateman ED, Brightling CE, Brusselle GG, Buhl R, Cruz AA, Duijts L, Drazen JM, FitzGerald JM, Fleming LJ, Inoue H, Ko FW, Krishnan JA, Levy ML, Lin J, Mortimer K, Pitrez PM, Sheikh A, Yorgancioglu AA, Boulet LP.	Eur Respir J. 2021 Oct 19:2102730. doi: 10.1183/13993003.02730-2021. Epub ahead of print. PMID: 34667060.
European Respiratory Society clinical practice guidelines for the diagnosis of asthma in children aged 5-16 years.	Gaillard EA, Kuehni CE, Turner S, Goutaki M, Holden KA, de Jong CCM, Lex C, Lo DKH, Lucas JS, Midulla F, Mozun R, Piacentini G, Rigau D, Rottier B, Thomas M, Tonia T, Usemann J, Yilmaz O, Zacharasiewicz A, Moeller A.	Eur Respir J. 2021 Nov 4;58(5):2004173. doi: 10.1183/13993003.04173-2020. PMID: 33863747.
Oral corticosteroid elimination via a personalised reduction algorithm in adults with severe, eosinophilic asthma treated with benralizumab (PONENTE): a multicentre, open-label, single-arm study.	Menzies-Gow A, Gurnell M, Heaney LG, Corren J, Bel EH, Maspero J, Harrison T, Jackson DJ, Price D, Lugogo N, Kreindler J, Burden A, de Giorgio-Miller A, Padilla K, Martin UJ, Garcia Gil E.	Lancet Respir Med. 2021 Oct 4:S2213-2600(21)00352-0. doi: 10.1016/S2213-2600(21)00352-0. Epub ahead of print. Erratum in: Lancet Respir Med. 2021 Oct 22;: PMID: 34619104.
Adverse drug reactions of leukotriene receptor antagonists in children with asthma: a systematic review.	Dixon EG, Rugg-Gunn CE, Sellick V, Sinha IP, Hawcutt DB.	BMJ Paediatr Open. 2021 Oct 13;5(1):e001206. doi: 10.1136/bmjpo-2021-001206. PMID: 34712847; PMCID: PMC8515462.
Clinical effectiveness and components of Home-pulmonary rehabilitation for people with chronic respiratory diseases: a systematic review protocol.	Uzzaman MN, Chan SC, Shunmugam RH, Engkasan JP, Agarwal D, Habib GMM, Hanafi NS, Jackson T, Jebaraj P, Khoo EM, Liew SM, Mirza FT, Pinnock H, Rabinovich RA.	BMJ Open. 2021 Oct 12;11(10):e050362. doi: 10.1136/bmjopen-2021-050362. PMID: 34642195; PMCID: PMC8513265.
Electronic reminders and rewards to improve adherence to inhaled asthma treatment in adolescents: a non-randomised feasibility study in tertiary care.	De Simoni A, Fleming L, Holliday L, Horne R, Priebe S, Bush A, Sheikh A, Griffiths C.	BMJ Open. 2021 Oct 29;11(10):e053268. doi: 10.1136/bmjopen-2021-053268. PMID: 34716166; PMCID: PMC8559117.
Commercial valved spacers versus home-made spacers for delivering bronchodilator therapy in pediatric acute asthma: a cost-effectiveness analysis.	Rodríguez-Martínez CE, Sossa-Briceño MP, Sinha IP.	J Asthma. 2021 Oct;58(10):1340-1347. doi: 10.1080/02770903.2020.1784195. Epub 2020 Jun 27. PMID: 32546110.
Characteristics of patients in platform C19, a COVID-19 research database combining primary care electronic health record and patient reported information.	Stanley B, Davis A, Jones R, Julious S, Ryan D, Jackson D, Halpin D, Pinnock H, Quint J, Khunti K, Heaney L, Oliver P, Siddiqui S, Kemppinen A, Appiagyei F, Roberts EJ, Hardjojo A, Carter V, Melle MV, Price D; Platform C19 committee.	PLoS One. 2021 Oct 19;16(10):e0258689. doi: 10.1371/journal.pone.0258689. PMID: 34665843; PMCID: PMC8525750.
Expert meeting report: towards a joint European roadmap to address the unmet needs and priorities of paediatric asthma patients on biologic therapy.	Golebski K, Dankelman LHM, Björkander S, Bønnelykke K, Brinkman P, Deschildre A, van Dijk YE, Fleming L, Grigg J, Hamelmann E, Hashimoto S, Kabesch M, Klevebro S, Maitland-van der Zee AH, Merid SK, Nieto A, Niggel J, Nilsson C, Potočnik U, Roberts G, Rusconi F, Saglani S, Valente E, van Drunen C, Wang G, Melén E, Vijverberg SJH.	ERJ Open Res. 2021 Nov 1;7(4):00381-2021. doi: 10.1183/23120541.00381-2021. PMID: 34729368; PMCID: PMC8558470.
The inflammatory profile of exacerbations in patients with severe refractory eosinophilic asthma receiving mepolizumab (the MEX study): a prospective observational study.	McDowell PJ, Diver S, Yang F, Borg C, Busby J, Brown V, Shrimanker R, Cox C, Brightling CE, Chaudhuri R, Pavord ID, Heaney LG; Medical Research Council: Refractory Asthma Stratification Programme (RASP-UK Consortium).	Lancet Respir Med. 2021 Oct;9(10):1174-1184. doi: 10.1016/S2213-2600(21)00004-7. Epub 2021 May 7. PMID: 33971168.
3TR: a pan-European cross-disease research consortium aimed at improving personalised biological treatment of asthma and COPD.	Porsbjerg C, Maitland-van der Zee AH, Brusselle G, Canonica GW, Agusti A, Faner R, Vogelmeier CF, Nawijn M, van den Berge M, Rusconi F, Pilette C, Ramiconi V, Coleman C, Chaudhuri R, Chung KF, Wedzicha J, Saglani S, Van der Schee MP, Heaney L, Bourdin A, Roberts G, Djukanovic R, Kuna P, Kupczyk M, Axmann J, Staudinger H, Clarke GW, Dahlen SE, Brightling C.	Eur Respir J. 2021 Oct 21;58(4):2102168. doi: 10.1183/13993003.02168-2021. PMID: 34675035.
Forthcoming UK asthma guidelines: an opportunity to improve asthma outcomes.	Bush A, Pavord ID.	Lancet. 2021 Oct 14:S0140-6736(21)02244-3. doi: 10.1016/S0140-6736(21)02244-3. Epub ahead of print. PMID: 34656285.
Comparison of epidemiologic surveillance and Google Trends data on asthma and allergic rhinitis in England.	Sousa-Pinto B, Antó JM, Sheikh A, de Lusignan S, Haahtela T, Fonseca JA, Bousquet J.	Allergy. 2021 Oct 19. doi: 10.1111/all.15139. Epub ahead of print. PMID: 34665881.

