Asthma UK Centre for Applied Research


Research outputs from members of the Centre, and other relevant publications



Title Authors Summary Reference

Greenhouse gas emissions associated with suboptimal asthma care in the UK: the SABINA healthCARe-Based envirONmental cost of treatment (CARBON) study.

Wilkinson AJK, Maslova E, Janson C, Radhakrishnan V, Quint JK, Budgen N, Tran TN, Xu Y, Menzies-Gow A, Bell JP.

“Findings of the study suggest that addressing the high burden of poorly controlled asthma, including curbing high SABA use and its associated risk of exacerbations, may significantly alleviate asthma care-related carbon emissions.

Thorax. 2024 Feb 27:thorax-2023-220259. doi: 10.1136/thorax-2023-220259. Online ahead of print.PMID: 38413192

Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma.

Wechsler ME, Scelo G, Larenas-Linnemann DES, Findings of the study highlight the importance of systematic comorbidity evaluation.

Am J Respir Crit Care Med. 2024 Feb 1;209(3):262-272. doi: 10.1164/rccm.202305-0808OC.PMID: 38016003

Effect of Individual Patient Characteristics and Treatment Choices on Reliever Medication Use in Moderate-Severe Asthma: A Poisson Analysis of Randomised Clinical Trials.

van Dijkman SC, Yorgancıoğlu A, Pavord I, Brusselle G, Pitrez PM, Oosterholt S, Fumali S, Majumdar A, Della Pasqua O Individual demographic and clinical characteristics, as well as exacerbation history can be considered an indicator of the degree of asthma control. 

Adv Ther. 2024 Mar;41(3):1201-1225. doi: 10.1007/s12325-023-02774-w. Epub 2024 Feb 1.PMID: 38296921 Free PMC article. Clinical Trial.

Predictors of persistent poor control and validation of ASSESS score: Longitudinal 5-year follow-up of severe asthma cohort.

Tiew PY, Tay TR, Chen W, Price DB, Ong KY, Chotirmall SH, Koh MS. “Bronchiectasis and gastroesophageal reflux disease are predictors for persistent poor asthma control and targeted traits for precision medicine in severe asthma. The ASSESS score has a good prediction for persistent poor asthma control over 5 years.

J Allergy Clin Immunol Glob. 2023 Nov 20;3(1):100188. doi: 10.1016/j.jacig.2023.100188. eCollection 2024 Feb.PMID: 38173699

The Association Between Short-Acting β2-Agonist Over-Prescription, and Patient-Reported Acquisition and Use on Asthma Control and Exacerbations: Data from Australia.

Price D, Jenkins C, Hancock K, Vella R, Heraud F, Le Cheng P, Murray R, Beekman M, Bosnic-Anticevich S, Botini F, Carter V, Catanzariti A, Doan J, Fletton K, Kichkin A, Le T, Le Lievre C, Lau CM, Novic D, Pakos J, Ranasinghe K, Roussos A, Samuel-King J, Sharma A, Stewart D, Willet B, Bateman E; OPCA Improving Asthma Outcomes in Australia Research Group.

In Australia, short-acting β2-agonists (SABA) are available both over the counter and on prescription, and the ease of access may impact SABA use in the Australian population.

Adv Ther. 2024 Mar;41(3):1262-1283. doi: 10.1007/s12325-023-02746-0. Epub 2024 Feb 4.PMID: 38310584 

Type-2 inflammation: a key treatable trait associated with lung function decline in chronic airways disease.

Petousi N, Pavord ID, Kent BD.

“Phenotyping all patients with asthma and COPD by measuring their type-2 biomarkers is essential for identifying those at risk of lung function decline, exacerbations, people remodelling and death, and will allow earlier targeting of treatment.

Thorax. 2024 Feb 19:thorax-2023-221329. doi: 10.1136/thorax-2023-221329. Online ahead of print.PMID: 38373823

Biomarkers Associated with Lung Function Decline and Dupilumab Response in Patients with Asthma.

Pavord ID, de Prado Gómez L, Brusselle G, Jackson DJ, Brightling CE, Papi A, Maspero JF, Rabe KF, Korn S, Zhang M, Soler X, Jacob-Nara JA, Hardin M; QUEST Lung Function Decline Study Group.

“The analysis provides robust data supporting FeNO as a clinically viable prognostic biomarker for accelerated Lung Function Decline and predictive of the treatment response to dupilumab. Additional research is needed to establish patterns of LFD in patients with moderate-to-severe asthma, as well as the prognostic and predictive role of FeNO.”

Am J Respir Crit Care Med. 2024 Feb 8. doi: 10.1164/rccm.202310-1751LE. Online ahead of print.PMID: 38329781 


Can We Test the Function of the Small Airways in Children Outside the Laboratory?

