Dr Maurice Gallagher
Location: Darwin 7.03
Member of the ASM, SGM and Biochemical societies
Recent and current co-workers:Jacqui Reyner, Katy Woodall, Sarah Shrimpton, Louise McGibbon, Peter Gwynne, Graham Dall, Jon Stanley
Course Organiser for Molecular Microbiology 3 and honours year vaccines elective. Also teaching on SFP 3 and Biotechnology 3 and 4. QA & QE officer for the School of Biological Sciences.
Our lab is focused around addressing issues of bacteriology and biotechnology. We use a wide range of approaches, including genetics, molecular (and synthetic) biology, microbial physiology, gene expression profiling (e.g. microarrays), gene cloning and disruption, low and high throughput sequencing (e.g. Solexa), protein expression and purification, proteomics, interactome analysis, and immunomics. However, our guiding principle is not based on using a range of technological approaches but rather, to define the key questions and issues that we wish to address, and then approach this in the most appropriate scientific manner.
Much of our current work is collaborative and has potential intellectual property value so is not published. However, our lab is focused mainly on studying bacterial pathogens, particularly those associated with food borne infection (e.g. Salmonella, Campylobacter, Clostridia) and medical implant infections (e.g. Staphylococcus, Streptococcus, Enterococcus, Enterobacter, Klebsiella). Key themes include:
We also have a long history of studying bacterial solute transport systems per se and as models for diseases such as cystic fibrosis and multi-drug resistance in cancer cells.
Pernagallo, S, Wu, M, Gallagher, MP and M Bradley (2011). Colonising new frontiers - microarrays reveal biofilm modulating polymers. J. Mater. Chem. Volume 21, Issue 1, Pages 96-101.
Morgan, HP, Estibeiro, P, Wear, MA, Max, KEA, Heinemann, U, Cubeddu, L, Gallagher, MP , Sadler, PJ, and MD Walkinshaw (2007). Sequence specificity of single-stranded DNA-binding proteins: a novel DNA microarray approach. Nucleic Acids Res. 35: e75.
Patching, SG, Baldwin, SA, Baldwin, AD, Young JD, Gallagher, MP , Henderson PJ and RB Herbert (2005) The nucleoside transport proteins, NupC and NupG, from Escherichia coli: specific structural motifs necessary for the binding of ligands. J. Org. Biomolec. Chem. 3(3), 462-470.
Gaze, W H, Burroughs, N, Gallagher, MP and EMH Wellington (2003) Interactions between Salmonella typhimurium and Acanthamoeba polyphaga, and observation of a new mode of intracellular growth within contractile vacuoles. Microbial Ecol. 46 (3), 358-369.
Goulsbra, A., Edwards, C., & M.P. Gallagher. (2001) Surface hygiene monitored using a reporter of fis expression in Escherichia coli. J. Applied Microbiol. 90, 1-6.
McCabe, P. M., Gallagher, M.P. & Deacon, J.W. (1999) Evidence for segregation of somatic incompatibility during hyphal tip subculture of Rhizoctonia solani AG 4. Mycological Research. 103(10), 1323-1331.
Taylor, P.D., Inchley, C.J. & Gallagher, M.P. (1998). The Salmonella typhimurium AhpC polypeptide is not essential for virulence in BALB/c mice but is recognised as an antigen during infection. Infect. Immun. 66, 3208-3217.
Craig, J.E., Boyle, D., Francis, K.P. and M.P. Gallagher. (1998). Expression of cspB in Salmonella typhimurium occurs below a threshold temperature. Microbiol. 144, 697-704.
Francis, K.P., Taylor, P.D., Inchley, C.J. & M.P. Gallagher. (1997) Identification of the ahp operon of Salmonella typhimurium as a macrophage-induced locus. J. Bacteriol. 179, 4046-4048.
Aarons, S.J., Sutherland I.W., Chakrabarty, A.M., and Gallagher, M.P. (1997). A novel gene algK from the alginate biosynthetic cluster of Pseudomonas aeruginosa. Microbiology 143, 641-652.
Francis, K.P. & Gallagher, M.P. (1993). Light emission from a Mu dlux transcriptional fusion in Salmonella typhimurium is stimulated by hydrogen peroxide and by interaction with the mouse macrophage cell line J774.2. Infect. Immun. 61, 640-649.
Hyde, S.C., Emsley, P., Hartshorn, M.J., Mimmack, M.L., Gileadi, U., Pearce, S.R., Gallagher, M.P. , Gill, D., Hubbard, R.E. & Higgins, C.F. (1990). Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport. Nature 346, 362-365.
Gallagher, M.P. , Marshall, R.D. & Wilson, R. (1989). L-Asparaginase as used in therapy of acute lymphoblastic leukaemia. Essays in Biochemistry 24, 1-40.
This article was published on Feb 8, 2012