September

Title	Authors	Reference
Heterogeneity within and between physician- diagnosed asthma and/or COPD: NOVELTY cohort.	Reddel HK, Vestbo J, Agustí A, Anderson GP, Bansal AT, Beasley R, Bel EH, Janson C, Make B, Pavord ID, Price D, Rapsomaniki E, Karlsson N, Finch DK, Nuevo J, de Giorgio-Miller A, Alacqua M, Hughes R, Müllerová H, Gerhardsson de Verdier M; NOVELTY study investigators.	Eur Respir J. 2021 Sep 23;58(3):2003927. doi: 10.1183/13993003.03927-2020. PMID: 33632799; PMCID: PMC8459130.
Recurrent Severe Preschool Wheeze: From Prespecified Diagnostic Labels to Underlying Endotypes.	Robinson PFM, Fontanella S, Ananth S, Martin Alonso A, Cook J, Kaya-de Vries D, Polo Silveira L, Gregory L, Lloyd C, Fleming L, Bush A, Custovic A, Saglani S.	Am J Respir Crit Care Med. 2021 Sep 1;204(5):523-535. doi: 10.1164/rccm.202009-3696OC. PMID: 33961755; PMCID: PMC8491264.
Asthma in pregnancy: An update.	Couillard S, Connolly C, Borg C, Pavord I.	Obstet Med. 2021 Sep;14(3):135-144. doi: 10.1177/1753495X20965072. Epub 2020 Nov 1. PMID: 34646341; PMCID: PMC8504309.
Perceptions of adolescents and young adults with allergy and/or asthma and their parents on EAACI guideline recommendations about transitional care: A European survey.	Khaleva E, Knibb R, DunnGalvin A, Vazquez-Ortiz M, Comberiati P, Alviani C, Garriga-Baraut T, Gowland MH, Gore C, Angier E, Blumchen K, Duca B, Hox V, Jensen B, Mortz CG, Pite H, Pfaar O, Santos AF, Sanchez-Garcia S, Timmermans F, Roberts G.	Allergy. 2021 Sep 26. doi: 10.1111/all.15109. Epub ahead of print. PMID: 34564855.
Knowledge, Attitudes, and Behavior Related to COVID-19 Testing: A Rapid Scoping Review.	Bevan I, Stage Baxter M, Stagg HR, Street A.	Diagnostics (Basel). 2021 Sep 15;11(9):1685. doi: 10.3390/diagnostics11091685. PMID: 34574026; PMCID: PMC8472251.
Dietary intake of vitamin A, lung function, and incident asthma in childhood.	Talaei M, Hughes DA, Mahmoud O, Emmett PM, Granell R, Guerra S, Shaheen SO.	Eur Respir J. 2021 Sep 24:2004407. doi: 10.1183/13993003.04407-2020. Epub ahead of print. PMID: 33795317.
Long-term safety and efficacy of dupilumab in patients with moderate-to-severe asthma (TRAVERSE): an open-label extension study.	Wechsler ME, Ford LB, Maspero JF, Pavord ID, Papi A, Bourdin A, Watz H, Castro M, Nenasheva NM, Tohda Y, Langton D, Cardona G, Domingo C, Park HS, Chapman KR, Mao X, Zhang Y, Khan AH, Deniz Y, Rowe PJ, Kapoor U, Khokhar FA, Mannent LP, Ruddy M, Laws E, Amin N, Hardin M.	Lancet Respir Med. 2021 Sep 28:S2213-2600(21)00322-2. doi: 10.1016/S2213-2600(21)00322-2. Epub ahead of print. PMID: 34597534.
Effectiveness and perceptions of using templates in long-term condition reviews: a systematic synthesis of quantitative and qualitative studies.	Morrissey M, Shepherd E, Kinley E, McClatchey K, Pinnock H.	Br J Gen Pract. 2021 Aug 26;71(710):e652-e659. doi: 10.3399/BJGP.2020.0963. PMID: 33690148; PMCID: PMC8321439.
Importance of distinguishing between asthma and chronic obstructive pulmonary disease in primary care.	D'Urzo AD, Price D, Kardos P, Maleki-Yazdi MR.	Can Fam Physician. 2021 Sep;67(9):661-667. doi: 10.46747/cfp.6709661. PMID: 34521707.
Intake of ni3 polyunsaturated fatty acids in childhood, FADS genotype and incident asthma.	Talaei M, Sdona E, Calder PC, Jones LR, Emmett PM, Granell R, Bergström A, Melén E, Shaheen SO.	Eur Respir J. 2021 Sep 2;58(3):2003633. doi: 10.1183/13993003.03633-2020. PMID: 33509958; PMCID: PMC8411098.
Eosinophilic and Noneosinophilic Asthma: An Expert Consensus Framework to Characterize Phenotypes in a Global Real-Life Severe Asthma Cohort.	Heaney LG, Perez de Llano L, Al-Ahmad M, Backer V, Busby J, Canonica GW, Christoff GC, Cosio BG, FitzGerald JM, Heffler E, Iwanaga T, Jackson DJ, Menzies-Gow AN, Papadopoulos NG, Papaioannou AI, Pfeffer PE, Popov TA, Porsbjerg CM, Rhee CK, Sadatsafavi M, Tohda Y, Wang E, Wechsler ME, Alacqua M, Altraja A, Bjermer L, Björnsdóttir US, Bourdin A, Brusselle GG, Buhl R, Costello RW, Hew M, Koh MS, Lehmann S, Lehtimäki L, Peters M, Taillé C, Taube C, Tran TN, Zangrilli J, Bulathsinhala L, Carter VA, Chaudhry I, Eleangovan N, Hosseini N, Kerkhof M, Murray RB, Price CA, Price DB.	Chest. 2021 Sep;160(3):814-830. doi: 10.1016/j.chest.2021.04.013. Epub 2021 Apr 19. PMID: 33887242.
ERS/EAACI statement on adherence to international adult asthma guidelines.	Mathioudakis AG, Tsilochristou O, Adcock IM, Bikov A, Bjermer L, Clini E, Flood B, Herth F, Horvath I, Kalayci O, Papadopoulos NG, Ryan D, Sanchez Garcia S, Correia-de-Sousa J, Tonia T, Pinnock H, Agache I, Janson C.	Eur Respir Rev. 2021 Sep 15;30(161):210132. doi: 10.1183/16000617.0132-2021. PMID: 34526316.
Paediatric severe asthma biologics service: from hospital to home.	Makhecha S, Jamalzadeh A, Irving S, Hall P, Sonnappa S, Saglani S, Bush A, Fleming L.	Arch Dis Child. 2021 Sep;106(9):900-902. doi: 10.1136/archdischild-2020-320626. Epub 2021 Feb 15. PMID: 33589471; PMCID: PMC8380910.
Impact of COVID-19 national lockdown on asthma exacerbations: interrupted time-series analysis of English primary care data.	Shah SA, Quint JK, Nwaru BI, Sheikh A.	Thorax. 2021 Sep;76(9):860-866. doi: 10.1136/thoraxjnl-2020-216512. Epub 2021 Mar 29. PMID: 33782080; PMCID: PMC8011425.
Developing an Asthma Self-management Intervention Through a Web-Based Design Workshop for People With Limited Health Literacy: User- Centered Design Approach.	Salim H, Lee PY, Sharif-Ghazali S, Cheong AT, Wong J, Young I, Pinnock H; RESPIRE Collaboration.	J Med Internet Res. 2021 Sep 9;23(9):e26434. doi: 10.2196/26434. PMID: 34499039; PMCID: PMC8461531.
ADRB2 haplotypes and asthma exacerbations in children and young adults: An individual participant data meta-analysis.	Karimi L, Vijverberg SJ, Engelkes M, Hernandez-Pacheco N, Farzan N, Soares P, Pino-Yanes M, Jorgensen AL, Eng C, Mukhopadhyay S, Schieck M, Kabesch M, Burchard EG, Chew FT, Sio YY, Potočnik U, Gorenjak M, Hawcutt DB, Palmer CN, Turner S, Janssens HM, Maitland-van der Zee AH, Verhamme KMC; PiCA and SysPharmPedia consortia.	Clin Exp Allergy. 2021 Sep;51(9):1157-1171. doi: 10.1111/cea.13965. Epub 2021 Jul 20. PMID: 34128573; PMCID: PMC8503671.
Insights into how Malaysian adults with limited health literacy self-manage and live with asthma: A Photovoice qualitative study.	Salim H, Young I, Lee PY, Shariff-Ghazali S, Pinnock H; RESPIRE collaboration.	Health Expect. 2021 Sep 12. doi: 10.1111/hex.13360. Epub ahead of print. PMID: 34514689.
Association Between a Type 2 Inflammatory Disease Burden Score and Outcomes Among Patients with Asthma.	Price D, Menzies-Gow A, Bachert C, Canonica GW, Kocks J, Khan AH, Ye F, Rowe PJ, Lu Y, Kamat S, Carter V, Voorham J.	J Asthma Allergy. 2021 Sep 29;14:1173-1183. doi: 10.2147/JAA.S321212. PMID: 34616157; PMCID: PMC8488033.
Impact of COVID-19 lockdown on emergency asthma admissions and deaths: national interrupted time series analyses for Scotland and Wales.	Davies GA, Alsallakh MA, Sivakumaran S, Vasileiou E, Lyons RA, Robertson C, Sheikh A; EAVE II Collaborators.	Thorax. 2021 Sep;76(9):867-873. doi: 10.1136/thoraxjnl-2020-216380. Epub 2021 Mar 29. PMID: 33782079; PMCID: PMC8011424.
Airway inflammation in severe asthmatics with acid gastro-oesophageal reflux.	Tanner N, Saglani S, Li AM, Bush A, Fleming L.	Thorax. 2021 Sep 8:thoraxjnl-2020-216304. doi: 10.1136/thoraxjnl-2020-216304. Epub ahead of print. PMID: 34497139.
Biologics in severe asthma: Which one, When and Where?	Rupani H, Murphy A, Bluer K, Renwick C, McQuitty P, Jackson DJ, Heaney LG, Chaudhuri R, Menzies-Gow A, Calvert J, Siddiqui S.	Clin Exp Allergy. 2021 Sep;51(9):1225-1228. doi: 10.1111/cea.13989. Epub 2021 Jul 26. PMID: 34289191.
Factors affecting adherence with treatment advice in a clinical trial of patients with severe asthma.	Busby J, Matthews JG, Chaudhuri R, Pavord ID, Hardman TC, Arron JR, Bradding P, Brightling CE, Choy DF, Cowan DC, Djukanovic R, Hanratty CE, Harrison TW, Holweg CT, Howarth PH, Fowler SJ, Lordan JL, Mansur AH, Menzies-Gow A, Niven RM, Robinson DS, Walker SM, Woodcock A, Heaney LG; investigators for the MRC Refractory Asthma Stratification Program.	Eur Respir J. 2021 Sep 24:2100768. doi: 10.1183/13993003.00768-2021. Epub ahead of print. PMID: 34561291.
Short-acting β<sub>2</sub>-agonist prescriptions are associated with poor clinical outcomes of asthma: the multi-country, cross- sectional SABINA III study.	Bateman ED, Price DB, Wang HC, Khattab A, Schonffeldt P, Catanzariti A, van der Valk RJP, Beekman MJHI.	Eur Respir J. 2021 Sep 24:2101402. doi: 10.1183/13993003.01402-2021. Epub ahead of print. PMID: 34561293.
COVID-19 and the mental health of children with respiratory illness.	Sinha IP, Murphy R, Biffin H, Gait L, Abrams EM, Lee AR, Gray-Ffrench M, Fernandes RM, Watson E, Hawcut DB, Southern KW, Brown A.	Lancet Respir Med. 2021 Sep;9(9):952-954. doi: 10.1016/S2213-2600(21)00319-2. Epub 2021 Jul 1. PMID: 34217380.
Fractional Exhaled Nitric Oxide Nonsuppression Identifies Corticosteroid-Resistant Type 2 Signaling in Severe Asthma.	Couillard S, Shrimanker R, Chaudhuri R, Mansur AH, McGarvey LP, Heaney LG,Fowler SJ, Bradding P, Pavord ID, Hinks TSC.	Am J Respir Crit Care Med. 2021 Sep 15;204(6):731-734. doi: 10.1164/rccm.202104-1040LE. PMID: 34129808; PMCID: PMC8521703.
Clinical effects of mepolizumab in patients with severe eosinophilic asthma according to background therapy: A meta-analysis.	Lugogo N, Liu MC, Pavord I, Mitchell PD, Smith SG, Mallett S, Albers FC, Bradford ES, Yancey SW, Bel EH.	J Allergy Clin Immunol Pract. 2021 Sep;9(9):3506-3509.e3. doi: 10.1016/j.jaip.2021.05.024. Epub 2021 Jun 7. PMID: 34111572.