Makrinioti H, Bush A.

Cohort studies pinpoint associations between early life lung function impairment and the development of asthma and COPD. DTG-SBW test is a measure of the uniformity of lung ventilation and gas mixing efficiency, feasible in a pediatric field setting.

Chest. 2024 Feb;165(2):241-242. doi: 10.1016/j.chest.2023.10.004.PMID: 38336434 

A simple and effective evidence-based approach to asthma management: ICS-formoterol reliever therapy.

Levy ML, Beasley R, Bostock B, Capstick TG, Crooks MG, Fleming L, Freeman D, Marsh V, Rupani H, Whittamore A, Barnes PJ, Bush A.

Traditionally, SABA inhalers are prescribed as the first step in managing asthma, however SABA monotherapy fails to alleviate inflammation. ICS-formoterol reliever alone reduces severe exacerbations compared with SABA monotherapy in mild asthma.

Br J Gen Pract. 2024 Jan 25;74(739):86-89. doi: 10.3399/bjgp24X736353. Print 2024 Feb.PMID: 38272684 

International variation in severe exacerbation rates in patients with severe asthma.

Lee TY, Price D, Yadav CP, Roy R, Mien LLH, Wang E, Wechsler ME, Jackson DJ, Busby J, Heaney LG, Pfeffer PE, Mahboub B, Perng Steve DW, Cosio BG, Perez-de-Llano L, Al-Lehebi R, Larenas-Linnemann D, Al-Ahmad M, Rhee CK, Iwanaga T, Heffler E, Canonica GW, Costello R, Papadopoulos NG, Papaioannou AI, Porsbjerg CM, Torres-Duque CA, Christoff GC, Popov TA, Hew M, Peters M, Gibson PG, Maspero J, Bergeron C, Cerda S, Contreras Contreras EA, Chen W, Sadatsafavi M.

Study shows a large between-country variation in observed severe exacerbation rate, suggesting adapted clinical recommendations for severe asthma.

Chest. 2024 Feb 21:S0012-3692(24)00264-2. doi: 10.1016/j.chest.2024.02.029. Online ahead of print.PMID: 38395297 

How have we measured trial outcomes of asthma attack treatment? A systematic review.

Howell I, Howell A, Ramakrishnan S, Bafadhel M, Pavord I.

Outcomes in randomised controlled trials of asthma attack treatment focus on short-term changes in lung function and may not capture patient-centred and economically important longer-term measures.”

ERJ Open Res. 2024 Feb 26;10(1):00660-2023. doi: 10.1183/23120541.00660-2023. eCollection 2024 Jan.PMID: 38410715 

Long-term air pollution exposure and risk of SARS-CoV-2 infection: A UK-wide cohort study.

Hajmohammadi H, Talaei M, Fecht D, Wang W, Vivaldi G, Faustini SE, Richter AG, Shaheen SO, Martineau AR, Sheikh A, Mudway IS, Griffiths CJ. Findings of the study suggest that the long-term burden of air pollution increased the risks of SARS-CoV-2 infection and has important implications for future pandemic preparedness. Respir Med. 2024 Feb 27:107567. doi: 10.1016/j.rmed.2024.107567. Online ahead of print.PMID: 38423343

Evaluating the Feasibility of a Community Pharmacy-Delivered Behaviour Change Intervention to Reduce Reliever Reliance in Asthma.

Foot H, Beyene K, Horne R, Fingleton J, Harrison J, Chan AHY. Brief pharmacy-delivered intervention is feasible and acceptable to patients and pharmacy staff, changing patients’ beliefs about SABA, as well as making pharmacists aware of SABA overuse. Patient Prefer Adherence. 2024 Feb 7;18:361-371. doi: 10.2147/PPA.S445763. eCollection 2024.PMID: 38344153 

Challenges in diagnosing asthma in children.

Chisholm K, Daines L, Turner S.

Asthma can be diagnosed in children under 5, but is unlikely to explain recurrent respiratory symptoms in children under 2”.

BMJ. 2024 Feb 13;384:e075924. doi: 10.1136/bmj-2023-075924.PMID: 38350681

Time-dependent gene-environment interactions are essential drivers of asthma initiation and persistence.

Chatziparasidis G, Chatziparasidi MR, Kantar A, Bush A. Study introduces the importance of the time variant in asthma pathogenesis and emphasize the long-term clinical significance of the time-dependent gene-environment interactions in childhood. Pediatr Pulmonol. 2024 Feb 21. doi: 10.1002/ppul.26935. Online ahead of print.PMID: 38380964





Publications 2020-2018

A summary of selected relevant publications by members of the Asthma UK Centre for Applied Research is available as both a PDF and an EXCEL sheet. Includes publications up to and including October 2020.