August

Title	Authors	Reference
Temporal trends and forecasting of COVID-19 hospitalisations and deaths in Scotland using a national real-time patient-level data platform: a statistical modelling study.	Simpson CR, Robertson C, Vasileiou E, Moore E, McCowan C, Agrawal U, Stagg HR, Docherty A, Mulholland R, Murray JLK, Ritchie LD, McMenamin J, Sheikh A.	Lancet Digit Health. 2021 Aug;3(8):e517-e525. doi: 10.1016/S2589-7500(21)00105-9. Epub 2021 Jul 5. PMID: 34238721; PMCID: PMC8257056.
Digital Inhalers for Asthma or Chronic Obstructive Pulmonary Disease: A Scientific Perspective.	Chan AHY, Pleasants RA, Dhand R, Tilley SL, Schworer SA, Costello RW, Merchant R	Pulm Ther. 2021 Aug 11. doi: 10.1007/s41030-021-00167-4. Epub ahead of print. PMID: 34379316.
Effect of smoke-free policies in outdoor areas and private places on children's tobacco smoke exposure and respiratory health: a systematic review and meta-analysis.	Radó MK, Mölenberg FJM, Westenberg LEH, Sheikh A, Millett C, Burdorf A, van Lenthe FJ, Been JV.	Lancet Public Health. 2021 Aug;6(8):e566-e578. doi: 10.1016/S2468-2667(21)00097-9. Epub 2021 Jul 16. PMID: 34274050.
Risk Predictors and Symptom Features of Long COVID Within a Broad Primary Care Patient Population Including Both Tested and Untested Patients.	Jones R, Davis A, Stanley B, Julious S, Ryan D, Jackson DJ, Halpin DMG, Hickman K, Pinnock H, Quint JK, Khunti K, Heaney LG, Oliver P, Siddiqui S, Pavord I, Jones DHM, Hyland M, Ritchie L, Young P, Megaw T, Davis S, Walker S,Holgate S, Beecroft S, Kemppinen A, Appiagyei F, Roberts EJ, Preston M, Hardjojo A, Carter V, van Melle M, Price D.	Pragmat Obs Res. 2021 Aug 11;12:93-104. doi:10.2147/POR.S316186. PMID: 34408531; PMCID: PMC8366779.
The Induction of Alpha-1 Antitrypsin by Vitamin D in Human T Cells Is TGF-β Dependent: A Proposed Anti-inflammatory Role in Airway Disease.	Chen YH, Cheadle CE, Rice LV, Pfeffer PE, Dimeloe S, Gupta A, Bush A, Gooptu B, Hawrylowicz CM.	Front Nutr. 2021 Aug 12;8:667203. doi: 10.3389/fnut.2021.667203. PMID: 34458299; PMCID: PMC8397538.
Asthma prescribing according to Arg16Gly beta-2 genotype: a randomised trial in adolescents.	Ruffles T, Jones CJ, Palmer C, Turner S, Grigg J, Tavendale R, Hogarth F, Rauchhaus P, Pilvinyte K, Hannah R, Smith H, Littleford R, Lipworth B, Mukhopadhyay S.	Eur Respir J. 2021 Aug 19;58(2):2004107. doi: 10.1183/13993003.04107-2020. PMID: 33479111.
From DREAM to REALITI-A and beyond: Mepolizumab for the treatment of eosinophil driven diseases.	Pavord ID, Bel EH, Bourdin A, Chan R, Han JK, Keene ON, Liu MC, Martin N, Papi A, Roufosse F, Steinfeld J, Wechsler ME, Yancey SW.	Allergy. 2021 Aug 17. doi: 10.1111/all.15056. Epub ahead of print. PMID: 34402066.
Association between pre-existing respiratory disease and its treatment, and severe COVID-19: a population cohort study.	Aveyard P, Gao M, Lindson N, Hartmann-Boyce J, Watkinson P, Young D, Coupland CAC, Tan PS, Clift AK, Harrison D, Gould DW, Pavord ID, Hippisley-Cox J.	Lancet Respir Med. 2021 Aug;9(8):909-923. doi: 10.1016/S2213-2600(21)00095-3. Epub 2021 Apr 1. PMID: 33812494; PMCID: PMC8016404.
Menopausal hormone therapy and women's health: An umbrella review.	Zhang GQ, Chen JL, Luo Y, Mathur MB, Anagnostis P, Nurmatov U, Talibov M, Zhang J, Hawrylowicz CM, Lumsden MA, Critchley H, Sheikh A, Lundbäck B, Lässer C, Kankaanranta H, Lee SH, Nwaru BI.	PLoS Med. 2021 Aug 2;18(8):e1003731. doi: 10.1371/journal.pmed.1003731. PMID: 34339416; PMCID: PMC8366967.
Sibship size, birth order and risk of asthma and allergy: protocol for a systematic review and meta-analysis.	Lisik D, Ioannidou A, Milani G, Nyassi S, Özuygur Ermis SS, Spolidoro GCI, Goksör E, Wennergren G, Nwaru BI.	BMJ Open. 2021 Aug 23;11(8):e045795. doi: 10.1136/bmjopen-2020-045795. PMID: 34426461.
Long-term corticosteroid use, adrenal insufficiency and the need for steroid-sparing treatment in adult severe asthma.	Gurnell M, Heaney LG, Price D, Menzies-Gow A.	J Intern Med. 2021 Aug;290(2):240-256. doi: 10.1111/joim.13273. Epub 2021 Apr 1. PMID: 33598993; PMCID: PMC8360169.
Effectiveness and perceptions of using templates in long-term condition reviews: a systematic synthesis of quantitative and qualitative studies.	Morrissey M, Shepherd E, Kinley E, McClatchey K, Pinnock H.	Br J Gen Pract. 2021 Aug 26;71(710):e652-e659. doi: 10.3399/BJGP.2020.0963. PMID: 33690148; PMCID: PMC8321439.
Does lung function change in the months after an asthma exacerbation in children?	Martin J, Pijnenburg MW, Roberts G, Pike KC, Petsky H, Chang AB, Szefler SJ, Gergen P, Vermeulen F, Vael R, Turner S.	Pediatr Allergy Immunol. 2021 Aug;32(6):1208-1216. doi: 10.1111/pai.13503. Epub 2021 Mar 29. PMID: 33721352.
The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease.	Adeloye D, Elneima O, Daines L, Poinasamy K, Quint JK, Walker S, Brightling CE, Siddiqui S, Hurst JR, Chalmers JD, Pfeffer PE, Novotny P, Drake TM, Heaney LG, Rudan I, Sheikh A, De Soyza A; International COVID-19 Airways Diseases Group.	Lancet Respir Med. 2021 Aug 17:S2213-2600(21)00286-1. doi: 10.1016/S2213-2600(21)00286-1. Epub ahead of print. PMID: 34416191; PMCID: PMC8372501.
Asthma phenotyping in primary care: applying the International Severe Asthma Registry eosinophil phenotype algorithm across all asthma severities.	Kerkhof M, Tran TN, Allehebi R, Canonica GW, Heaney LG, Hew M, Perez de Llano L, Wechsler ME, Bulathsinhala L, Carter VA, Chaudhry I, Eleangovan N, Murray RB, Price CA, Price DB.	J Allergy Clin Immunol Pract. 2021 Aug 14:S2213-2198(21)00897-7. doi: 10.1016/j.jaip.2021.07.056. Epub ahead of print. PMID: 34403837.
Biologicals in childhood severe asthma: the European PERMEABLE survey on the <i>status quo</i>.	Santos-Valente E, Buntrock-Döpke H, Abou Taam R, Arasi S, Bakirtas A, Lozano Blasco J, Bønnelykke K, Craiu M, Cutrera R, Deschildre A, Elnazir B, Fleming L, Frey U, Gappa M, Nieto García A, Skamstrup Hansen K, Hanssens L, Jahnz-Rozyk K, Jesenak M, Kerzel S, Kopp MV, Koppelman GH, Krivec U, MacLeod KA, Mäkelä M, Melén E, Mezei G, Moeller A, Moreira A, Pohunek P, Minić P, Rutjes NWP, Sammut P, Schwerk N, Szépfalusi Z, Turkalj M, Tzotcheva I, Ulmeanu A, Verhulst S, Xepapadaki P, Niggel J, Vijverberg S, Maitland-van der Zee AH, Potočnik U, Reinartz SM, van Drunen CM, Kabesch M.	ERJ Open Res. 2021 Aug 16;7(3):00143-2021. doi: 10.1183/23120541.00143-2021. PMID: 34409097; PMCID: PMC8365152.
Sociocultural influences on asthma self- management in a multicultural society: A qualitative study amongst Malaysian adults.	Koh WM, Abu Bakar AI, Hussein N, Pinnock H, Liew SM, Hanafi NS, Pang YK, Ho BK, Mohamed Isa S, Sheikh A, Khoo EM.	Health Expect. 2021 Aug 27. doi: 10.1111/hex.13352. Epub ahead of print. PMID: 34449970.
Ethnic and social inequalities in COVID-19 outcomes in Scotland: protocol for early pandemic evaluation and enhanced surveillance of COVID-19 (EAVE II).	Henery P, Vasileiou E, Hainey KJ, Buchanan D, Harrison E, Leyland AH, Alexis T, Robertson C, Agrawal U, Ritchie L, Stock SJ, McCowan C, Docherty A, Kerr S, Marple J, Wood R, Moore E, Simpson CR, Sheikh A, Katikireddi SV.	BMJ Open. 2021 Aug 10;11(8):e048852. doi: 10.1136/bmjopen-2021-048852. PMID: 34376451; PMCID: PMC8359861.
Addressing a system failure to diagnose COPD and asthma.	Roberts CM, Calvert J, Hickman K, Quint JK, Sinha IP, Singh SJ, Hurst JR.	Lancet Respir Med. 2021 Aug;9(8):814-816. doi: 10.1016/S2213-2600(21)00272-1. Epub 2021 Jun 15. PMID: 34144000.
A feasibility trial of a digital mindfulness-based intervention to improve asthma-related quality of life for primary care patients with asthma.	Ainsworth B, Stanescu S, Stuart B, Russell D, Liddiard M, Djukanovic R,Thomas M	J Behav Med. 2021 Aug 27. doi: 10.1007/s10865-021-00249-3. Epub ahead of print. PMID: 34448986.
Lung health in LMICs: tackling challenges ahead.	Khoo EM, Li D, Ungan M, Jordan R, Pinnock H.	Lancet. 2021 Aug 7;398(10299):488-489. doi: 10.1016/S0140-6736(21)01230-7. PMID: 34364520.
Associations between smoke-free vehicle legislation and childhood admissions to hospital for asthma in Scotland: an interrupted time-series analysis of whole-population data.	Mackay DF, Turner SW, Semple SE, Dick S, Pell JP.	Lancet Public Health. 2021 Aug;6(8):e579-e586. doi: 10.1016/S2468-2667(21)00129-8. Epub 2021 Jul 16. PMID: 34274049.
COVID-19 vaccines: addressing hesitancy in young people with allergies.	Abrams EM, Shaker M, Sinha I, Greenhawt M	Lancet Respir Med. 2021 Aug 17:S2213-2600(21)00370-2. doi: 10.1016/S2213-2600(21)00370-2. Epub ahead of print. PMID: 34416192; PMCID: PMC8372552.
Derivation of a prototype asthma attack risk scale centred on blood eosinophils and exhaled nitric oxide.	Couillard S, Laugerud A, Jabeen M, Ramakrishnan S, Melhorn J, Hinks T, Pavord I.	Thorax. 2021 Aug 6:thoraxjnl-2021-217325. doi: 10.1136/thoraxjnl-2021-217325. Epub ahead of print. PMID: 34362839.
Aeroallergen sensitization for detecting asthma in primary care: A diagnostic test accuracy study.	Kocks JWH, Andringa HJH, van Heijst E, Louis R, Ojanguren Arranz I, Riemersma RA, Ryan D, Usmani OS, Flokstra-de Blok BMJ.	Clin Exp Allergy. 2021 Aug;51(8):1080-1084. doi: 10.1111/cea.13888. Epub2021 May 11. PMID: 33914988.
Dupilumab efficacy in adolescents with uncontrolled, moderate-to-severe asthma: LIBERTY ASTHMA QUEST.	Maspero JF, FitzGerald JM, Pavord ID, Rice MS, Maroni J, Rowe PJ, Pirozzi G, Amin N, Ruddy M, Graham NMH, Teper A, Hardin M.	Allergy. 2021 Aug;76(8):2621-2624. doi: 10.1111/all.14872. Epub 2021 May 10. PMID: 33905544; PMCID: PMC8360078.
Predicted COVID-19 positive cases, hospitalisations, and deaths associated with the Delta variant of concern, June- July, 2021.	Shah SA, Moore E, Robertson C, McMenamin J, Katikireddi SV, Simpson CR, Shi T, Agrawal U, McCowan C, Stock S, Ritchie LD, Sheikh A; Public Health Scotland and the EAVE II Collaborators.	Lancet Digit Health. 2021 Sep;3(9):e539-e541. doi: 10.1016/S2589-7500(21)00175-8. Epub 2021 Aug 9. PMID: 34384736; PMCID: PMC8352493.

July

Title	Authors	Reference
Factors Associated with Frequent Exacerbations in the UK Severe Asthma Registry.	Yang F, Busby J, Heaney LG, Menzies-Gow A, Pfeffer PE, Jackson DJ, Mansur AH, Siddiqui S, Brightling CE, Niven R, Thomson NC, Chaudhuri R; UK Severe Asthma Registry.	J Allergy Clin Immunol Pract. 2021 Jul;9(7):2691-2701.e1. doi: 10.1016/j.jaip.2020.12.062. Epub 2021 Jan 15. PMID: 33460858.
Heterogeneity within and between physician- diagnosed asthma and/or COPD: NOVELTY cohort.	Reddel HK, Vestbo J, Agustí A, Anderson GP, Bansal AT, Beasley R, Bel EH, Janson C, Make B, Pavord ID, Price D, Rapsomaniki E, Karlsson N, Finch DK, Nuevo J, de Giorgio-Miller A, Alacqua M, Hughes R, Müllerová H, Gerhardsson de Verdier M; NOVELTY study investigators.	Eur Respir J. 2021 Jul 1:2003927. doi: 10.1183/13993003.03927-2020. Epub ahead of print. PMID: 33632799.
Vitamin D and coronavirus disease 2019 (COVID-19): rapid evidence review.	Raisi-Estabragh Z, Martineau AR, Curtis EM, Moon RJ, Darling A, Lanham-New S, Ward KA, Cooper C, Munroe PB, Petersen SE, Harvey NC.	Aging Clin Exp Res. 2021 Jul;33(7):2031-2041. doi: 10.1007/s40520-021-01894-z. Epub 2021 Jun 12. PMID: 34118024; PMCID: PMC8195723.
Temporal trends and forecasting of COVID-19 hospitalisations and deaths in Scotland using a national real-time patient-level data platform: a statistical modelling study.	Simpson CR, Robertson C, Vasileiou E, Moore E, McCowan C, Agrawal U, Stagg HR, Docherty A, Mulholland R, Murray JLK, Ritchie LD, McMenamin J, Sheikh A.	Lancet Digit Health. 2021 Aug;3(8):e517-e525. doi: 10.1016/S2589-7500(21)00105-9. Epub 2021 Jul 5. PMID: 34238721; PMCID: PMC8257056.
Reducing the hidden burden of severe asthma: recognition and referrals from primary practice.	Humbert M, Bourdin A, Papadopoulos NG, Holgate ST, Hanania NA, Halpin DMG, Chapman KR, Gavornikova M, Price DB, Kaplan A, Heaney LG.	J Asthma. 2021 Jul;58(7):849-854. doi: 10.1080/02770903.2020.1759084. Epub 2020 May 13. PMID: 32347748.
How I do it. Work-up of severe asthma.	Couillard S, Jackson DJ, Wechsler ME, Pavord ID.	Chest. 2021 Jul 12:S0012-3692(21)01325-8. doi: 10.1016/j.chest.2021.07.008. Epub ahead of print. PMID: 34265308.
The TANDEM trial: protocol for the process evaluation of a randomised trial of a complex intervention for anxiety and/or depression in people living with chronic obstructive pulmonary disease (COPD).	Kelly M, Steed L, Sohanpal R, Pinnock H, Barradell A, Dibao-Dina C, Mammoliti KM, Wileman V, Rowland V, Newton S, Moore A, Taylor S.	Trials. 2021 Jul 26;22(1):495. doi: 10.1186/s13063-021-05460-w. PMID: 34311766; PMCID: PMC8313120.
Identifying patients at risk of poor asthma outcomes associated with making inhaler technique errors.	Barbara SA, Kritikos V, Price DB, Bosnic-Anticevich S.	J Asthma. 2021 Jul;58(7):967-978. doi: 10.1080/02770903.2020.1742353. Epub 2020 Mar 31. PMID: 32162572.
Effect of smoke-free policies in outdoor areas and private places on children's tobacco smoke exposure and respiratory health: a systematic review and meta-analysis.	Radó MK, Mölenberg FJM, Westenberg LEH, Sheikh A, Millett C, Burdorf A, van Lenthe FJ, Been JV.	Lancet Public Health. 2021 Aug;6(8):e566-e578. doi: 10.1016/S2468-2667(21)00097-9. Epub 2021 Jul 16. PMID: 34274050.
Defining a Severe Asthma Super-Responder: Findings from a Delphi Process.	Upham JW, Le Lievre C, Jackson DJ, Masoli M, Wechsler ME, Price DB; Delphi Panel.	J Allergy Clin Immunol Pract. 2021 Jul 13:S2213-2198(21)00772-8. doi: 10.1016/j.jaip.2021.06.041. Epub ahead of print. PMID: 34271216.
Balancing the needs of the many and the few: where next for adult asthma guidelines?	Shaw DE, Heaney LG, Thomas M, Beasley R, Gibson PG, Pavord ID.	Lancet Respir Med. 2021 Jul;9(7):786-794. doi: 10.1016/S2213-2600(21)00021-7. Epub 2021 Feb 24. PMID: 33639099.
Management Strategies to Reduce Exacerbations in non-T2 Asthma.	Murphy RC, Pavord ID, Alam R, Altman MC.	J Allergy Clin Immunol Pract. 2021 Jul;9(7):2588-2597. doi: 10.1016/j.jaip.2021.04.033. PMID: 34246435.
Implementing spirometry and fractional exhaled nitric oxide testing in childhood asthma management in UK primary care: an observational study to examine training and implementation cost and impact on patient's health use and outcome.	Yang Y, Lo DK, Beardsmore C, Roland D, Richardson M, Danvers L, Wilson A, Gaillard EA.	Arch Dis Child. 2021 Jul 9:archdischild-2020-319310. doi: 10.1136/archdischild-2020-319310. Epub ahead of print. PMID: 34244168.
Hormone Replacement Therapy and Risk of Severe Asthma Exacerbation in Perimenopausal and Postmenopausal Women: 17-Year National Cohort Study.	Nwaru BI, Shah SA, Tibble H, Pillinger R, McLean S, Ryan D, Critchley H, Hawrylowicz CM, Simpson CR, Soyiri IN, Appiagyei F, Price D, Sheikh A.	J Allergy Clin Immunol Pract. 2021 Jul;9(7):2751-2760.e1. doi: 10.1016/j.jaip.2021.02.052. Epub 2021 Mar 8. PMID: 33705997.
A real-life comparative effectiveness study into the addition of antibiotics to the management of asthma exacerbations in primary care.	Murray CS, Lucas SJ, Blakey J, Kaplan A, Papi A, Paton J, Phipatanakul W, Price D, Teoh OH, Thomas M, Turner S, Papadopoulos NG.	Eur Respir J. 2021 Jul 1;58(1):2003599. doi: 10.1183/13993003.03599-2020. PMID: 33419889.
Effect of high-intensity interval training in adolescents with asthma: The eXercise for Asthma with Commando Joe's® (X4ACJ) trial.	Winn CON, Mackintosh KA, Eddolls WTB, Stratton G, Wilson AM, McNarry MA, Davies GA.	J Sport Health Sci. 2021 Jul;10(4):488-498. doi: 10.1016/j.jshs.2019.05.009. Epub 2019 May 30. PMID: 34304826.
Pre-existing asthma as a comorbidity does not modify cytokine responses and severity of COVID-19.	Luo J, Chen YL, Chen W, Duncan DA, Mentzer A, Knight JC, Ogg G, Klenerman P, Pavord ID, Xue L.	Allergy Asthma Clin Immunol. 2021 Jul 8;17(1):67. doi: 10.1186/s13223-021-00569-8. PMID: 34238349; PMCID: PMC8264490.
Asthma and high-intensity interval training have no effect on clustered cardiometabolic risk or arterial stiffness in adolescents.	McNarry MA, Lester L, Ellins EA, Halcox JP, Davies G, Winn CON, MackintoshKA.	Eur J Appl Physiol.2021 Jul;121(7):1967-1978. doi: 10.1007/s00421-020-04590-4. Epub 2021 Mar 29. PMID: 33778908; PMCID: PMC8192411.
House dust mite (HDM) and storage mite (SM) molecular sensitisation profiles and association with clinical outcomes in allergic asthma and rhinitis: protocol for a systematic review.	Matos-Semedo F, Cruz C, Inácio F, Gama JMR, Nwaru BI, Taborda-Barata L.	BMJ Open. 2021 Jul 26;11(7):e046519. doi: 10.1136/bmjopen-2020-046519. PMID: 34312197.
Operational definitions of paediatric asthma used in epidemiological studies: A systematic review.	Islam MS, Huq S, Ahmed S, Roy S, Schwarze J, Sheikh A, Saha SK, Cunningham S, Nair H; RESPIRE collaboration.	J Glob Health. 2021 Jul 17;11:04032. doi: 10.7189/jogh.11.04032. PMID: 34326990; PMCID: PMC8285759.
An external validation of the QCovid risk prediction algorithm for risk of mortality from COVID-19 in adults: a national validation cohort study in England.	Nafilyan V, Humberstone B, Mehta N, Diamond I, Coupland C, Lorenzi L, Pawelek P, Schofield R, Morgan J, Brown P, Lyons R, Sheikh A, Hippisley-Cox J.	Lancet Digit Health. 2021 Jul;3(7):e425-e433. doi: 10.1016/S2589-7500(21)00080-7. Epub 2021 May 25. PMID: 34049834; PMCID: PMC8148652.
Patients' and Clinicians' Perceived Trust in Internet-of-Things Systems to Support Asthma Self-management: Qualitative Interview Study.	Hui CY, McKinstry B, Fulton O, Buchner M, Pinnock H.	JMIR Mhealth Uhealth. 2021 Jul 16;9(7):e24127. doi: 10.2196/24127. PMID: 34269684.
High Use of SABAs is Associated with Higher Exacerbation Rate in Dutch Patients with Asthma.	Baron AJ, Flokstra-de Blok BMJ, Kerstjens HAM, Koopmans-Klein G, Price DB, Sellink AA, Tsiligianni I, Kocks JWH.	J Asthma Allergy. 2021 Jul 12;14:851-861. doi: 10.2147/JAA.S292943. PMID: 34285512; PMCID: PMC8285233.
Management of asthma in childhood: study protocol of a systematic evidence update by the Paediatric Asthma in Real Life (PeARL) Think Tank.	Mathioudakis AG, Miligkos M, Boccabella C, Alimani GS, Custovic A, Deschildre A, Ducharme FM, Kalayci O, Murray C, Garcia AN, Phipatanakul W, Price D, Sheikh A, Agache IO, Bacharier L, Beloukas A, Bentley A, Bonini M, Castro- Rodriguez JA, De Carlo G, Craig T, Diamant Z, Feleszko W, Felton T, Gern JE, Grigg J, Hedlin G, Hossny EM, Ierodiakonou D, Jartti T, Kaplan A, Lemanske RF, Le Souëf PN, Mäkelä MJ, Mathioudakis GA, Matricardi P, Mitrogiorgou M, Morais- Almeida M, Nagaraju K, Papageorgiou E, Pité H, Pitrez PMC, Pohunek P, Roberts G, Tsiligianni I, Turner S, Vijverberg S, Winders TA, Wong GW, Xepapadaki P, Zar HJ, Papadopoulos NG.	BMJ Open. 2021 Jul 2;11(7):e048338. doi: 10.1136/bmjopen-2020-048338. PMID: 34215609; PMCID: PMC8256789.
Medication Adherence in Patients With Severe Asthma Prescribed Oral Corticosteroids in the U-BIOPRED Cohort.	Alahmadi FH, Simpson AJ, Gomez C, Ericsson M, Thörngren JO, Wheelock CE, Shaw DE, Fleming LJ, Roberts G, Riley J, Bates S, Sousa AR, Knowles R, Bansal AT, Corfield J, Pandis I, Sun K, Bakke PS, Caruso M, Chanez P, Dahlén B, Horvath I, Krug N, Montuschi P, Singer F, Wagers S, Adcock IM, Djukanovic R, Chung KF, Sterk PJ, Dahlen SE, Fowler SJ; U-BIOPRED Study Group.	Chest. 2021 Jul;160(1):53-64. doi: 10.1016/j.chest.2021.02.023. Epub 2021 Feb 19. PMID: 33610577.
Cluster Analysis of Inflammatory Biomarker Expression in the International Severe Asthma Registry.	Denton E, Price DB, Tran TN, Canonica GW, Menzies-Gow A, FitzGerald JM, Sadatsafavi M, Perez de Llano L, Christoff G, Quinton A, Rhee CK, Brusselle G, Ulrik C, Lugogo N, Hore-Lacy F, Chaudhry I, Bulathsinhala L, Murray RB, Carter VA, Hew M.	J Allergy Clin Immunol Pract. 2021 Jul;9(7):2680-2688.e7. doi: 10.1016/j.jaip.2021.02.059. Epub 2021 Mar 18. PMID: 33744476.
Biologics in severe asthma: Which one, When and Where?	Rupani H, Murphy A, Bluer K, Renwick C, McQuitty P, Jackson DJ, Heaney LG, Chaudhuri R, Menzies-Gow A, Calvert J, Siddiqui S.	Clin Exp Allergy. 2021 Jul 21. doi: 10.1111/cea.13989. Epub ahead of print. PMID: 34289191.
Associations between smoke-free vehicle legislation and childhood admissions to hospital for asthma in Scotland: an interrupted time-series analysis of whole-population data.	Mackay DF, Turner SW, Semple SE, Dick S, Pell JP.	Lancet Public Health. 2021 Aug;6(8):e579-e586. doi: 10.1016/S2468-2667(21)00129-8. Epub 2021 Jul 16. PMID: 34274049.
COVID-19 and the mental health of children with respiratory illness.	Sinha IP, Murphy R, Biffin H, Gait L, Abrams EM, Lee AR, Gray-Ffrench M, Fernandes RM, Watson E, Hawcut DB, Southern KW, Brown A.	Lancet Respir Med. 2021 Jul 1:S2213-2600(21)00319-2. doi: 10.1016/S2213-2600(21)00319-2. Epub ahead of print. PMID: 34217380.
Barriers to implementing asthma self-management in Malaysian primary care: qualitative study exploring the perspectives of healthcare professionals.	Lee PY, Cheong AT, Ghazali SS, Salim H, Wong J, Hussein N, Ramli R, Pinnock H, Liew SM, Hanafi NS, Bakar AIA, Ahad AM, Pang YK, Chinna K, Khoo EM.	NPJ Prim Care Respir Med. 2021 Jul 7;31(1):38. doi: 10.1038/s41533-021-00250-y. PMID: 34234145; PMCID: PMC8263608.
A 3-month period of electronic monitoring can provide important information to the healthcare team to assess adherence and improve asthma control.	Jochmann A, Artusio L, Usemann J, Jamalzadeh A, Bush A, Frey U, Fleming LJ.	ERJ Open Res. 2021 Jul 26;7(3):00726-2020. doi: 10.1183/23120541.00726-2020. PMID: 34322543; PMCID: PMC8311129.
A Proposed Revision of the Stepwise Treatment Algorithm in Asthma.	Beasley R, Bruce P, Hatter L, Braithwaite I, Semprini A, Kearns C, Weatherall M, Pavord ID.	Am J Respir Crit Care Med. 2021 Jul 1;204(1):100-103. doi: 10.1164/rccm.202101-0224LE. PMID: 33789069.

June

Title	Authors	Reference
Spotlight on microRNAs in allergy and asthma.	Weidner J, Bartel S, Kılıç A, Zissler UM, Renz H, Schwarze J, Schmidt-Weber CB, Maes T, Rebane A, Krauss-Etschmann S, Rådinger M.	Allergy. 2021 Jun;76(6):1661-1678. doi: 10.1111/all.14646. Epub 2020 Nov 20. PMID: 33128813; PMCID: PMC8246745.
ARIA-EAACI care pathways for allergen immunotherapy in respiratory allergy.	Bousquet J, Pfaar O, Agache I, Bedbrook A, Akdis CA, Canonica GW, Chivato T, Al-Ahmad M, Abdul Latiff AH, Ansotegui IJ, Bachert C, Baharuddin A, Bergmann KC, Bindslev-Jensen C, Bjermer L, Bonini M, Bosnic-Anticevich S, Bosse I, Brough HA, Brussino L, Calderon MA, Caraballo L, Cardona V, Carreiro-Martins P, Casale T, Cecchi L, Cepeda Sarabia AM, Chkhartishvili E, Chu DK, Cirule I, Cruz AA, Czarlewski W, Del Giacco S, Demoly P, Devillier P, Dokic D, Durham SL, Ebisawa M, El-Gamal Y, Emuzyte R, Gamkrelidze A, Fauquert JL, Fiocchi A, Fokkens WJ, Fonseca JA, Fontaine JF, Gawlik R, Gelincik A, Gemicioglu B, Gereda JE, Gerth van Wijk R, Gomez RM, Gotua M, Grisle I, Guzmán MA, Haahtela T, Halken S, Heffler E, Hoffmann-Sommergruber K, Hossny E, Hrubiško M, Irani C, Ivancevich JC, Ispayeva Z, Julge K, Kaidashev I, Kalayci O, Khaitov M, Klimek L, Knol E, Kowalski ML, Kraxner H, Kull I, Kuna P, Kvedariene V, Kritikos V, Lauerma A, Lau S, Laune D, Levin M, Larenas-Linnemann DE, Lodrup Carlsen KC, Lombardi C, Lourenço OM, Mahboub B, Malling HJ, Manning P, Marshall GD, Melén E, Meltzer EO, Miculinic N, Milenkovic B, Moin M, Montefort S, Morais-Almeida M, Mortz CG, Mösges R, Mullol J, Namazova Baranova L, Neffen H, Nekam K, Niedoszytko M, Odemyr M, O'Hehir RE, Ollert M, O'Mahony L, Ohta K, Okamoto Y, Okubo K, Pajno GB, Palomares O, Palkonen S, Panzner P, G Papadopoulos N, Park HS, Passalacqua G, Patella V, Pawankar R, Pham-Thi N, Plavec D, Popov TA, Recto M, Regateiro FS, Riggioni C, Roberts G, Rodriguez-Gonzales M, Rosario N, Rottem M, Rouadi PW, Ryan D, Samolinski B, Sanchez-Borges M, Serpa FS, Sastre J, Scadding GK, Shamji MH, Schmid-Grendelmeier P, Schünemann HJ, Sheikh A, Scichilone N, Sisul JC, Sofiev M, Solé D, Sooronbaev T, Soto-Martinez M, Soto-Quiros M, Sova M, Schwarze J, Skypala I, Suppli-Ulrik C, Taborda-Barata L, Todo-Bom A, Torres MJ, Valentin- Rostan M, Tomazic PV, Valero A, Toppila-Salmi S, Tsiligianni I, Untersmayr E, Urrutia-Pereira M, Valiulis A, Valovirta E, Vandenplas O, Ventura MT, Vichyanond P, Wagenmann M, Wallace D, Walusiak-Skorupa J, Wang Y, Waserman S, Wong GW, Yorgancioglu A, Yusuf OM, Zernotti M, Zhang L, Zidarn M, Zuberbier T, Jutel M.	Clin Transl Allergy. 2021 Jun 9;11(4):e12014. doi: 10.1002/clt2.12014. PMID: 34136127; PMCID: PMC8190541.
Predicting asthma-related crisis events using routine electronic healthcare data.	Noble M, Burden A, Stirling S, Clark A, Musgrave S, Al Sallakh M, Price D, Davies G, Pinnock H, Pond M, Sheikh A, Sims E, Walker S, Wilson A.	Br J Gen Pract. 2021 Jun 15:BJGP.2020.1042. doi: 10.3399/BJGP.2020.1042. Epub ahead of print. PMID: 34133316.
A randomised controlled trial of the effect of a connected inhaler system on medication adherence in uncontrolled asthmatic patients.	Moore A, Preece A, Sharma R, Heaney LG, Costello RW, Wise RA, Ludwig-Sengpiel A, Mosnaim G, Rees J, Tomlinson R, Tal-Singer R, Stempel DA, Barnes N.	Eur Respir J. 2021 Jun 4;57(6):2003103. doi: 10.1183/13993003.03103-2020. PMID: 33334936; PMCID: PMC8176348.
Fungal sensitization and positive fungal culture from sputum in children with asthma are associated with reduced lung function and acute asthma attacks respectively.	Welsh KG, Holden KA, Wardlaw AJ, Satchwell J, Monteiro W, Pashley CH, Gaillard EA.	Clin Exp Allergy. 2021 Jun;51(6):790-800. doi: 10.1111/cea.13799. Epub 2020 Dec 13. PMID: 33274520.
Vitamin D and coronavirus disease 2019 (COVID-19): rapid evidence review.	Raisi-Estabragh Z, Martineau AR, Curtis EM, Moon RJ, Darling A, Lanham-New S, Ward KA, Cooper C, Munroe PB, Petersen SE, Harvey NC.	Aging Clin Exp Res. 2021 Jul;33(7):2031-2041. doi: 10.1007/s40520-021-01894-z. Epub 2021 Jun 12. PMID: 34118024; PMCID: PMC8195723.
Treatment patterns among non-active users of maintenance asthma medication in the United Kingdom: a retrospective cohort study in the Clinical Practice Research Datalink.	Gibbons DC, Aggarwal B, Fairburn-Beech J, Hinds D, Fletcher M, Bosnic- Anticevich S, Price D.	J Asthma. 2021 Jun;58(6):793-804. doi: 10.1080/02770903.2020.1728767. Epub 2020 Feb 23. PMID: 32090642.
Physical activity and sedentary time in children and adolescents with asthma: A systematic review and meta-analysis.	Mackintosh KA, McNarry MA, Berntsen S, Steele J, Sejersted E, Westergren T.	Scand J Med Sci Sports. 2021 Jun;31(6):1183-1195. doi: 10.1111/sms.13937. Epub 2021 Feb 28. PMID: 33576534.
The influence of individual characteristics and non-respiratory diseases on blood eosinophil count.	Amaral R, Jacinto T, Malinovschi A, Janson C, Price D, Fonseca JA, Alving K.	Clin Transl Allergy. 2021 Jun 3;11(4):e12036. doi: 10.1002/clt2.12036. PMID: 34123365; PMCID: PMC8175041.
Chronic respiratory disease surveys in adults in low- and middle- income countries: A systematic scoping review of methodological approaches and outcomes.	Hanafi NS, Agarwal D, Chippagiri S, Brakema EA, Pinnock H, Sheikh A, Liew SM, Ng CW, Isaac R, Chinna K, Wong LP, Hussein N, Abu Bakar AI, Pang YK, Juvekar S, Khoo EM.	J Glob Health. 2021 Jun 19;11:04026. doi: 10.7189/jogh.11.04026. PMID: 34221357; PMCID: PMC8248510.
Patient characteristics, biomarkers, and exacerbation risk in severe, uncontrolled asthma.	Kraft M, Brusselle G, Mark FitzGerald J, Pavord ID, Keith M, Fagerås M, Garcia Gil E, Hirsch I, Goldman M, Colice G.	Eur Respir J. 2021 Jun 10:2100413. doi: 10.1183/13993003.00413-2021. Epub ahead of print. PMID: 34112734.
Health information technology and digital innovation for national learning health and care systems.	Sheikh A, Anderson M, Albala S, Casadei B, Franklin BD, Richards M, Taylor D, Tibble H, Mossialos E	Lancet Digit Health. 2021 Jun;3(6):e383-e396. doi: 10.1016/S2589-7500(21)00005-4. Epub 2021 May 6. PMID: 33967002.
Realising the full potential of data-enabled trials in the UK: a call for action.	Sydes MR, Barbachano Y, Bowman L, Denwood T, Farmer A, Garfield-Birkbeck S, Gibson M, Gulliford MC, Harrison DA, Hewitt C, Logue J, Navaie W, Norrie J, O'Kane M, Quint JK, Rycroft-Malone J, Sheffield J, Smeeth L, Sullivan F, Tizzard J, Walker P, Wilding J, Williamson PR, Landray M, Morris A, Walker RR, Williams HC, Valentine J; Data Enabled Trials Group Workshop Group members.	BMJ Open. 2021 Jun 16;11(6):e043906. doi: 10.1136/bmjopen-2020-043906. PMID: 34135032; PMCID: PMC8211043.
Baseline FeNO as a prognostic biomarker for subsequent severe asthma exacerbations in patientswith uncontrolled, moderate-to-severe asthma receiving placebo in the LIBERTY ASTHMA QUEST study: a post-hoc analysis.	Busse WW, Wenzel SE, Casale TB, FitzGerald JM, Rice MS, Daizadeh N, Deniz Y, Patel N, Harel S, Rowe PJ, Graham NMH, O'Riordan T, Pavord ID.	Lancet Respir Med. 2021 Jun 25:S2213-2600(21)00124-7. doi: 10.1016/S2213-2600(21)00124-7. Epub ahead of print. PMID: 34181876.
FeNO Non-Suppression Identifies Corticosteroid-Resistant Type-2 Signaling in Severe Asthma.	Couillard S, Shrimanker R, Chaudhuri R, Mansur AH, McGarvey LP, Heaney LG, Fowler SJ, Bradding P, Pavord ID, Hinks TSC; MRC UK Refractory Asthma Stratification programme (RASP-UK).	Am J Respir Crit Care Med. 2021 Jun 15. doi: 10.1164/rccm.202104-1040LE. Epub ahead of print. PMID: 34129808.
Persistence of Eosinophilic Asthma Endotype and Clinical Outcomes: A Real-World Observational Study.	Tran TN, Kerkhof M, Carter V, Price DB.	J Asthma Allergy. 2021 Jun 25;14:727-742. doi: 10.2147/JAA.S306416. PMID: 34211281; PMCID: PMC8242130.
Self-care support of diet and the gut in the routine care of school-age children with long-term conditions: An integrative review.	Cave L, Milnes LJ, McHugh GA.	J Child Health Care. 2021 Jun 30:13674935211029124. doi: 10.1177/13674935211029124. Epub ahead of print. PMID: 34190624.
When adherence and inhalation technique matter: Difficult-to-control pediatric asthma in low- to middle-income countries.	Rodriguez-Martinez CE, Sossa-Briceño MP, Sinha IP.	Pediatr Pulmonol. 2021 Jun;56(6):1366-1373. doi: 10.1002/ppul.25342. Epub 2021 Mar 8. PMID: 33684267.
Artificial Intelligence/Machine Learning in Respiratory Medicine and Potential Role in Asthma and COPD Diagnosis.	Kaplan A, Cao H, FitzGerald JM, Iannotti N, Yang E, Kocks JWH, Kostikas K, Price D, Reddel HK, Tsiligianni I, Vogelmeier CF, Pfister P, Mastoridis P.	J Allergy Clin Immunol Pract. 2021 Jun;9(6):2255-2261. doi: 10.1016/j.jaip.2021.02.014. Epub 2021 Feb 19. PMID: 33618053.
Mixed methods process evaluation of my breathing matters, a digital intervention to support self-management of asthma.	Greenwell K, Ainsworth B, Bruton A, Murray E, Russell D, Thomas M, Yardley L.	NPJ Prim Care Respir Med. 2021 Jun 4;31(1):35. doi: 10.1038/s41533-021-00248-6. PMID: 34088903; PMCID: PMC8178311.
Addressing a system failure to diagnose COPD and asthma.	Roberts CM, Calvert J, Hickman K, Quint JK, Sinha IP, Singh SJ, Hurst JR.	Lancet Respir Med. 2021 Jun 15:S2213-2600(21)00272-1. doi: 10.1016/S2213-2600(21)00272-1. Epub ahead of print. PMID: 34144000.
Evidence-based European guidelines for the diagnosis of asthma in children aged 5-16 years.	Gaillard EA, Moeller A.	Lancet Respir Med. 2021 Jun;9(6):558-560. doi: 10.1016/S2213-2600(21)00183-1. Epub 2021 Apr 21. PMID:33894141.
Clinical effects of mepolizumab in patients with severe eosinophilic asthma according to background therapy: A meta-analysis.	Lugogo N, Liu MC, Pavord I, Mitchell PD, Smith SG, Mallett S, Albers FC, Bradford ES, Yancey SW, Bel EH.	J Allergy Clin Immunol Pract. 2021 Jun 7:S2213-2198(21)00647-4. doi: 10.1016/j.jaip.2021.05.024. Epub ahead of print. PMID: 34111572.
SARS-CoV-2 Delta VOC in Scotland: demographics, risk of hospital admission, and vaccine effectiveness.	Sheikh A, McMenamin J, Taylor B, Robertson C; Public Health Scotland and the EAVE II Collaborators.	Lancet. 2021 Jun 26;397(10293):2461-2462. doi: 10.1016/S0140-6736(21)01358-1. Epub 2021 Jun 14. PMID: 34139198; PMCID: PMC8201647.

May

Title	Authors	Reference
Hormone replacement therapy and asthma onset in menopausal women: National cohort study.	Shah SA, Tibble H, Pillinger R, McLean S, Ryan D, Critchley H, Price D, Hawrylowicz CM, Simpson CR, Soyiri IN, Appiagyei F, Sheikh A, Nwaru BI.	J Allergy Clin Immunol. 2021 May;147(5):1662-1670. doi: 10.1016/j.jaci.2020.11.024. Epub 2020 Dec 3. PMID: 33279576.
COVID-19 information for people living with asthma: A rapid review of publicly available information.	McClatchey K, Jackson T, Delaney B, Morgan N, Pinnock H, Chan AHY.	J Allergy Clin Immunol Pract. 2021 May;9(5):2070-2072. doi: 10.1016/j.jaip.2021.01.003. Epub 2021 Jan 18. PMID: 33476786; PMCID: PMC7813501.
Risk of Rehospitalization and Death in Patients Hospitalized Due to Asthma.	Ekström M, Nwaru BI, Wiklund F, Telg G, Janson C.	J Allergy Clin Immunol Pract. 2021 May;9(5):1960-1968.e4. doi: 10.1016/j.jaip.2020.12.030. Epub 2020 Dec 24. PMID: 33359587.
Psychosocial working conditions and the subjective prognosis of gainful employment among employees with asthma: a cross-sectional study.	Heinrichs K, Hummel S, Gholami J, Schultz K, Wild B, Li J, Sheikh A, Loerbroks A.	DisabilRehabil. 2021 May;43(9):1299-1306. doi: 10.1080/09638288.2019.1662496. Epub 2019 Sep 14. PMID: 31522569.
Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials.	Jolliffe DA, Camargo CA Jr, Sluyter JD, Aglipay M, Aloia JF, Ganmaa D, Bergman P, Bischoff-Ferrari HA, Borzutzky A, Damsgaard CT, Dubnov-Raz G, Esposito S, Gilham C, Ginde AA, Golan-Tripto I, Goodall EC, Grant CC, Griffiths CJ, Hibbs AM, Janssens W, Khadilkar AV, Laaksi I, Lee MT, Loeb M, Maguire JL, Majak P, Mauger DT, Manaseki-Holland S, Murdoch DR, Nakashima A, Neale RE, Pham H, Rake C, Rees JR, Rosendahl J, Scragg R, Shah D, Shimizu Y, Simpson-Yap S, Trilok-Kumar G, Urashima M, Martineau AR.	Lancet Diabetes Endocrinol. 2021 May;9(5):276-292. doi: 10.1016/S2213-8587(21)00051-6. Epub 2021 Mar 30. PMID: 33798465.
Study protocol of the Edinburgh and Lothian Virus Intervention Study in Kids: a randomised controlled trial of hypertonic saline nose drops in children with upper respiratory tract infections (ELVISKids).	Ramalingam S, Graham C, Oatey K, Rayson P, Stoddart A, Sheikh A, Cunningham S; ELVIS Kids Trial Investigators.	BMJ Open. 2021 May 5;11(5):e049964. doi: 10.1136/bmjopen-2021-049964. PMID: 33952557; PMCID: PMC8103393.
Risk factors for asthma attacks and poor control in children: a prospective observational study in UK primary care.	Lo D, Beardsmore C, Roland D, Richardson M, Yang Y, Danvers L, Wilson A, Gaillard EA.	Arch Dis Child. 2021 May 20:archdischild-2020-320110. doi: 10.1136/archdischild-2020-320110. Epub ahead of print. PMID: 34016593.
Health information technology and digital innovation for national learning health and care systems.	Sheikh A, Anderson M, Albala S, Casadei B, Franklin BD, Richards M, Taylor D, Tibble H, Mossialos E.	Lancet Digit Health. 2021 Jun;3(6):e383-e396. doi: 10.1016/S2589-7500(21)00005-4. Epub 2021 May 6. PMID: 33967002.
Interim findings from first-dose mass COVID-19 vaccination roll-out and COVID-19 hospital admissions in Scotland: a national prospective cohort study.	Vasileiou E, Simpson CR, Shi T, Kerr S, Agrawal U, Akbari A, Bedston S, Beggs J, Bradley D, Chuter A, de Lusignan S, Docherty AB, Ford D, Hobbs FR, Joy M, Katikireddi SV, Marple J, McCowan C, McGagh D, McMenamin J, Moore E, Murray JL, Pan J, Ritchie L, Shah SA, Stock S, Torabi F, Tsang RS, Wood R, Woolhouse M, Robertson C, Sheikh A.	Lancet. 2021 May 1;397(10285):1646-1657. doi: 10.1016/S0140-6736(21)00677-2. Epub 2021 Apr 23. PMID: 33901420; PMCID: PMC8064669.
Precision Medicine for Paediatric Severe Asthma: Current Status and Future Direction.	Ramphul M, Lo DKH, Gaillard EA.	J Asthma Allergy. 2021 May 20;14:525-538. doi: 10.2147/JAA.S265657. PMID: 34045872; PMCID: PMC8144021.
Recurrent Severe Preschool Wheeze: From Pre-Specified Diagnostic Labels to Underlying Endotypes.	Robinson PFM, Fontanella S, Ananth S, Martin Alonso A, Cook J, Kaya-de Vries D, Polo Silveira L, Gregory L, Lloyd C, Fleming L, Bush A, Custovic A, Saglani S.	Am J Respir Crit Care Med. 2021 May 7. doi: 10.1164/rccm.202009-3696OC. Epub ahead of print. PMID: 33961755.
Ventilation heterogeneity in children with severe asthma.	Nuttall AG, Beardsmore CS, Gaillard EA.	Eur J Pediatr. 2021 May 13. doi: 10.1007/s00431-021-04101-3. Epub ahead of print. PMID: 33987684.
An external validation of the QCovid risk prediction algorithm for risk of mortality from COVID-19 in adults: a national validation cohort study in England.	Nafilyan V, Humberstone B, Mehta N, Diamond I, Coupland C, Lorenzi L, Pawelek P, Schofield R, Morgan J, Brown P, Lyons R, Sheikh A, Hippisley-Cox J.	Lancet Digit Health. 2021 May 25:S2589-7500(21)00080-7. doi: 10.1016/S2589-7500(21)00080-7. Epub ahead of print. PMID: 34049834; PMCID: PMC8148652.
The effects of social distancing and self-isolation during the COVID-19 pandemic on adults diagnosed with asthma: A qualitative study.	Tyson L, Hardeman W, Stratton G, Wilson AM, Semlyen J.	J Health Psychol. 2021 May 4:13591053211012766. doi: 10.1177/13591053211012766. Epub ahead of print. PMID: 33947267.
Evidence suggests dexamethasone is a better choice than prednisolone for acute asthma attacks in children.	Sinha IP.	Arch Dis Child. 2021 May 24:archdischild-2020-321499. doi: 10.1136/archdischild-2020-321499. Epub ahead of print. PMID: 34031028.
Piling Pelion upon Ossa: surely we already have enough non-evidence based ways of treating acute asthma?	Levy ML, Fleming L, Goldring S, Bush A.	Arch DisChild. 2021 May 25:archdischild-2020-321498. doi: 10.1136/archdischild-2020-321498. Epub ahead of print. PMID: 34035036.
Treatment of mild- to-moderate asthma in childhood and adolescence in 2021.	Abrams EM, Shaker M, Greenhawt M, Fernandes RM, Sinha I.	Lancet Respir Med. 2021 May;9(5):443-445. doi: 10.1016/S2213-2600(21)00135-1. Epub 2021 Mar 12. PMID: 33721559.
The inflammatory profile of exacerbations in patients with severe refractory eosinophilic asthma receiving mepolizumab (the MEX study): a prospective observational study.	McDowell PJ, Diver S, Yang F, Borg C, Busby J, Brown V, Shrimanker R, Cox C, Brightling CE, Chaudhuri R, Pavord ID, Heaney LG; Medical Research Council: Refractory Asthma Stratification Programme (RASP-UK Consortium).	Lancet Respir Med. 2021 May 7:S2213-2600(21)00004-7. doi: 10.1016/S2213-2600(21)00004-7. Epub ahead of print. PMID: 33971168.
The Role of Mobile Health Technologies in Stratifying Patients for AIT and Its Cessation: The ARIA -EAACI Perspective.	Bousquet J, Jutel M, Pfaar O, Fonseca JA, Agache I, Czarlewski W, Bachert C, Bergmann KC, Cruz AA, Klimek L, Kvedariene V, Larenas-Linnemann DE, Papadopoulos NG, Patella V, Regateiro FS, Scichilone N, Shamji MH, Sheikh A, Valovirta E, Ventura MT, Zuberbier T.	J Allergy Clin Immunol Pract. 2021 May;9(5):1805-1812. doi: 10.1016/j.jaip.2021.02.035. Epub 2021 Mar 1. PMID: 33662672.
Publisher Correction: School-based self-management interventions for asthma among primary school children: a systematic review.	Ramdzan SN, Suhaimi J, Harris KM, Khoo EM, Liew SM, Cunningham S, Pinnock H.	NPJ Prim Care Respir Med. 2021 May 6;31(1):26. doi: 10.1038/s41533-021-00240-0. Erratum for: NPJ Prim Care Respir Med. 2021 Apr 1;31(1):18. PMID: 33958596; PMCID: PMC8102472.

April

Title	Authors	Reference
Potential Severe Asthma Hidden in UK Primary Care.	Ryan D, Heatley H, Heaney LG, Jackson DJ, Pfeffer PE, Busby J, Menzies-Gow AN, Jones R, Tran TN, Al-Ahmad M, Backer V, Belhassen M, Bosnic-Anticevich S, Bourdin A, Bulathsinhala L, Carter V, Chaudhry I, Eleangovan N, FitzGerald JM, Gibson PG, Hosseini N, Kaplan A, Murray RB, Rhee CK, Van Ganse E, Price DB.	J Allergy Clin Immunol Pract. 2021 Apr;9(4):1612-1623.e9. doi: 10.1016/j.jaip.2020.11.053. Epub 2020 Dec 9. PMID: 33309935.
European Respiratory Society clinical practice guidelines for the diagnosis of asthma in children aged 5-16 years.	Gaillard EA, Kuehni CE, Turner S, Goutaki M, Holden KA, de Jong CCM, Lex C, Lo DKH, Lucas JS, Midulla F, Mozun R, Piacentini G, Rigau D, Rottier B, Thomas M, Tonia T, Usemann J, Yilmaz O, Zacharasiewicz A, Moeller A.	Eur Respir J. 2021 Apr 19:2004173. doi: 10.1183/13993003.04173-2020. Epub ahead of print. PMID: 33863747.
COVID-19 is not a driver of clinically significant viral wheeze and asthma.	Roland D, Teo KW, Bandi S, Lo D, Gaillard EA.	Arch Dis Child. 2021 Apr;106(4):e22. doi: 10.1136/archdischild-2020-320776. Epub 2020 Oct 16. PMID: 33067308.
Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials.	Jolliffe DA, Camargo CA Jr, Sluyter JD, Aglipay M, Aloia JF, Ganmaa D, Bergman P, Bischoff-Ferrari HA, Borzutzky A, Damsgaard CT, Dubnov-Raz G, Esposito S, Gilham C, Ginde AA, Golan-Tripto I, Goodall EC, Grant CC, Griffiths CJ, Hibbs AM, Janssens W, Khadilkar AV, Laaksi I, Lee MT, Loeb M, Maguire JL, Majak P, Mauger DT, Manaseki-Holland S, Murdoch DR, Nakashima A, Neale RE, Pham H, Rake C, Rees JR, Rosendahl J, Scragg R, Shah D, Shimizu Y, Simpson-Yap S, Trilok-Kumar G, Urashima M, Martineau AR.	Lancet Diabetes Endocrinol. 2021 May;9(5):276-292. doi: 10.1016/S2213-8587(21)00051-6. Epub 2021 Mar 30. PMID: 33798465.
Patients' and Clinicians' Visions of a Future Internet-of-Things System to Support Asthma Self-Management: Mixed Methods Study.	Hui CY, McKinstry B, Fulton O, Buchner M, Pinnock H.	J Med Internet Res. 2021 Apr 13;23(4):e22432. doi: 10.2196/22432. PMID: 33847592.
Association between pre-existing respiratory disease and its treatment, and severe COVID-19: a population cohort study.	Aveyard P, Gao M, Lindson N, Hartmann-Boyce J, Watkinson P, Young D, Coupland CAC, Tan PS, Clift AK, Harrison D, Gould DW, Pavord ID, Hippisley-Cox J.	Lancet Respir Med. 2021 Apr 1:S2213-2600(21)00095-3. doi: 10.1016/S2213-2600(21)00095-3. Epub ahead of print. PMID: 33812494; PMCID: PMC8016404.
Eosinophilic and non-eosinophilic asthma: an expert consensus framework to characterize phenotypes in a global real-life severe asthma cohort.	Heaney LG, Perez de Llano L, Al-Ahmad M, Backer V, Busby J, Canonica GW, Christoff GC, Cosio BG, FitzGerald JM, Heffler E, Iwanaga T, Jackson DJ, Menzies-Gow AN, Papadopoulos NG, Papaioannou AI, Pfeffer PE, Popov TA, Porsbjerg CM, Rhee CK, Sadatsafavi M, Tohda Y, Wang E, Wechsler ME, Alacqua M, Altraja A, Bjermer L, Björnsdóttir US, Bourdin A, Brusselle GG, Buhl R, Costello RW, Hew M, Siyue MK, Lehmann S, Lehtimäki L, Peters M, Taillé C, Taube C, Tran TN, Zangrilli J, Bulathsinhala L, Carter VA, Chaudhry I, Eleangovan N, Hosseini N, Kerkhof M, Murray RB, Price CA, Price DB.	Chest. 2021 Apr 19:S0012-3692(21)00700-5. doi: 10.1016/j.chest.2021.04.013. Epub ahead of print. PMID: 33887242.
Impact of COVID-19 national lockdown on asthma exacerbations: interrupted time-series analysis of English primary care data.	Shah SA, Quint JK, Nwaru BI, Sheikh A.	Thorax. 2021 Mar 29:thoraxjnl-2020-216512. doi: 10.1136/thoraxjnl-2020-216512. Epub ahead of print. PMID: 33782080; PMCID: PMC8011425.
Informing the public health response to COVID-19: a systematic review of risk factors for disease, severity, and mortality.	Flook M, Jackson C, Vasileiou E, Simpson CR, Muckian MD, Agrawal U, McCowan C, Jia Y, Murray JLK, Ritchie LD, Robertson C, Stock SJ, Wang X, Woolhouse MEJ, Sheikh A, Stagg HR.	BMC Infect Dis. 2021 Apr 12;21(1):342. doi: 10.1186/s12879-021-05992-1. PMID: 33845766; PMCID: PMC8040367.
Asthma and high-intensity interval training have no effect on clustered cardiometabolic risk or arterial stiffness in adolescents.	McNarry MA, Lester L, Ellins EA, Halcox JP, Davies G, Winn CON, Mackintosh KA.	Eur J Appl Physiol. 2021 Mar 29. doi: 10.1007/s00421-020-04590-4. Epub ahead of print. PMID: 33778908.
Patients' experiences of asthma exacerbation and management: a qualitative study of severe asthma.	Song WJ, Won HK, Lee SY, Park HK, Cho YS, Chung KF, Heaney LG, Joung WJ.	ERJ Open Res. 2021 Apr 6;7(2):00528-2020. doi: 10.1183/23120541.00528-2020. PMID: 33834052; PMCID: PMC8021804.
Impact of COVID-19 lockdown on emergency asthma admissions and deaths: national interrupted time series analyses for Scotland and Wales.	Davies GA, Alsallakh MA, Sivakumaran S, Vasileiou E, Lyons RA, Robertson C, Sheikh A; EAVE II Collaborators.	Thorax. 2021 Mar 29:thoraxjnl-2020-216380. doi: 10.1136/thoraxjnl-2020-216380. Epub ahead of print. PMID: 33782079; PMCID: PMC8011424.
Artificial Intelligence-enabled analysis of social media data to understand public perceptions of COVID-19 contact tracing apps.	Cresswell K, Tahir A, Sheikh Z, Hussain Z, Domínguez Hernández A, Harrison E, Williams R, Sheikh A, Hussain A.	J Med Internet Res. 2021 Apr 17. doi: 10.2196/26618. Epub ahead of print. PMID: 33939622.
School-based self-management interventions for asthma among primary school children: a systematic review.	Ramdzan SN, Suhaimi J, Harris KM, Khoo EM, Liew SM, Cunningham S, Pinnock H.	NPJ Prim Care Respir Med. 2021 Apr 1;31(1):18.doi: 10.1038/s41533-021-00230-2. PMID: 33795691; PMCID: PMC8016947.
Evidence-based European guidelines for the diagnosis of asthma in children aged 5-16 years.	Gaillard EA, Moeller A.	Lancet Respir Med. 2021 Apr 21:S2213-2600(21)00183-1. doi: 10.1016/S2213-2600(21)00183-1. Epub ahead of print. PMID: 33894141.

March

Title	Authors	Reference
Measuring and reporting treatment adherence: What can we learn by comparing two respiratory conditions?	Tibble H, Flook M, Sheikh A, Tsanas A, Horne R, Vrijens B, De Geest S, Stagg HR.	Br J Clin Pharmacol. 2021 Mar;87(3):825-836. doi: 10.1111/bcp.14458. Epub 2020 Jul 27. PMID: 32639589.
Characterisation of patients with severe asthma in the UK Severe Asthma Registry in the biologic era.	Jackson DJ, Busby J, Pfeffer PE, Menzies-Gow A, Brown T, Gore R, Doherty M, Mansur AH, Message S, Niven R, Patel M, Heaney LG; UK Severe Asthma Registry.	Thorax. 2021 Mar;76(3):220-227. doi: 10.1136/thoraxjnl-2020-215168. Epub 2020 Dec 9. PMID: 33298582; PMCID: PMC7892381.
Steroid-filled rant: or another fashion accessory?	Bush A, Levy M, Fleming L.	Arch Dis Child. 2021 Mar;106(3):211-212. doi: 10.1136/archdischild-2020-319462. Epub 2020 May 7. PMID: 32381520.
Hormone Replacement Therapy and Risk of Severe Asthma Exacerbation in Perimenopausal and Postmenopausal Women: 17-Year National Cohort Study.	Nwaru BI, Shah SA, Tibble H, Pillinger R, McLean S, Ryan D, Critchley H, Hawrylowicz CM, Simpson CR, Soyiri IN, Appiagyei F, Price D, Sheikh A.	J Allergy Clin Immunol Pract. 2021 Mar 8:S2213-2198(21)00295-6. doi: 10.1016/j.jaip.2021.02.052. Epub ahead of print. PMID: 33705997.
Clinical Development of Mepolizumab for the Treatment of Severe Eosinophilic Asthma: On the Path to Personalized Medicine.	Pavord ID, Menzies-Gow A, Buhl R, Chanez P, Dransfield M, Lugogo N, Keene ON, Bradford ES, Yancey SW.	J Allergy Clin Immunol Pract. 2021 Mar;9(3):1121-1132.e7. doi: 10.1016/j.jaip.2020.08.039. Epub 2020 Sep 2. PMID: 32889223.
Heterogeneity within and between physician- diagnosed asthma and/or COPD: NOVELTY cohort.	Reddel HK, Vestbo J, Agustí A, Anderson GP, Bansal AT, Beasley R, Bel EH, Janson C, Make B, Pavord ID, Price D, Rapsomaniki E, Karlsson N, Finch DK, Nuevo J, de Giorgio-Miller A, Alacqua M, Hughes R, Müllerová H, Gerhardsson de Verdier M; NOVELTY study investigators.	Eur Respir J. 2021 Feb 25:2003927. doi: 10.1183/13993003.03927-2020. Epub ahead of print. PMID: 33632799.
Effectiveness and perceptions of using templates in long-term condition reviews: a systematic synthesis of quantitative and qualitative studies.	Morrissey M, Shepherd E, Kinley E, McClatchey K, Pinnock H.	Br J Gen Pract. 2021 Mar 9:BJGP.2020.0963. doi: 10.3399/BJGP.2020.0963. Epub ahead of print. PMID: 33690148.
Level of education and asthma control in adult-onset asthma.	Ilmarinen P, Stridsman C, Bashir M, Tuomisto LE, Vähätalo I, Goksör E, Kankaanranta H, Backman H, Langhammer A, Piirilä P, Rönmark E, Lundbäck B, Nwaru BI, Wennergren G.	J Asthma. 2021 Mar 10:1-20. doi: 10.1080/02770903.2021.1871742. Epub ahead of print. PMID: 33497270.
When adherence and inhalation technique matter: Difficult-to-control pediatric asthma in low- to middle-income countries.	Rodriguez-Martinez CE, Sossa-Briceño MP, Sinha IP.	Pediatr Pulmonol. 2021 Mar 8. doi: 10.1002/ppul.25342. Epub ahead of print. PMID: 33684267.
Cluster analysis of inflammatory biomarker expression in the International Severe Asthma Registry (ISAR).	Denton E, Price DB, Tran TN, Canonica GW, Menzies-Gow A, FitzGerald JM, Sadatsafavi M, Perez de Llano L, Christoff G, Quinton A, Rhee CK, Brusselle G, Ulrik C, Lugogo N, Hore-Lacy F, Chaudhry I, Bulathsinhala L, Murray RB, Carter VA, Hew M.	J Allergy Clin Immunol Pract. 2021 Mar 17:S2213-2198(21)00311-1. doi: 10.1016/j.jaip.2021.02.059. Epub ahead of print. PMID: 33744476.
Treatment of mild-to-moderate asthma in childhood and adolescence in 2021.	Abrams EM, Shaker M, Greenhawt M, Fernandes RM, Sinha I.	Lancet Respir Med. 2021 Mar 12:S2213-2600(21)00135-1. doi: 10.1016/S2213-2600(21)00135-1. Epub ahead of print. PMID: 33721559.

February

Title	Authors	Reference
Empowering children and young people who have asthma.	Sinha IP, Brown L, Fulton O, Gait L, Grime C, Hepworth C, Lilley A, Murray M, Simba J	Arch Dis Child. 2021 Feb;106(2):125-129. doi: 10.1136/archdischild-2020-318788. Epub 2020 Jul 24. PMID: 32709687.
Fractional exhaled nitric oxide and asthma treatment adherence.	Butler CA, Heaney LG	Curr Opin Allergy Clin Immunol. 2021 Feb 1;21(1):59-64. doi: 10.1097/ACI.0000000000000704. PMID: 33369570.
The cost-effectiveness of azithromycin in reducing exacerbations in uncontrolled asthma.	O'Neill C, Gibson PG, Heaney LG, Upham JW, Yang IA, Reynolds PN, Hodge S, Jenkins CR, Peters M, Marks GB, James AL, Simpson JL.	Eur Respir J. 2021 Feb 17;57(2):2002436. doi: 10.1183/13993003.02436-2020. PMID: 33008933.
Discordant use of short-acting β<sub>2</sub> agonists in children and adults with severe, uncontrolled asthma from the U-BIOPRED cohort.	Gorlanova O, Tischhauser E, Adcock IM, Chung KF, Fleming L, Meier D, Sterk PJ, Roberts G, Roberts A, Singer F, Sousa AR, Uddin M, Frey U; U-BIOPRED Study Group.	Pediatr Pulmonol. 2021 Feb;56(2):338-340. doi: 10.1002/ppul.25171. Epub 2020 Nov 24. PMID: 33231935.
Balancing the needs of the many and the few: where next for adult asthma guidelines?	Shaw DE, Heaney LG, Thomas M, Beasley R, Gibson PG, Pavord ID.	Lancet Respir Med. 2021 Feb 24:S2213-2600(21)00021-7. doi: 10.1016/S2213-2600(21)00021-7. Epub ahead of print. PMID: 33639099.
Physical activity and sedentary time in children and adolescents with asthma: A systematic review and meta-analysis.	Mackintosh KA, McNarry MA, Berntsen S, Steele J, Sejersted E, Westergren T.	Scand J Med Sci Sports. 2021 Feb 12. doi: 10.1111/sms.13937. Epub ahead of print. PMID: 33576534.
Association of socioeconomic deprivation with asthma care, outcomes, and deaths in Wales: A 5-year national linked primary and secondary care cohort study.	Alsallakh MA, Rodgers SE, Lyons RA, Sheikh A, Davies GA	PLoS Med. 2021 Feb 12;18(2):e1003497. doi: 10.1371/journal.pmed.1003497. PMID: 33577558; PMCID: PMC7880491.
Level of education and asthma control in adult-onset asthma.	Ilmarinen P, Stridsman C, Bashir M, Tuomisto LE, Vähätalo I, Goksör E, Kankaanranta H, Backman H, Langhammer A, Piirilä P, Rönmark E, Lundbäck B, Nwaru BI, Wennergren G.	J Asthma. 2021 Jan 26:1-13. doi: 10.1080/02770903.2021.1871742. Epub ahead of print. PMID: 33497270.
Effect of Monthly Vitamin D Supplementation on Preventing Exacerbations of Asthma or Chronic Obstructive Pulmonary Disease in Older Adults: Post Hoc Analysis of a Randomized Controlled Trial.	Camargo CA Jr, Toop L, Sluyter J, Lawes CMM, Waayer D, Khaw KT, Martineau AR, Scragg R.	Nutrients. 2021 Feb 6;13(2):521. doi: 10.3390/nu13020521. PMID: 33561963; PMCID: PMC7915442.
ERS International Congress 2020: highlights from the General Pneumology Assembly.	Daines L, Buekers J, Bolado BA, Kocks JWH, Vagheggini G, Poberezhets V, Vogiatzis I, Pinnock H, Vanfleteren LEGW.	ERJ Open Res. 2021 Feb 8;7(1):00841-2020. doi: 10.1183/23120541.00841-2020. PMID: 33585656; PMCID: PMC7869601.
Medication adherence in patients with severe asthma prescribed oral corticosteroids in the U-BIOPRED cohort.	Alahmadi FH, Simpson AJ, Gomez C, Ericsson M, Thörngren JO, Wheelock C, Shaw DE, Fleming LJ, Roberts G, Riley J, Bates S, Sousa AR, Knowles R, Bansal AT, Corfield J, Pandis I, Sun K, Bakke PS, Caruso M, Chanez P, Dahlén B, Horvath I, Krug N, Montuschi P, Singer F, Wagers S, Adcock IM, Djukanovic R, Chung KF, Sterk PJ, Dahlen SE, Fowler SJ; U-BIOPRED Study Group.	Chest. 2021 Feb 18:S0012-3692(21)00288-9. doi: 10.1016/j.chest.2021.02.023. Epub ahead of print. PMID: 33610577.
Paediatric severe asthma biologics service: from hospital to home.	Makhecha S, Jamalzadeh A, Irving S, Hall P, Sonnappa S, Saglani S, Bush A, Fleming L.	Arch Dis Child. 2021 Feb 15:archdischild-2020-320626. doi: 10.1136/archdischild-2020-320626. Epub ahead of print. PMID: 33589471.
The impact of the first COVID-19 surge on severe asthma patients in the UK. Which is worse: the virus or the lockdown?	Smith SJ, Busby J, Heaney LG, Pfeffer PE, Jackson DJ, Yang F, Fowler SJ, Menzies-Gow A, Idris E, Brown T, Gore R, Faruqi S, Dennison P, Dodd JW, Doe S, Mansur AH, Priyadarshi R, Holmes J, Hearn A, Al-Aqqad H, Loewenthal L, Cooper A, Fox L, Selvan M, Crooks MG, Thompson A, Higbee D, Fawdon M, Nathwani V, Holmes L, Chaudhuri R.	ERJ Open Res. 2021 Feb 1;7(1):00768-2020. doi: 10.1183/23120541.00768-2020. PMID: 33564672; PMCID: PMC7681958.

January

Title	Authors	Reference
COVID-19 information for people living with asthma: A rapid review of publicly available information.	McClatchey K, Jackson T, Delaney B, Morgan N, Pinnock H, Chan AHY	J Allergy Clin Immunol Pract. 2021 Jan 18:S2213-2198(21)00058-1. doi: 10.1016/j.jaip.2021.01.003. Epub ahead of print. PMID: 33476786; PMCID: PMC7813501.
Dupilumab is effective in type 2-high asthma patients receiving high-dose inhaled corticosteroids at baseline.	Bourdin A, Papi AA, Corren J, Virchow JC, Rice MS, Deniz Y, Djandji M, Rowe P, Pavord ID	Allergy. 2021 Jan;76(1):269-280. doi: 10.1111/all.14611. Epub 2020 Oct 21. PMID: 33010038; PMCID: PMC7820970.
Assessment of adherence to corticosteroids in asthma by drug monitoring or fractional exhaled nitric oxide: A literature review.	Alahmadi F, Peel A, Keevil B, Niven R, Fowler SJ	Clin Exp Allergy. 2021 Jan;51(1):49-62. doi:10.1111/cea.13787. Epub 2020 Nov 27. PMID: 33190234; PMCID: PMC7839457.
Composite type-2 biomarker strategy versus a symptom-risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial.	Heaney LG, Busby J, Hanratty CE, Djukanovic R, Woodcock A, Walker SM, Hardman TC, Arron JR, Choy DF, Bradding P, Brightling CE, Chaudhuri R, Cowan DC, Mansur AH, Fowler SJ, Niven RM, Howarth PH, Lordan JL, Menzies-Gow A, Harrison TW, Robinson DS, Holweg CTJ, Matthews JG, Pavord ID; investigators for the MRC Refractory Asthma Stratification Programme	Lancet Respir Med. 2021 Jan;9(1):57-68. doi: 10.1016/S2213-2600(20)30397-0. Epub 2020 Sep 8. Erratum in: Lancet Respir Med. 2021 Jan 4;: PMID: 32916135; PMCID: PMC7783382.
A real-life comparative effectiveness study into the addition of antibiotics to the management of asthma exacerbations in primary care.	Murray CS, Lucas SJ, Blakey J, Kaplan A, Papi A, Paton J, Phipatanakul W, Price D, Teoh OH, Thomas M, Turner S, Papadopoulos NG	Eur Respir J. 2021 Jan 8:2003599. doi: 10.1183/13993003.03599-2020. Epub ahead of print. PMID: 33419889.
Factors associated with frequent exacerbations in the UK Severe Asthma Registry.	Yang F, Busby J, Heaney LG, Menzies-Gow A, Pfeffer PE, Jackson DJ, Mansur AH, Siddiqui S, Brightling CE, Niven R, Thomson NC, Chaudhuri R; UK Severe Asthma Registry	J Allergy Clin Immunol Pract. 2021 Jan 15:S2213-2198(21)00054-4. doi: 10.1016/j.jaip.2020.12.062. Epub ahead of print. PMID: 33460858.
Development and validation of a self-report measure of practical barriers to medication adherence - the Medication Practical barriers to Adherence Questionnaire (MPRAQ).	Chan AHY, Vervloet M, Lycett H, Brabers A, van Dijk L, Horne R	Br J Clin Pharmacol. 2021 Jan 24. doi: 10.1111/bcp.14744. Epub ahead of print. PMID: 33486802.
Asthma prescribing according to Arg16Gly beta-2 genotype: a randomised trial in adolescents.	Ruffles T, Jones CJ, Palmer C, Turner S, Grigg J, Tavendale R, Hogarth F, Rauchhaus P, Pilvinyte K, Hannah R, Smith H, Littleford R, Lipworth B, Mukhopadhyay S.	Eur Respir J. 2021 Jan 21:2004107. doi: 10.1183/13993003.04107-2020. Epub ahead of print. PMID: 33479111.
Identifying strategies to overcome roadblocks to utilising near real-time healthcare and administrative data to create a Scotland-wide learning health system.	Mukherjee M, Cresswell K, Sheikh A	Health Informatics J. 2021 Jan-Mar;27(1):1460458220977579. doi: 10.1177/1460458220977579. PMID: 33446033.

2020

December

Title	Authors	Reference
A golden age of asthma research.	O'Byrne PM, Pavord ID.	Eur Respir J. 2020 Dec 24;56(6):2003820. doi: 10.1183/13993003.03820-2020.
Attenuating COVID-19 infection and inflammation: Lessons from asthma.	Bardin PG, Johnston SL.	Respirology. 2020 Dec;25(12):1233-1234. doi: 10.1111/resp.13961. Epub 2020 Oct 13.
Hormone replacement therapy and asthma onset in menopausal women: National cohort study.	Shah SA, Tibble H, Pillinger R, McLean S, Ryan D, Critchley H, Price D, Hawrylowicz CM, Simpson CR, Soyiri IN, Appiagyei F, Sheikh A, Nwaru BI.	J Allergy Clin Immunol. 2020 Dec 3:S0091-6749(20)31697-3. doi: 10.1016/j.jaci.2020.11.024. Epub ahead of print.
Linkage of primary care prescribing records and pharmacy dispensing Records in the Salford Lung Study: application in asthma.	Tibble H, Lay-Flurrie J, Sheikh A, Horne R, Mizani MA, Tsanas A; Salford Lung Study Team.	BMC Med Res Methodol. 2020 Dec 10;20(1):303. doi: 10.1186/s12874-020-01184-8.
SERIES: eHealth in primary care. Part 4: Addressing the challenges of implementation.	Versluis A, van Luenen S, Meijer E, Honkoop PJ, Pinnock H, Mohr DC, Neves AL, Chavannes NH, van der Kleij RMJJ.	Eur J Gen Pract. 2020 Dec;26(1):140-145. doi: 10.1080/13814788.2020.1826431.
Risk of re-hospitalization and death in patients hospitalized due to asthma.	Ekström M, Nwaru BI, Wiklund F, Telg G, Janson C.	J Allergy Clin Immunol Pract. 2020 Dec 24:S2213-2198(20)31362-3. doi: 10.1016/j.jaip.2020.12.030. Epub ahead of print.
Characterisation of patients with severe asthma in the UK Severe Asthma Registry in the biologic era.	Jackson DJ, Busby J, Pfeffer PE, Menzies-Gow A, Brown T, Gore R, Doherty M, Mansur AH, Message S, Niven R, Patel M, Heaney LG; UK Severe Asthma Registry.	Thorax. 2020 Dec 9:thoraxjnl-2020-215168. doi: 10.1136/thoraxjnl-2020-215168. Epub ahead of print.
Potential severe asthma hidden in UK primary care.	Ryan D, Heatley H, Heaney LG, Jackson DJ, Pfeffer PE, Busby J, Menzies-Gow AN, Jones R, Tran TN, Al-Ahmad M, Backer V, Belhassen M, Bosnic-Anticevich S, Bourdin A, Bulathsinhala L, Carter V, Chaudhry I, Eleangovan N, FitzGerald JM, Gibson PG, Hosseini N, Kaplan A, Murray RB, Rhee CK, Van Ganse E, Price DB.	J Allergy Clin Immunol Pract. 2020 Dec 9:S2213-2198(20)31327-1. doi: 10.1016/j.jaip.2020.11.053. Epub ahead of print.
Vitamin D supplementation to prevent acute respiratory infections: systematic review and meta-analysis of aggregate data from randomised controlled trials.	Jolliffe DA, Camargo CA, Sluyter JD, Aglipay M, Aloia JF, Ganmaa D, Bergman P, Borzutzky A, Damsgaard CT, Dubnov-Raz G, Esposito S, Gilham C, Ginde AA, Golan-Tripto I, Goodall EC, Grant CC, Griffiths CJ, Hibbs AM, Janssens W, Khadilkar AV, Laaksi I, Lee MT, Loeb M, Maguire JL, Majak P, Mauger DT, Manaseki-Holland S, Murdoch DR, Nakashima A, Neale RE, Pham H, Rake C, Rees JR, Rosendahl J, Scragg R, Shah D, Shimizu Y, Simpson-Yap S, Kumar GT, Urashima M, Martineau AR.	medRxiv [Preprint]. 2020 Nov 25:2020.07.14.20152728. doi: 10.1101/2020.07.14.20152728.
Systemic adverse effects from inhaled corticosteroid use in asthma: a systematic review.	Patel R, Naqvi SA, Griffiths C, Bloom CI.	BMJ Open Respir Res. 2020 Dec;7(1):e000756. doi: 10.1136/bmjresp-2020-000756.
Evaluating the real-life effect of MP-AzeFlu on asthma outcomes in patients with allergic rhinitis and asthma in UK primary care.	De Jong HJI, Voorham J, Scadding GK, Bachert C, Canonica GW, Smith P, Wahn U, Ryan D, Castillo JA, Carter VA, Murray RB, Price DB.	World Allergy Organ J. 2020 Dec 19;13(12):100490. doi: 10.1016/j.waojou.2020.100490.
Vaccine effectiveness of live attenuated and trivalent inactivated influenza vaccination in 2010/11 to 2015/16: the SIVE II record linkage study.	Simpson CR, Lone NI, Kavanagh K, Englishby T, Robertson C, McMenamin J, Wissman BV, Vasileiou E, Butler CC, Ritchie LD, Gunson R, Schwarze J, Sheikh A.	Health Technol Assess. 2020 Dec;24(67):1-66. doi: 10.3310/hta24670.

November

Title	Authors	Reference
An update on controversies in e-cigarettes.	Bhatt JM, Ramphul M, Bush A.	Paediatr Respir Rev. 2020 Nov;36:75-86. doi: 10.1016/j.prrv.2020.09.003. Epub 2020 Sep 26.
Impact of COVID-19 on accident and emergency attendances and emergency and planned hospital admissions in Scotland: an interrupted time-series analysis.	Mulholland RH, Wood R, Stagg HR, Fischbacher C, Villacampa J, Simpson CR, Vasileiou E, McCowan C, Stock SJ, Docherty AB, Ritchie LD, Agrawal U, Robertson C, Murray JL, MacKenzie F, Sheikh A.	J R Soc Med. 2020 Nov;113(11):444-453. doi: 10.1177/0141076820962447. Epub 2020 Oct 4.
Systematic review of clinical effectiveness, components, and delivery of pulmonary rehabilitation in low-resource settings.	Habib GMM, Rabinovich R, Divgi K, Ahmed S, Saha SK, Singh S, Uddin A, Uzzaman MN, Pinnock H.	NPJ Prim Care Respir Med. 2020 Nov 19;30(1):52. doi: 10.1038/s41533-020-00210-y.
Spirometry and FeNO testing for asthma in children in UK primary care: a prospective observational cohort study of feasibility and acceptability.	Lo D, Beardsmore C, Roland D, Richardson M, Yang Y, Danvers L, Wilson A, Gaillard EA.	Br J Gen Pract. 2020 Oct 29;70(700):e809-e816. doi: 10.3399/bjgp20X713033.
Process evaluation within pragmatic randomised controlled trials: what is it, why is it done, and can we find it?-a systematic review.	French C, Pinnock H, Forbes G, Skene I, Taylor SJC.	Trials. 2020 Nov 9;21(1):916. doi: 10.1186/s13063-020-04762-9.
eNose breath prints as a surrogate biomarker for classifying patients with asthma by atopy.	Abdel-Aziz MI, Brinkman P, Vijverberg SJH, Neerincx AH, de Vries R, Dagelet YWF, Riley JH, Hashimoto S, Montuschi P, Chung KF, Djukanovic R, Fleming LJ, Murray CS, Frey U, Bush A, Singer F, Hedlin G, Roberts G, Dahlén SE, Adcock IM, Fowler SJ, Knipping K, Sterk PJ, Kraneveld AD, Maitland-van der Zee AH; U-BIOPRED Study Group; Amsterdam UMC Breath Research Group.	J Allergy Clin Immunol. 2020 Nov;146(5):1045-1055. doi: 10.1016/j.jaci.2020.05.038. Epub 2020 Jun 10.
Hormonal contraception and the risk of severe asthma exacerbation: 17-year population- based cohort study.	Nwaru BI, Tibble H, Shah SA, Pillinger R, McLean S, Ryan DP, Critchley H, Price DB, Hawrylowicz CM, Simpson CR, Soyiri IN, Appiagyei F, Sheikh A.	Thorax. 2020 Nov 23:thoraxjnl-2020-215540. doi: 10.1136/thoraxjnl-2020-215540. Epub ahead of print.
SABA Reliance Questionnaire (SRQ): Identifying Patient Beliefs Underpinning Reliever Overreliance in Asthma.	Chan AHY, Katzer CB, Horne R, Haughney J, Correia de Sousa J, Williams S, Kaplan A.	J Allergy Clin Immunol Pract. 2020 Nov-Dec;8(10):3482-3489.e1. doi: 10.1016/j.jaip.2020.07.014. Epub 2020 Jul 20.
Air pollution and health: recent advances in air pollution epidemiology to inform the European Green Deal: a joint workshop report of ERS, WHO, ISEE and HEI.	Hoffmann B, Roebbel N, Gumy S, Forastiere F, Brunekreef B, Jarosinska D, Walker KD, van Erp AM, O'Keefe R, Greenbaum D, Williams M, Krzyzanowski M, Kelly FJ, Brauer M, Bruyninckx H, Boogaard H.	Eur Respir J. 2020 Nov 5;56(5):2002575. doi: 10.1183/13993003.02575-2020.
Oral prednisolone for acute lower respiratory tract infection in clinically unrecognised asthma: an exploratory analysis of the Oral Steroids for Acute Cough (OSAC) randomised controlled trial.	Hawkey S, Young GJ, Little P, Moore M, Hay AD.	BJGP Open. 2020 Nov 3:bjgpopen20X101099. doi: 10.3399/bjgpopen20X101099. Epub ahead of print.
Asthma in children during the COVID-19 pandemic: lessons from lockdown and future directions for management.	Gupta A, Bush A, Nagakumar P.	Lancet Respir Med. 2020 Nov;8(11):1070-1071. doi: 10.1016/S2213-2600(20)30278-2. Epub 2020 Jun 25.

Publications 2020-2018

A summary of selected relevant publications by members of the Asthma UK Centre for Applied Research is available as both a PDF and an EXCEL sheet. Includes publications up to and including October 2020.

AUKCAR PUBLICATIONS 2020-2018 - PDF (1.03 MB PDF)

AUKCAR PUBLICATIONS 2020-2018 - Excel (71.45 KB Excel)

This article was published on 25 Apr, 2024